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The map label for this gene is pdhR [H]

Identifier: 157372246

GI number: 157372246

Start: 4451469

End: 4452233

Strand: Reverse

Name: pdhR [H]

Synonym: Spro_4012

Alternate gene names: 157372246

Gene position: 4452233-4451469 (Counterclockwise)

Preceding gene: 157372250

Following gene: 157372245

Centisome position: 81.71

GC content: 56.73

Gene sequence:

>765_bases
ATGGCCTACAGCAAAATCCGCCAACCCAAGTTGTCAGACGTCATCGAGCAGCAGCTCGAACACCTGATCCTCGAGGGAAC
ACTGCGTCCAGGCGAAAAACTGCCACCGGAGCGTGAACTGGCGAAACAATTTGATGTTTCCCGTCCTTCTCTGAGAGAGG
CTATCCAGCGCCTGGAAGCCAAAGGGTTGCTCCTGCGCCGTCAGGGCGGTGGCACCTTTGTACAAACTAATCTGTGGCAG
AGCTTTAGCGATCCGCTGGCTGAACTGCTGGCCGACCATCCTGAATCACAATTCGATCTGTTGGAAACCCGTCATGCCCT
CGAAGGCATTGCTGCCTATTACGCGGCGTTGCGCGGTACCGACGAAGATCTGGCACGCATCCGCGATTGCCATATGCTGA
TTCAGCAGGCCCAGGACAGCGGCGATCTCGACGCCGAAGCCGACGCGGTCATGCAATACCAAATCGCCGTGACCGAAGCT
GCCCACAACGTTGTGTTACTGCACCTGCTGCGCTGTATGGGGCCGATGCTGGAACAGAACGTCCGTCAGAACTTTGAATT
GCTCTACTCGCGCCGTGAGATGTTGGCAAAAGTGAGCAGCCACCGCGCCGGAATTTTTGAGGCGATTGTGGCACGCGAGC
CAGAAAAAGCTCGTGAAGCCTCGCACCGCCATTTGGCGTTTATCGAGGAAATCTTGCTGGATCTCAGTCGGGAGCATACC
CGACGCGAGAGATCGCTGCGGCGTCTCCAGCAACGCAAGGATTAA

Upstream 100 bases:

>100_bases
CCATATGGACAGGAGGTGAATACTTTGTTACTTTACCGTCACGTTTTTGAAATTGGTATTACCAATTGACTCCGCGCCAT
TCGCAGAGAAGAAATCACCC

Downstream 100 bases:

>100_bases
GAGCGGTTCTCTTCAGGGCACACCAGCCTGCGGGGTTTACGTTCGAAGTGCTTAATTAAGCATTTAAGTAAGCGGCAACT
AAACTGATGGGCCTGTCTTC

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAYSKIRQPKLSDVIEQQLEHLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQ
SFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLARIRDCHMLIQQAQDSGDLDAEADAVMQYQIAVTEA
AHNVVLLHLLRCMGPMLEQNVRQNFELLYSRREMLAKVSSHRAGIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHT
RRERSLRRLQQRKD

Sequences:

>Translated_254_residues
MAYSKIRQPKLSDVIEQQLEHLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQ
SFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLARIRDCHMLIQQAQDSGDLDAEADAVMQYQIAVTEA
AHNVVLLHLLRCMGPMLEQNVRQNFELLYSRREMLAKVSSHRAGIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHT
RRERSLRRLQQRKD
>Mature_253_residues
AYSKIRQPKLSDVIEQQLEHLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQS
FSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLARIRDCHMLIQQAQDSGDLDAEADAVMQYQIAVTEAA
HNVVLLHLLRCMGPMLEQNVRQNFELLYSRREMLAKVSSHRAGIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHTR
RERSLRRLQQRKD

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=87.6068376068376, Blast_Score=412, Evalue=1e-117,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=35.5371900826446, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789353, Length=236, Percent_Identity=30.0847457627119, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790780, Length=222, Percent_Identity=32.8828828828829, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI48994955, Length=225, Percent_Identity=30.2222222222222, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082208, Length=223, Percent_Identity=29.5964125560538, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29202; Mature: 29071

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKIRQPKLSDVIEQQLEHLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQTNLWQSFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGT
HCHHEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DEDLARIRDCHMLIQQAQDSGDLDAEADAVMQYQIAVTEAAHNVVLLHLLRCMGPMLEQN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYSRREMLAKVSSHRAGIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRLQQRKD
HHHHHHHHHHHHCC
>Mature Secondary Structure 
AYSKIRQPKLSDVIEQQLEHLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQTNLWQSFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGT
HCHHEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DEDLARIRDCHMLIQQAQDSGDLDAEADAVMQYQIAVTEAAHNVVLLHLLRCMGPMLEQN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYSRREMLAKVSSHRAGIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRLQQRKD
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]