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The map label for this gene is aceE [H]

Identifier: 157372245

GI number: 157372245

Start: 4448635

End: 4451298

Strand: Reverse

Name: aceE [H]

Synonym: Spro_4011

Alternate gene names: 157372245

Gene position: 4451298-4448635 (Counterclockwise)

Preceding gene: 157372246

Following gene: 157372244

Centisome position: 81.69

GC content: 54.17

Gene sequence:

>2664_bases
ATGTCAGAACGTTTAAACAATGACGTGGATCCGATCGAAACCCGCGACTGGCTGCAGGCGATCGAATCGGTCATCCGTGA
AGAGGGTGTTGAGCGAGCTCAGTTTCTGATTGATCAGGTTCTGGGTGAAGCCCGTAAAGGCGGTGTTAGCGTTGCAGCCG
GTGCTGCGGCTCACAACTACGTCAACACCATCGCGGTGGAAGACGAACCTGCTTACCCTGGTAACCTGGATCTTGAGCGT
CGTATCCGCAGCGCTATTCGCTGGAATGCGGTAATGACCGTTCTTCGTGCTTCCAAAAAAGATCTGGATCTGGGCGGCCA
CATGGCTTCCTTCCAATCTTCTGCGACCTTCTATGAAGTCTGCTTCAACCACTTCTTCCGTGCACGCACCGAACAAGATG
GCGGCGATCTGGTTTACTTCCAGGGCCACATCTCTCCGGGCGTTTACGCACGTGCCTTCCTTGAAGGCCGCTTGACCGAA
GACCAAATGAATAACTTCCGTCAGGAAGTTCACGGTAAAGGCCTGTCGTCTTACCCGCATCCTAAATTGATGCCGGAATT
CTGGCAGTTCCCGACCGTTTCCATGGGCCTGGGCCCAATCAGCGCCATCTATCAAGCGAAGTTCCTGAAATATCTGGAAC
ACCGTGGCCTGAAGAACACCTCTGCTCAAACCGTTTACGCCTTCCTGGGCGACGGCGAGATGGATGAGCCGGAATCCAAG
GGCGCGATCACCATCGCTACCCGTGAGAAGCTGGACAACCTGGTATTCGTCATCAACTGCAACCTGCAGCGTCTGGACGG
CCCGGTCACCGGTAACGGCAAGATCATCAATGAGCTGGAAGGCATCTTCGCGGGCGCAGGCTGGCAGGTACTGAAAGTGA
TCTGGGGTGGTCGTTGGGATGAACTGCTGCGTAAAGATACCAGCGGCAAGCTGATCCAACTGATGAACGAAACCCTGGAC
GGCGACTACCAGACCTTCAAATCCAAAGACGGCGCTTACGTACGTGAGCACTTCTTCGGTCGCTTCCCGGAAACTGCTGC
GTTGGTCAAAGATATGACCGACGAAGAGATCTGGGCGCTGAACCGTGGCGGTCACGATCCGAAGAAAGTCTTTGCTGCAC
TGAAAAAAGCGCAGGACACCCAAGGCAAACCAACCGTTATCCTGGCCCATACCATCAAAGGTTACGGCATGGGTGAAACC
GCGGAAGGTAAAAACATTGCTCACCAGGTGAAGAAAATGAACATGGAAGGGGTTCACCACTTCCGCGATCGTTTCAACGT
GCCGGTTGCCGATGCTGACATCGAAAAACTGCCGTACGTCACCTTCGAGAAAGATTCCGAAGAGTACAAATATCTGCACG
AACGTCGTCAGGCGCTGGCAGGCTATGTGCCTACCCGTATGCCGAAGTTCACCGAGAAGCTGGAAATGCCGGCTCTGGCA
GACTTCAGCTCCTTGCTGGAAGAGCAGAACAAAGAAATTTCTACCACCATCGCCTTCGTGCGTGCCCTGAACGTGATGCT
GAAGAACAAGTCGATCAAAGATCGCCTGGTTCCAATCATTGCCGACGAAGCTCGTACCTTCGGCATGGAAGGTCTGTTCC
GTCAGATCGGTATCTACAGCCCGAACGGCCAGCAGTACACTCCGCAGGACCGTGAGCAGGTTGCTTACTACAAAGAAGAC
GAGAAAGGCCAGATCCTGCAGGAAGGCATCAACGAACTGGGTGCAGCCTCTTCATGGTTGGCCGCAGCGACTTCCTACAG
CACCAACGATCTGCCAATGATCCCGTTCTACATCTACTATTCGATGTTCGGTTTCCAGCGTATCGGTGACCTGTGCTGGG
CAGCAGGCGACCAACAGGCGCGCGGCTTCCTGGTAGGCGGTACTTCAGGCCGTACCACCCTGAACGGTGAAGGTCTGCAG
CACGAAGACGGCCACAGCCACATCCAGTCCCTGACTATTCCTAACTGTATCTCTTACGATCCAGCTTACGCGTACGAAGT
GGCAGTGATCATGCACGACGGTCTGGTTCGCATGTACGGTGACGCGCAAGAAAACGTCTACTACTACATCACCACGCTGA
ACGAAAACTACCACATGCCGGCTATGCCGCAGGGTGCAGAAGAAGGTATCCGTAAAGGTATCTACAAGCTGGACACTCTG
GCAGGCAGCAAAGGCAAGGTTCAGTTGCTGGGTTCAGGTTCTATCCTGCGTCACGTTCGTGAAGCGGCGAAGATCCTGGC
TGACGATTACGGCGTGGGTTCTGACATCTACAGCGTGACTTCCTTCACTGAACTGGCGCGTGATGGCCAGGATTGTGAGC
GTTGGAACATGCTGCACCCAACCGAAACTCCGCGCGTACCTTACATCGCTCAGGTGATGAACGAAGCGCCGGCGGTTGCG
TCTACCGACTACATGAAGCTGTTCGCAGAACAGGTTCGTACTTACGTTCCAGCCAGCGACTATCGCGTTCTGGGTACTGA
CGGCTTCGGTCGTTCAGACAGCCGCGAAAACCTGCGCCACCACTTTGAAGTTGATGCTTCTTACGTTGTGGTTGCTGCAC
TGGGTGAACTGGCTAAACGCGGTGAAATCGAAGCTTCTGTGGTAGCTGATGCGATTAAGAAATTCGACATCAACCCAGAA
AAAGTTAACCCGCGTCTGGCATAA

Upstream 100 bases:

>100_bases
AGCGGCAACTAAACTGATGGGCCTGTCTTCGTGTGTTTTGCCTCAGAACACAGGAAGACAGGCTCCAAAACAAACCATTA
GACAGATAAGGAATACCACC

Downstream 100 bases:

>100_bases
GAGGTACAGAAGAATGTCTATCGAAATTAAAGTACCGGACATCGGTGCAGACGAAGTGGAAATCACCGAAATTCTGGTGA
AAGTGGGCGATAAAGTTGAA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSERLNNDVDPIETRDWLQAIESVIREEGVERAQFLIDQVLGEARKGGVSVAAGAAAHNYVNTIAVEDEPAYPGNLDLER
RIRSAIRWNAVMTVLRASKKDLDLGGHMASFQSSATFYEVCFNHFFRARTEQDGGDLVYFQGHISPGVYARAFLEGRLTE
DQMNNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPISAIYQAKFLKYLEHRGLKNTSAQTVYAFLGDGEMDEPESK
GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFAGAGWQVLKVIWGGRWDELLRKDTSGKLIQLMNETLD
GDYQTFKSKDGAYVREHFFGRFPETAALVKDMTDEEIWALNRGGHDPKKVFAALKKAQDTQGKPTVILAHTIKGYGMGET
AEGKNIAHQVKKMNMEGVHHFRDRFNVPVADADIEKLPYVTFEKDSEEYKYLHERRQALAGYVPTRMPKFTEKLEMPALA
DFSSLLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKED
EKGQILQEGINELGAASSWLAAATSYSTNDLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLVGGTSGRTTLNGEGLQ
HEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLVRMYGDAQENVYYYITTLNENYHMPAMPQGAEEGIRKGIYKLDTL
AGSKGKVQLLGSGSILRHVREAAKILADDYGVGSDIYSVTSFTELARDGQDCERWNMLHPTETPRVPYIAQVMNEAPAVA
STDYMKLFAEQVRTYVPASDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIEASVVADAIKKFDINPE
KVNPRLA

Sequences:

>Translated_887_residues
MSERLNNDVDPIETRDWLQAIESVIREEGVERAQFLIDQVLGEARKGGVSVAAGAAAHNYVNTIAVEDEPAYPGNLDLER
RIRSAIRWNAVMTVLRASKKDLDLGGHMASFQSSATFYEVCFNHFFRARTEQDGGDLVYFQGHISPGVYARAFLEGRLTE
DQMNNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPISAIYQAKFLKYLEHRGLKNTSAQTVYAFLGDGEMDEPESK
GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFAGAGWQVLKVIWGGRWDELLRKDTSGKLIQLMNETLD
GDYQTFKSKDGAYVREHFFGRFPETAALVKDMTDEEIWALNRGGHDPKKVFAALKKAQDTQGKPTVILAHTIKGYGMGET
AEGKNIAHQVKKMNMEGVHHFRDRFNVPVADADIEKLPYVTFEKDSEEYKYLHERRQALAGYVPTRMPKFTEKLEMPALA
DFSSLLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKED
EKGQILQEGINELGAASSWLAAATSYSTNDLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLVGGTSGRTTLNGEGLQ
HEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLVRMYGDAQENVYYYITTLNENYHMPAMPQGAEEGIRKGIYKLDTL
AGSKGKVQLLGSGSILRHVREAAKILADDYGVGSDIYSVTSFTELARDGQDCERWNMLHPTETPRVPYIAQVMNEAPAVA
STDYMKLFAEQVRTYVPASDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIEASVVADAIKKFDINPE
KVNPRLA
>Mature_886_residues
SERLNNDVDPIETRDWLQAIESVIREEGVERAQFLIDQVLGEARKGGVSVAAGAAAHNYVNTIAVEDEPAYPGNLDLERR
IRSAIRWNAVMTVLRASKKDLDLGGHMASFQSSATFYEVCFNHFFRARTEQDGGDLVYFQGHISPGVYARAFLEGRLTED
QMNNFRQEVHGKGLSSYPHPKLMPEFWQFPTVSMGLGPISAIYQAKFLKYLEHRGLKNTSAQTVYAFLGDGEMDEPESKG
AITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFAGAGWQVLKVIWGGRWDELLRKDTSGKLIQLMNETLDG
DYQTFKSKDGAYVREHFFGRFPETAALVKDMTDEEIWALNRGGHDPKKVFAALKKAQDTQGKPTVILAHTIKGYGMGETA
EGKNIAHQVKKMNMEGVHHFRDRFNVPVADADIEKLPYVTFEKDSEEYKYLHERRQALAGYVPTRMPKFTEKLEMPALAD
FSSLLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDE
KGQILQEGINELGAASSWLAAATSYSTNDLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLVGGTSGRTTLNGEGLQH
EDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLVRMYGDAQENVYYYITTLNENYHMPAMPQGAEEGIRKGIYKLDTLA
GSKGKVQLLGSGSILRHVREAAKILADDYGVGSDIYSVTSFTELARDGQDCERWNMLHPTETPRVPYIAQVMNEAPAVAS
TDYMKLFAEQVRTYVPASDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIEASVVADAIKKFDINPEK
VNPRLA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=887, Percent_Identity=89.0642615558061, Blast_Score=1674, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99311; Mature: 99180

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLNNDVDPIETRDWLQAIESVIREEGVERAQFLIDQVLGEARKGGVSVAAGAAAHNY
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHC
VNTIAVEDEPAYPGNLDLERRIRSAIRWNAVMTVLRASKKDLDLGGHMASFQSSATFYEV
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHH
CFNHFFRARTEQDGGDLVYFQGHISPGVYARAFLEGRLTEDQMNNFRQEVHGKGLSSYPH
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PKLMPEFWQFPTVSMGLGPISAIYQAKFLKYLEHRGLKNTSAQTVYAFLGDGEMDEPESK
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC
GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFAGAGWQVLKVIWGGRWD
CCEEEEEHHHHCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHH
ELLRKDTSGKLIQLMNETLDGDYQTFKSKDGAYVREHFFGRFPETAALVKDMTDEEIWAL
HHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHCCCCCHHEEE
NRGGHDPKKVFAALKKAQDTQGKPTVILAHTIKGYGMGETAEGKNIAHQVKKMNMEGVHH
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHH
FRDRFNVPVADADIEKLPYVTFEKDSEEYKYLHERRQALAGYVPTRMPKFTEKLEMPALA
HHHHCCCCCCCCCHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHH
DFSSLLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYS
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
PNGQQYTPQDREQVAYYKEDEKGQILQEGINELGAASSWLAAATSYSTNDLPMIPFYIYY
CCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDLCWAAGDQQARGFLVGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYD
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCCCCCCCCC
PAYAYEVAVIMHDGLVRMYGDAQENVYYYITTLNENYHMPAMPQGAEEGIRKGIYKLDTL
CCHHEEEEEEECCCHHEECCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AGSKGKVQLLGSGSILRHVREAAKILADDYGVGSDIYSVTSFTELARDGQDCERWNMLHP
CCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCC
TETPRVPYIAQVMNEAPAVASTDYMKLFAEQVRTYVPASDYRVLGTDGFGRSDSRENLRH
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HFEVDASYVVVAALGELAKRGEIEASVVADAIKKFDINPEKVNPRLA
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCC
>Mature Secondary Structure 
SERLNNDVDPIETRDWLQAIESVIREEGVERAQFLIDQVLGEARKGGVSVAAGAAAHNY
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHC
VNTIAVEDEPAYPGNLDLERRIRSAIRWNAVMTVLRASKKDLDLGGHMASFQSSATFYEV
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHH
CFNHFFRARTEQDGGDLVYFQGHISPGVYARAFLEGRLTEDQMNNFRQEVHGKGLSSYPH
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PKLMPEFWQFPTVSMGLGPISAIYQAKFLKYLEHRGLKNTSAQTVYAFLGDGEMDEPESK
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCC
GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFAGAGWQVLKVIWGGRWD
CCEEEEEHHHHCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHH
ELLRKDTSGKLIQLMNETLDGDYQTFKSKDGAYVREHFFGRFPETAALVKDMTDEEIWAL
HHHHCCCCCHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCHHHHHHHCCCCCHHEEE
NRGGHDPKKVFAALKKAQDTQGKPTVILAHTIKGYGMGETAEGKNIAHQVKKMNMEGVHH
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHH
FRDRFNVPVADADIEKLPYVTFEKDSEEYKYLHERRQALAGYVPTRMPKFTEKLEMPALA
HHHHCCCCCCCCCHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHH
DFSSLLEEQNKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYS
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
PNGQQYTPQDREQVAYYKEDEKGQILQEGINELGAASSWLAAATSYSTNDLPMIPFYIYY
CCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDLCWAAGDQQARGFLVGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYD
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCCCCCCCCC
PAYAYEVAVIMHDGLVRMYGDAQENVYYYITTLNENYHMPAMPQGAEEGIRKGIYKLDTL
CCHHEEEEEEECCCHHEECCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AGSKGKVQLLGSGSILRHVREAAKILADDYGVGSDIYSVTSFTELARDGQDCERWNMLHP
CCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCC
TETPRVPYIAQVMNEAPAVASTDYMKLFAEQVRTYVPASDYRVLGTDGFGRSDSRENLRH
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
HFEVDASYVVVAALGELAKRGEIEASVVADAIKKFDINPEKVNPRLA
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]