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The map label for this gene is hpt [H]

Identifier: 157372232

GI number: 157372232

Start: 4432957

End: 4433493

Strand: Reverse

Name: hpt [H]

Synonym: Spro_3998

Alternate gene names: 157372232

Gene position: 4433493-4432957 (Counterclockwise)

Preceding gene: 157372233

Following gene: 157372230

Centisome position: 81.37

GC content: 54.75

Gene sequence:

>537_bases
ATGAAACACACTGTAGAAGTAATGATTTCCGAGCAGGAAGTTAAGACCCGTATCGCCGAACTTGGCCGCCAGATCACCGA
AGATTACCGCGATAGCGGCAGTGATATGGTGCTGGTCGGGCTGCTGCGCGGTTCCTTTATGTTCATGGCCGATCTGTGTC
GCACCATTGAAGTGCCGCATGAGGTCGACTTTATGACCGCCTCCAGCTACGGCAGCGGCATGTCCACCACCCGTGACGTG
AAAATCCTCAAGGATTTGGATGAAGACATCCGTGGCAAAGACGTGCTGATCGTCGAAGACATCATTGACTCCGGCAATAC
GCTGAACAAAGTGCGCGAAATTCTGGCGTTGCGCGGGCCGAAATCACTGGCGATTTGCACCCTGCTGGACAAGCCTGAAC
GTCGTGAAGTCGAAGTGCCGGTGGAGTACGTGGGCTTCCCGATCCCGGACGAGTTCGTGGTGGGTTATGGCATCGATTAC
GCTCAGCGTTATCGCCATTTGCCGTACGTCGGCAAAGTAGTGCTGCTGGACGAGTAA

Upstream 100 bases:

>100_bases
GATCTACCCCCATGGAAAACCGGGCGGCGCACTCGCGTCGCCAGCGGCGTCAGGCTATGCTAAACTCTGCGCCCTTCTTC
CGGCAACTGACCTGAAAACT

Downstream 100 bases:

>100_bases
TATGCGGTGGGCGCGGTTTGCCGCGCCCCTGACAGGATTAAATACCCTTATCCTGCTGCAGTGTAGCCATCGCCTTGCGA
TAGCCCATTTCCAGGCTTTC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MKHTVEVMISEQEVKTRIAELGRQITEDYRDSGSDMVLVGLLRGSFMFMADLCRTIEVPHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLNKVREILALRGPKSLAICTLLDKPERREVEVPVEYVGFPIPDEFVVGYGIDY
AQRYRHLPYVGKVVLLDE

Sequences:

>Translated_178_residues
MKHTVEVMISEQEVKTRIAELGRQITEDYRDSGSDMVLVGLLRGSFMFMADLCRTIEVPHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLNKVREILALRGPKSLAICTLLDKPERREVEVPVEYVGFPIPDEFVVGYGIDY
AQRYRHLPYVGKVVLLDE
>Mature_178_residues
MKHTVEVMISEQEVKTRIAELGRQITEDYRDSGSDMVLVGLLRGSFMFMADLCRTIEVPHEVDFMTASSYGSGMSTTRDV
KILKDLDEDIRGKDVLIVEDIIDSGNTLNKVREILALRGPKSLAICTLLDKPERREVEVPVEYVGFPIPDEFVVGYGIDY
AQRYRHLPYVGKVVLLDE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=174, Percent_Identity=35.0574712643678, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=30.635838150289, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI87081689, Length=178, Percent_Identity=88.7640449438202, Blast_Score=325, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=36.046511627907, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20142; Mature: 20142

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTVEVMISEQEVKTRIAELGRQITEDYRDSGSDMVLVGLLRGSFMFMADLCRTIEVPH
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
EVDFMTASSYGSGMSTTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLNKVREILALRGP
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHCCCC
KSLAICTLLDKPERREVEVPVEYVGFPIPDEFVVGYGIDYAQRYRHLPYVGKVVLLDE
CCEEEEEECCCCCCCCEECCHHHCCCCCCCHHEEECCCCHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure
MKHTVEVMISEQEVKTRIAELGRQITEDYRDSGSDMVLVGLLRGSFMFMADLCRTIEVPH
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
EVDFMTASSYGSGMSTTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLNKVREILALRGP
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHCCCC
KSLAICTLLDKPERREVEVPVEYVGFPIPDEFVVGYGIDYAQRYRHLPYVGKVVLLDE
CCEEEEEECCCCCCCCEECCHHHCCCCCCCHHEEECCCCHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]