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The map label for this gene is fhuD [H]

Identifier: 157372211

GI number: 157372211

Start: 4408455

End: 4409363

Strand: Reverse

Name: fhuD [H]

Synonym: Spro_3977

Alternate gene names: 157372211

Gene position: 4409363-4408455 (Counterclockwise)

Preceding gene: 157372212

Following gene: 157372210

Centisome position: 80.92

GC content: 57.76

Gene sequence:

>909_bases
ATGCCTGATTCCTCCGATTTTCACCATGACGCCGTTCGCCGACGCCTGTTGACGGCAATGGCGCTGTCACCCTTGTTGTT
TTCTTTGCCGGGACAAGCCGCAGCCACGCCGCCTGACCTTGCGCGTATTGTGGCGCTGGAATGGCTGCCGATTGAGCTGC
TGTTGGCGCTGGGGGTTACCCCGCTGGCGGTCGCTGATATCCATAACTACAACCTGTGGGTGGAAGAGCCAAAGTTGCCG
GCCTCGGTGATTGATGTCGGTCAGCGCACCGAACCTAACCTCGAGCTGTTACAGCAGCTTCAGCCATCGCTGATGTTGCT
GTCGAAAGGCTATGGCCCCACGCCGCAAAAGCTGGAGCCGATAGCGCCCTCAATGAGCTTTAGCTTCAACGACGGCAGCG
GCAAGCCGCTGACGGTGGCCAGGCAGTCACTGCAGGCATTGGCGCAGCGGTTGGGGCTGGAAACCCGGGCGGTGCAGCAT
TTGGCTCAGTTTGACCGCTTTATTCAGGATGCGCGTCAGCGTCTGCATTCATACACCACACGGCCATTGCTGATGTTTTC
ACTGATCGACACTCGCCATGCGCTGGTCATTGGCCAGAAAAGCCTGTTCCAGGAAGTGATGGATCAGCTTGGAATAATCA
ATGCCTGGGAAGGGGAAACCAACTTTTGGGGCACGGCAGTGGTGGGGATTGAACGTCTGGCGGTGGTGAAAAGTGCGCGG
GCGATTTATCTCGACCACGGTAATCAGGAAATGTTGAAGAAAGTCAGTTCCACCCCGCTGTGGCAGGCATTACCGTTCGT
GCGGCAGAATCAATTGCGCCAGGTGCCGGCGGTGTGGTTCTACGGGGCAACGCTGTCGGCGATGCGCTTCTGTCATCTGC
TGGAGCAGGCGCAGGAGAGTTATTCATGA

Upstream 100 bases:

>100_bases
TGGATCTGATGCAGGGCGAGGTGCTGGAACAAATTTACGGTATTCCTATGGGAACGCTGCCACATCCAAGCGGCGGTGCG
CCGGTGAGTTTTGTCTACTG

Downstream 100 bases:

>100_bases
GCGCGCGCATCCGGGCATTTCCGCTGACGCTGGTACTGCTGCTGTTGGCTGCGGCTGGCGGCCTGACTCTCTACAACCTG
TTGCAACAACTGCCCTGGGC

Product: iron-hydroxamate transporter substrate-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPDSSDFHHDAVRRRLLTAMALSPLLFSLPGQAAATPPDLARIVALEWLPIELLLALGVTPLAVADIHNYNLWVEEPKLP
ASVIDVGQRTEPNLELLQQLQPSLMLLSKGYGPTPQKLEPIAPSMSFSFNDGSGKPLTVARQSLQALAQRLGLETRAVQH
LAQFDRFIQDARQRLHSYTTRPLLMFSLIDTRHALVIGQKSLFQEVMDQLGIINAWEGETNFWGTAVVGIERLAVVKSAR
AIYLDHGNQEMLKKVSSTPLWQALPFVRQNQLRQVPAVWFYGATLSAMRFCHLLEQAQESYS

Sequences:

>Translated_302_residues
MPDSSDFHHDAVRRRLLTAMALSPLLFSLPGQAAATPPDLARIVALEWLPIELLLALGVTPLAVADIHNYNLWVEEPKLP
ASVIDVGQRTEPNLELLQQLQPSLMLLSKGYGPTPQKLEPIAPSMSFSFNDGSGKPLTVARQSLQALAQRLGLETRAVQH
LAQFDRFIQDARQRLHSYTTRPLLMFSLIDTRHALVIGQKSLFQEVMDQLGIINAWEGETNFWGTAVVGIERLAVVKSAR
AIYLDHGNQEMLKKVSSTPLWQALPFVRQNQLRQVPAVWFYGATLSAMRFCHLLEQAQESYS
>Mature_301_residues
PDSSDFHHDAVRRRLLTAMALSPLLFSLPGQAAATPPDLARIVALEWLPIELLLALGVTPLAVADIHNYNLWVEEPKLPA
SVIDVGQRTEPNLELLQQLQPSLMLLSKGYGPTPQKLEPIAPSMSFSFNDGSGKPLTVARQSLQALAQRLGLETRAVQHL
AQFDRFIQDARQRLHSYTTRPLLMFSLIDTRHALVIGQKSLFQEVMDQLGIINAWEGETNFWGTAVVGIERLAVVKSARA
IYLDHGNQEMLKKVSSTPLWQALPFVRQNQLRQVPAVWFYGATLSAMRFCHLLEQAQESYS

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=286, Percent_Identity=56.6433566433566, Blast_Score=324, Evalue=5e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 33766; Mature: 33635

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSSDFHHDAVRRRLLTAMALSPLLFSLPGQAAATPPDLARIVALEWLPIELLLALGVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PLAVADIHNYNLWVEEPKLPASVIDVGQRTEPNLELLQQLQPSLMLLSKGYGPTPQKLEP
HHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCC
IAPSMSFSFNDGSGKPLTVARQSLQALAQRLGLETRAVQHLAQFDRFIQDARQRLHSYTT
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLLMFSLIDTRHALVIGQKSLFQEVMDQLGIINAWEGETNFWGTAVVGIERLAVVKSAR
CHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCC
AIYLDHGNQEMLKKVSSTPLWQALPFVRQNQLRQVPAVWFYGATLSAMRFCHLLEQAQES
EEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YS
CC
>Mature Secondary Structure 
PDSSDFHHDAVRRRLLTAMALSPLLFSLPGQAAATPPDLARIVALEWLPIELLLALGVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PLAVADIHNYNLWVEEPKLPASVIDVGQRTEPNLELLQQLQPSLMLLSKGYGPTPQKLEP
HHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCC
IAPSMSFSFNDGSGKPLTVARQSLQALAQRLGLETRAVQHLAQFDRFIQDARQRLHSYTT
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLLMFSLIDTRHALVIGQKSLFQEVMDQLGIINAWEGETNFWGTAVVGIERLAVVKSAR
CHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCC
AIYLDHGNQEMLKKVSSTPLWQALPFVRQNQLRQVPAVWFYGATLSAMRFCHLLEQAQES
EEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]