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The map label for this gene is fhuB [H]

Identifier: 157372210

GI number: 157372210

Start: 4406470

End: 4408458

Strand: Reverse

Name: fhuB [H]

Synonym: Spro_3976

Alternate gene names: 157372210

Gene position: 4408458-4406470 (Counterclockwise)

Preceding gene: 157372211

Following gene: 157372209

Centisome position: 80.91

GC content: 62.9

Gene sequence:

>1989_bases
ATGAGCGCGCGCATCCGGGCATTTCCGCTGACGCTGGTACTGCTGCTGTTGGCTGCGGCTGGCGGCCTGACTCTCTACAA
CCTGTTGCAACAACTGCCCTGGGCATTATGGGGGCAGGCGCTGATGGCGCCGAACATCGACGATGTGCAGCAAATGCTGT
TCCACTATAGCCTGTTGCCGCGGCTGTCGGTCTCTCTGTTGGCCGGTGCCGGGCTGGGATTGGTCGGCGTGCTGTTCCAG
CAGGTTTTGCGCAATCCGCTGGCGGAGCCGGCAACGCTTGGCGTTTCCGCCGGGGCCCAGCTTGGGTTGACTGTCGCTAC
GCTGTGGATGTTGCCCGGCGGCGAGTTGACTCGCCAGTTGGCCGCCATGGCGGGGGCGGTCGTGGTCGGTGGGCTGGTGT
TCGGCGTGGCCTGGGGCAAACGCATGTCGCCGGTGACGCTGATCCTGGCCGGGCTGGTGCTGGGCTTGTACTGCGGTGCG
GTCAACAGTCTGCTGGCGTTGTTCAATTACGATCAGCTGCAGGGGGTGTTCCTGTGGAGTACCGGAGCGCTGAATCAGCA
AGACTGGAGCAACGTACAGTTTATTCTGCCGCGCCTGCTGGTGGCCGGGCTGTTGGCGGTGCTGCTGCTGCGCCCACTGA
CGCTGCTGGGCCTGGACGATGGCGTGGCACGCAATCTTGGGCTCGGGCTGTCGATGGCGCGTTTCTGCGCGCTGGCAGTG
GCAATTATCTTCAGCGCCATGTTGGTGAATGCCGTTGGGGTGATTGGTTTTATCGGCCTGTTTGCTCCGCTGATGGCTAA
AATGCTGGGGGCGCGTCGGTTGGCGCACCGCATGATGTTGGCACCGCTGCTGGGGGCTCTGCTGTTGTGGTTAACCGATC
AGGTGATGATCTGGCTGACGCAGGTATGGCGAGAAGTGCCGACCGGTGCGGCTACCGCGCTATTTGGTGCACCACTGTTG
TTATGGTTGCTACCGCGCCTGCGTAGTGCTTCGACACCACCGCCGATGAATCTGGGCGATAAGGTACCGGCCGAACGTGG
CCACTTGGTGGTGTGGGTGACGCTGGCAGGGGCGGTGCTGTTGGCCGGTATTGCCGTTGCGCTGATGTTTGGCCAAAACG
CTGCCGGCTGGCACTGGAGCCAGGGTGCCCAGCTGGAGTCATTGCTGCCGTGGCGCTGGCCTCGGGTGTTGTCGGCACTG
GCCGCGGGCATGATGTTGGCGGTGGCAGGGACCCTAATCCAAAAACTGACCGGTAACCCAATGGCCAGCCCGGAAGTCCT
GGGTATCAGCTCGGGAGCCGCCTTTGGCGTGGTGATGATGCTGCTGATAGTTCCGGGTGATGCCTTTGTCTGGTTGTTGC
CGGCAGGCAGCCTGGGGGCCGCGGGAACCCTGCTGGTGATCATGATTGCCGCCGGGCGCGGAGGCTTCTCCACCGAGCGT
ATGCTGCTGGCCGGTATCGCGCTCAGCACGGCGTTTACCACCACCATTTTCCTGCTGCTGGCCAGTGGCGATCCGCGTAC
CGGTGGGCTGCTGACCTGGATTTCCGGCTCCACCTATTCGGTGACGCCAGAGCAAGCAGTGCGTACGGCGGTCATTGCGC
TTGCGCTGATTGCGTTGGCGCCGCTGTGTCGTCGTTGGCTCAGTATCCTGCCGCTCGGCAGTGCCACTGCCCGTTCGGTG
GGCATTGCCCTGACGCCGGTGCGCTTGAGCATTCTGCTGCTGGCCGCCACGCTGACTGCCATGGCAACGCTGACCGTAGG
GCCATTGAGCTTTATCGGCCTGATGGCGCCGCATATGGCGCGGATGTTGGGTTTCCGCCGTGCTTTACCGCAGATGGTGA
TTGCCGGGCTGTTAGGTGGGCTGCTGATGGTATTTGCCGACTGGTGCGGACGCATGGTGATGTTCCCGTACCAAATACCC
GCCGGGCTGCTGGCGACCTTTATCGGCGCGCCGTATTTCGTTTACCTGTTGCGCAAGCAAACCTCGTAA

Upstream 100 bases:

>100_bases
AGAATCAATTGCGCCAGGTGCCGGCGGTGTGGTTCTACGGGGCAACGCTGTCGGCGATGCGCTTCTGTCATCTGCTGGAG
CAGGCGCAGGAGAGTTATTC

Downstream 100 bases:

>100_bases
ACGACCCGGCGACTCCGGTTTTTGCTCTCAAAGGCTCAGCATTGCTGGGCCTTGTTTTTTTTGTATTTACAGACTGTTGC
AGCGCTTTGCGCAACGCTGC

Product: iron-hydroxamate transporter permease

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MSARIRAFPLTLVLLLLAAAGGLTLYNLLQQLPWALWGQALMAPNIDDVQQMLFHYSLLPRLSVSLLAGAGLGLVGVLFQ
QVLRNPLAEPATLGVSAGAQLGLTVATLWMLPGGELTRQLAAMAGAVVVGGLVFGVAWGKRMSPVTLILAGLVLGLYCGA
VNSLLALFNYDQLQGVFLWSTGALNQQDWSNVQFILPRLLVAGLLAVLLLRPLTLLGLDDGVARNLGLGLSMARFCALAV
AIIFSAMLVNAVGVIGFIGLFAPLMAKMLGARRLAHRMMLAPLLGALLLWLTDQVMIWLTQVWREVPTGAATALFGAPLL
LWLLPRLRSASTPPPMNLGDKVPAERGHLVVWVTLAGAVLLAGIAVALMFGQNAAGWHWSQGAQLESLLPWRWPRVLSAL
AAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVMMLLIVPGDAFVWLLPAGSLGAAGTLLVIMIAAGRGGFSTER
MLLAGIALSTAFTTTIFLLLASGDPRTGGLLTWISGSTYSVTPEQAVRTAVIALALIALAPLCRRWLSILPLGSATARSV
GIALTPVRLSILLLAATLTAMATLTVGPLSFIGLMAPHMARMLGFRRALPQMVIAGLLGGLLMVFADWCGRMVMFPYQIP
AGLLATFIGAPYFVYLLRKQTS

Sequences:

>Translated_662_residues
MSARIRAFPLTLVLLLLAAAGGLTLYNLLQQLPWALWGQALMAPNIDDVQQMLFHYSLLPRLSVSLLAGAGLGLVGVLFQ
QVLRNPLAEPATLGVSAGAQLGLTVATLWMLPGGELTRQLAAMAGAVVVGGLVFGVAWGKRMSPVTLILAGLVLGLYCGA
VNSLLALFNYDQLQGVFLWSTGALNQQDWSNVQFILPRLLVAGLLAVLLLRPLTLLGLDDGVARNLGLGLSMARFCALAV
AIIFSAMLVNAVGVIGFIGLFAPLMAKMLGARRLAHRMMLAPLLGALLLWLTDQVMIWLTQVWREVPTGAATALFGAPLL
LWLLPRLRSASTPPPMNLGDKVPAERGHLVVWVTLAGAVLLAGIAVALMFGQNAAGWHWSQGAQLESLLPWRWPRVLSAL
AAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVMMLLIVPGDAFVWLLPAGSLGAAGTLLVIMIAAGRGGFSTER
MLLAGIALSTAFTTTIFLLLASGDPRTGGLLTWISGSTYSVTPEQAVRTAVIALALIALAPLCRRWLSILPLGSATARSV
GIALTPVRLSILLLAATLTAMATLTVGPLSFIGLMAPHMARMLGFRRALPQMVIAGLLGGLLMVFADWCGRMVMFPYQIP
AGLLATFIGAPYFVYLLRKQTS
>Mature_661_residues
SARIRAFPLTLVLLLLAAAGGLTLYNLLQQLPWALWGQALMAPNIDDVQQMLFHYSLLPRLSVSLLAGAGLGLVGVLFQQ
VLRNPLAEPATLGVSAGAQLGLTVATLWMLPGGELTRQLAAMAGAVVVGGLVFGVAWGKRMSPVTLILAGLVLGLYCGAV
NSLLALFNYDQLQGVFLWSTGALNQQDWSNVQFILPRLLVAGLLAVLLLRPLTLLGLDDGVARNLGLGLSMARFCALAVA
IIFSAMLVNAVGVIGFIGLFAPLMAKMLGARRLAHRMMLAPLLGALLLWLTDQVMIWLTQVWREVPTGAATALFGAPLLL
WLLPRLRSASTPPPMNLGDKVPAERGHLVVWVTLAGAVLLAGIAVALMFGQNAAGWHWSQGAQLESLLPWRWPRVLSALA
AGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVMMLLIVPGDAFVWLLPAGSLGAAGTLLVIMIAAGRGGFSTERM
LLAGIALSTAFTTTIFLLLASGDPRTGGLLTWISGSTYSVTPEQAVRTAVIALALIALAPLCRRWLSILPLGSATARSVG
IALTPVRLSILLLAATLTAMATLTVGPLSFIGLMAPHMARMLGFRRALPQMVIAGLLGGLLMVFADWCGRMVMFPYQIPA
GLLATFIGAPYFVYLLRKQTS

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=661, Percent_Identity=68.2299546142209, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=325, Percent_Identity=35.3846153846154, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790741, Length=278, Percent_Identity=37.0503597122302, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=35.9712230215827, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=34.1379310344828, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=33.8129496402878, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 69753; Mature: 69622

Theoretical pI: Translated: 11.27; Mature: 11.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARIRAFPLTLVLLLLAAAGGLTLYNLLQQLPWALWGQALMAPNIDDVQQMLFHYSLLP
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLSVSLLAGAGLGLVGVLFQQVLRNPLAEPATLGVSAGAQLGLTVATLWMLPGGELTRQL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
AAMAGAVVVGGLVFGVAWGKRMSPVTLILAGLVLGLYCGAVNSLLALFNYDQLQGVFLWS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEEEE
TGALNQQDWSNVQFILPRLLVAGLLAVLLLRPLTLLGLDDGVARNLGLGLSMARFCALAV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHH
AIIFSAMLVNAVGVIGFIGLFAPLMAKMLGARRLAHRMMLAPLLGALLLWLTDQVMIWLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVWREVPTGAATALFGAPLLLWLLPRLRSASTPPPMNLGDKVPAERGHLVVWVTLAGAVL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHH
LAGIAVALMFGQNAAGWHWSQGAQLESLLPWRWPRVLSALAAGMMLAVAGTLIQKLTGNP
HHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MASPEVLGISSGAAFGVVMMLLIVPGDAFVWLLPAGSLGAAGTLLVIMIAAGRGGFSTER
CCCCCEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHH
MLLAGIALSTAFTTTIFLLLASGDPRTGGLLTWISGSTYSVTPEQAVRTAVIALALIALA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHH
PLCRRWLSILPLGSATARSVGIALTPVRLSILLLAATLTAMATLTVGPLSFIGLMAPHMA
HHHHHHHHHCCCCCHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLGFRRALPQMVIAGLLGGLLMVFADWCGRMVMFPYQIPAGLLATFIGAPYFVYLLRKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHCCHHHHHHHHHHHHHHHHHHHC
TS
CC
>Mature Secondary Structure 
SARIRAFPLTLVLLLLAAAGGLTLYNLLQQLPWALWGQALMAPNIDDVQQMLFHYSLLP
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH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CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]