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The map label for this gene is lyx [H]

Identifier: 157372170

GI number: 157372170

Start: 4360466

End: 4361947

Strand: Direct

Name: lyx [H]

Synonym: Spro_3936

Alternate gene names: 157372170

Gene position: 4360466-4361947 (Clockwise)

Preceding gene: 157372169

Following gene: 157372171

Centisome position: 80.03

GC content: 62.21

Gene sequence:

>1482_bases
ATGGACTATTGGTTGGGGCTGGACTGCGGTGGCACCTTTATCAAAGCCGGGCTGTATGACCGTCAGGGGGCTGAGCTGAG
CATCGCTCGCCGCAACCTGGAAATTATCTCGCCCCAACCGGGTTGGGCGGAGCGGGATATGCCTGCGCTATGGCACACCG
CTGCCGAGGTGATCCGCGAGTTGCTGGCCCGCAACAAGATTGCTGTCGGTGATATTCAGGCCGTCGGCATCTCGGCGCAG
GGCAAAGGAGCGTTTCTGCTGGACCAGCAAGGGCAGCCACTGGGCAATGCCATGCTGTCTTCTGACCAGCGCGCACTGGC
GCTGGTGCAGGAATGGCAAAAACAGGGCGTGCCGCAGACGCTGTATCCGCAGACCCGGCAAACGCTGTGGACCGGCCACC
CGGTGTCGCTGCTGCGCTGGGTTCGGCAGCATCAGCCGGAACGTTATCGCCAGATCGGCAGCGTGCTGATGGCCCACGAT
TATCTGCGCTACTGCCTGACCGGCGAGTTGGCCTGTGAAGAAACCAATATCTCCGAATCCAATCTTTACCAAATGGCCGG
GGGTCGCTATGACCCGGCGCTGGCACAGCTGCTGGGCATTGGCGACATCATGCCCACCCTGCCGCCGATTGTCGGTTCGG
CCGAAATCGCCGGACGGATCAACGCCGCCGCTGCAAAGGCAACCGGGCTATTGGCAGGTACGCCAGTGGTCGGCGGGCTG
TTCGATGTGGTGTCCACCGCGCTGTGCGCCGGGCTACACGACGAAACGCGGCTCAACGCAGTGATGGGCACCTGGTCGGT
TACCAGCGGCATTACCGACAAAATCACCGACGGTTTCGACCACCCGTTTGTTTATGGTCGCCACGCCGAAGCCGGCAAAT
ACATTGTGCACGAAGCCAGCCCAACCTCTGCCGCCAACCTGGAGTGGTTCTGCCGACAATGGGGGCTGCAGGACTACGCC
CAGCTCAACGACTGGGTGGCAACGCTGCCGAAAGCCGACAGCAGCCTGCTGTTCGTTCCCTTCCTGTACGGCTCCAACGC
CGGGCTGGGCCTGAGCGCCAGCTTCCATGGCATGCAGGCCTTCCACCAGCGTGAGCATTTGGTACAGGCGATTTATGAAG
GCGTGGTGTTCTGTCATATGACCCACCTCAACCGCATGCGGCAACGCTTCCCTGCGGCTACCGCGCTGCGCGTCACCGGC
GGTCCGGCCAAATCCGCCCCCTGGATGCAAATGTTCGCCGACGTCAGCGGCCTGCCGGTGGAACTGCCGCAGGTGGAAGA
AACCGGCTGCCTGGGTGCAGCCATGGCGGCAATGGTCGGCAGCGGCGTATTCAGCGATTTCACTGCCACCCAGCGAACGC
TGGCACCGCGCATCGAACGGGTGCTGCCGGACGCAGCAGCAGCAGAGGCTTACGGTAAAAAATATCAATGTTATCAGGCG
CTGGTAGCCACGCTGCAATCCATCCAGAAGGAGGCCCTATGA

Upstream 100 bases:

>100_bases
AGGACGTCGGCGTTTACAGCCTGGCGGTATCACTGGCCATTGCCTCGGTGCTGGCGCTGATGCTGCCGAACAAATGCGAC
CAAAGCGCGAGGGCCGAATA

Downstream 100 bases:

>100_bases
GCAACAAACCGCGTCTGCAACTGGCGCTCGATCACACCCGGCTGGACGCCGCCCTGCAAACGGCAGAACGCCTGCAGCCG
CACGTCGACATTATCGAGGC

Product: carbohydrate kinase FGGY

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDYWLGLDCGGTFIKAGLYDRQGAELSIARRNLEIISPQPGWAERDMPALWHTAAEVIRELLARNKIAVGDIQAVGISAQ
GKGAFLLDQQGQPLGNAMLSSDQRALALVQEWQKQGVPQTLYPQTRQTLWTGHPVSLLRWVRQHQPERYRQIGSVLMAHD
YLRYCLTGELACEETNISESNLYQMAGGRYDPALAQLLGIGDIMPTLPPIVGSAEIAGRINAAAAKATGLLAGTPVVGGL
FDVVSTALCAGLHDETRLNAVMGTWSVTSGITDKITDGFDHPFVYGRHAEAGKYIVHEASPTSAANLEWFCRQWGLQDYA
QLNDWVATLPKADSSLLFVPFLYGSNAGLGLSASFHGMQAFHQREHLVQAIYEGVVFCHMTHLNRMRQRFPAATALRVTG
GPAKSAPWMQMFADVSGLPVELPQVEETGCLGAAMAAMVGSGVFSDFTATQRTLAPRIERVLPDAAAAEAYGKKYQCYQA
LVATLQSIQKEAL

Sequences:

>Translated_493_residues
MDYWLGLDCGGTFIKAGLYDRQGAELSIARRNLEIISPQPGWAERDMPALWHTAAEVIRELLARNKIAVGDIQAVGISAQ
GKGAFLLDQQGQPLGNAMLSSDQRALALVQEWQKQGVPQTLYPQTRQTLWTGHPVSLLRWVRQHQPERYRQIGSVLMAHD
YLRYCLTGELACEETNISESNLYQMAGGRYDPALAQLLGIGDIMPTLPPIVGSAEIAGRINAAAAKATGLLAGTPVVGGL
FDVVSTALCAGLHDETRLNAVMGTWSVTSGITDKITDGFDHPFVYGRHAEAGKYIVHEASPTSAANLEWFCRQWGLQDYA
QLNDWVATLPKADSSLLFVPFLYGSNAGLGLSASFHGMQAFHQREHLVQAIYEGVVFCHMTHLNRMRQRFPAATALRVTG
GPAKSAPWMQMFADVSGLPVELPQVEETGCLGAAMAAMVGSGVFSDFTATQRTLAPRIERVLPDAAAAEAYGKKYQCYQA
LVATLQSIQKEAL
>Mature_493_residues
MDYWLGLDCGGTFIKAGLYDRQGAELSIARRNLEIISPQPGWAERDMPALWHTAAEVIRELLARNKIAVGDIQAVGISAQ
GKGAFLLDQQGQPLGNAMLSSDQRALALVQEWQKQGVPQTLYPQTRQTLWTGHPVSLLRWVRQHQPERYRQIGSVLMAHD
YLRYCLTGELACEETNISESNLYQMAGGRYDPALAQLLGIGDIMPTLPPIVGSAEIAGRINAAAAKATGLLAGTPVVGGL
FDVVSTALCAGLHDETRLNAVMGTWSVTSGITDKITDGFDHPFVYGRHAEAGKYIVHEASPTSAANLEWFCRQWGLQDYA
QLNDWVATLPKADSSLLFVPFLYGSNAGLGLSASFHGMQAFHQREHLVQAIYEGVVFCHMTHLNRMRQRFPAATALRVTG
GPAKSAPWMQMFADVSGLPVELPQVEETGCLGAAMAAMVGSGVFSDFTATQRTLAPRIERVLPDAAAAEAYGKKYQCYQA
LVATLQSIQKEAL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=478, Percent_Identity=22.8033472803347, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI42794763, Length=462, Percent_Identity=24.6753246753247, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI164663828, Length=559, Percent_Identity=23.9713774597496, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI41393575, Length=484, Percent_Identity=25.4132231404959, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790005, Length=487, Percent_Identity=63.4496919917865, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=510, Percent_Identity=27.4509803921569, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1789987, Length=501, Percent_Identity=27.1457085828343, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1790361, Length=479, Percent_Identity=24.0083507306889, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789168, Length=456, Percent_Identity=22.8070175438596, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24656367, Length=498, Percent_Identity=22.6907630522088, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 53616; Mature: 53616

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYWLGLDCGGTFIKAGLYDRQGAELSIARRNLEIISPQPGWAERDMPALWHTAAEVIRE
CCEEEEECCCCHHHCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHH
LLARNKIAVGDIQAVGISAQGKGAFLLDQQGQPLGNAMLSSDQRALALVQEWQKQGVPQT
HHHCCCEEECCEEEEEEECCCCCEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCC
LYPQTRQTLWTGHPVSLLRWVRQHQPERYRQIGSVLMAHDYLRYCLTGELACEETNISES
CCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHH
NLYQMAGGRYDPALAQLLGIGDIMPTLPPIVGSAEIAGRINAAAAKATGLLAGTPVVGGL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEECCCHHHHH
FDVVSTALCAGLHDETRLNAVMGTWSVTSGITDKITDGFDHPFVYGRHAEAGKYIVHEAS
HHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCHHHHCCCCCCCEEECCCCCCCCEEEEECC
PTSAANLEWFCRQWGLQDYAQLNDWVATLPKADSSLLFVPFLYGSNAGLGLSASFHGMQA
CCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
FHQREHLVQAIYEGVVFCHMTHLNRMRQRFPAATALRVTGGPAKSAPWMQMFADVSGLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCC
ELPQVEETGCLGAAMAAMVGSGVFSDFTATQRTLAPRIERVLPDAAAAEAYGKKYQCYQA
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHH
LVATLQSIQKEAL
HHHHHHHHHHHCC
>Mature Secondary Structure
MDYWLGLDCGGTFIKAGLYDRQGAELSIARRNLEIISPQPGWAERDMPALWHTAAEVIRE
CCEEEEECCCCHHHCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHH
LLARNKIAVGDIQAVGISAQGKGAFLLDQQGQPLGNAMLSSDQRALALVQEWQKQGVPQT
HHHCCCEEECCEEEEEEECCCCCEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCC
LYPQTRQTLWTGHPVSLLRWVRQHQPERYRQIGSVLMAHDYLRYCLTGELACEETNISES
CCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHH
NLYQMAGGRYDPALAQLLGIGDIMPTLPPIVGSAEIAGRINAAAAKATGLLAGTPVVGGL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEECCCHHHHH
FDVVSTALCAGLHDETRLNAVMGTWSVTSGITDKITDGFDHPFVYGRHAEAGKYIVHEAS
HHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCHHHHCCCCCCCEEECCCCCCCCEEEEECC
PTSAANLEWFCRQWGLQDYAQLNDWVATLPKADSSLLFVPFLYGSNAGLGLSASFHGMQA
CCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
FHQREHLVQAIYEGVVFCHMTHLNRMRQRFPAATALRVTGGPAKSAPWMQMFADVSGLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCC
ELPQVEETGCLGAAMAAMVGSGVFSDFTATQRTLAPRIERVLPDAAAAEAYGKKYQCYQA
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHH
LVATLQSIQKEAL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]