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The map label for this gene is galR [H]

Identifier: 157372067

GI number: 157372067

Start: 4243012

End: 4244031

Strand: Direct

Name: galR [H]

Synonym: Spro_3832

Alternate gene names: 157372067

Gene position: 4243012-4244031 (Clockwise)

Preceding gene: 157372063

Following gene: 157372069

Centisome position: 77.87

GC content: 59.12

Gene sequence:

>1020_bases
ATGGCTACCATAAAGGATGTTGCCAGGCTGGCGGGTGTTTCCGTGGCCACGGTATCCCGCGTAATAAACCATTCCCCGAA
GGCCAGCGAAAGCTCACGCACCGCCGTGCTGGCCGCGATGGAACAACTGCAGTACCACCCAAACGCCAACGCCCGCGCGC
TGGCGCAGCAATCGACCGAAACGCTGGGGCTGATCGTCTCCGACGTGTCCGATCCCTTTTTTGGCGCTATGGTCAAAGCG
GTCGAACAGGTGGCCTACGCTACCCACAACTTCTTGCTGATTGGCAACGGTTACCATGAGGCAGAAAAAGAGCGTCAGGC
GATTGAACAACTGGTACGGCACCGCTGTGCAGCACTGGTGGTGCATGCCAAAAAGCTGACCGATCCTGAGTTAAGCGGCT
GGATGCAGCAGATCCCGGGGATGGTGCTGATTAACCGCACGCTGCCGGGCTTTGAATCGCGCTGTGTGGCGCTGGACGAC
CGCTATGGTGCCTGGCTGGCGACTCGCCATCTGATTCAACAGGGACATCAGCGTATTGCCATCGTCTGCTCCACCCACCA
AATTTCCGACGCCGCAGACCGCCTGCAGGGTTATCTCGATGCATTGCAGGAGCATGGCATTGCGGTAGATGAAAGGCTGA
TTGCCTACGGAGAGCCGGACGAAATCGGCGGTGAACAAGCGATGACCGAGTTGCTCGGGCGCGGTAAAAACTTCACCGCA
GTGACCTGTTATAACGATTCGATGGCCGCAGGCGCGCTCTCGGTGCTGAGCGACAACAGCGTGGATGTGCCGGGCCAAAT
GTCGTTGATTGGCTTTGATGACGTGTTGATTTCACGCTATCTGCGCCCCCGCCTGACCACCATCCGCTATCCGGTGGTGG
CCATGGCGACCCAGGCGGCCGAACTGGCACTGGCGCTGGCCAATAACCAGCCGCTGCCGGAGATCACCAATATGTTCAGC
CCGACGCTGGTGCGCCGCCACTCGGTGGCCAGCATCAATAACGTTTACGAGCAGAACTAG

Upstream 100 bases:

>100_bases
TGCAACAGCCGCCACAAGTTGCGATCGCCAGCGCTTGCAGCCCCGGGTTTTTTCCGCAAGACTGAGGAATGTAAGCGATT
ACCCAGGATGTATGACAGAT

Downstream 100 bases:

>100_bases
TCCAGCTCGCGGTGATAGAGCCGCACCGGGCGGTCAGGGTAGTCCAGCGCGTCGCCGATATAGTGCCAGCCGTGACGTTC
GTAATAGCCACTGAAGTCAC

Product: DNA-binding transcriptional regulator GalR

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MATIKDVARLAGVSVATVSRVINHSPKASESSRTAVLAAMEQLQYHPNANARALAQQSTETLGLIVSDVSDPFFGAMVKA
VEQVAYATHNFLLIGNGYHEAEKERQAIEQLVRHRCAALVVHAKKLTDPELSGWMQQIPGMVLINRTLPGFESRCVALDD
RYGAWLATRHLIQQGHQRIAIVCSTHQISDAADRLQGYLDALQEHGIAVDERLIAYGEPDEIGGEQAMTELLGRGKNFTA
VTCYNDSMAAGALSVLSDNSVDVPGQMSLIGFDDVLISRYLRPRLTTIRYPVVAMATQAAELALALANNQPLPEITNMFS
PTLVRRHSVASINNVYEQN

Sequences:

>Translated_339_residues
MATIKDVARLAGVSVATVSRVINHSPKASESSRTAVLAAMEQLQYHPNANARALAQQSTETLGLIVSDVSDPFFGAMVKA
VEQVAYATHNFLLIGNGYHEAEKERQAIEQLVRHRCAALVVHAKKLTDPELSGWMQQIPGMVLINRTLPGFESRCVALDD
RYGAWLATRHLIQQGHQRIAIVCSTHQISDAADRLQGYLDALQEHGIAVDERLIAYGEPDEIGGEQAMTELLGRGKNFTA
VTCYNDSMAAGALSVLSDNSVDVPGQMSLIGFDDVLISRYLRPRLTTIRYPVVAMATQAAELALALANNQPLPEITNMFS
PTLVRRHSVASINNVYEQN
>Mature_338_residues
ATIKDVARLAGVSVATVSRVINHSPKASESSRTAVLAAMEQLQYHPNANARALAQQSTETLGLIVSDVSDPFFGAMVKAV
EQVAYATHNFLLIGNGYHEAEKERQAIEQLVRHRCAALVVHAKKLTDPELSGWMQQIPGMVLINRTLPGFESRCVALDDR
YGAWLATRHLIQQGHQRIAIVCSTHQISDAADRLQGYLDALQEHGIAVDERLIAYGEPDEIGGEQAMTELLGRGKNFTAV
TCYNDSMAAGALSVLSDNSVDVPGQMSLIGFDDVLISRYLRPRLTTIRYPVVAMATQAAELALALANNQPLPEITNMFSP
TLVRRHSVASINNVYEQN

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789202, Length=331, Percent_Identity=80.0604229607251, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=56.2874251497006, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=37.4251497005988, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=33.5329341317365, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=32.5301204819277, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=30.9090909090909, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1787580, Length=319, Percent_Identity=26.9592476489028, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787906, Length=325, Percent_Identity=28.9230769230769, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=25.5591054313099, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786540, Length=337, Percent_Identity=27.0029673590504, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790689, Length=322, Percent_Identity=25.4658385093168, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=23.9482200647249, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37001; Mature: 36869

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVARLAGVSVATVSRVINHSPKASESSRTAVLAAMEQLQYHPNANARALAQQSTE
CCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TLGLIVSDVSDPFFGAMVKAVEQVAYATHNFLLIGNGYHEAEKERQAIEQLVRHRCAALV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VHAKKLTDPELSGWMQQIPGMVLINRTLPGFESRCVALDDRYGAWLATRHLIQQGHQRIA
HHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
IVCSTHQISDAADRLQGYLDALQEHGIAVDERLIAYGEPDEIGGEQAMTELLGRGKNFTA
EEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHCCHHHHHHHHHHCCCCEEE
VTCYNDSMAAGALSVLSDNSVDVPGQMSLIGFDDVLISRYLRPRLTTIRYPVVAMATQAA
EEEECCCHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELALALANNQPLPEITNMFSPTLVRRHSVASINNVYEQN
HHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATIKDVARLAGVSVATVSRVINHSPKASESSRTAVLAAMEQLQYHPNANARALAQQSTE
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TLGLIVSDVSDPFFGAMVKAVEQVAYATHNFLLIGNGYHEAEKERQAIEQLVRHRCAALV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
VHAKKLTDPELSGWMQQIPGMVLINRTLPGFESRCVALDDRYGAWLATRHLIQQGHQRIA
HHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
IVCSTHQISDAADRLQGYLDALQEHGIAVDERLIAYGEPDEIGGEQAMTELLGRGKNFTA
EEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCHHCCHHHHHHHHHHCCCCEEE
VTCYNDSMAAGALSVLSDNSVDVPGQMSLIGFDDVLISRYLRPRLTTIRYPVVAMATQAA
EEEECCCHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELALALANNQPLPEITNMFSPTLVRRHSVASINNVYEQN
HHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6283521; 9278503; 6350601; 8188660; 8982002 [H]