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The map label for this gene is argA

Identifier: 157372047

GI number: 157372047

Start: 4212673

End: 4213998

Strand: Direct

Name: argA

Synonym: Spro_3812

Alternate gene names: 157372047

Gene position: 4212673-4213998 (Clockwise)

Preceding gene: 157372043

Following gene: 157372060

Centisome position: 77.31

GC content: 56.49

Gene sequence:

>1326_bases
GTGAAGGAACGTAGTACAGAGCTGGTCCAAGGATTCCGTCACTCAGTTCCCTATATCAACGCCCACCGTGGCAAGACGTT
TGTCGTTATGCTGGGTGGCGAAGCCATAGAACATGAGAACTTTGCCAACATCGTTAACGACATCGGGCTGCTGCATAGTC
TGGGTATTCGTTTAGTCGTGGTCTATGGTGCCCGGCCGCAGATTGACGTCAATCTGGCGCAGCATAATCTCGAACCGATT
TATCACAAGCACACCCGCGTCACCGACGCCCATACGCTGGAGCTGGTTAAACAGGCGGCGGGTCTGCTGCAACTGGATAT
CACCGCCCGGCTGTCAATGAGCCTCAACAACACGCCATTGCAGGGCGCGCATATCAACGTGGTCAGCGGTAATTTTATTA
TCGCCCAGCCACTGGGGATTGATGACGGTGTGGACTACTGCCACAGCGGCCGCATCCGCCGTATTGATGAAGAAGCCATT
CACCGTCAGCTCGATAGCAACGCCATCGTGCTGATTGGCCCGGTGGCCGTTTCCGTTACCGGCGAAAGCTTTAACCTGAC
CTCAGAAGAAGTGGCAACTCAGTTGGCCGTCAAGCTGAAAGCCGAGAAAATGATCGGCTTCTGTTCGTCACAGGGGGTCA
CCAATCAGGAAGGCACCATCATTTCCGAACTGTTCCCCAACGACGCGCAAAAACGCATCGAGGAGCTGGAAGAGCATGGC
GACTATCATTCCGGCACCGTGCGTTTCCTGCGTGGCGCGGTGAAGGCCTGCCGCAGCGGCGTACGCCGCAGCCACCTGAT
CAGCTATCAGGAAGACGGTGCGCTGGTGCAGGAACTGTTTTCACGCGATGGTATAGGCACCCAGATAGTGATGGAGAGCG
CTGAACAGGTGCGCCGGGCGACGATTAACGATATCGGCGGCATCCTCGAGCTGATCCGTCCGCTTGAGCAGCAGGGCATC
TTGGTGCGCCGCTCACGTGAGCAACTGGAGATGGAGATCGACAAATTCACCATTATTGAGCGCGATAACCTGACCATCGC
TTGCGCGGCGCTGTATCCGTTCCCGGAAGAGAAGATTGGTGAGATGGCCTGCGTTGCGGTTCATCCTGATTACCGCAGCT
CGTCACGGGGTGAAATGCTGCTGCAACGGGTGGAGAGTCAGGCACGCCAGATGGGCCTGCGTAAGCTGTTTGTGCTGACT
ACGCGCAGCATCCACTGGTTCCAGGAACGTGGTTTCACGCCGGCGGAAGTCGACGTGCTACCGGTTGAGAAACAGGCGCT
GTACAACTACCAACGCCGTTCCAAGATTTTGCTGGCGGATCTGTAA

Upstream 100 bases:

>100_bases
CCCCCGACAAAGAAATAGAGATAATTTCTCACTTGCCATCAGGGCAAGAAAAGAATAAAAATACAAAAATATCGTATAAA
TATGCAAATGAGGTTTGGCC

Downstream 100 bases:

>100_bases
TGGTTGGCGGGCGCAGCGTGCTGCGCCCATGGGCACTTAAGCCTTGAGCTGCAACCGCTCCGCCAATCCGCTACGGCGCT
GGGTCGGAGTGCGGATCGCC

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFANIVNDIGLLHSLGIRLVVVYGARPQIDVNLAQHNLEPI
YHKHTRVTDAHTLELVKQAAGLLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGIDDGVDYCHSGRIRRIDEEAI
HRQLDSNAIVLIGPVAVSVTGESFNLTSEEVATQLAVKLKAEKMIGFCSSQGVTNQEGTIISELFPNDAQKRIEELEEHG
DYHSGTVRFLRGAVKACRSGVRRSHLISYQEDGALVQELFSRDGIGTQIVMESAEQVRRATINDIGGILELIRPLEQQGI
LVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEMLLQRVESQARQMGLRKLFVLT
TRSIHWFQERGFTPAEVDVLPVEKQALYNYQRRSKILLADL

Sequences:

>Translated_441_residues
MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFANIVNDIGLLHSLGIRLVVVYGARPQIDVNLAQHNLEPI
YHKHTRVTDAHTLELVKQAAGLLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGIDDGVDYCHSGRIRRIDEEAI
HRQLDSNAIVLIGPVAVSVTGESFNLTSEEVATQLAVKLKAEKMIGFCSSQGVTNQEGTIISELFPNDAQKRIEELEEHG
DYHSGTVRFLRGAVKACRSGVRRSHLISYQEDGALVQELFSRDGIGTQIVMESAEQVRRATINDIGGILELIRPLEQQGI
LVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEMLLQRVESQARQMGLRKLFVLT
TRSIHWFQERGFTPAEVDVLPVEKQALYNYQRRSKILLADL
>Mature_441_residues
MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFANIVNDIGLLHSLGIRLVVVYGARPQIDVNLAQHNLEPI
YHKHTRVTDAHTLELVKQAAGLLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGIDDGVDYCHSGRIRRIDEEAI
HRQLDSNAIVLIGPVAVSVTGESFNLTSEEVATQLAVKLKAEKMIGFCSSQGVTNQEGTIISELFPNDAQKRIEELEEHG
DYHSGTVRFLRGAVKACRSGVRRSHLISYQEDGALVQELFSRDGIGTQIVMESAEQVRRATINDIGGILELIRPLEQQGI
LVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEKIGEMACVAVHPDYRSSSRGEMLLQRVESQARQMGLRKLFVLT
TRSIHWFQERGFTPAEVDVLPVEKQALYNYQRRSKILLADL

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain

Homologues:

Organism=Escherichia coli, GI1789181, Length=441, Percent_Identity=87.0748299319728, Blast_Score=810, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320913, Length=302, Percent_Identity=21.8543046357616, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGA_SERP5 (A8GIG8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480036.1
- ProteinModelPortal:   A8GIG8
- SMR:   A8GIG8
- STRING:   A8GIG8
- GeneID:   5606903
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3812
- eggNOG:   COG0548
- HOGENOM:   HBG545264
- OMA:   APYIHAF
- ProtClustDB:   PRK05279
- BioCyc:   SPRO399741:SPRO_3812-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01105
- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167
- Gene3D:   G3DSA:3.40.1160.10
- Gene3D:   G3DSA:3.40.630.30
- PIRSF:   PIRSF000423
- TIGRFAMs:   TIGR01890

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1; SSF53633 Aa_kinase; SSF55729 Acyl_CoA_acyltransferase

EC number: =2.3.1.1

Molecular weight: Translated: 49371; Mature: 49371

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51186 GNAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFANIVNDIGLLHSLGIRLVV
CCCCHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHCCCHHHHHHHHHHHHHHCCEEEEE
VYGARPQIDVNLAQHNLEPIYHKHTRVTDAHTLELVKQAAGLLQLDITARLSMSLNNTPL
EECCCCCEEEEHHHCCCCCHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEEEEEECCCCCC
QGAHINVVSGNFIIAQPLGIDDGVDYCHSGRIRRIDEEAIHRQLDSNAIVLIGPVAVSVT
CCCEEEEEECCEEEEECCCCCCCCHHHHCCCCEECCHHHHHHHCCCCEEEEEEEEEEEEE
GESFNLTSEEVATQLAVKLKAEKMIGFCSSQGVTNQEGTIISELFPNDAQKRIEELEEHG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCC
DYHSGTVRFLRGAVKACRSGVRRSHLISYQEDGALVQELFSRDGIGTQIVMESAEQVRRA
CCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TINDIGGILELIRPLEQQGILVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEKIG
HHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCEEEEEECCCCEEEEEEECCCCHHHHC
EMACVAVHPDYRSSSRGEMLLQRVESQARQMGLRKLFVLTTRSIHWFQERGFTPAEVDVL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHCCCCCCCEEEE
PVEKQALYNYQRRSKILLADL
ECCHHHHHHHHHHCEEEEECC
>Mature Secondary Structure
MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFANIVNDIGLLHSLGIRLVV
CCCCHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHCCCHHHHHHHHHHHHHHCCEEEEE
VYGARPQIDVNLAQHNLEPIYHKHTRVTDAHTLELVKQAAGLLQLDITARLSMSLNNTPL
EECCCCCEEEEHHHCCCCCHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEEEEEECCCCCC
QGAHINVVSGNFIIAQPLGIDDGVDYCHSGRIRRIDEEAIHRQLDSNAIVLIGPVAVSVT
CCCEEEEEECCEEEEECCCCCCCCHHHHCCCCEECCHHHHHHHCCCCEEEEEEEEEEEEE
GESFNLTSEEVATQLAVKLKAEKMIGFCSSQGVTNQEGTIISELFPNDAQKRIEELEEHG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCC
DYHSGTVRFLRGAVKACRSGVRRSHLISYQEDGALVQELFSRDGIGTQIVMESAEQVRRA
CCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TINDIGGILELIRPLEQQGILVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEKIG
HHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCEEEEEECCCCEEEEEEECCCCHHHHC
EMACVAVHPDYRSSSRGEMLLQRVESQARQMGLRKLFVLTTRSIHWFQERGFTPAEVDVL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEHHCCHHHHHHCCCCCCCEEEE
PVEKQALYNYQRRSKILLADL
ECCHHHHHHHHHHCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA