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The map label for this gene is acrE [H]

Identifier: 157371934

GI number: 157371934

Start: 4089542

End: 4090714

Strand: Direct

Name: acrE [H]

Synonym: Spro_3699

Alternate gene names: 157371934

Gene position: 4089542-4090714 (Clockwise)

Preceding gene: 157371933

Following gene: 157371935

Centisome position: 75.05

GC content: 59.51

Gene sequence:

>1173_bases
ATGAACAAAAACGCATTATGCTTAACCGGCAGCTTACTGCTGTGCGGCGGTCTGCTGCTTACCGGTTGTAAAGATAAAAA
CCCTAAGGCCACGCAGCTTCCGCCGCATCCGGTCGGTGTAGTCACCTTGCGCTCTCAGCCACTGGCAATAAAAACAGAAC
TGCCGGGTCGCACCAATGCTTACCGCACGGCGGAAGTCCGGCCCCAGGTCAGCGGTATTGTCCTCAAGCGCCAGTTTGTC
GAAGGCAGTGACGTGCAGGCTGGCCAATCGCTGTATCAGATCGACCCGGCCAGCTATCAGGCCGCCTGCGACAGCGCGCT
GGGCGATCTGAAAAAGGCCCAGGCCAGCAGCGAAATAGCGCATCTGACCGTAAAGCGTGAGCAACCGCTGCGGGCCAAAA
ACTACGTCAGCCCGCAGGAGTTCGACACCAGCGTGGCTCAAGCCAGGCAGGCCGATGCCGATGTTATCGCCGCCCGCGCA
GCACTGGAAAGCGCACGTATCAACCTGCAGTACACCAAGGTTATTGCGCCAATCTCCGGGCGCATCGGCAAATCCAGCGT
CACCGAAGGTGCGCTGGTGACCTCCAGCCAGAGCAGCGCGCTGGCGACGGTGCAACAATTGGATCCGATGTATGTCGACG
TCACCCAGTCCAGCGACGATTTCCTCAAGCTTAAACAGGCTATCGCCTCCGGTACCATTACCCACAACGGCGGCAAAGTG
CCGGTCAGCCTGATCCTGAATAACGGCCAGCGTTATCAGCCGACTGGCACCCTGGAATTCTCCGACGTCACCGTTGACCA
AAGCACCGGTTCCATTACCCTGCGCGCCATCATCCCTAATCCGCAGCATAGCCTGCTGCCCGGCATGTATGTCCGCGCCG
AGATTGACCAGGGGCAGCAGAAAAACGCGCTATTGGTGCCGCAGCAAGGTATCACTCGCAACCCGCGCGGCGAAGCCACG
GCGCTGATTGTCGACGCCCACAATAAAGCACAGTTACGTCAGGTGATCGCCAGCCAGGCGATTGGTGACAAATGGTTGGT
GACGTCGGGGTTGCAGGCCGGCGACAAAGTGATCGTCAGCGGCCTGATGCGCCTGAAGCCGGGCATGCAGGTACGGGCAA
CGGAAGAGACGCCGGACACCGCTCAGGCCTTGTCTGACGTCTATCACGGTTAA

Upstream 100 bases:

>100_bases
CCGCTGTGATTATTCCGTAAAATACACCGCAATCAGTCTCTTTCTGTATTTAATCAGCCGCCAGACCGCATTGCGATACC
CTCTGGCCAACGGGATAATC

Downstream 100 bases:

>100_bases
GGGGCGCCAAGGCATGTCTAATTTCTTTATCAACCGCCCGATATTTGCCTGGGTCATCGCCATCATCGTCATGATGGCCG
GTGCCCTGTCCATCATGAAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNKNALCLTGSLLLCGGLLLTGCKDKNPKATQLPPHPVGVVTLRSQPLAIKTELPGRTNAYRTAEVRPQVSGIVLKRQFV
EGSDVQAGQSLYQIDPASYQAACDSALGDLKKAQASSEIAHLTVKREQPLRAKNYVSPQEFDTSVAQARQADADVIAARA
ALESARINLQYTKVIAPISGRIGKSSVTEGALVTSSQSSALATVQQLDPMYVDVTQSSDDFLKLKQAIASGTITHNGGKV
PVSLILNNGQRYQPTGTLEFSDVTVDQSTGSITLRAIIPNPQHSLLPGMYVRAEIDQGQQKNALLVPQQGITRNPRGEAT
ALIVDAHNKAQLRQVIASQAIGDKWLVTSGLQAGDKVIVSGLMRLKPGMQVRATEETPDTAQALSDVYHG

Sequences:

>Translated_390_residues
MNKNALCLTGSLLLCGGLLLTGCKDKNPKATQLPPHPVGVVTLRSQPLAIKTELPGRTNAYRTAEVRPQVSGIVLKRQFV
EGSDVQAGQSLYQIDPASYQAACDSALGDLKKAQASSEIAHLTVKREQPLRAKNYVSPQEFDTSVAQARQADADVIAARA
ALESARINLQYTKVIAPISGRIGKSSVTEGALVTSSQSSALATVQQLDPMYVDVTQSSDDFLKLKQAIASGTITHNGGKV
PVSLILNNGQRYQPTGTLEFSDVTVDQSTGSITLRAIIPNPQHSLLPGMYVRAEIDQGQQKNALLVPQQGITRNPRGEAT
ALIVDAHNKAQLRQVIASQAIGDKWLVTSGLQAGDKVIVSGLMRLKPGMQVRATEETPDTAQALSDVYHG
>Mature_390_residues
MNKNALCLTGSLLLCGGLLLTGCKDKNPKATQLPPHPVGVVTLRSQPLAIKTELPGRTNAYRTAEVRPQVSGIVLKRQFV
EGSDVQAGQSLYQIDPASYQAACDSALGDLKKAQASSEIAHLTVKREQPLRAKNYVSPQEFDTSVAQARQADADVIAARA
ALESARINLQYTKVIAPISGRIGKSSVTEGALVTSSQSSALATVQQLDPMYVDVTQSSDDFLKLKQAIASGTITHNGGKV
PVSLILNNGQRYQPTGTLEFSDVTVDQSTGSITLRAIIPNPQHSLLPGMYVRAEIDQGQQKNALLVPQQGITRNPRGEAT
ALIVDAHNKAQLRQVIASQAIGDKWLVTSGLQAGDKVIVSGLMRLKPGMQVRATEETPDTAQALSDVYHG

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=383, Percent_Identity=62.1409921671018, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1786668, Length=386, Percent_Identity=63.2124352331606, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789929, Length=371, Percent_Identity=54.9865229110512, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI87082036, Length=346, Percent_Identity=27.1676300578035, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081796, Length=333, Percent_Identity=25.5255255255255, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41589; Mature: 41589

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNALCLTGSLLLCGGLLLTGCKDKNPKATQLPPHPVGVVTLRSQPLAIKTELPGRTNA
CCCCCEEEECHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCC
YRTAEVRPQVSGIVLKRQFVEGSDVQAGQSLYQIDPASYQAACDSALGDLKKAQASSEIA
EEEEECCCCHHEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEE
HLTVKREQPLRAKNYVSPQEFDTSVAQARQADADVIAARAALESARINLQYTKVIAPISG
EEEEECCCCCCHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEEEECCCC
RIGKSSVTEGALVTSSQSSALATVQQLDPMYVDVTQSSDDFLKLKQAIASGTITHNGGKV
CCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCEEECCCCE
PVSLILNNGQRYQPTGTLEFSDVTVDQSTGSITLRAIIPNPQHSLLPGMYVRAEIDQGQQ
EEEEEEECCCEECCCCCEEEEEEEEECCCCCEEEEEEECCCCHHCCCCEEEEEECCCCCC
KNALLVPQQGITRNPRGEATALIVDAHNKAQLRQVIASQAIGDKWLVTSGLQAGDKVIVS
CCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
GLMRLKPGMQVRATEETPDTAQALSDVYHG
HHHHCCCCCEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNKNALCLTGSLLLCGGLLLTGCKDKNPKATQLPPHPVGVVTLRSQPLAIKTELPGRTNA
CCCCCEEEECHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCC
YRTAEVRPQVSGIVLKRQFVEGSDVQAGQSLYQIDPASYQAACDSALGDLKKAQASSEIA
EEEEECCCCHHEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEE
HLTVKREQPLRAKNYVSPQEFDTSVAQARQADADVIAARAALESARINLQYTKVIAPISG
EEEEECCCCCCHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEEEECCCC
RIGKSSVTEGALVTSSQSSALATVQQLDPMYVDVTQSSDDFLKLKQAIASGTITHNGGKV
CCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCEEECCCCE
PVSLILNNGQRYQPTGTLEFSDVTVDQSTGSITLRAIIPNPQHSLLPGMYVRAEIDQGQQ
EEEEEEECCCEECCCCCEEEEEEEEECCCCCEEEEEEECCCCHHCCCCEEEEEECCCCCC
KNALLVPQQGITRNPRGEATALIVDAHNKAQLRQVIASQAIGDKWLVTSGLQAGDKVIVS
CCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
GLMRLKPGMQVRATEETPDTAQALSDVYHG
HHHHCCCCCEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]