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The map label for this gene is exuT [H]

Identifier: 157371834

GI number: 157371834

Start: 3978025

End: 3979332

Strand: Reverse

Name: exuT [H]

Synonym: Spro_3599

Alternate gene names: 157371834

Gene position: 3979332-3978025 (Counterclockwise)

Preceding gene: 157371838

Following gene: 157371833

Centisome position: 73.03

GC content: 58.26

Gene sequence:

>1308_bases
ATGAGTGTGGAAATTAATCAAAGGGTCGTCGACAGCGGCCGGCGTAAATTTAAATCACTGCGCTGGTGGATGCTGGCGCT
GTTTCTGCTGGGTGTCACGGTTAACTACATCACTCGTAACTCGCTGGGCATCCTGGCACCTGAGCTGAAAACCAGCCTGA
ACATGACCACCGAGCAGTATTCCTGGGTGGTTGCGTCGTTCCAACTGGCCTATACGGTGTTTCAGCCGATCTGCGGTTGG
CTGATCGATGTGATTGGCCTGAAGATGGGGTTCCTGATCTGCGCCAGCATCTGGGCGGTGGTTTGCATGATGCATGCCGG
GGCCGGCACCTGGGTGCAGTTGGCGATCCTGCGCTTCTTTATGGGCGGGGCAGAAGCGGCGGCTACGCCGGCCAACGCCA
AGGCGATTTCCGACTGGTTCCCGAAGAAGGAACGGCCCATCGCCGCCGGTTGGGCGGGCGTCGGGTTTTCTATTGGCGCC
ATGCTGGCACCGCCGATCATCGTTATTGCCCACGTCTCCTTTGGCTGGCAGGGCGCTTTCCTGTTTTCCGGCGCTCTGGC
GTTGCTTTGGGTGGTGCTGTGGTGGCGGTTCTACCACTCGCCGCAGCAGCACCCCAATCTGAGCCAGCAGGAGCTGGATC
TGATCCGCGAAGACAACGAGCCGGAGTTACCCCGACTGCCTTTCCTCAAGTCGTTGGCCATTCTCTGCCGAAACAAAAAG
TTCTACGGCATTGCCATTCCGGCCTTTCTCGCCGAGCCGGCCTGGGCGGTATTCAGTTTCTGGGTGCCGCTGTATTTGGC
CACCGAACGTGGCATGGATTTAAAACACATCGCCATGTTTGCCTGGCTGCCGTTTTTGGCGGCGGACATCGGCAGCGTCG
CCAGCGGCTATCTCACCACTTTGTACCGTAAATGGTTCGGCTGCAGCCGCGTTAACTCGGTGGTTGCCAGCTCGGTCACC
GGCGCATTCATGATGGTCTCGCTGGCGTTCGTCGCGATCACCAAAGATCCCTATGTGGCGATCGCCCTGATCTCGATCGG
CGGTTTCGGCCATCAGGTGATCTCCTGCATGCTCAGCGCGCTGGTGGTGGAATCATTCGATAAAAATCAGGTAGCGACGG
TCAACGGTATGCGCGGCTCCAGCGCCTGGATCGCCAGCTTCCTGTTCACGCTGCTGATCGGCGCGGTCTCCGATACCGTC
GGTTTCAACCCGCTGTTTATCGCCATGGGCTTCTTCGACCTGATCGGCGCCGTATTCCTGATTGCCTTGATCGCCGAACG
TGGCGGTAAAAAAACACTTAATAGTTAA

Upstream 100 bases:

>100_bases
AGCATAATGCAATTTAACACCACCCATACCTTCGCTAACCAAACGTACCCTACCAAAAAGCGCGCTGTGTCACCGGGCAG
CCGTCGTGGAGAGAAGACAG

Downstream 100 bases:

>100_bases
GTTGGATGCCTATGAAAACCTTAAAAAATTGGACGTTGGCCGGTCAGTATGCCGATCGCATTGAGCTGTTGGTCGATGAA
CGTCACCTGTTCTGCCTGTA

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSVEINQRVVDSGRRKFKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWVVASFQLAYTVFQPICGW
LIDVIGLKMGFLICASIWAVVCMMHAGAGTWVQLAILRFFMGGAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGA
MLAPPIIVIAHVSFGWQGAFLFSGALALLWVVLWWRFYHSPQQHPNLSQQELDLIREDNEPELPRLPFLKSLAILCRNKK
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKHIAMFAWLPFLAADIGSVASGYLTTLYRKWFGCSRVNSVVASSVT
GAFMMVSLAFVAITKDPYVAIALISIGGFGHQVISCMLSALVVESFDKNQVATVNGMRGSSAWIASFLFTLLIGAVSDTV
GFNPLFIAMGFFDLIGAVFLIALIAERGGKKTLNS

Sequences:

>Translated_435_residues
MSVEINQRVVDSGRRKFKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWVVASFQLAYTVFQPICGW
LIDVIGLKMGFLICASIWAVVCMMHAGAGTWVQLAILRFFMGGAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGA
MLAPPIIVIAHVSFGWQGAFLFSGALALLWVVLWWRFYHSPQQHPNLSQQELDLIREDNEPELPRLPFLKSLAILCRNKK
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKHIAMFAWLPFLAADIGSVASGYLTTLYRKWFGCSRVNSVVASSVT
GAFMMVSLAFVAITKDPYVAIALISIGGFGHQVISCMLSALVVESFDKNQVATVNGMRGSSAWIASFLFTLLIGAVSDTV
GFNPLFIAMGFFDLIGAVFLIALIAERGGKKTLNS
>Mature_434_residues
SVEINQRVVDSGRRKFKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWVVASFQLAYTVFQPICGWL
IDVIGLKMGFLICASIWAVVCMMHAGAGTWVQLAILRFFMGGAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAM
LAPPIIVIAHVSFGWQGAFLFSGALALLWVVLWWRFYHSPQQHPNLSQQELDLIREDNEPELPRLPFLKSLAILCRNKKF
YGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKHIAMFAWLPFLAADIGSVASGYLTTLYRKWFGCSRVNSVVASSVTG
AFMMVSLAFVAITKDPYVAIALISIGGFGHQVISCMLSALVVESFDKNQVATVNGMRGSSAWIASFLFTLLIGAVSDTVG
FNPLFIAMGFFDLIGAVFLIALIAERGGKKTLNS

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=361, Percent_Identity=24.0997229916898, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367193, Length=415, Percent_Identity=45.3012048192771, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI87082320, Length=435, Percent_Identity=24.367816091954, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789152, Length=432, Percent_Identity=23.8425925925926, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789515, Length=417, Percent_Identity=23.5011990407674, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI2367379, Length=418, Percent_Identity=24.8803827751196, Blast_Score=118, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI115533554, Length=322, Percent_Identity=23.9130434782609, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=292, Percent_Identity=22.2602739726027, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573708, Length=374, Percent_Identity=24.331550802139, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573707, Length=374, Percent_Identity=24.331550802139, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573299, Length=297, Percent_Identity=23.5690235690236, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24658666, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24658658, Length=298, Percent_Identity=22.1476510067114, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550460, Length=321, Percent_Identity=23.98753894081, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20130135, Length=316, Percent_Identity=25.6329113924051, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24655255, Length=280, Percent_Identity=25, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24655271, Length=320, Percent_Identity=26.5625, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24584153, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639764, Length=363, Percent_Identity=22.3140495867769, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550495, Length=444, Percent_Identity=23.6486486486486, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47812; Mature: 47681

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEINQRVVDSGRRKFKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
SWVVASFQLAYTVFQPICGWLIDVIGLKMGFLICASIWAVVCMMHAGAGTWVQLAILRFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MGGAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAMLAPPIIVIAHVSFGWQGAF
HCCCHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHH
LFSGALALLWVVLWWRFYHSPQQHPNLSQQELDLIREDNEPELPRLPFLKSLAILCRNKK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKHIAMFAWLPFLAADIGSVASGYLTT
EEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRKWFGCSRVNSVVASSVTGAFMMVSLAFVAITKDPYVAIALISIGGFGHQVISCMLSA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHHHH
LVVESFDKNQVATVNGMRGSSAWIASFLFTLLIGAVSDTVGFNPLFIAMGFFDLIGAVFL
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IALIAERGGKKTLNS
HHHHHHCCCCCCCCC
>Mature Secondary Structure 
SVEINQRVVDSGRRKFKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
SWVVASFQLAYTVFQPICGWLIDVIGLKMGFLICASIWAVVCMMHAGAGTWVQLAILRFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MGGAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAMLAPPIIVIAHVSFGWQGAF
HCCCHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHH
LFSGALALLWVVLWWRFYHSPQQHPNLSQQELDLIREDNEPELPRLPFLKSLAILCRNKK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKHIAMFAWLPFLAADIGSVASGYLTT
EEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRKWFGCSRVNSVVASSVTGAFMMVSLAFVAITKDPYVAIALISIGGFGHQVISCMLSA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHHHH
LVVESFDKNQVATVNGMRGSSAWIASFLFTLLIGAVSDTVGFNPLFIAMGFFDLIGAVFL
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IALIAERGGKKTLNS
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]