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The map label for this gene is guaB [H]

Identifier: 157371831

GI number: 157371831

Start: 3972630

End: 3974093

Strand: Reverse

Name: guaB [H]

Synonym: Spro_3596

Alternate gene names: 157371831

Gene position: 3974093-3972630 (Counterclockwise)

Preceding gene: 157371833

Following gene: 157371830

Centisome position: 72.93

GC content: 58.06

Gene sequence:

>1464_bases
ATGCTACGCATCGCAAAAGAAGCACTGACATTCGACGACGTTCTCCTGGTTCCAGCTCACTCTACGGTTCTGCCTAATAC
CGCTGAGCTCGGCACCCAATTGACCAAAACCATCCACCTGAATATCCCTATGCTGTCCGCAGCCATGGACACCGTTACCG
AAGCCAATCTGGCTATCGCGCTGGCGCAGGAAGGCGGTTTAGGCTTCATCCACAAAAACATGTCCATCGAGCGTCAGGCT
GAAGAAGTCCGCCGCGTGAAAAAACATGAAAGCGGCGTGGTCACCGATCCACAGGCCGTGACTCCGACCACCACCCTGAA
AGAAGTGAAAGAACTGACCGCGCGTAACGGCTTTGCCGGCTACCCGGTCGTGACCGAAGAAAACGAACTGGTCGGCATCA
TCACCGGCCGTGACGTACGCTTCGTCACCGATCTGAACCAGCCTGTTACCGCCGTGATGACGCCGAAAGAGCGCCTGGTT
ACGGTGAAAGAAGGTGAAGCGCGTGAAGTCGTGCTGCAGAAAATGCACGAAAAACGCGTTGAGAAAGCGCTGGTGGTAGA
CGACCAGTTCCATCTGCTGGGTATGATCACCGTCAAAGACTTCCAAAAAGCGGAACGCAAGCCAAACGCCTGTAAAGACG
AGCATGGCCGTCTGCGCGTTGGTGCTGCGGTTGGCGCCGGAGCAGGTAACGAAGAGCGCGTTGATGCGCTGGTCGCTGCC
GGCGTTGACGTCCTGCTGATTGACTCCTCCCACGGCCATTCCGAAGGCGTATTACAGCGCATTCGTGAAACCCGCGCCAA
ATACCCGGATCTGCAGATCGTTGGCGGCAACGTCGCGACCGCTTCAGGCGCCAAAGCGCTGGCTGATGCCGGTGTTAGCG
CGGTGAAAGTGGGTATCGGCCCTGGTTCCATCTGTACCACTCGTATCGTTACCGGCGTTGGCGTACCGCAGATCACCGCT
ATCGCCGACGCGGTTGAAGCGCTGGAAGGCACCGGTATTCCGGTTATCGCCGACGGCGGCATCCGTTTCTCCGGTGACAT
CGCCAAAGCCATCGCGGCTGGTGCATCCTGTGTGATGGTCGGCTCCATGCTGGCGGGTACCGAAGAATCTCCGGGCGAAA
TCGAGCTGTATCAGGGCCGTTCGTTCAAATCCTATCGCGGTATGGGTTCACTGGGCGCGATGTCCAAAGGCTCTTCCGAC
CGTTACTTCCAGACCGATAACGCCGCCGACAAACTGGTGCCGGAAGGTATCGAAGGCCGCGTGGCTTACAAAGGCATGCT
GAAAGCGATTGTTCACCAGCAAATGGGCGGTCTGCGCTCTTGCATGGGCCTGACCGGCTGCGGCACCATCGACGAGCTGC
GCACCAAGGCTGAATTTGTGCGCATCAGCGGCGCCGGCATTCAGGAAAGCCACGTGCACGATGTGACCATCACCAAAGAG
TCACCGAACTACCGCATGGGTTAA

Upstream 100 bases:

>100_bases
AGTTTTTGTGCGAAAGTACTGGAGGCAACCGATTACGCTCTGTATAATGCCGCGGCAATATTTTATCTTTTTCACAGCCC
ACTCTGGTGAGATATTGCCC

Downstream 100 bases:

>100_bases
TGCTTTAACTTCTCCTGCGGGAGAAGCCGGGGTGGGGCGTAACGCTTCACCCCGAAAACACTATTTTCGCTCTTTTTCTC
TGTTGCTGGAATTCGCCTCA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTKTIHLNIPMLSAAMDTVTEANLAIALAQEGGLGFIHKNMSIERQA
EEVRRVKKHESGVVTDPQAVTPTTTLKEVKELTARNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVTAVMTPKERLV
TVKEGEAREVVLQKMHEKRVEKALVVDDQFHLLGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATASGAKALADAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
IADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVAYKGMLKAIVHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE
SPNYRMG

Sequences:

>Translated_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTKTIHLNIPMLSAAMDTVTEANLAIALAQEGGLGFIHKNMSIERQA
EEVRRVKKHESGVVTDPQAVTPTTTLKEVKELTARNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVTAVMTPKERLV
TVKEGEAREVVLQKMHEKRVEKALVVDDQFHLLGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATASGAKALADAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
IADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVAYKGMLKAIVHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE
SPNYRMG
>Mature_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTKTIHLNIPMLSAAMDTVTEANLAIALAQEGGLGFIHKNMSIERQA
EEVRRVKKHESGVVTDPQAVTPTTTLKEVKELTARNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVTAVMTPKERLV
TVKEGEAREVVLQKMHEKRVEKALVVDDQFHLLGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATASGAKALADAGVSAVKVGIGPGSICTTRIVTGVGVPQITA
IADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSD
RYFQTDNAADKLVPEGIEGRVAYKGMLKAIVHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE
SPNYRMG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=460, Percent_Identity=41.7391304347826, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI217035146, Length=462, Percent_Identity=40.6926406926407, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=40.4761904761905, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=40.6926406926407, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=40.6926406926407, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=40.7982261640798, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI217035148, Length=462, Percent_Identity=39.8268398268398, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI217035150, Length=462, Percent_Identity=37.4458874458874, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=35.3658536585366, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=34.8178137651822, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=34.8178137651822, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=34.8178137651822, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=34.9593495934959, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=93.8398357289528, Blast_Score=872, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=36.6515837104072, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=35.7740585774059, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.2978723404255, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=37.4429223744292, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=38.8090349075975, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=465, Percent_Identity=39.1397849462366, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=448, Percent_Identity=40.625, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.8888888888889, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=41.1764705882353, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=40.2464065708419, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=40.2464065708419, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI28571163, Length=445, Percent_Identity=41.123595505618, Blast_Score=295, Evalue=5e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51611; Mature: 51611

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTKTIHLNIPMLSAAMDTVTEANLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCHHHHHHHEEEEEEECCCHHHHHHHHHHHCCEEEE
LAQEGGLGFIHKNMSIERQAEEVRRVKKHESGVVTDPQAVTPTTTLKEVKELTARNGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
YPVVTEENELVGIITGRDVRFVTDLNQPVTAVMTPKERLVTVKEGEAREVVLQKMHEKRV
CCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEECCCCHHHHHHHHHHHHHH
EKALVVDDQFHLLGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
HHHEEECCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATASGAKALADAGVSAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCEEEEEECC
PGSICTTRIVTGVGVPQITAIADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHHHH
GSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCC
VAYKGMLKAIVHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCCCEEEEEEEEC
SPNYRMG
CCCCCCC
>Mature Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTAELGTQLTKTIHLNIPMLSAAMDTVTEANLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCHHHHHHHEEEEEEECCCHHHHHHHHHHHCCEEEE
LAQEGGLGFIHKNMSIERQAEEVRRVKKHESGVVTDPQAVTPTTTLKEVKELTARNGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
YPVVTEENELVGIITGRDVRFVTDLNQPVTAVMTPKERLVTVKEGEAREVVLQKMHEKRV
CCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEECCCCHHHHHHHHHHHHHH
EKALVVDDQFHLLGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
HHHEEECCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIVGGNVATASGAKALADAGVSAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCHHHHHHCCCEEEEEECC
PGSICTTRIVTGVGVPQITAIADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHHHH
GSMLAGTEESPGEIELYQGRSFKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCEEECCCCHHHCCCCCCCCC
VAYKGMLKAIVHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCCCEEEEEEEEC
SPNYRMG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]