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The map label for this gene is tktA [H]

Identifier: 157371717

GI number: 157371717

Start: 3853104

End: 3855098

Strand: Direct

Name: tktA [H]

Synonym: Spro_3480

Alternate gene names: 157371717

Gene position: 3853104-3855098 (Clockwise)

Preceding gene: 157371716

Following gene: 157371718

Centisome position: 70.71

GC content: 62.36

Gene sequence:

>1995_bases
ATGTCCTCTCGTAAAGAGCTTGCCAACGCCATCCGCGCACTCAGCATGGACGCCGTACAAAAAGCAAATTCCGGCCACCC
GGGTGCACCTATGGGCATGGCGGACATCGCCGAAGTCCTGTGGCGTGACTACCTGAACCACAACCCGACCAACCCGCACT
GGGCTGACCGTGACCGCTTCGTCCTCTCCAACGGCCATGGCTCCATGCTGATTTACAGCCTGTTGCACCTCACCGGCTAC
GACCTGCCGATGAGCGAGCTGGAAAACTTCCGCCAGCTGCACTCCAAAACCCCGGGCCACCCGGAATACGGCTACACCCC
AGGCGTGGAAACCACCACCGGCCCACTGGGTCAGGGCATCGCCAACGCCGTCGGTTTCGCCATTGCCGAACGCACCCTGG
GCGCGCAGTTCAACCGTCCGGGTCATGACATCGTCGACCACCACACCTACGCTTTTATGGGCGACGGCTGCATGATGGAA
GGCATCTCCCACGAAGTCTGTTCGCTGGCCGGTACCCTCAAGCTCGGCAAACTGACCGCGTTCTACGATGACAACGGCAT
CTCCATCGACGGTCACGTCGAAGGCTGGTTCACCGACAACACCGCCGAGCGCTTTGAAGCCTACGGCTGGCACGTGGTGC
GTCACGTTGACGGCCACAACCCGGACGCCATCAAGGCCGCCATTGAAGAAGCCCGCAAGGTCACCGACAAGCCGTCGCTG
CTGATGTGCAAAACCGTGATTGGTTTCGGCTCCCCGAACAAGGCCGGTACCCACGACGTGCACGGTGCTGCGCTGGGCGC
CGCCGAAGTGGCCGCCACCCGCGAAGCGCTGGGCTGGAAATACGCCGCCTTCGAAATCCCGCAGGACATCTATGCCCAGT
GGGATGCCAAAGAAGCCGGCAAGGCCAAAGAAGCGGCCTGGAACGACAAGTTCGCCGCCTACGCCAAAGCCTTCCCGGAA
CTGGCTGCCGAGTTCAAACGCCGTGTGAACGGTGAACTGCCGGCCAACTGGAAAGCCGAAGCCAAAGCCTTCGTGGAAAA
ACTGCAGGCCAACCCGGCCAATATCGCCAGCCGCAAGGCCTCGCAGAACGCACTGGAAACCTTCGGCAAGGTGCTGCCTG
AATTCCTCGGCGGCTCCGCTGACCTGGCACCAAGCAACCTGACCATGTGGTCCGGCTCCAAGCCACTCAACGAAGACCTG
GCGGGTAACTACATCCACTACGGCGTGCGCGAGTTCGGCATGACCGCCATCACCAACGGCATCGCGCTGCACGGCGGCTT
CCTGCCGTACTCGGCGACCTTCCTGATGTTCGTGGAATACGCCCGTAATGCGGTGCGTATGGCGGCGCTGATGAAAATCC
GCAACGTGTTCGTCTACACCCATGACTCCATCGGTCTGGGCGAAGACGGCCCGACGCACCAGCCGGTTGAGCAGATGGCC
AGCCTGCGCGTGACCCCGAACATGAGCACCTGGCGTCCGTGTGACCAGGTGGAATCGGCGGTCGCCTGGCAGTACGGCAT
CGAGCGCAACGACGGCCCGACCACGCTGATTTTCTCACGTCAGAACCTGACCCAGCAGCCGCGTAGCGCAGAGCAACTGG
CCAACGTTTACCGTGGCGGTTATGTCCTGAAGGACTGCGCCGGGACGCCGGACGTCATTCTGATTGCCACCGGTTCGGAA
GTGGGTATCACCGTGGAAGCGGCAGACCAGCTGACTGCGGCGGGCCGCAAGGTGCGCGTGGTCTCCATGCCGTCTACCGA
CGCGTTCGACAAGCAGGATGCGGCGTACCGTGAATCCGTGCTGCCGGCGGCAGTGAGCGCACGCGTGGCGGTAGAAGCAG
GTATCGCGGACTACTGGTACAAGTATGTGGGCCTGAACGGCGCCATCGTGGGCATGACCAGCTTCGGCGAGTCTGCCCCG
GCAGAGCAGCTGTTCAAAGAGTTTGGCTTCACCGTGGACAACGTGGTAGCCAAGGCGCAGGCACTGCTGAAATAG

Upstream 100 bases:

>100_bases
CGGTTGAAAAACTGGCCGAAGGTATCCGCCTGTTCGCCGTTGACCAGCAAAAGCTGGAAGATATGCTGGCCGCTGAACTG
TAATCACACTGGAGTAAAAC

Downstream 100 bases:

>100_bases
TTCCCTCTCCCCCTGGAGAGGATGAAGCCATCAGCCCGGCACATTGCCGGGCTTTTTCGTTCTGGCTGAAGCTCTTTTTA
TATCTCATATTCGCCCTTAC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPE
LAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDL
AGNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRSAEQLANVYRGGYVLKDCAGTPDVILIATGSE
VGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTSFGESAP
AEQLFKEFGFTVDNVVAKAQALLK

Sequences:

>Translated_664_residues
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPE
LAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDL
AGNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRSAEQLANVYRGGYVLKDCAGTPDVILIATGSE
VGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTSFGESAP
AEQLFKEFGFTVDNVVAKAQALLK
>Mature_663_residues
SSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGYD
LPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEG
ISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSLL
MCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPEL
AAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLA
GNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMAS
LRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRSAEQLANVYRGGYVLKDCAGTPDVILIATGSEV
GITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTSFGESAPA
EQLFKEFGFTVDNVVAKAQALLK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=693, Percent_Identity=26.2626262626263, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI4507521, Length=693, Percent_Identity=26.2626262626263, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI133778974, Length=680, Percent_Identity=25.2941176470588, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=84.4645550527903, Blast_Score=1187, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=72.9198184568835, Blast_Score=1039, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=675, Percent_Identity=24, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=48.4351713859911, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=45.5357142857143, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45551847, Length=607, Percent_Identity=27.3476112026359, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45550715, Length=607, Percent_Identity=27.3476112026359, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24645119, Length=573, Percent_Identity=26.7015706806283, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24666278, Length=687, Percent_Identity=24.0174672489083, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72071; Mature: 71940

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTLKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCHHHHCCHHHHHHHHHHEEECCEEE
FYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
EECCCCEEECCCEEEEEECCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAG
EEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCHHCC
KAKEAAWNDKFAAYAKAFPELAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLAGNYIHYGVREFGMTAITNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
IALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRSAEQLANVYRGG
HEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
YVLKDCAGTPDVILIATGSEVGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEEECCCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
LPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTSFGESAPAEQLFKEFGFTVDNVVAKAQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC
>Mature Secondary Structure 
SSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTLKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCHHHHCCHHHHHHHHHHEEECCEEE
FYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
EECCCCEEECCCEEEEEECCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAG
EEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCHHCC
KAKEAAWNDKFAAYAKAFPELAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLAGNYIHYGVREFGMTAITNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
IALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRSAEQLANVYRGG
HEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
YVLKDCAGTPDVILIATGSEVGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEEECCCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
LPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTSFGESAPAEQLFKEFGFTVDNVVAKAQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]