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The map label for this gene is mmuM [H]

Identifier: 157371708

GI number: 157371708

Start: 3843229

End: 3844167

Strand: Direct

Name: mmuM [H]

Synonym: Spro_3471

Alternate gene names: 157371708

Gene position: 3843229-3844167 (Clockwise)

Preceding gene: 157371707

Following gene: 157371713

Centisome position: 70.53

GC content: 60.81

Gene sequence:

>939_bases
ATGTCGGTTAACAACCCTGTCGCCACACTCTTGAGCGCCCACCCTACGCTGATTTTAGACGGCGCACTGGCCACCGAACT
GGAAGCCCGCGGCTGCGATCTGAGCGATCCGCTGTGGTCGGCAAAAGTGCTGATTGAAAACCCTGAGCTGATTTATCAGG
TGCATCTCGACTATTTCAACGCCGGAGCGCAGTGCGCCATCACCGCCAGCTATCAGGCCACGCCACAAGGCTTTCTGCGC
CGTGGTTTGGATCAAGCGCAGTCACTGGCGCTGATCGCCAAAAGCGTGCAGTTGGCGCAGCAGGCACGCCGCGATTATCT
GGCACAACACCCGCAGGCCGCACCGCTGCTGATTGCCGGCTCGGTGGGGCCCTATGGCGCTTATCTGGCCGATGGATCTG
AATATCGCGGTGATTACTCGCTGCCGCAGGAAGAGATGATCGCCTTCCACCGCCCGCGCATCAGCGCACTGGCCGAGGCC
GGGGTGGATTTACTGGCCTGCGAGACTCTGCCGTCCTTCAGCGAACTGCAGGCGTTGCTGACGCTGTTGGAAGAGTTCCC
AACCCTGGGTGCCTGGTTCGCTTTCACCCTGCGCGACAGTCAACACCTCAGCGACGGGACGCCGCTGACCGAGGTCATGG
CAGCGCTGCACGCCAATCCACAGGTGCTGGCGATTGGCATTAACTGCATTGCGCTGGAAAATGTGGCCCCGGCGCTGCAG
CAATTTGCCGCACTGGCTGACAAGCCGCTGCTGGTCTATCCGAACTCGGGTGAACACTACGACGCGGTAAGTAAAACCTG
GCATGCCTGTGGGGGGGCACATGGCAGTCTGATTGATCAAATTGGCGAATGGCAACGCATCGGCGCCCGGCTGATTGGCG
GCTGTTGCCGCACGACACCGCAGGATATCCACCAGATCGCCACACGCTGCAGGGCATAA

Upstream 100 bases:

>100_bases
CGCATCGCGCTTTACTGCGGGCTGCCCTTTGTCGCCCTGTGCTACATCGCCTATTACCTGACCCGCCGTGCCGGGCAAAA
AACCTCTCTGGGAGAGAATC

Downstream 100 bases:

>100_bases
AATAAAAAAAGCCTCCGGCGCCGAAACGCTGGAGGCTTGTAGTCACTTAAGGCTTATAACGGCGTGGTCTGCGCTTCCAC
CACGGCCAGCGCGACCATAT

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSVNNPVATLLSAHPTLILDGALATELEARGCDLSDPLWSAKVLIENPELIYQVHLDYFNAGAQCAITASYQATPQGFLR
RGLDQAQSLALIAKSVQLAQQARRDYLAQHPQAAPLLIAGSVGPYGAYLADGSEYRGDYSLPQEEMIAFHRPRISALAEA
GVDLLACETLPSFSELQALLTLLEEFPTLGAWFAFTLRDSQHLSDGTPLTEVMAALHANPQVLAIGINCIALENVAPALQ
QFAALADKPLLVYPNSGEHYDAVSKTWHACGGAHGSLIDQIGEWQRIGARLIGGCCRTTPQDIHQIATRCRA

Sequences:

>Translated_312_residues
MSVNNPVATLLSAHPTLILDGALATELEARGCDLSDPLWSAKVLIENPELIYQVHLDYFNAGAQCAITASYQATPQGFLR
RGLDQAQSLALIAKSVQLAQQARRDYLAQHPQAAPLLIAGSVGPYGAYLADGSEYRGDYSLPQEEMIAFHRPRISALAEA
GVDLLACETLPSFSELQALLTLLEEFPTLGAWFAFTLRDSQHLSDGTPLTEVMAALHANPQVLAIGINCIALENVAPALQ
QFAALADKPLLVYPNSGEHYDAVSKTWHACGGAHGSLIDQIGEWQRIGARLIGGCCRTTPQDIHQIATRCRA
>Mature_311_residues
SVNNPVATLLSAHPTLILDGALATELEARGCDLSDPLWSAKVLIENPELIYQVHLDYFNAGAQCAITASYQATPQGFLRR
GLDQAQSLALIAKSVQLAQQARRDYLAQHPQAAPLLIAGSVGPYGAYLADGSEYRGDYSLPQEEMIAFHRPRISALAEAG
VDLLACETLPSFSELQALLTLLEEFPTLGAWFAFTLRDSQHLSDGTPLTEVMAALHANPQVLAIGINCIALENVAPALQQ
FAALADKPLLVYPNSGEHYDAVSKTWHACGGAHGSLIDQIGEWQRIGARLIGGCCRTTPQDIHQIATRCRA

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=316, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786456, Length=309, Percent_Identity=67.6375404530744, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1790450, Length=316, Percent_Identity=24.6835443037975, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569783, Length=143, Percent_Identity=35.6643356643357, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322966, Length=324, Percent_Identity=31.4814814814815, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324982, Length=323, Percent_Identity=27.5541795665635, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323983, Length=90, Percent_Identity=40, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585077, Length=313, Percent_Identity=36.741214057508, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129603, Length=321, Percent_Identity=38.3177570093458, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 33594; Mature: 33462

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNNPVATLLSAHPTLILDGALATELEARGCDLSDPLWSAKVLIENPELIYQVHLDYFN
CCCCCHHHHHHHCCCCEEECCHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEEEHHHC
AGAQCAITASYQATPQGFLRRGLDQAQSLALIAKSVQLAQQARRDYLAQHPQAAPLLIAG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
SVGPYGAYLADGSEYRGDYSLPQEEMIAFHRPRISALAEAGVDLLACETLPSFSELQALL
CCCCCCCEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEECCCCCCHHHHHHHH
TLLEEFPTLGAWFAFTLRDSQHLSDGTPLTEVMAALHANPQVLAIGINCIALENVAPALQ
HHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEECEEEEHHHHHHHHH
QFAALADKPLLVYPNSGEHYDAVSKTWHACGGAHGSLIDQIGEWQRIGARLIGGCCRTTP
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
QDIHQIATRCRA
HHHHHHHHHHCC
>Mature Secondary Structure 
SVNNPVATLLSAHPTLILDGALATELEARGCDLSDPLWSAKVLIENPELIYQVHLDYFN
CCCCHHHHHHHCCCCEEECCHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEEEHHHC
AGAQCAITASYQATPQGFLRRGLDQAQSLALIAKSVQLAQQARRDYLAQHPQAAPLLIAG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
SVGPYGAYLADGSEYRGDYSLPQEEMIAFHRPRISALAEAGVDLLACETLPSFSELQALL
CCCCCCCEECCCCCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEECCCCCCHHHHHHHH
TLLEEFPTLGAWFAFTLRDSQHLSDGTPLTEVMAALHANPQVLAIGINCIALENVAPALQ
HHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEECEEEEHHHHHHHHH
QFAALADKPLLVYPNSGEHYDAVSKTWHACGGAHGSLIDQIGEWQRIGARLIGGCCRTTP
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
QDIHQIATRCRA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]