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The map label for this gene is yeiQ [H]

Identifier: 157371476

GI number: 157371476

Start: 3572506

End: 3573987

Strand: Direct

Name: yeiQ [H]

Synonym: Spro_3239

Alternate gene names: 157371476

Gene position: 3572506-3573987 (Clockwise)

Preceding gene: 157371474

Following gene: 157371478

Centisome position: 65.56

GC content: 58.77

Gene sequence:

>1482_bases
ATGAAGACTATCGCCAACTCACCGCTTCCCGACGCTGTCCAGCAACCGCGCTATGACCGCAGCACATTACAAAGCCGCAT
GGTGCACATTGGATTCGGAGCCTTTCACCGCGCCCATCAGGCACTGCTGACCGACCGGGTATTGAACCGCCAGGGGGGAG
ACTGGGGGATTTGTGAGATCAGCCTGTTCGGTGGCGACATTCTGTTCCAGACGCTGCGTCAGCAAGACCATCTTTATAGC
GTGCTGGAAAAAGGCGCTGAGGGGGATCAGGCGATAGTGATCTGGGCCGTGCATGAAAGCGTACACCGCAAACTGGAAGG
GATCGGTGCCGTGCTGGAAAAACTGGCGGAACCGCAGGTAGCCATCGTCTCAATGACCATCACCGAAAAAGGCTACTGCA
TCGAACCCGGTAGCGGGAAACTGGATCTGCAACACCAGGGGATCCGCGCCGATCTTGCCAACCCCGCTCAACCCATTACG
GTACCCGGCATTCTGGTCGAAGCCCTGCGCCTGCGCCTGGAACGCGGTCTGCCCGCCTTTACCCTGCTCTCTTGCGATAA
TATTCCCGAAAACGGCCATGTACTGCGCAACGCCATCATCGGCCTGGCGCAGGCGCGTGACGGCGCCCTGGCAGATTGGA
TTGCCCAGCAGGTCAGTTTCCCCAGTACTATGGTCGACCGCATTGTTCCAGCCGCCACCGCGGAAACGCTCGATGAAGTG
GCTGCCGCATTGGGCGGCGTACGTGATGAATGCGCCATCGCCTGCGAGCCCTTTATCCAATGGGTGGTGGAAGATAATTT
TGTCGCAGGCCGTCCGGCCTGGGAACTGGCCGGTGCGCAGTTGGTAAATGACGTACTGCCTTTTGAACAAATGAAGCTGC
GTATGCTGAACGGCAGTCATTCCTTCCTGGCCTACCTGGGTTATCTGGGGGGGTATCAGTATATAAACGACTGTATGGCC
GACGAGTCTTATCGCCAAGCGGCACACCACCTGATGCTGGCCGAGCAGGCACCGACGCTCAGCGTCAGCGGTATCGATCT
GGCCGCCTATGCCGCGCAGTTGATTGAACGCTACAGCAATCCGGCGCTGCAACATCGCACCTGGCAAATCGCCATGGATG
GCACACAAAAATTGCCACAGCGGATGCTGGATTCGGTTCGTTGGCATCTGCAGCATGGCGGCAGCTATGCCGGTTTGGCG
CTGGGTGTGGCAGCCTGGATGCGCTATGTCGGCGGCGTGGATGATGCCGGTCAGCCGATTGATATCCGCGATCCGCTGCT
GACAACGCTGCAACAGACGGTGGCCGCAACGCCGGACGATGAACAACGCGTAAAAGCCCTGTTGGCGTTGAAAGCCGTTT
TTGGTGAACAACTGCCGGCAAATGAGGCGTTTGTGGCGGCGGTTACCCGCGCCTATATTTCCCTGCGCGATCGCGGGGCG
CGCCAAACGGTGCAGAATTGGGTTTCGACTCAGTTGGCTTGA

Upstream 100 bases:

>100_bases
CGAAAAAGGTAAGCGCCGTGCCGTTTTCCATTCGCAAAACTGGTCTGATAACTTCTTAAAAGTTCCCGGCCAGCACCTTT
TACCCAGCTTGGAGCCATGC

Downstream 100 bases:

>100_bases
TACCCGGTTAAACCAGACCCTGACTTGAAAGGCCAGGGGGAAAATGGCCATGCCGGATGTCCGGCATGGCCGAACGACTT
AACGATAAACTACCGTCATT

Product: mannitol dehydrogenase domain-containing protein

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MKTIANSPLPDAVQQPRYDRSTLQSRMVHIGFGAFHRAHQALLTDRVLNRQGGDWGICEISLFGGDILFQTLRQQDHLYS
VLEKGAEGDQAIVIWAVHESVHRKLEGIGAVLEKLAEPQVAIVSMTITEKGYCIEPGSGKLDLQHQGIRADLANPAQPIT
VPGILVEALRLRLERGLPAFTLLSCDNIPENGHVLRNAIIGLAQARDGALADWIAQQVSFPSTMVDRIVPAATAETLDEV
AAALGGVRDECAIACEPFIQWVVEDNFVAGRPAWELAGAQLVNDVLPFEQMKLRMLNGSHSFLAYLGYLGGYQYINDCMA
DESYRQAAHHLMLAEQAPTLSVSGIDLAAYAAQLIERYSNPALQHRTWQIAMDGTQKLPQRMLDSVRWHLQHGGSYAGLA
LGVAAWMRYVGGVDDAGQPIDIRDPLLTTLQQTVAATPDDEQRVKALLALKAVFGEQLPANEAFVAAVTRAYISLRDRGA
RQTVQNWVSTQLA

Sequences:

>Translated_493_residues
MKTIANSPLPDAVQQPRYDRSTLQSRMVHIGFGAFHRAHQALLTDRVLNRQGGDWGICEISLFGGDILFQTLRQQDHLYS
VLEKGAEGDQAIVIWAVHESVHRKLEGIGAVLEKLAEPQVAIVSMTITEKGYCIEPGSGKLDLQHQGIRADLANPAQPIT
VPGILVEALRLRLERGLPAFTLLSCDNIPENGHVLRNAIIGLAQARDGALADWIAQQVSFPSTMVDRIVPAATAETLDEV
AAALGGVRDECAIACEPFIQWVVEDNFVAGRPAWELAGAQLVNDVLPFEQMKLRMLNGSHSFLAYLGYLGGYQYINDCMA
DESYRQAAHHLMLAEQAPTLSVSGIDLAAYAAQLIERYSNPALQHRTWQIAMDGTQKLPQRMLDSVRWHLQHGGSYAGLA
LGVAAWMRYVGGVDDAGQPIDIRDPLLTTLQQTVAATPDDEQRVKALLALKAVFGEQLPANEAFVAAVTRAYISLRDRGA
RQTVQNWVSTQLA
>Mature_493_residues
MKTIANSPLPDAVQQPRYDRSTLQSRMVHIGFGAFHRAHQALLTDRVLNRQGGDWGICEISLFGGDILFQTLRQQDHLYS
VLEKGAEGDQAIVIWAVHESVHRKLEGIGAVLEKLAEPQVAIVSMTITEKGYCIEPGSGKLDLQHQGIRADLANPAQPIT
VPGILVEALRLRLERGLPAFTLLSCDNIPENGHVLRNAIIGLAQARDGALADWIAQQVSFPSTMVDRIVPAATAETLDEV
AAALGGVRDECAIACEPFIQWVVEDNFVAGRPAWELAGAQLVNDVLPFEQMKLRMLNGSHSFLAYLGYLGGYQYINDCMA
DESYRQAAHHLMLAEQAPTLSVSGIDLAAYAAQLIERYSNPALQHRTWQIAMDGTQKLPQRMLDSVRWHLQHGGSYAGLA
LGVAAWMRYVGGVDDAGQPIDIRDPLLTTLQQTVAATPDDEQRVKALLALKAVFGEQLPANEAFVAAVTRAYISLRDRGA
RQTVQNWVSTQLA

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=486, Percent_Identity=63.3744855967078, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=484, Percent_Identity=58.0578512396694, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790779, Length=487, Percent_Identity=58.7268993839836, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1790028, Length=250, Percent_Identity=28, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI48994885, Length=511, Percent_Identity=24.0704500978474, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=469, Percent_Identity=38.8059701492537, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6320765, Length=469, Percent_Identity=38.8059701492537, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 53959; Mature: 53959

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIANSPLPDAVQQPRYDRSTLQSRMVHIGFGAFHRAHQALLTDRVLNRQGGDWGICEI
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SLFGGDILFQTLRQQDHLYSVLEKGAEGDQAIVIWAVHESVHRKLEGIGAVLEKLAEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCE
AIVSMTITEKGYCIEPGSGKLDLQHQGIRADLANPAQPITVPGILVEALRLRLERGLPAF
EEEEEEEECCCEEECCCCCCEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
TLLSCDNIPENGHVLRNAIIGLAQARDGALADWIAQQVSFPSTMVDRIVPAATAETLDEV
EEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAALGGVRDECAIACEPFIQWVVEDNFVAGRPAWELAGAQLVNDVLPFEQMKLRMLNGSH
HHHHCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCH
SFLAYLGYLGGYQYINDCMADESYRQAAHHLMLAEQAPTLSVSGIDLAAYAAQLIERYSN
HHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCC
PALQHRTWQIAMDGTQKLPQRMLDSVRWHLQHGGSYAGLALGVAAWMRYVGGVDDAGQPI
CCHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DIRDPLLTTLQQTVAATPDDEQRVKALLALKAVFGEQLPANEAFVAAVTRAYISLRDRGA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
RQTVQNWVSTQLA
HHHHHHHHHHCCC
>Mature Secondary Structure
MKTIANSPLPDAVQQPRYDRSTLQSRMVHIGFGAFHRAHQALLTDRVLNRQGGDWGICEI
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
SLFGGDILFQTLRQQDHLYSVLEKGAEGDQAIVIWAVHESVHRKLEGIGAVLEKLAEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCE
AIVSMTITEKGYCIEPGSGKLDLQHQGIRADLANPAQPITVPGILVEALRLRLERGLPAF
EEEEEEEECCCEEECCCCCCEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
TLLSCDNIPENGHVLRNAIIGLAQARDGALADWIAQQVSFPSTMVDRIVPAATAETLDEV
EEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AAALGGVRDECAIACEPFIQWVVEDNFVAGRPAWELAGAQLVNDVLPFEQMKLRMLNGSH
HHHHCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCH
SFLAYLGYLGGYQYINDCMADESYRQAAHHLMLAEQAPTLSVSGIDLAAYAAQLIERYSN
HHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCC
PALQHRTWQIAMDGTQKLPQRMLDSVRWHLQHGGSYAGLALGVAAWMRYVGGVDDAGQPI
CCHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DIRDPLLTTLQQTVAATPDDEQRVKALLALKAVFGEQLPANEAFVAAVTRAYISLRDRGA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
RQTVQNWVSTQLA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]