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The map label for this gene is cbl [H]

Identifier: 157371157

GI number: 157371157

Start: 3210859

End: 3211812

Strand: Reverse

Name: cbl [H]

Synonym: Spro_2917

Alternate gene names: 157371157

Gene position: 3211812-3210859 (Counterclockwise)

Preceding gene: 157371158

Following gene: 157371156

Centisome position: 58.94

GC content: 52.73

Gene sequence:

>954_bases
ATGAACTTTCAACAATTAAAAATTATTCGGGAATCGGCGCGCTGCAACTACAACCTGACCGAGGTAGCCAACACTTTATT
TACCTCACAATCTGGGGTCAGTCGTCATATTCGGGAACTTGAAGAAGAACTGGGTATTGAGATATTTATCCGCCGTGGCA
AACGTTTATTAGGCATGACCGAGCCGGGCAAAGAACTGCTGGTGGTGGCAGAACGCATCCTGAATGATGCCAATAATATC
CGCCGTCTGGCAGACGTATTCAGCAGCAACGACGCCGGTCAGTTGCACATCGCCACTACCCATACCCAGGCGCGCTACAG
CCTGCCGGGGGTGATCAAAGAGTTCCGCGCGCTGTATCCACGGGTGAGAGTGGTGCTGAATCAGGGCAGCCCTGAGGAAA
TCGTTGGCATGCTGGCCTCTGGCGAAGCCGATATCGGCATTGCCAGTGAAAGGCTGATGAGTGATGAGTCTCTGGCGGCG
TTTCCCTACTACCGCTGGCACCACACCATACTGGTACCGGAAGGGCATGAACTGACCCGTCAGCCGCAGGTGACGCTGGA
AATGCTCAGCACCTTGCCGCTGATCACCTATCGACAGGGTATTACCGGCCGTTCACGGCTGGATAGCGCTTTCAAAGCCG
CCGGGCTAACGCCGGATATCGCCTTAAGCGCGCAGGATTCAGATGTGATTAAGACCTATGTCGAACTGGGGTTGGGAGTG
GGGGTGTTGGCGGATATGTCTTACGAGAAGGAACGCGACCATGGGTTGGTCAGCCTTAACGCCGAACATCTGTTCGAACC
CAATACCGTTTGGTTAGGTTTGAAACGCAGTCAGTTACAACGTAACTATGCCTGGCGATTTATCCAGCTGTGTAACCCGA
CGTTGTCGCTGACTGAAATCAAAGACAAAGTATTTTCCTCACAGCTCGATACGGTGATCGATTACCAGATTTAG

Upstream 100 bases:

>100_bases
TAGCATGAAAATGCATAACTAAAGGTTATTTCTTATTTGTCCCCTTACCCCAGACTCCGTATCACTGTGTTTAACAATAT
TGTTCGACCGGGGGGAGTGG

Downstream 100 bases:

>100_bases
TTCAGACGCCGGGCATAGGGCCCGGTGATTTCGCAAAATCCCGCCTGCTTAATAATCAAAATCTCAGCTATAGACATAAA
AAGAATATCTATAGTTATTT

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MNFQQLKIIRESARCNYNLTEVANTLFTSQSGVSRHIRELEEELGIEIFIRRGKRLLGMTEPGKELLVVAERILNDANNI
RRLADVFSSNDAGQLHIATTHTQARYSLPGVIKEFRALYPRVRVVLNQGSPEEIVGMLASGEADIGIASERLMSDESLAA
FPYYRWHHTILVPEGHELTRQPQVTLEMLSTLPLITYRQGITGRSRLDSAFKAAGLTPDIALSAQDSDVIKTYVELGLGV
GVLADMSYEKERDHGLVSLNAEHLFEPNTVWLGLKRSQLQRNYAWRFIQLCNPTLSLTEIKDKVFSSQLDTVIDYQI

Sequences:

>Translated_317_residues
MNFQQLKIIRESARCNYNLTEVANTLFTSQSGVSRHIRELEEELGIEIFIRRGKRLLGMTEPGKELLVVAERILNDANNI
RRLADVFSSNDAGQLHIATTHTQARYSLPGVIKEFRALYPRVRVVLNQGSPEEIVGMLASGEADIGIASERLMSDESLAA
FPYYRWHHTILVPEGHELTRQPQVTLEMLSTLPLITYRQGITGRSRLDSAFKAAGLTPDIALSAQDSDVIKTYVELGLGV
GVLADMSYEKERDHGLVSLNAEHLFEPNTVWLGLKRSQLQRNYAWRFIQLCNPTLSLTEIKDKVFSSQLDTVIDYQI
>Mature_317_residues
MNFQQLKIIRESARCNYNLTEVANTLFTSQSGVSRHIRELEEELGIEIFIRRGKRLLGMTEPGKELLVVAERILNDANNI
RRLADVFSSNDAGQLHIATTHTQARYSLPGVIKEFRALYPRVRVVLNQGSPEEIVGMLASGEADIGIASERLMSDESLAA
FPYYRWHHTILVPEGHELTRQPQVTLEMLSTLPLITYRQGITGRSRLDSAFKAAGLTPDIALSAQDSDVIKTYVELGLGV
GVLADMSYEKERDHGLVSLNAEHLFEPNTVWLGLKRSQLQRNYAWRFIQLCNPTLSLTEIKDKVFSSQLDTVIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=317, Percent_Identity=67.5078864353312, Blast_Score=436, Evalue=1e-124,
Organism=Escherichia coli, GI1787530, Length=296, Percent_Identity=45.6081081081081, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=28.135593220339, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=31.4009661835749, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790208, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=238, Percent_Identity=26.890756302521, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790399, Length=252, Percent_Identity=23.015873015873, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787806, Length=294, Percent_Identity=22.4489795918367, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082132, Length=136, Percent_Identity=30.8823529411765, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35741; Mature: 35741

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIRESARCNYNLTEVANTLFTSQSGVSRHIRELEEELGIEIFIRRGKRLLGMT
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCEEECCC
EPGKELLVVAERILNDANNIRRLADVFSSNDAGQLHIATTHTQARYSLPGVIKEFRALYP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
RVRVVLNQGSPEEIVGMLASGEADIGIASERLMSDESLAAFPYYRWHHTILVPEGHELTR
HHEEEECCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCC
QPQVTLEMLSTLPLITYRQGITGRSRLDSAFKAAGLTPDIALSAQDSDVIKTYVELGLGV
CCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCH
GVLADMSYEKERDHGLVSLNAEHLFEPNTVWLGLKRSQLQRNYAWRFIQLCNPTLSLTEI
HHHHCCCCCHHCCCCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHH
KDKVFSSQLDTVIDYQI
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNFQQLKIIRESARCNYNLTEVANTLFTSQSGVSRHIRELEEELGIEIFIRRGKRLLGMT
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCEEECCC
EPGKELLVVAERILNDANNIRRLADVFSSNDAGQLHIATTHTQARYSLPGVIKEFRALYP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
RVRVVLNQGSPEEIVGMLASGEADIGIASERLMSDESLAAFPYYRWHHTILVPEGHELTR
HHEEEECCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCC
QPQVTLEMLSTLPLITYRQGITGRSRLDSAFKAAGLTPDIALSAQDSDVIKTYVELGLGV
CCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCH
GVLADMSYEKERDHGLVSLNAEHLFEPNTVWLGLKRSQLQRNYAWRFIQLCNPTLSLTEI
HHHHCCCCCHHCCCCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHH
KDKVFSSQLDTVIDYQI
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]