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The map label for this gene is wzc [H]

Identifier: 157371133

GI number: 157371133

Start: 3176498

End: 3178681

Strand: Reverse

Name: wzc [H]

Synonym: Spro_2893

Alternate gene names: 157371133

Gene position: 3178681-3176498 (Counterclockwise)

Preceding gene: 157371134

Following gene: 157371132

Centisome position: 58.34

GC content: 58.1

Gene sequence:

>2184_bases
ATGATGAAGAACAACGCATTGCCGATTGTGATGGCTGAACAGGACGACAAACTGGAGTGGGAGCGCCTGATTGGCCCGCT
GTGGGATAACCGCTGGCGCATTCTGCTGGTGACCGGCGTCGCCGGTATTCTGGGCTGCGCTTATGCACTGATGGCGACGC
CAATCTATCAGGCTACGGCCCTGGTACAGGTGGAAAAGCAGCTCTCGGGCGATTCATTGCTGCGTGAAACGCTGGACAGC
TCTATTGGCGGCTCCATCGGGCAGAACTCGGCGACTCAGGACGAGGTTTCGCTGGCGAAATCGCGCTACGTGATTGGCAA
AACCGTCGACGATCTTGGTCTGACTGTGCGTATCAGCCCGGATTACTTCCCGCTGCTTGGCAAGGGCATTGCCCGCCTGA
GCGGTGAAACGCCGCCGCTGTTGAACATCTCCGGCATGAAGGTGCCGGCGGTCATGCAGGGCCAGGAACTGACCCTGACC
GCAGAAGATCAACAGCGTTATAGCCTGAGCCATGACGGCAAAAAATTGTTCAGCGGCAGCGTGGGGCAAGCCCTGCAGCA
GGGCGGTTGGGCAATGAATGTGACCGCGCTGGAGGCCTTGCCGGGCACGACTTTCACTATAGTTAACGTGCCGCGCCAGA
AAGCGGTGGACGACCTGCGCAATATGCTTGACGTTGCCCCCGGCGGCAAGGAAAGCGGCATCATGACCTTCAGCCTGGCG
GGGGAAGATCCGCAGCGTGCAGAGGCGGTGCTCAAAAGCATCACCGACAACTATTTGCAACAGAACGTGGATCGCAAAAC
CGAGGAGGCGCAGCGCATGCTGGCCTTCCTGCACGAGCAGTTACCTCGTACTCAGAGCTCGCTCAACAACGCCGAAAATC
AACTTAATCAGTTCCGTCAGCAAAACGACTCGGTAGATTTGTCACTCGAGGCCAAATCGGTGCTGGATACCCAGGTTCAG
CTTGAAGGCCAGTTGAATGAGCTGACCTTCAAAGAGGCGGAAATCTCCAAGCTTTATACCCGCGTGCATCCGGCCTATCG
GGCGCTGTTGGAAAAACGCGCCACGCTGGAAGCGGAAAAAGCCCGCCTTGGCAAGCAGGTACAAAGCCTGCCGAAAACCC
AGCAGGAAATTCTGCGCTTAACCCGCGACGTGCAGGTGGACCAGCAGGTCTATATGCAACTGATGAACAAACAGCAGGAG
TTGAGCATCAGCAAGGCCGGCACGGTGGGCAACATCCGTATTATCGATGAGGCGGAAACCGGTCTGCGCCCGGTGCAGCC
GCAAAAGGCGATGATTGTGTTGTTTGCGCTGCTTATGGGGGGCGTGCTGTCAGCCTCGGTGGTGGTGTTGCGCGCCGCGC
TTCATCGCGGCATCGGTGACACCGATACGCTGGAAAAGCGCGGTATCAGCGTGTACGCCACGGTGCCACTGTCGCCATGG
CAGCAAAAGCGCAACCGCGCTCAGCAGCAACTGTTGACTAAACACGGCAGCGGCAAACTGCCGATATTGGCGCAGGAGGA
ACCGGAAGATTTATCCGTTGAGGCGATCCGCAGCCTGCGCACCAGCCTGCACTTCGCCATGATGGAGGCCAAAAACAACA
TTCTGATGGTCTCGGGCGCCAGCCCCGCCAGCGGCAAAAGCTTTACCAGTACCAACCTGGCGGTGGTGATCGCTCAGGCC
GGTCAGCGGGTGTTGTTGATCGACGCCGATATGCGCAAAGGCTTTTTGCACCGCTGGTTGAACAACAGCGCCAAGGCCGG
TCTTTCAGACATGCTGTCCGGACTGATCGCACCCGACCAGGCGGTGAAGAAAACCGATATCGCCAATCTGGACTTTGTGC
CGCGCGGCCAGGTGCCGCCGAACCCGTCCGAATTGCTGATGCATCAGCGCTTTGCCGATTTCCTGCGCTGGGCGGGGCAA
AATTACGATCTGGTACTGATCGACACGCCGCCGGTACTGGCGGTAACCGACGCCGCCATCGTTGGCCATCATGCCGGTAC
GGCGCTGATGGTGGTGCGTTTTGAGGTCAACACCGTCAGACAGATTGAAACCAGTATCCGTCGCTTCGAGCAGAACGGCG
TGACGATTAAAGGGGTGATCCTCAACGGCATGGTGAAAAAAACCGCCACCGATGCCGGTTACTATGCTTTTGCTTACCCC
AGCCACCAGGAAAAGGTTCAGTAA

Upstream 100 bases:

>100_bases
AGCCAGTTGGCACCGACCATTTCCAGCTTTAACGACCTTAGCGAGGCCACGTTGCGGGTCCGTAATTGGTAAACCCGTAA
CGGTGACTTAAGGAATACTG

Downstream 100 bases:

>100_bases
CCGCATGAAAGCGATGCTGATGAACTCCCTGTGGTTGATGTTGGAACGGGTATCGCTGAGCCTGTCAGGCATTTTTGTTT
CGGTGTACGTGGCGCGCTAC

Product: non-specific protein-tyrosine kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATALVQVEKQLSGDSLLRETLDS
SIGGSIGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISPDYFPLLGKGIARLSGETPPLLNISGMKVPAVMQGQELTLT
AEDQQRYSLSHDGKKLFSGSVGQALQQGGWAMNVTALEALPGTTFTIVNVPRQKAVDDLRNMLDVAPGGKESGIMTFSLA
GEDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQSSLNNAENQLNQFRQQNDSVDLSLEAKSVLDTQVQ
LEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEKARLGKQVQSLPKTQQEILRLTRDVQVDQQVYMQLMNKQQE
LSISKAGTVGNIRIIDEAETGLRPVQPQKAMIVLFALLMGGVLSASVVVLRAALHRGIGDTDTLEKRGISVYATVPLSPW
QQKRNRAQQQLLTKHGSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGASPASGKSFTSTNLAVVIAQA
GQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPDQAVKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQ
NYDLVLIDTPPVLAVTDAAIVGHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVTIKGVILNGMVKKTATDAGYYAFAYP
SHQEKVQ

Sequences:

>Translated_727_residues
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATALVQVEKQLSGDSLLRETLDS
SIGGSIGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISPDYFPLLGKGIARLSGETPPLLNISGMKVPAVMQGQELTLT
AEDQQRYSLSHDGKKLFSGSVGQALQQGGWAMNVTALEALPGTTFTIVNVPRQKAVDDLRNMLDVAPGGKESGIMTFSLA
GEDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQSSLNNAENQLNQFRQQNDSVDLSLEAKSVLDTQVQ
LEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEKARLGKQVQSLPKTQQEILRLTRDVQVDQQVYMQLMNKQQE
LSISKAGTVGNIRIIDEAETGLRPVQPQKAMIVLFALLMGGVLSASVVVLRAALHRGIGDTDTLEKRGISVYATVPLSPW
QQKRNRAQQQLLTKHGSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGASPASGKSFTSTNLAVVIAQA
GQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPDQAVKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQ
NYDLVLIDTPPVLAVTDAAIVGHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVTIKGVILNGMVKKTATDAGYYAFAYP
SHQEKVQ
>Mature_727_residues
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATALVQVEKQLSGDSLLRETLDS
SIGGSIGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISPDYFPLLGKGIARLSGETPPLLNISGMKVPAVMQGQELTLT
AEDQQRYSLSHDGKKLFSGSVGQALQQGGWAMNVTALEALPGTTFTIVNVPRQKAVDDLRNMLDVAPGGKESGIMTFSLA
GEDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQSSLNNAENQLNQFRQQNDSVDLSLEAKSVLDTQVQ
LEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEKARLGKQVQSLPKTQQEILRLTRDVQVDQQVYMQLMNKQQE
LSISKAGTVGNIRIIDEAETGLRPVQPQKAMIVLFALLMGGVLSASVVVLRAALHRGIGDTDTLEKRGISVYATVPLSPW
QQKRNRAQQQLLTKHGSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGASPASGKSFTSTNLAVVIAQA
GQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPDQAVKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQ
NYDLVLIDTPPVLAVTDAAIVGHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVTIKGVILNGMVKKTATDAGYYAFAYP
SHQEKVQ

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=724, Percent_Identity=49.3093922651934, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=704, Percent_Identity=47.0170454545455, Blast_Score=648, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 79911; Mature: 79911

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATA
CCCCCCCEEEECCCCCCCCHHHHHCHHCCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHH
LVQVEKQLSGDSLLRETLDSSIGGSIGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISP
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCEEECCCHHHCCEEEEECC
DYFPLLGKGIARLSGETPPLLNISGMKVPAVMQGQELTLTAEDQQRYSLSHDGKKLFSGS
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCEEEEEECCCHHHCCCCCCHHHHCCH
VGQALQQGGWAMNVTALEALPGTTFTIVNVPRQKAVDDLRNMLDVAPGGKESGIMTFSLA
HHHHHHHCCCEEEEEEHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
GEDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQSSLNNAENQLNQFRQ
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QNDSVDLSLEAKSVLDTQVQLEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEK
CCCCEEEEEEHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLGKQVQSLPKTQQEILRLTRDVQVDQQVYMQLMNKQQELSISKAGTVGNIRIIDEAET
HHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCHHCCCCCCEEEEEECCCC
GLRPVQPQKAMIVLFALLMGGVLSASVVVLRAALHRGIGDTDTLEKRGISVYATVPLSPW
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCHH
QQKRNRAQQQLLTKHGSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGA
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
SPASGKSFTSTNLAVVIAQAGQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPDQ
CCCCCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
AVKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQNYDLVLIDTPPVLAVTDAAI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECHHH
VGHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVTIKGVILNGMVKKTATDAGYYAFAYP
HCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCCCEEEEECC
SHQEKVQ
CHHHCCC
>Mature Secondary Structure
MMKNNALPIVMAEQDDKLEWERLIGPLWDNRWRILLVTGVAGILGCAYALMATPIYQATA
CCCCCCCEEEECCCCCCCCHHHHHCHHCCCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHH
LVQVEKQLSGDSLLRETLDSSIGGSIGQNSATQDEVSLAKSRYVIGKTVDDLGLTVRISP
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCEEECCCHHHCCEEEEECC
DYFPLLGKGIARLSGETPPLLNISGMKVPAVMQGQELTLTAEDQQRYSLSHDGKKLFSGS
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCEEEEEECCCHHHCCCCCCHHHHCCH
VGQALQQGGWAMNVTALEALPGTTFTIVNVPRQKAVDDLRNMLDVAPGGKESGIMTFSLA
HHHHHHHCCCEEEEEEHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
GEDPQRAEAVLKSITDNYLQQNVDRKTEEAQRMLAFLHEQLPRTQSSLNNAENQLNQFRQ
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QNDSVDLSLEAKSVLDTQVQLEGQLNELTFKEAEISKLYTRVHPAYRALLEKRATLEAEK
CCCCEEEEEEHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLGKQVQSLPKTQQEILRLTRDVQVDQQVYMQLMNKQQELSISKAGTVGNIRIIDEAET
HHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCHHCCCCCCEEEEEECCCC
GLRPVQPQKAMIVLFALLMGGVLSASVVVLRAALHRGIGDTDTLEKRGISVYATVPLSPW
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCHH
QQKRNRAQQQLLTKHGSGKLPILAQEEPEDLSVEAIRSLRTSLHFAMMEAKNNILMVSGA
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
SPASGKSFTSTNLAVVIAQAGQRVLLIDADMRKGFLHRWLNNSAKAGLSDMLSGLIAPDQ
CCCCCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
AVKKTDIANLDFVPRGQVPPNPSELLMHQRFADFLRWAGQNYDLVLIDTPPVLAVTDAAI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECHHH
VGHHAGTALMVVRFEVNTVRQIETSIRRFEQNGVTIKGVILNGMVKKTATDAGYYAFAYP
HCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCCCEEEEECC
SHQEKVQ
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]