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The map label for this gene is erg3 [H]

Identifier: 157371104

GI number: 157371104

Start: 3143947

End: 3145080

Strand: Reverse

Name: erg3 [H]

Synonym: Spro_2864

Alternate gene names: 157371104

Gene position: 3145080-3143947 (Counterclockwise)

Preceding gene: 157371105

Following gene: 157371103

Centisome position: 57.72

GC content: 56.88

Gene sequence:

>1134_bases
ATGAGCGAACTGGCGATGCCGATCCTGTTCATGCTGTTTGTGGTGATTGGCGAGGCGCTGGTGTTGCAGTATGCACAGCG
CCAGCAGGTCAACTGGCACGATCTGGTGTTCAATCTCAACTCCGGCCATATCATGCTGTGGTTGTTCCGCGGGCTGGAAA
TCACCTGTTACGGCTATGTGGCGGCGCACTTCAGCCTGGATCTGCTGAGCAGTTGGCCACCGGTGCTGATGTGGCTGTTT
GCCCTGCTGGCGTGGGACTTCGGCTTTTACTGGTTGCATCGCTTGCATCATCACCTGCGCGTGCTGTGGGCGGTACATGT
GGTGCATCATCAGGGTGAGCATTTCAATCTGTCGCTGGGGGTGCGCAATTCCTGGTATTCGTCGTTGACCTCGATCCCGT
TCTTTTTATTGTTGGCGTTGCTGGGCGTGCCGCTGTCGGTGTTTGTCACGGTTTCTATCCTGCACTACAGCATCCAATTG
TTTAACCATAATGCGCTGACCCCCAAACTCGGCTGGCTGGAGCATATTCTTGTTACGCCAGCGCACCATCGGGTGCATCA
CGTTAAAGATATGGCCTATTCGAACCAGAACTTTGGCGGCAGTTTTATTTTTTGGGACAAGCTGTTTGGCACTTTTTGCC
CGAGCCTGCCGGAAACGCCGTTTGTGTATGGCGTTAGCGGCGATAAACCTTCCGCCAATCCGTTCTGGGCCAGCAATCTG
CCATTCTTGCGTTACTTTCGCCTGCGTTGGCGGCCCAGGGCGAGCAACGGCCGATTCCGCTACTCGGCGCTTAGCGTGTT
CAGCGGCGCCATGCTGCTGTTTGCGCTGGTGATTGGCTATGTTTACCAGTACGGCTATGGCTACAGCGATATCAGCTGGC
CGCAAATGGCGCTGCTGGTGTTGCTGGCGTTGGGCTCGATGGCGCTGGGCGGCATGACCGAAGGGCGTCGCTGGGCGGTT
GTCGCCTGGTTGATGATTACGCTGAGCCTTCCGCTGCTGTTTATTGGTTACCTCGGATGGTCGCAGCGTTATTGGCATCT
CGCGATGGCCTTGATCACATTGCACGGGGTTTGCGTGGCGCTAGGCTGGGGCCGCGTGCGCGCTCTTAAGCCGGTGGAGG
AAACCCATGGCTGA

Upstream 100 bases:

>100_bases
TGGTCGATCTGGTCAGTGGGGCGTTGCTGGCATTTTTGGCCGGCTGGTTGGTTCAGCGCAAACAAAGCTGGCGGCGTAAT
GCCACCAAAGGAGAGATAGG

Downstream 100 bases:

>100_bases
CACACTGGCACCACTGAAGTTTCCCGCCGACGGTGAGCAGGCGTTTCATCGTGATCTTAAAAGGGCGGCTCATGCCTATC
TGGCCGGTGACCATCGCTAT

Product: fatty acid hydroxylase

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSELAMPILFMLFVVIGEALVLQYAQRQQVNWHDLVFNLNSGHIMLWLFRGLEITCYGYVAAHFSLDLLSSWPPVLMWLF
ALLAWDFGFYWLHRLHHHLRVLWAVHVVHHQGEHFNLSLGVRNSWYSSLTSIPFFLLLALLGVPLSVFVTVSILHYSIQL
FNHNALTPKLGWLEHILVTPAHHRVHHVKDMAYSNQNFGGSFIFWDKLFGTFCPSLPETPFVYGVSGDKPSANPFWASNL
PFLRYFRLRWRPRASNGRFRYSALSVFSGAMLLFALVIGYVYQYGYGYSDISWPQMALLVLLALGSMALGGMTEGRRWAV
VAWLMITLSLPLLFIGYLGWSQRYWHLAMALITLHGVCVALGWGRVRALKPVEETHG

Sequences:

>Translated_377_residues
MSELAMPILFMLFVVIGEALVLQYAQRQQVNWHDLVFNLNSGHIMLWLFRGLEITCYGYVAAHFSLDLLSSWPPVLMWLF
ALLAWDFGFYWLHRLHHHLRVLWAVHVVHHQGEHFNLSLGVRNSWYSSLTSIPFFLLLALLGVPLSVFVTVSILHYSIQL
FNHNALTPKLGWLEHILVTPAHHRVHHVKDMAYSNQNFGGSFIFWDKLFGTFCPSLPETPFVYGVSGDKPSANPFWASNL
PFLRYFRLRWRPRASNGRFRYSALSVFSGAMLLFALVIGYVYQYGYGYSDISWPQMALLVLLALGSMALGGMTEGRRWAV
VAWLMITLSLPLLFIGYLGWSQRYWHLAMALITLHGVCVALGWGRVRALKPVEETHG
>Mature_376_residues
SELAMPILFMLFVVIGEALVLQYAQRQQVNWHDLVFNLNSGHIMLWLFRGLEITCYGYVAAHFSLDLLSSWPPVLMWLFA
LLAWDFGFYWLHRLHHHLRVLWAVHVVHHQGEHFNLSLGVRNSWYSSLTSIPFFLLLALLGVPLSVFVTVSILHYSIQLF
NHNALTPKLGWLEHILVTPAHHRVHHVKDMAYSNQNFGGSFIFWDKLFGTFCPSLPETPFVYGVSGDKPSANPFWASNLP
FLRYFRLRWRPRASNGRFRYSALSVFSGAMLLFALVIGYVYQYGYGYSDISWPQMALLVLLALGSMALGGMTEGRRWAVV
AWLMITLSLPLLFIGYLGWSQRYWHLAMALITLHGVCVALGWGRVRALKPVEETHG

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=178, Percent_Identity=38.7640449438202, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144659, Length=162, Percent_Identity=30.2469135802469, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 43253; Mature: 43122

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELAMPILFMLFVVIGEALVLQYAQRQQVNWHDLVFNLNSGHIMLWLFRGLEITCYGYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEEEEECCCEEEEEEHH
AAHFSLDLLSSWPPVLMWLFALLAWDFGFYWLHRLHHHLRVLWAVHVVHHQGEHFNLSLG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
VRNSWYSSLTSIPFFLLLALLGVPLSVFVTVSILHYSIQLFNHNALTPKLGWLEHILVTP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
AHHRVHHVKDMAYSNQNFGGSFIFWDKLFGTFCPSLPETPFVYGVSGDKPSANPFWASNL
CHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
PFLRYFRLRWRPRASNGRFRYSALSVFSGAMLLFALVIGYVYQYGYGYSDISWPQMALLV
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LLALGSMALGGMTEGRRWAVVAWLMITLSLPLLFIGYLGWSQRYWHLAMALITLHGVCVA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LGWGRVRALKPVEETHG
HCCCHHHCCCCHHHCCC
>Mature Secondary Structure 
SELAMPILFMLFVVIGEALVLQYAQRQQVNWHDLVFNLNSGHIMLWLFRGLEITCYGYV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEEEEECCCEEEEEEHH
AAHFSLDLLSSWPPVLMWLFALLAWDFGFYWLHRLHHHLRVLWAVHVVHHQGEHFNLSLG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
VRNSWYSSLTSIPFFLLLALLGVPLSVFVTVSILHYSIQLFNHNALTPKLGWLEHILVTP
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
AHHRVHHVKDMAYSNQNFGGSFIFWDKLFGTFCPSLPETPFVYGVSGDKPSANPFWASNL
CHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
PFLRYFRLRWRPRASNGRFRYSALSVFSGAMLLFALVIGYVYQYGYGYSDISWPQMALLV
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LLALGSMALGGMTEGRRWAVVAWLMITLSLPLLFIGYLGWSQRYWHLAMALITLHGVCVA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LGWGRVRALKPVEETHG
HCCCHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]