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The map label for this gene is pepA [H]

Identifier: 157371088

GI number: 157371088

Start: 3126111

End: 3127520

Strand: Direct

Name: pepA [H]

Synonym: Spro_2848

Alternate gene names: 157371088

Gene position: 3126111-3127520 (Clockwise)

Preceding gene: 157371087

Following gene: 157371089

Centisome position: 57.37

GC content: 62.48

Gene sequence:

>1410_bases
ATGCAATCAATCGATATTTACCGCGCTAACGGCGCGAGCGAGCGTCAACAAGTGATCCTGTTTGCCGCCGCAGAAGACCA
ACTGCCTGCCACATTGCAAAATGCCGGTCTGCAACGGGCGGCCGTCGGCGTACTTTATCCACTGGGTGACAGCCGTTTTG
CGCTCAACATCGGCACGCCGCTGACCCCTGCCGCGCTGCAGGATGCCGGTGCGGCGATCGCCGCCGGGCAAAAAGACTAC
GGGCTGCAACAGCTCCGCCTGACGCTGGCCCCGGAATTACCGGCTGATGCCGAGAATTGGCGCTGGTTGCTGTTCGGCCT
GCGTTTAGGGGCTTACCGCTATCAGCATCACGCCAGCGCGACGCTCACCGATCCCACCCTGCCACTGGCTAGCCAGGACG
CGGCCACCCAGGCCCTGTGCGACTGGGCCAATCTGCATGCCGAAGGCGTGATCGCCGGTCGCGAACTGATGAATAAACCG
GCCAATATTCTCTATCCAGAGAGCTTTGTAGAAGCGGTAGCACAGTTGCCCTTCCGTCATCTTCGCCAGGAGGTATTGGG
GGATGAACAAATGGCGGAGCTGGGCTTTGGCGGCCTGCTCGGGGTCGGCCAGGGCAGCGCCCGTGCGTCGCAGTTGCTGA
TCCTCGATCACCACCCGGCCAATGCCCGCCACACGCTGGCACTGGTCGGCAAAGGCGTTACCTTCGACAGCGGCGGCATC
AGTATCAAAGGCGCGGCACGCATGAGCACCATGAAGTTCGATATGGGCGGTGCCGCCGCGGTGGTGGGCGCCATGCGCAT
TATCGACGCACTGCAATTACCCATCCGCGTCATTGGCCTGTGCGGATTGGTGGAAAACATGCCCTCCTCCCGCGCCCAAC
GGCCTGGTGACGTTGTCACTATGCACAATGGTAAATCGGTGGAGATCATTTCCACCGACGCCGAAGGCCGCATGGTGCTG
GCGGACGTGATCAGCTATGCCCAGCAACGCTTCCAGCCGGATTATCTGCTGGATATCGCGACCCTGACCGGCGGCGCCGG
CGTGGCGCTGGGCAAGGAATATGCCGCCATGATGGGCAACGACGAAGCTTTTCTGGCGCAGGTCACCCAGGCGGGTCAGG
TCAGCGCAGAACCGGTGTGGCCGATGCCGCACGGCGGCTGGTATCGCGGCGTGCTGAAGTCTGAATTCGCCGACTACCGC
CACGGCGGTGAAGATCCACACGGCAGCCCGTGCGTGGCGGCGACCTTTATCAGCGAATTCGTGCAACCGGGTCAACGCTG
GGCGCATCTGGACATCGCCGCCATGTCGACCGATATGCCGCACCGCAAACTGTATGCCAACGGCGCGTCCTCATTCGGCG
TGCTGCTGCTGGCACGGCTGAGTTCCCTGCTTGCCGAAACGGAGCACTAA

Upstream 100 bases:

>100_bases
CGGCAGTTTCCTGGCGATCGTGCCGCTGTTGATCGCCTTTATCTTCTCGTCCAAACAAATGATGGAAAGCCTCACCCGTG
GGGCGGTTAAAGGGTAACTT

Downstream 100 bases:

>100_bases
TGGCTTACGTAGAATTGCTTGATATCAACAAACGCTATGACAACGGCTATCAGGCCGCCAGCAACGTTAATCTGCAGGTG
GAAAAAGGCGAATTTGTGGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MQSIDIYRANGASERQQVILFAAAEDQLPATLQNAGLQRAAVGVLYPLGDSRFALNIGTPLTPAALQDAGAAIAAGQKDY
GLQQLRLTLAPELPADAENWRWLLFGLRLGAYRYQHHASATLTDPTLPLASQDAATQALCDWANLHAEGVIAGRELMNKP
ANILYPESFVEAVAQLPFRHLRQEVLGDEQMAELGFGGLLGVGQGSARASQLLILDHHPANARHTLALVGKGVTFDSGGI
SIKGAARMSTMKFDMGGAAAVVGAMRIIDALQLPIRVIGLCGLVENMPSSRAQRPGDVVTMHNGKSVEIISTDAEGRMVL
ADVISYAQQRFQPDYLLDIATLTGGAGVALGKEYAAMMGNDEAFLAQVTQAGQVSAEPVWPMPHGGWYRGVLKSEFADYR
HGGEDPHGSPCVAATFISEFVQPGQRWAHLDIAAMSTDMPHRKLYANGASSFGVLLLARLSSLLAETEH

Sequences:

>Translated_469_residues
MQSIDIYRANGASERQQVILFAAAEDQLPATLQNAGLQRAAVGVLYPLGDSRFALNIGTPLTPAALQDAGAAIAAGQKDY
GLQQLRLTLAPELPADAENWRWLLFGLRLGAYRYQHHASATLTDPTLPLASQDAATQALCDWANLHAEGVIAGRELMNKP
ANILYPESFVEAVAQLPFRHLRQEVLGDEQMAELGFGGLLGVGQGSARASQLLILDHHPANARHTLALVGKGVTFDSGGI
SIKGAARMSTMKFDMGGAAAVVGAMRIIDALQLPIRVIGLCGLVENMPSSRAQRPGDVVTMHNGKSVEIISTDAEGRMVL
ADVISYAQQRFQPDYLLDIATLTGGAGVALGKEYAAMMGNDEAFLAQVTQAGQVSAEPVWPMPHGGWYRGVLKSEFADYR
HGGEDPHGSPCVAATFISEFVQPGQRWAHLDIAAMSTDMPHRKLYANGASSFGVLLLARLSSLLAETEH
>Mature_469_residues
MQSIDIYRANGASERQQVILFAAAEDQLPATLQNAGLQRAAVGVLYPLGDSRFALNIGTPLTPAALQDAGAAIAAGQKDY
GLQQLRLTLAPELPADAENWRWLLFGLRLGAYRYQHHASATLTDPTLPLASQDAATQALCDWANLHAEGVIAGRELMNKP
ANILYPESFVEAVAQLPFRHLRQEVLGDEQMAELGFGGLLGVGQGSARASQLLILDHHPANARHTLALVGKGVTFDSGGI
SIKGAARMSTMKFDMGGAAAVVGAMRIIDALQLPIRVIGLCGLVENMPSSRAQRPGDVVTMHNGKSVEIISTDAEGRMVL
ADVISYAQQRFQPDYLLDIATLTGGAGVALGKEYAAMMGNDEAFLAQVTQAGQVSAEPVWPMPHGGWYRGVLKSEFADYR
HGGEDPHGSPCVAATFISEFVQPGQRWAHLDIAAMSTDMPHRKLYANGASSFGVLLLARLSSLLAETEH

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=304, Percent_Identity=39.4736842105263, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI47155554, Length=293, Percent_Identity=37.542662116041, Blast_Score=177, Evalue=3e-44,
Organism=Escherichia coli, GI1790710, Length=311, Percent_Identity=42.1221864951768, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=37.2239747634069, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=294, Percent_Identity=36.0544217687075, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=240, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221379063, Length=287, Percent_Identity=37.2822299651568, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI221379062, Length=287, Percent_Identity=37.2822299651568, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21357381, Length=287, Percent_Identity=37.2822299651568, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21355725, Length=281, Percent_Identity=33.4519572953737, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24661038, Length=281, Percent_Identity=33.8078291814947, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129969, Length=290, Percent_Identity=35.1724137931034, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24662227, Length=290, Percent_Identity=32.0689655172414, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161077148, Length=303, Percent_Identity=30.03300330033, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20130057, Length=303, Percent_Identity=30.03300330033, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21355645, Length=334, Percent_Identity=29.940119760479, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24662223, Length=334, Percent_Identity=29.940119760479, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI19922386, Length=326, Percent_Identity=30.6748466257669, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI20129963, Length=315, Percent_Identity=30.7936507936508, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646701, Length=282, Percent_Identity=30.1418439716312, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24646703, Length=282, Percent_Identity=30.1418439716312, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21358201, Length=282, Percent_Identity=30.1418439716312, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50051; Mature: 50051

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIDIYRANGASERQQVILFAAAEDQLPATLQNAGLQRAAVGVLYPLGDSRFALNIGTP
CCCCEEEECCCCCCCEEEEEEEECCCCCCHHHHHCCCHHHHEEEEEECCCCEEEEECCCC
LTPAALQDAGAAIAAGQKDYGLQQLRLTLAPELPADAENWRWLLFGLRLGAYRYQHHASA
CCHHHHHHCCCEEECCCCCCCHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHCCCC
TLTDPTLPLASQDAATQALCDWANLHAEGVIAGRELMNKPANILYPESFVEAVAQLPFRH
EECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECHHHHCCCCCEECCHHHHHHHHHCCHHH
LRQEVLGDEQMAELGFGGLLGVGQGSARASQLLILDHHPANARHTLALVGKGVTFDSGGI
HHHHHHCCHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCEEECCCCE
SIKGAARMSTMKFDMGGAAAVVGAMRIIDALQLPIRVIGLCGLVENMPSSRAQRPGDVVT
EEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEE
MHNGKSVEIISTDAEGRMVLADVISYAQQRFQPDYLLDIATLTGGAGVALGKEYAAMMGN
EECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
DEAFLAQVTQAGQVSAEPVWPMPHGGWYRGVLKSEFADYRHGGEDPHGSPCVAATFISEF
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VQPGQRWAHLDIAAMSTDMPHRKLYANGASSFGVLLLARLSSLLAETEH
HCCCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSIDIYRANGASERQQVILFAAAEDQLPATLQNAGLQRAAVGVLYPLGDSRFALNIGTP
CCCCEEEECCCCCCCEEEEEEEECCCCCCHHHHHCCCHHHHEEEEEECCCCEEEEECCCC
LTPAALQDAGAAIAAGQKDYGLQQLRLTLAPELPADAENWRWLLFGLRLGAYRYQHHASA
CCHHHHHHCCCEEECCCCCCCHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHCCCC
TLTDPTLPLASQDAATQALCDWANLHAEGVIAGRELMNKPANILYPESFVEAVAQLPFRH
EECCCCCCCCCCHHHHHHHHHHHHCCCCCEEECHHHHCCCCCEECCHHHHHHHHHCCHHH
LRQEVLGDEQMAELGFGGLLGVGQGSARASQLLILDHHPANARHTLALVGKGVTFDSGGI
HHHHHHCCHHHHHHCCCCEEECCCCCCCCCEEEEEECCCCCCCEEEEEEECCEEECCCCE
SIKGAARMSTMKFDMGGAAAVVGAMRIIDALQLPIRVIGLCGLVENMPSSRAQRPGDVVT
EEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEE
MHNGKSVEIISTDAEGRMVLADVISYAQQRFQPDYLLDIATLTGGAGVALGKEYAAMMGN
EECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
DEAFLAQVTQAGQVSAEPVWPMPHGGWYRGVLKSEFADYRHGGEDPHGSPCVAATFISEF
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VQPGQRWAHLDIAAMSTDMPHRKLYANGASSFGVLLLARLSSLLAETEH
HCCCCCEEEEEEEECCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]