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The map label for this gene is pntB [H]

Identifier: 157370824

GI number: 157370824

Start: 2840514

End: 2841908

Strand: Reverse

Name: pntB [H]

Synonym: Spro_2584

Alternate gene names: 157370824

Gene position: 2841908-2840514 (Counterclockwise)

Preceding gene: 157370825

Following gene: 157370810

Centisome position: 52.16

GC content: 57.2

Gene sequence:

>1395_bases
ATGTCTGGAGGATTAGTTACAGCTGCATACATTGTTGCCGCTATCCTGTTTATCTGTAGTCTGGCCGGCCTGTCGCGCCA
TGAAACGTCCAAGCGGGGCAACCTGTTTGGCGTCGCCGGGATGGCGATTGCGCTGATCGCCACCATCCTCGGGCCGGATT
CCGGCAACGTGGGCTGGATCATCATCGCGATGATTATCGGGGGTTCCATCGGGGTTTATCTGGCGAAAAAGGTCGAAATG
ACCGAAATGCCAGAGCTGGTTGCGGTACTGCACAGTTTTGTGGGGCTGGCGGCGGTTCTGGTGGGCTTGAACAGCTACCT
GGATCACGGCGCGCCAATGGAGCCGGTGATGGAGAATATCCATCTGACCGAAGTGTTCCTTGGCATCTTTATCGGTGCGG
TTACTTTCACCGGTTCGATTGTCGCGTTCGGCAAACTGCGCGGCATCATCTCTTCCAAACCGCTGGCGTTGCCAAACCGA
CACAAAATGAACCTGGCGGCACTGGTCGTTTCCTTCGTCCTGTTGGTGGTGTTTGTTCGCGCCGACAGCGTGGGTTGGCA
AGCGGTGGCACTGGTGCTGATGACCGCTATCGCGCTGGCGTTTGGCTGGCATCTGGTGGCTTCCATCGGCGGTGCCGACA
TGCCGGTCGTAGTGTCGATGCTCAACTCCTATTCGGGTTGGGCGGCAGCGGCAGCGGGTTTCATGTTGAGCAACGATTTG
CTGATCGTGACCGGTGCGTTGGTGGGTTCTTCGGGGGCCATCCTGTCTTACATCATGTGTAAGGCGATGAACCGTTCGTT
TATCAGCGTGATCGCCGGAGGCTTCGGTACCGATGGCTCTTCGACCGGTAATGCGGAAGAAATGGGCGAGTATCGCGAAA
CCACCGCGGAAGAAGTTGCCGAGCAGTTGAAAAACTCCACGTCGGTAATCATCACCCCAGGCTACGGCATGGCGGTAGCG
CAGGCGCAGTACCCGGTGGCGGAAATCACCGAGAAACTGCGCGCTCGTGGTATCAAGGTGCGTTTCGGTATTCATCCGGT
TGCCGGGCGTTTACCGGGCCACATGAACGTGCTGTTGGCCGAAGCCAAGGTGCCATATGACGTGGTGCTGGAGATGGATG
AAATCAATGACGATTTCGCTGATACCGACACCGTGCTGGTGATCGGCGCCAACGACACGGTGAACCCGGCCGCACTGGAA
GATCCGCGCAGTCCAATCGCCGGTATGCCAGTGCTGGAAGTGTGGAAAGCGCAGAATGTGATTGCCTTTAAGCGTTCGAT
GAACACCGGCTATGCCGGCGTGCAGAACCCGCTGTTCTTTAAAGAGAACACCCAGATGCTGTTTGGCGATGCCAAAGAGA
GTGTGGAAGCGATACTGCGTGCGCTGCAGGCATAA

Upstream 100 bases:

>100_bases
TCCTTTATCGCCGTGCTGATCGCCAGCATCAACATTTTTGGTGGATTCACCGTCACTCAGCGCATGCTGAAGATGTTCCG
CAAGAACTAAGGGGTAGCAT

Downstream 100 bases:

>100_bases
CGGAAGCAAATAAAAACGGGCCTTTTCGGCCCGTTTCTTTATGCGTCAAACATCAATCCTCGTCGTCGTGCTCATCGTCC
TCATCGACTTCGATCGGGCA

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSGGLVTAAYIVAAILFICSLAGLSRHETSKRGNLFGVAGMAIALIATILGPDSGNVGWIIIAMIIGGSIGVYLAKKVEM
TEMPELVAVLHSFVGLAAVLVGLNSYLDHGAPMEPVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLRGIISSKPLALPNR
HKMNLAALVVSFVLLVVFVRADSVGWQAVALVLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDL
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGNAEEMGEYRETTAEEVAEQLKNSTSVIITPGYGMAVA
QAQYPVAEITEKLRARGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAALE
DPRSPIAGMPVLEVWKAQNVIAFKRSMNTGYAGVQNPLFFKENTQMLFGDAKESVEAILRALQA

Sequences:

>Translated_464_residues
MSGGLVTAAYIVAAILFICSLAGLSRHETSKRGNLFGVAGMAIALIATILGPDSGNVGWIIIAMIIGGSIGVYLAKKVEM
TEMPELVAVLHSFVGLAAVLVGLNSYLDHGAPMEPVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLRGIISSKPLALPNR
HKMNLAALVVSFVLLVVFVRADSVGWQAVALVLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDL
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGNAEEMGEYRETTAEEVAEQLKNSTSVIITPGYGMAVA
QAQYPVAEITEKLRARGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAALE
DPRSPIAGMPVLEVWKAQNVIAFKRSMNTGYAGVQNPLFFKENTQMLFGDAKESVEAILRALQA
>Mature_463_residues
SGGLVTAAYIVAAILFICSLAGLSRHETSKRGNLFGVAGMAIALIATILGPDSGNVGWIIIAMIIGGSIGVYLAKKVEMT
EMPELVAVLHSFVGLAAVLVGLNSYLDHGAPMEPVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLRGIISSKPLALPNRH
KMNLAALVVSFVLLVVFVRADSVGWQAVALVLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLL
IVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGNAEEMGEYRETTAEEVAEQLKNSTSVIITPGYGMAVAQ
AQYPVAEITEKLRARGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAALED
PRSPIAGMPVLEVWKAQNVIAFKRSMNTGYAGVQNPLFFKENTQMLFGDAKESVEAILRALQA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=454, Percent_Identity=50.8810572687225, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI122939153, Length=454, Percent_Identity=50.8810572687225, Blast_Score=448, Evalue=1e-126,
Organism=Escherichia coli, GI1787886, Length=462, Percent_Identity=88.0952380952381, Blast_Score=827, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=461, Percent_Identity=49.4577006507592, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48863; Mature: 48732

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGLVTAAYIVAAILFICSLAGLSRHETSKRGNLFGVAGMAIALIATILGPDSGNVGWI
CCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHH
IIAMIIGGSIGVYLAKKVEMTEMPELVAVLHSFVGLAAVLVGLNSYLDHGAPMEPVMENI
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
HLTEVFLGIFIGAVTFTGSIVAFGKLRGIISSKPLALPNRHKMNLAALVVSFVLLVVFVR
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ADSVGWQAVALVLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCE
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGNAEEMGEYRETTAEEVA
EEEEEHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EQLKNSTSVIITPGYGMAVAQAQYPVAEITEKLRARGIKVRFGIHPVAGRLPGHMNVLLA
HHHCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCEEEEECCCHHCCCCCCCCEEEEE
EAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAALEDPRSPIAGMPVLEVWKAQNV
CCCCCHHHEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCH
IAFKRSMNTGYAGVQNPLFFKENTQMLFGDAKESVEAILRALQA
HHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGGLVTAAYIVAAILFICSLAGLSRHETSKRGNLFGVAGMAIALIATILGPDSGNVGWI
CCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHH
IIAMIIGGSIGVYLAKKVEMTEMPELVAVLHSFVGLAAVLVGLNSYLDHGAPMEPVMENI
HHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
HLTEVFLGIFIGAVTFTGSIVAFGKLRGIISSKPLALPNRHKMNLAALVVSFVLLVVFVR
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ADSVGWQAVALVLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCE
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGNAEEMGEYRETTAEEVA
EEEEEHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EQLKNSTSVIITPGYGMAVAQAQYPVAEITEKLRARGIKVRFGIHPVAGRLPGHMNVLLA
HHHCCCCEEEEECCCCCCHHHCCCCHHHHHHHHHHCCEEEEECCCHHCCCCCCCCEEEEE
EAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAALEDPRSPIAGMPVLEVWKAQNV
CCCCCHHHEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCH
IAFKRSMNTGYAGVQNPLFFKENTQMLFGDAKESVEAILRALQA
HHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]