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The map label for this gene is lip2 [H]

Identifier: 157370782

GI number: 157370782

Start: 2798017

End: 2798931

Strand: Reverse

Name: lip2 [H]

Synonym: Spro_2542

Alternate gene names: 157370782

Gene position: 2798931-2798017 (Counterclockwise)

Preceding gene: 157370783

Following gene: 157370780

Centisome position: 51.37

GC content: 62.51

Gene sequence:

>915_bases
ATGCCGCTTGACTCACAGATTGCCCGTTTTCTGGCGGAAACGACAGATGCCGCCGCGCCTGAATCCCTGAGTGAAATGCG
TGCTGCCGCGCAGGCCGGGTTGTTGGCGTTGCAGGGGGAAGCAGAAGCCAGTGGCGGCGTCCGTGATGGAAGTGTGACCG
CTGACGATGGCCATGAGATCGCCGTTCGCGCTTATGCGCCGCTGGGCGTGACGCAGGGTGAACCTCTGCCCGCGATGCTG
TACGCCCACGGCGGCGGTTGGTGTCTGGGGACGCTGGCGCTGTACGACCAGCCTTGCCAGGCGCTGGCCAATGCCACCGG
GCGGGTGATCTTGTCGGTTGATTATCGTCTGGCGCCGGAGCATCCGTATCCGCGGCCGCTGGAAGACCTGTATCAGGCAC
TGTGCGACGTGGTTGAACGGGCCGATGAGTGGGGCGTTGACGTTACGCGCCTTGCGGTTGGTGGCGACAGCGCCGGTGGC
AATCTGGCCGCCGCCGTGGCGCTGTTGGCCCGCGACCGGAATGGCCCACGGATTGAACATCAACTGTTGCTGTATCCGGC
GTTAAGTCGCGCTATGGATACGGCGAGTTACCAGGCTTATGCGCAGGGTTACTACCTGACCAGGGAGGTCATGGAGTTTT
GCTGGGGGCAGTATCTGGGGGACGGAGCCCAGGGGCATGCCCCTTACGCAGAACCGCTGCATGCCGCAACGTTGCGGCAG
TTGCCACCGGCGACTATTCTGAGTTGTGAGTACGATCCGTTGCGCGATGAGGCCGAGCATTATGCCCAGCGGTTGCGTGA
AGATGGGGTCGCGGTGCGCTGTGAACGGTTGCCGGGCATGGTACACGCCTGCATTCATATGCTGGGTTTGACCCCGGCAG
CGCGAGTGTTATTCGATAAGGTTGGTTCGAAGTAA

Upstream 100 bases:

>100_bases
CGCGGCGAAACGGTCGCTGGCTGCGGTCATTTCATCACCGAAGAGTGCCATGAGGCGTTTATCGCTCTGGTAGTGCCATT
CTTGTCAGGGAGCCTGGCCG

Downstream 100 bases:

>100_bases
AGCCCAGGCTGTTATCTGGGTGAGAATCCCCCTCTCCCGGGGGAGAGGGCCGGGGTTAGGGGAAACAGACAGAACCCTCT
CCAGGGGGAGAGGGTCGGGG

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MPLDSQIARFLAETTDAAAPESLSEMRAAAQAGLLALQGEAEASGGVRDGSVTADDGHEIAVRAYAPLGVTQGEPLPAML
YAHGGGWCLGTLALYDQPCQALANATGRVILSVDYRLAPEHPYPRPLEDLYQALCDVVERADEWGVDVTRLAVGGDSAGG
NLAAAVALLARDRNGPRIEHQLLLYPALSRAMDTASYQAYAQGYYLTREVMEFCWGQYLGDGAQGHAPYAEPLHAATLRQ
LPPATILSCEYDPLRDEAEHYAQRLREDGVAVRCERLPGMVHACIHMLGLTPAARVLFDKVGSK

Sequences:

>Translated_304_residues
MPLDSQIARFLAETTDAAAPESLSEMRAAAQAGLLALQGEAEASGGVRDGSVTADDGHEIAVRAYAPLGVTQGEPLPAML
YAHGGGWCLGTLALYDQPCQALANATGRVILSVDYRLAPEHPYPRPLEDLYQALCDVVERADEWGVDVTRLAVGGDSAGG
NLAAAVALLARDRNGPRIEHQLLLYPALSRAMDTASYQAYAQGYYLTREVMEFCWGQYLGDGAQGHAPYAEPLHAATLRQ
LPPATILSCEYDPLRDEAEHYAQRLREDGVAVRCERLPGMVHACIHMLGLTPAARVLFDKVGSK
>Mature_303_residues
PLDSQIARFLAETTDAAAPESLSEMRAAAQAGLLALQGEAEASGGVRDGSVTADDGHEIAVRAYAPLGVTQGEPLPAMLY
AHGGGWCLGTLALYDQPCQALANATGRVILSVDYRLAPEHPYPRPLEDLYQALCDVVERADEWGVDVTRLAVGGDSAGGN
LAAAVALLARDRNGPRIEHQLLLYPALSRAMDTASYQAYAQGYYLTREVMEFCWGQYLGDGAQGHAPYAEPLHAATLRQL
PPATILSCEYDPLRDEAEHYAQRLREDGVAVRCERLPGMVHACIHMLGLTPAARVLFDKVGSK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=311, Percent_Identity=29.5819935691318, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI206597554, Length=332, Percent_Identity=27.4096385542169, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI157041239, Length=275, Percent_Identity=29.0909090909091, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI68051721, Length=308, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI61966717, Length=301, Percent_Identity=26.578073089701, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI157041237, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI226423947, Length=191, Percent_Identity=32.9842931937173, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI21328446, Length=92, Percent_Identity=39.1304347826087, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1786682, Length=242, Percent_Identity=30.1652892561983, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17567059, Length=264, Percent_Identity=28.4090909090909, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=154, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=145, Percent_Identity=33.7931034482759, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=146, Percent_Identity=34.2465753424658, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656084, Length=111, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24656076, Length=111, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20130169, Length=111, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32642; Mature: 32511

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDSQIARFLAETTDAAAPESLSEMRAAAQAGLLALQGEAEASGGVRDGSVTADDGHEI
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEECCCCCEE
AVRAYAPLGVTQGEPLPAMLYAHGGGWCLGTLALYDQPCQALANATGRVILSVDYRLAPE
EEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECEECCC
HPYPRPLEDLYQALCDVVERADEWGVDVTRLAVGGDSAGGNLAAAVALLARDRNGPRIEH
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHH
QLLLYPALSRAMDTASYQAYAQGYYLTREVMEFCWGQYLGDGAQGHAPYAEPLHAATLRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LPPATILSCEYDPLRDEAEHYAQRLREDGVAVRCERLPGMVHACIHMLGLTPAARVLFDK
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHCCCHHHHHHHHH
VGSK
HCCC
>Mature Secondary Structure 
PLDSQIARFLAETTDAAAPESLSEMRAAAQAGLLALQGEAEASGGVRDGSVTADDGHEI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEECCCCCEE
AVRAYAPLGVTQGEPLPAMLYAHGGGWCLGTLALYDQPCQALANATGRVILSVDYRLAPE
EEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECEECCC
HPYPRPLEDLYQALCDVVERADEWGVDVTRLAVGGDSAGGNLAAAVALLARDRNGPRIEH
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHH
QLLLYPALSRAMDTASYQAYAQGYYLTREVMEFCWGQYLGDGAQGHAPYAEPLHAATLRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LPPATILSCEYDPLRDEAEHYAQRLREDGVAVRCERLPGMVHACIHMLGLTPAARVLFDK
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHCCCHHHHHHHHH
VGSK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]