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The map label for this gene is gyaR [H]

Identifier: 157370692

GI number: 157370692

Start: 2684993

End: 2685958

Strand: Reverse

Name: gyaR [H]

Synonym: Spro_2452

Alternate gene names: 157370692

Gene position: 2685958-2684993 (Counterclockwise)

Preceding gene: 157370695

Following gene: 157370690

Centisome position: 49.29

GC content: 56.42

Gene sequence:

>966_bases
ATGAATCCTCATTTGTTGATCATTATCGAGCTGGCACCTGAATATTGGCAGCGCTTCGAGCTGGCGGGGTTTTGCGTACA
CATCACTACATCGATAGCGGTCTGGACGGCGCAAAGGCCAGACGACATCGTCAAAGTAAAAGCCGTACTCACCAACGGTT
CAACCGGACTTCACGCCGACGAAATCGCCATATTGCCGGGGTTGGAGATTATCTGCGCCCAAGGTGCCGGTTATGAAAAT
GTCGATATTGTTGCGGCTCAGGCCCGTGGCATCATTGTGACTCATGGCCCAGGCACCAATGATGCTTCGGTGGCCGATCA
CGCCATTGCACTGTTGATGGCTATTGCCCGCGGGATCCCACAGGCCGATACGGCAGTGCGCCGAGGGGAATGGCAGCAGG
CACGGCAAGTTCGGCCGATGGTCTCCGGTAAGAAATTGGGCATTCTCGGCCTCGGGAATATCGGTATGCAGATTGCCCGC
CGTGGGGAGATGGGTTTTGGCATGTCGGTGGCTTATCACAACCGCATGCCGCGTGCCGATACGCCTTATCTTTATATTCC
TACGGCCGCCGCCCTGGCCGAATGGGCGGACTTTATGGTGATAGCCACTCCAGGCGGCATAGCAACCCGCCATATCGTGG
ATGCGGAGGTACTGACTACCCTTGGCCCAAATGGGTTTCTGATCAATATCGCGCGAGGCAGCGTGGTGGATACGCTGGCA
CTTATCGATGCTCTGGAGCATCATCTCATCGCCGGTGCGGCCCTGGATGTGGTAGAAGGGGAACCCGCAGTACCCCCGGA
ATTAATCCAACTTGCCAATGTGATTCTAACGCCGCATATCGCCGGGCGTTCCCCGGAGGCGATAGCGGCAACGGTGCAGT
TGGTACTCGACAATCTCAATGCGCATTTCTCTGGGGAATCGGTGCTTACGCCGGTTGTTCCCCCAGGGCTTTTAACCAAG
CAATGA

Upstream 100 bases:

>100_bases
ATCAGCGCACAACATTACCTTCGAACATCCGCATTTTCTGCCCTGAGACACTGAGAGGGTTGCGCTATGCTGATCATGGC
CACCTTATGGAGTGTTACCC

Downstream 100 bases:

>100_bases
AGGCGTCAATCTTCGGCCACTGGCGGTCGGAAAGTGTCGATACATAGTAGTGCTGGTCACATTTCAGCTCCATTTTCGGG
AATGGTGCCACCAGTTCACC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MNPHLLIIIELAPEYWQRFELAGFCVHITTSIAVWTAQRPDDIVKVKAVLTNGSTGLHADEIAILPGLEIICAQGAGYEN
VDIVAAQARGIIVTHGPGTNDASVADHAIALLMAIARGIPQADTAVRRGEWQQARQVRPMVSGKKLGILGLGNIGMQIAR
RGEMGFGMSVAYHNRMPRADTPYLYIPTAAALAEWADFMVIATPGGIATRHIVDAEVLTTLGPNGFLINIARGSVVDTLA
LIDALEHHLIAGAALDVVEGEPAVPPELIQLANVILTPHIAGRSPEAIAATVQLVLDNLNAHFSGESVLTPVVPPGLLTK
Q

Sequences:

>Translated_321_residues
MNPHLLIIIELAPEYWQRFELAGFCVHITTSIAVWTAQRPDDIVKVKAVLTNGSTGLHADEIAILPGLEIICAQGAGYEN
VDIVAAQARGIIVTHGPGTNDASVADHAIALLMAIARGIPQADTAVRRGEWQQARQVRPMVSGKKLGILGLGNIGMQIAR
RGEMGFGMSVAYHNRMPRADTPYLYIPTAAALAEWADFMVIATPGGIATRHIVDAEVLTTLGPNGFLINIARGSVVDTLA
LIDALEHHLIAGAALDVVEGEPAVPPELIQLANVILTPHIAGRSPEAIAATVQLVLDNLNAHFSGESVLTPVVPPGLLTK
Q
>Mature_321_residues
MNPHLLIIIELAPEYWQRFELAGFCVHITTSIAVWTAQRPDDIVKVKAVLTNGSTGLHADEIAILPGLEIICAQGAGYEN
VDIVAAQARGIIVTHGPGTNDASVADHAIALLMAIARGIPQADTAVRRGEWQQARQVRPMVSGKKLGILGLGNIGMQIAR
RGEMGFGMSVAYHNRMPRADTPYLYIPTAAALAEWADFMVIATPGGIATRHIVDAEVLTTLGPNGFLINIARGSVVDTLA
LIDALEHHLIAGAALDVVEGEPAVPPELIQLANVILTPHIAGRSPEAIAATVQLVLDNLNAHFSGESVLTPVVPPGLLTK
Q

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=249, Percent_Identity=31.7269076305221, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=30.6772908366534, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=30.6772908366534, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=31.3492063492063, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=30.8681672025724, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789279, Length=219, Percent_Identity=36.0730593607306, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=27.0676691729323, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=293, Percent_Identity=29.0102389078498, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=248, Percent_Identity=27.0161290322581, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=283, Percent_Identity=31.095406360424, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=255, Percent_Identity=30.5882352941176, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=225, Percent_Identity=32.8888888888889, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=174, Percent_Identity=29.8850574712644, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=173, Percent_Identity=28.9017341040462, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=269, Percent_Identity=29.7397769516729, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24585514, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574282, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45552429, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574284, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45551003, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574286, Length=290, Percent_Identity=28.2758620689655, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=28.0632411067194, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=258, Percent_Identity=29.8449612403101, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=30.2040816326531, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=30.2040816326531, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=30.2040816326531, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=30.2040816326531, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=30.2040816326531, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33986; Mature: 33986

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPHLLIIIELAPEYWQRFELAGFCVHITTSIAVWTAQRPDDIVKVKAVLTNGSTGLHAD
CCCCEEEEEEECHHHHHHHHHCEEEEEEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCC
EIAILPGLEIICAQGAGYENVDIVAAQARGIIVTHGPGTNDASVADHAIALLMAIARGIP
CEEECCCCEEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
QADTAVRRGEWQQARQVRPMVSGKKLGILGLGNIGMQIARRGEMGFGMSVAYHNRMPRAD
CHHHHHHCCCHHHHHHCCHHCCCCEEEEEEECCHHHHHHHCCCCCCCEEEEECCCCCCCC
TPYLYIPTAAALAEWADFMVIATPGGIATRHIVDAEVLTTLGPNGFLINIARGSVVDTLA
CCEEEECCHHHHHHHHCEEEEECCCCCCCCEEECHHHHHHCCCCCEEEEECCCCHHHHHH
LIDALEHHLIAGAALDVVEGEPAVPPELIQLANVILTPHIAGRSPEAIAATVQLVLDNLN
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
AHFSGESVLTPVVPPGLLTKQ
CCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MNPHLLIIIELAPEYWQRFELAGFCVHITTSIAVWTAQRPDDIVKVKAVLTNGSTGLHAD
CCCCEEEEEEECHHHHHHHHHCEEEEEEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCC
EIAILPGLEIICAQGAGYENVDIVAAQARGIIVTHGPGTNDASVADHAIALLMAIARGIP
CEEECCCCEEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
QADTAVRRGEWQQARQVRPMVSGKKLGILGLGNIGMQIARRGEMGFGMSVAYHNRMPRAD
CHHHHHHCCCHHHHHHCCHHCCCCEEEEEEECCHHHHHHHCCCCCCCEEEEECCCCCCCC
TPYLYIPTAAALAEWADFMVIATPGGIATRHIVDAEVLTTLGPNGFLINIARGSVVDTLA
CCEEEECCHHHHHHHHCEEEEECCCCCCCCEEECHHHHHHCCCCCEEEEECCCCHHHHHH
LIDALEHHLIAGAALDVVEGEPAVPPELIQLANVILTPHIAGRSPEAIAATVQLVLDNLN
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
AHFSGESVLTPVVPPGLLTKQ
CCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA