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The map label for this gene is yegE [H]

Identifier: 157370660

GI number: 157370660

Start: 2651424

End: 2653298

Strand: Direct

Name: yegE [H]

Synonym: Spro_2420

Alternate gene names: 157370660

Gene position: 2651424-2653298 (Clockwise)

Preceding gene: 157370656

Following gene: 157370675

Centisome position: 48.66

GC content: 52.32

Gene sequence:

>1875_bases
ATGTACGAACCCTGTTTTCCAGAAAATGAAACCGAACGGCTGTCGGTTCTGCATTCACTCAACGTACTGGACACGAATTC
GGTAGAGAAATTAGACCGGGTCACGCGCCTGGCCGCCAAATATTTTGGCGTCAGTATTGCCCTGATTTCCTTGATCGATC
GTGAACGCCAATGGTTCCTTTCTCGCTCGGGTTTGGAGGCACGGGAATCGCCACGCAATATTTCGTTTTGCGGTCATGCC
ATTTTGCAACGTGATGCGTTGGTGGTGCCGGATACCGCGGCCGATCCACGTTTCTTCGACAACCCCTTGGTCACCGGTGG
GCCAAAAATCGGTTTTTATGCCGGGCAACCCTTGTTGTCTCTGGATGGTCTGCCGCTGGGTACCCTGTGCATTATCGACG
GTCACCCACAGGCGTTCTCTTCAGAGATGGTGCATGATTTACGAGATTTTGCCGCCGTTATCGAAGAGTATTTACACAGT
ATTGAGCGTGATATTTATACCGAGGCTCTGAAATCAAACCTGCAACGTAGCGAAGCCTTATTTGAACAGACCTTTTCACA
AGCGGCAGTGGGCATGGCCCTGGTCTCATTAGAGGGATATTGGCTGCGGGTGAATCCGCGGCTCTGTGAAATGTTGCAGT
ACCCTGAACGGGCACTGCTGGAGCGTACCTTCCAGGACATTACCTATAGCGAAGACCTGCACAACGACCTCGGGCTGCTG
CAACAGTTATTGGCCAATGAAATAGACACCTATTCGATGGAAAAGCGCTATATCCGCGCTGATGGCTCAAGGATTTGGGT
TCAGCTTACCGTGTCGCTTAATCGTCTGCCCAATGGTGAGCCCCATCATTTTATCTCGGTTATTGTCGATATCAGCGAGC
GCAAAGCGGCAGAGGCCGACCTCTACACTCTGCAACATGAGCTCGAAGACAGGGTAGTGACACGTACCCGTGAGTTGAAT
TTTGCCGTTAATAAACTCAATCACGAGATTGCCAATCGGGCACTCACAGAGCTGCAACTGAGTAGTGAAAAAGAACGTCT
GCGGGCCATTACCGATAATATGCCGGCCTTGATCAGCCAGATCGACGCCAATGAGCGTTATCTGTTTGCCAACAGCGCTT
ACAAAAGCTGGTTCGGTCTGGATGAATCTCACCTCAGCGCGATGACCGTACAGGCATTTATGGGCGACGAGGCTTATGCC
GCAGCCAAGCCTATGATCGAGCGGGCGTTAAAGGGGGAAACCGTCAGTTTTGAGAACGAACTGCAAACGCGCCAGGGGAC
AGCGATCATTCATAACACCCTGGTACCCAGCGAAACCCGGGGCTTTTATATTCTTTCCATGGATATTACCGAGCTTAAAC
GTTTGCAGCGGCGGTTAGAGTACGACGTTTCTCATGACATGCTGACCGGGTTAACCAATCGGCGGGCTTTCTTGCTCCGG
TTAGGCGCGACGCTGCAGGCTTGTTGCCCACAGCAGCAGATGGCGTTGCTGTTTATCGATCTTGATGGTTTCAAAACGCT
TAACGACAGTTTTGGCCATGATTTCGGCGATCTTATCCTGAAAACCTTCGCCGAATTGCTCAGTGTCTGTGCCGGGCCTC
ATCACAGCGTTTCGCGCCTCGCCGGCGATGAGTTTACTGTCATTCTCTGGCCTTTGGCGCATCCGCAGCTGCAGGTCAGC
GCGTTTTGCGAGAGCGTGTTGGCCAGGTTGGCGGCAACGGAACGAGTCGGTAATCAAAACGTGAGACTCTCTGCCAGTAT
CGGTGCAGCCATTACTTCTGGCGACGATATGAGCGCCGAAGCCCTGCTGACCAAAGCAGACGATGCCATGTATCAGGCCA
AATCCGCCGGCAAAGGGACCTATGCTATCCGTTAA

Upstream 100 bases:

>100_bases
AATAAGTCATTTACGGTGCGGTGTTAAGCCATTAAAGGTAACGGCTAGCCATGCAGGTTGTGAATCAGCATCGCCCAGAA
AGGATAAGCCGGAGCAACCT

Downstream 100 bases:

>100_bases
TGCGAGCCTGCGCTGGTGGCAGCCCAACCAAGGAGAGCTGGGCTGCCGTTAAAGGCAATCAATGTGCCAAGCCGTCTTCA
AAGCAATTCAGTGATAATAA

Product: PAS/PAC sensor-containing diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFLSRSGLEARESPRNISFCGHA
ILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLSLDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHS
IERDIYTEALKSNLQRSEALFEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYPERALLERTFQDITYSEDLHNDLGLL
QQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEADLYTLQHELEDRVVTRTRELN
FAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQIDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYA
AAKPMIERALKGETVSFENELQTRQGTAIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
LGATLQACCPQQQMALLFIDLDGFKTLNDSFGHDFGDLILKTFAELLSVCAGPHHSVSRLAGDEFTVILWPLAHPQLQVS
AFCESVLARLAATERVGNQNVRLSASIGAAITSGDDMSAEALLTKADDAMYQAKSAGKGTYAIR

Sequences:

>Translated_624_residues
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFLSRSGLEARESPRNISFCGHA
ILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLSLDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHS
IERDIYTEALKSNLQRSEALFEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYPERALLERTFQDITYSEDLHNDLGLL
QQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEADLYTLQHELEDRVVTRTRELN
FAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQIDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYA
AAKPMIERALKGETVSFENELQTRQGTAIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
LGATLQACCPQQQMALLFIDLDGFKTLNDSFGHDFGDLILKTFAELLSVCAGPHHSVSRLAGDEFTVILWPLAHPQLQVS
AFCESVLARLAATERVGNQNVRLSASIGAAITSGDDMSAEALLTKADDAMYQAKSAGKGTYAIR
>Mature_624_residues
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFLSRSGLEARESPRNISFCGHA
ILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLSLDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHS
IERDIYTEALKSNLQRSEALFEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYPERALLERTFQDITYSEDLHNDLGLL
QQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEADLYTLQHELEDRVVTRTRELN
FAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQIDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYA
AAKPMIERALKGETVSFENELQTRQGTAIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
LGATLQACCPQQQMALLFIDLDGFKTLNDSFGHDFGDLILKTFAELLSVCAGPHHSVSRLAGDEFTVILWPLAHPQLQVS
AFCESVLARLAATERVGNQNVRLSASIGAAITSGDDMSAEALLTKADDAMYQAKSAGKGTYAIR

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=128, Percent_Identity=43.75, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87081881, Length=172, Percent_Identity=37.7906976744186, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787541, Length=183, Percent_Identity=32.7868852459016, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1788956, Length=152, Percent_Identity=37.5, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082007, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081977, Length=157, Percent_Identity=33.7579617834395, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693134, Length=165, Percent_Identity=32.1212121212121, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787262, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786584, Length=170, Percent_Identity=31.1764705882353, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787816, Length=156, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788085, Length=156, Percent_Identity=26.2820512820513, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 70030; Mature: 70030

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFL
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRSGLEARESPRNISFCGHAILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLS
HCCCCCHHCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCEE
LDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHSIERDIYTEALKSNLQRSEAL
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYPERALLERTFQDITYSEDLHNDLGLL
HHHHHHHHHHHHHHEEECCEEEEECHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHH
QQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEAD
HHHHHHHCCCHHHHHHHEECCCCEEEEEEEEEECCCCCCCCCEEEEEEEEHHHHHHHHHH
LYTLQHELEDRVVTRTRELNFAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYAAAKPMIERALKGETVSFENE
CCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
LQTRQGTAIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
HHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEHH
LGATLQACCPQQQMALLFIDLDGFKTLNDSFGHDFGDLILKTFAELLSVCAGPHHSVSRL
HCCHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AGDEFTVILWPLAHPQLQVSAFCESVLARLAATERVGNQNVRLSASIGAAITSGDDMSAE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCHH
ALLTKADDAMYQAKSAGKGTYAIR
HHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFL
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRSGLEARESPRNISFCGHAILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLS
HCCCCCHHCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCEE
LDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHSIERDIYTEALKSNLQRSEAL
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYPERALLERTFQDITYSEDLHNDLGLL
HHHHHHHHHHHHHHEEECCEEEEECHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHH
QQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEAD
HHHHHHHCCCHHHHHHHEECCCCEEEEEEEEEECCCCCCCCCEEEEEEEEHHHHHHHHHH
LYTLQHELEDRVVTRTRELNFAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYAAAKPMIERALKGETVSFENE
CCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
LQTRQGTAIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
HHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEHH
LGATLQACCPQQQMALLFIDLDGFKTLNDSFGHDFGDLILKTFAELLSVCAGPHHSVSRL
HCCHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AGDEFTVILWPLAHPQLQVSAFCESVLARLAATERVGNQNVRLSASIGAAITSGDDMSAE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCHH
ALLTKADDAMYQAKSAGKGTYAIR
HHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]