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The map label for this gene is aes [C]

Identifier: 157370606

GI number: 157370606

Start: 2581039

End: 2581902

Strand: Reverse

Name: aes [C]

Synonym: Spro_2366

Alternate gene names: 157370606

Gene position: 2581902-2581039 (Counterclockwise)

Preceding gene: 157370608

Following gene: 157370605

Centisome position: 47.38

GC content: 56.48

Gene sequence:

>864_bases
ATGAACATGGACCTGCTGTTTGATGATCTGTCAGTACGCGCGGTGCAATACAATGCCCGCAACTCGGTAGAGGATTTTGA
CGCCTGCATGACGCAATACGCGACGCTGGCTACCCAGGCCAAGGCGCAAACGCCGGGGATTTATGACATCCACTACGGCA
TGGGCATTGCCGAACGTCTGGATCTGTTCCCGGCCGCCAACCAGCCTGCGCCACTGTTGGTCTTTATTCACGGTGGATAT
TGGCACTCCCAACGCAAGGAAGAAGCCTGCTCGATGGCCGCCAGCTTCACCCGCCACGGCGTAGCGGTGGCCACGCTGGA
ATATACCCTGCAGCCGGAAGCCACACTGGCGGAAATCGTTCGTGAGGTGCGCAGCGCGATAGCCTGGCTTTATCACCATG
CCGGCCAATATGGCATCGATCCCGAGCGTATTTTTGTCAGTGGCAGCTCGGCGGGCGGCCACCTGAGCGGCATGCTGATC
GCCGATGACTGGCAGCATCTTTATCAGGTACCGGTCAATGTGATTAAAGGGGCGCTGGCGCTAAGTGGCTTGTACGATAT
TCGCCCGCTGTGTGATATCTACGTGAATGACTGGATGCGTCTGACGTCAGAACAGGCGGCAACGCTCAGCCCGCTATTTA
TGCTGCCGGAAAAGGCCAATGCGCCGCAGATCCTGCTCGACGTAGGAGCCAAAGAAACCCAGGGCTTTAAAAACCAGACG
CTGGCCTACTACGCCGCCTGCCGCGAAAAAGGGCTTAATGTCACGCTGCTGGAAGACCGACACTGCAACCATTTCACCCT
GGTGAACGAATTGGCTAATTCTGACAGTGCCATGTTCAAACGCGTCATGGCGATGATTATGTAA

Upstream 100 bases:

>100_bases
TGCATGCTACGCCATATCACTGTTTGTACTGGGCAGCATTAAGGAGCAAACCTCAAAACCGGATCAGGCAGATGATGGGC
AATACCCTCAAGGAGACAAT

Downstream 100 bases:

>100_bases
CGCCGCCCAAACGGCAGAATAGCGCCCGGCTATTCTGCCAAGGTCATTTTATTAAGATCAATTGCGCCTTTGCTATGCAC
AAAATTGACTAAGGCGAAGG

Product: putative esterase

Products: alcohol; a carboxylate [C]

Alternate protein names: Alpha/Beta Hydrolase Fold-3 Domain Protein; Alpha/Beta Hydrolase Domain-Containing Protein; Esterase/Lipase; Lipase; Esterase/Lipase/Thioesterase; Esterase/Lipase/Thioesterase Family Protein; Lipase/Esterase; Esterase/Lipase-Like Protein; Arylformamidase; Carboxylesterase Family Protein; Alpha/Beta Hydrolase; N-Acetylanthranilate Amidase; Alpha/Beta Hydrolase Fold-3 Domain-Containing Protein; Carboxylesterase; Hydrolase; Esterase/Lipase/Thiestherase Protein; Aylformamidase; Para-Nitrobenzyl Esterase; Lipoprotein; Dipeptidyl Aminopeptidases/Acylaminoacyl-Peptidases-Like; Alpha/Beta Hydrolase Family Protein; Peptidase; Esterase LipC; Alpha/Beta Hydrolase Fold; Coagulation Factor 5/8 Type Domain Protein; Lipase/Esterase Protein; Dienelactone Hydrolase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNMDLLFDDLSVRAVQYNARNSVEDFDACMTQYATLATQAKAQTPGIYDIHYGMGIAERLDLFPAANQPAPLLVFIHGGY
WHSQRKEEACSMAASFTRHGVAVATLEYTLQPEATLAEIVREVRSAIAWLYHHAGQYGIDPERIFVSGSSAGGHLSGMLI
ADDWQHLYQVPVNVIKGALALSGLYDIRPLCDIYVNDWMRLTSEQAATLSPLFMLPEKANAPQILLDVGAKETQGFKNQT
LAYYAACREKGLNVTLLEDRHCNHFTLVNELANSDSAMFKRVMAMIM

Sequences:

>Translated_287_residues
MNMDLLFDDLSVRAVQYNARNSVEDFDACMTQYATLATQAKAQTPGIYDIHYGMGIAERLDLFPAANQPAPLLVFIHGGY
WHSQRKEEACSMAASFTRHGVAVATLEYTLQPEATLAEIVREVRSAIAWLYHHAGQYGIDPERIFVSGSSAGGHLSGMLI
ADDWQHLYQVPVNVIKGALALSGLYDIRPLCDIYVNDWMRLTSEQAATLSPLFMLPEKANAPQILLDVGAKETQGFKNQT
LAYYAACREKGLNVTLLEDRHCNHFTLVNELANSDSAMFKRVMAMIM
>Mature_287_residues
MNMDLLFDDLSVRAVQYNARNSVEDFDACMTQYATLATQAKAQTPGIYDIHYGMGIAERLDLFPAANQPAPLLVFIHGGY
WHSQRKEEACSMAASFTRHGVAVATLEYTLQPEATLAEIVREVRSAIAWLYHHAGQYGIDPERIFVSGSSAGGHLSGMLI
ADDWQHLYQVPVNVIKGALALSGLYDIRPLCDIYVNDWMRLTSEQAATLSPLFMLPEKANAPQILLDVGAKETQGFKNQT
LAYYAACREKGLNVTLLEDRHCNHFTLVNELANSDSAMFKRVMAMIM

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI192807282, Length=255, Percent_Identity=27.843137254902, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI224465228, Length=260, Percent_Identity=27.6923076923077, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920830, Length=272, Percent_Identity=25.7352941176471, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.1.- [C]

Molecular weight: Translated: 31911; Mature: 31911

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMDLLFDDLSVRAVQYNARNSVEDFDACMTQYATLATQAKAQTPGIYDIHYGMGIAERL
CCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
DLFPAANQPAPLLVFIHGGYWHSQRKEEACSMAASFTRHGVAVATLEYTLQPEATLAEIV
HHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHH
REVRSAIAWLYHHAGQYGIDPERIFVSGSSAGGHLSGMLIADDWQHLYQVPVNVIKGALA
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
LSGLYDIRPLCDIYVNDWMRLTSEQAATLSPLFMLPEKANAPQILLDVGAKETQGFKNQT
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHCCCCHHH
LAYYAACREKGLNVTLLEDRHCNHFTLVNELANSDSAMFKRVMAMIM
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHC
>Mature Secondary Structure
MNMDLLFDDLSVRAVQYNARNSVEDFDACMTQYATLATQAKAQTPGIYDIHYGMGIAERL
CCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
DLFPAANQPAPLLVFIHGGYWHSQRKEEACSMAASFTRHGVAVATLEYTLQPEATLAEIV
HHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHH
REVRSAIAWLYHHAGQYGIDPERIFVSGSSAGGHLSGMLIADDWQHLYQVPVNVIKGALA
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
LSGLYDIRPLCDIYVNDWMRLTSEQAATLSPLFMLPEKANAPQILLDVGAKETQGFKNQT
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHCCCCHHH
LAYYAACREKGLNVTLLEDRHCNHFTLVNELANSDSAMFKRVMAMIM
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA