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The map label for this gene is fumC [H]

Identifier: 157370519

GI number: 157370519

Start: 2481484

End: 2482881

Strand: Direct

Name: fumC [H]

Synonym: Spro_2279

Alternate gene names: 157370519

Gene position: 2481484-2482881 (Clockwise)

Preceding gene: 157370518

Following gene: 157370522

Centisome position: 45.54

GC content: 57.22

Gene sequence:

>1398_bases
ATGGCTGCCGTTCGTATTGAAAAAGACTCTATGGGCCCGATTGAAGTGTCGGCCGATCGGCTATGGGGGGCGCAAACTCA
GCGTTCTCTGGAGCACTTCCGTATTTCTTCTGAAAAGATGCCGACCGCCTTGATCCATGCGCTGGCGTTGACCAAACGCG
CGGCGGCCAGCGTGAATATGGACCTGGGTTTACTGCCTGCCGAGCGTGCCAATGCCATTATCAGCGCCGCCGATGAAGTG
CTGGCGGATCAACATGCCAATGAATTCCCCTTGTCGATTTGGCAAACCGGCTCCGGCACCCAGACCAACATGAATATGAA
TGAAGTGTTGGCCAACCGTGCCAGTGAGCTGTTGGGCGGGGTCCGTGGCGAAGAGCGTCGAGTGCATCCGAACGACGACG
TCAACAAGAGCCAGAGTTCCAATGACGTGTTCCCAACCGCGATGCACGTGGCCGCGGTGATCGCGGTGCGTGAGCACCTG
ATCCCCGAACTGAAAGTGCTGCATAAAACCCTGAGCGACAAGGCAGAGGCCTACCGCGATATCGTCAAAATTGGCCGTAC
CCATTTGCAGGATGCGACCCCGCTGACCCTCGGCCAGGAGATTTCCGGCTGGGCAGCCATGCTGGCGCATAATCTGCAGC
ACATTGAAGCCAGTATCCCGCATATCAGTGAGCTGGCGTTGGGCGGTACCGCCGTGGGTACCGGTTTGAATACCCATCCG
GAATACGCGGTTCGCGTTGCCAAGGCGCTGGCTGACCTGACCGGGCAGCCGTTCGTTACCGCACCCAACAAATTTGAAGC
GCTGGCCACCTGCGATGCGTTGGTACACGGCCACGGCGCGCTGAAAGGGCTGGCGGCTTCGCTGATGAAAATTGCCAACG
ATGTACGCTGGTTATCCTCCGGCCCGCGTTGCGGTATCGGGGAAATTTCGATTCCGGAAAACGAACCGGGTAGTTCCATC
ATGCCGGGCAAGGTCAACCCAACCCAGTGCGAAGCGATGACCATGCTGTGCGCACAGGTGCTGGGCAACGACGTAGCGGT
GAATATCGGCGGTGCTTCCGGCAACTTTGAGTTAAACGTGTTCCGACCTATGGTGATCCACAACTATTTGCAATCCATTC
GCCTGCTGGCCGACGGTATGCAGGGCTTTAATGAGCACTGTGCGGTGGGTATCGAACCTAACCGTGACCGTATCAGCCAG
TTGCTGAATGAGTCACTGATGCTGGTGACCGCGCTCAATACCCATATTGGTTATGACAAAGCGGCAGAAATCGCCAAGAA
AGCGCACAAGGAAGGCCTGACGCTGAAAGCCTCGGCGCTGAAACTGGGCTACCTGACCGAAGAGGAATTCGACCTGTGGG
TGCGCCCGGAAGATATGGTCGGCAGCATGAAGAAGTAA

Upstream 100 bases:

>100_bases
CGAATAGTTATTATGTCACTATACTGGTTGGGGTGTGCCGGCGGGCATGAGCGCGTTGGCGTAATCGTACATTTTTAGGA
ATTGTACTAAGGAGATCGTG

Downstream 100 bases:

>100_bases
TCGATAGCACCAGTGGCAAAGGGCTTACTTGAGGTAAGCCTTTTTTATTGAGAGAAATGCCTGGAGCCGGATGGTCATCG
TCTGCGAGTGTGCAGCCTCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAAVRIEKDSMGPIEVSADRLWGAQTQRSLEHFRISSEKMPTALIHALALTKRAAASVNMDLGLLPAERANAIISAADEV
LADQHANEFPLSIWQTGSGTQTNMNMNEVLANRASELLGGVRGEERRVHPNDDVNKSQSSNDVFPTAMHVAAVIAVREHL
IPELKVLHKTLSDKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLAHNLQHIEASIPHISELALGGTAVGTGLNTHP
EYAVRVAKALADLTGQPFVTAPNKFEALATCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVLGNDVAVNIGGASGNFELNVFRPMVIHNYLQSIRLLADGMQGFNEHCAVGIEPNRDRISQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKASALKLGYLTEEEFDLWVRPEDMVGSMKK

Sequences:

>Translated_465_residues
MAAVRIEKDSMGPIEVSADRLWGAQTQRSLEHFRISSEKMPTALIHALALTKRAAASVNMDLGLLPAERANAIISAADEV
LADQHANEFPLSIWQTGSGTQTNMNMNEVLANRASELLGGVRGEERRVHPNDDVNKSQSSNDVFPTAMHVAAVIAVREHL
IPELKVLHKTLSDKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLAHNLQHIEASIPHISELALGGTAVGTGLNTHP
EYAVRVAKALADLTGQPFVTAPNKFEALATCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSI
MPGKVNPTQCEAMTMLCAQVLGNDVAVNIGGASGNFELNVFRPMVIHNYLQSIRLLADGMQGFNEHCAVGIEPNRDRISQ
LLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKASALKLGYLTEEEFDLWVRPEDMVGSMKK
>Mature_464_residues
AAVRIEKDSMGPIEVSADRLWGAQTQRSLEHFRISSEKMPTALIHALALTKRAAASVNMDLGLLPAERANAIISAADEVL
ADQHANEFPLSIWQTGSGTQTNMNMNEVLANRASELLGGVRGEERRVHPNDDVNKSQSSNDVFPTAMHVAAVIAVREHLI
PELKVLHKTLSDKAEAYRDIVKIGRTHLQDATPLTLGQEISGWAAMLAHNLQHIEASIPHISELALGGTAVGTGLNTHPE
YAVRVAKALADLTGQPFVTAPNKFEALATCDALVHGHGALKGLAASLMKIANDVRWLSSGPRCGIGEISIPENEPGSSIM
PGKVNPTQCEAMTMLCAQVLGNDVAVNIGGASGNFELNVFRPMVIHNYLQSIRLLADGMQGFNEHCAVGIEPNRDRISQL
LNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKASALKLGYLTEEEFDLWVRPEDMVGSMKK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=61.822125813449, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI266458395, Length=68, Percent_Identity=55.8823529411765, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1787896, Length=464, Percent_Identity=84.051724137931, Blast_Score=801, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=451, Percent_Identity=40.7982261640798, Blast_Score=337, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=59.1792656587473, Blast_Score=569, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=62.1538461538461, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=56.2770562770563, Blast_Score=529, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=59.3478260869565, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=59.3478260869565, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=59.002169197397, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=57.9175704989154, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=50.7592190889371, Blast_Score=477, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50142; Mature: 50011

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVRIEKDSMGPIEVSADRLWGAQTQRSLEHFRISSEKMPTALIHALALTKRAAASVNM
CCEEEECCCCCCCEEECHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERANAIISAADEVLADQHANEFPLSIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCC
VRGEERRVHPNDDVNKSQSSNDVFPTAMHVAAVIAVREHLIPELKVLHKTLSDKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLAHNLQHIEASIPHISELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCCCCCCH
EYAVRVAKALADLTGQPFVTAPNKFEALATCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVLGNDVAVNIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPMVIHNYLQSIRLLADGMQGFNEHCAVGIEPNRDRISQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHCEEECCCCCHHHHHHHHCCCEEEEEEHHHHCCCHH
AAEIAKKAHKEGLTLKASALKLGYLTEEEFDLWVRPEDMVGSMKK
HHHHHHHHHHCCCEEEEHHEEECCCCCCCCCEEECCHHHHCCCCC
>Mature Secondary Structure 
AAVRIEKDSMGPIEVSADRLWGAQTQRSLEHFRISSEKMPTALIHALALTKRAAASVNM
CEEEECCCCCCCEEECHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
DLGLLPAERANAIISAADEVLADQHANEFPLSIWQTGSGTQTNMNMNEVLANRASELLGG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCC
VRGEERRVHPNDDVNKSQSSNDVFPTAMHVAAVIAVREHLIPELKVLHKTLSDKAEAYRD
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHLQDATPLTLGQEISGWAAMLAHNLQHIEASIPHISELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHCCCCCCCCH
EYAVRVAKALADLTGQPFVTAPNKFEALATCDALVHGHGALKGLAASLMKIANDVRWLSS
HHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGEISIPENEPGSSIMPGKVNPTQCEAMTMLCAQVLGNDVAVNIGGASGNFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
FRPMVIHNYLQSIRLLADGMQGFNEHCAVGIEPNRDRISQLLNESLMLVTALNTHIGYDK
HHHHHHHHHHHHHHHHHHHHHCHHHCEEECCCCCHHHHHHHHCCCEEEEEEHHHHCCCHH
AAEIAKKAHKEGLTLKASALKLGYLTEEEFDLWVRPEDMVGSMKK
HHHHHHHHHHCCCEEEEHHEEECCCCCCCCCEEECCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]