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The map label for this gene is sufS

Identifier: 157370423

GI number: 157370423

Start: 2384346

End: 2385566

Strand: Direct

Name: sufS

Synonym: Spro_2183

Alternate gene names: 157370423

Gene position: 2384346-2385566 (Clockwise)

Preceding gene: 157370422

Following gene: 157370424

Centisome position: 43.76

GC content: 57.99

Gene sequence:

>1221_bases
ATGAGTTTTCCGATTGAACGGGTACGCAGTGAATTTCCGCTGTTGGCACGAGAAGTCAATGGCCAGCCGCTGGCTTACCT
CGACAGTGCCGCCAGCGCGCAGAAACCGCAGGCAGTCATCGATCGCGAGCTGGATTTTTACCGTCATGGCTACGCGGCGG
TACACCGCGGTATTCATACGTTAAGCGCCGAAGCGACGCAGGAAATGGAAGCGGTGCGTGAAAAGGTGGCGGCGTTTATC
AATGCCGGTTCGGCGGAAGAGATAATCTTCGTCAAGGGCACTACCGAAGGCATCAATCTGGTAGCCAACAGTTTTGGCCG
CCACTTTTTGCAGCCCGGTGACAGCATTATCATCACCGAGATGGAGCACCACGCCAACATCGTACCCTGGCAGATGCTGG
CACAGGAACGCGGATTAAATCTGCGTGTCTGGCCGCTACAGCCAGATGGCACCCTGGATTTGGCCCGGTTGCCGGGCTTG
ATCGACGCGTCAACCAAACTATTGGCGCTAACCCAGGTGTCCAACGTGTTGGGCACGGTGAACCCGGTGCAGGAAATTAC
GGCCCAGGCAAAAGCGGCGGGCCTGAAGGTACTGATTGACGGTGCGCAGGCAGTGATGCACCAGCGGGTGGATGTTCAGG
CGCTGGATTGCGATTTCTACGTGTTCTCCGGGCATAAGCTGTATGGGCCTTCCGGCATCGGTATTCTTTACGGTCGTCAG
GCACTGTTGCAGCAAATGCCACCCTGGGAAGGGGGCGGGTCGATGATCCAACAGGTCAGCCTGACGGCAGGAACCACCTA
CGCCGAGCCACCGTGGCGCTTTGAGGCCGGTTCACCCAACACCGCCGGCATGATGGGATTAGGTGCGGCAATTGACTATG
TGAATACTCTGGGGCTGGAGGCGATTGGTGACTACGAGCAGTCGCTGATGCATTACGCGCTGGAGGCTCTGCAACAGGTA
CCCCGGCTTAAAATCTACGGCCCGGCGGAGCGTGCCGGAGTGATCGCCTTTAACCTGGGTGAGCACCACGCCTATGACGT
CGGCAGCTTCCTGGATCAGTACGGCATTGCCATTCGTACCGGCCACCATTGCGCGATGCCGCTGATGGCGTTCTATAATG
TGCCGAGCATGTGCCGCGCTTCGTTGGCGTTATATAATACGCGCGATGAAGTAGACCGGCTGGTGGCCGGATTGCAGCGT
ATCCAGAAACTGCTGGGATAG

Upstream 100 bases:

>100_bases
CCTTTGCCGCGGAGCTGACCGAGGGGATTGGCAACGACACCATCCGTGAATCGGTGTTGGCGCGGATTGCACAGCGCCTG
GCGGGGCCGGGGGAGGCAGC

Downstream 100 bases:

>100_bases
GACAAACCGGGGCTTTATCCCTCCGGGTGAATAAATATCGGTAGTCAGTGACATGGGGTCGGCATGCCGGCCCCTGAATG
ATTGAAAGGATCCTCATGGC

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSFPIERVRSEFPLLAREVNGQPLAYLDSAASAQKPQAVIDRELDFYRHGYAAVHRGIHTLSAEATQEMEAVREKVAAFI
NAGSAEEIIFVKGTTEGINLVANSFGRHFLQPGDSIIITEMEHHANIVPWQMLAQERGLNLRVWPLQPDGTLDLARLPGL
IDASTKLLALTQVSNVLGTVNPVQEITAQAKAAGLKVLIDGAQAVMHQRVDVQALDCDFYVFSGHKLYGPSGIGILYGRQ
ALLQQMPPWEGGGSMIQQVSLTAGTTYAEPPWRFEAGSPNTAGMMGLGAAIDYVNTLGLEAIGDYEQSLMHYALEALQQV
PRLKIYGPAERAGVIAFNLGEHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYNVPSMCRASLALYNTRDEVDRLVAGLQR
IQKLLG

Sequences:

>Translated_406_residues
MSFPIERVRSEFPLLAREVNGQPLAYLDSAASAQKPQAVIDRELDFYRHGYAAVHRGIHTLSAEATQEMEAVREKVAAFI
NAGSAEEIIFVKGTTEGINLVANSFGRHFLQPGDSIIITEMEHHANIVPWQMLAQERGLNLRVWPLQPDGTLDLARLPGL
IDASTKLLALTQVSNVLGTVNPVQEITAQAKAAGLKVLIDGAQAVMHQRVDVQALDCDFYVFSGHKLYGPSGIGILYGRQ
ALLQQMPPWEGGGSMIQQVSLTAGTTYAEPPWRFEAGSPNTAGMMGLGAAIDYVNTLGLEAIGDYEQSLMHYALEALQQV
PRLKIYGPAERAGVIAFNLGEHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYNVPSMCRASLALYNTRDEVDRLVAGLQR
IQKLLG
>Mature_405_residues
SFPIERVRSEFPLLAREVNGQPLAYLDSAASAQKPQAVIDRELDFYRHGYAAVHRGIHTLSAEATQEMEAVREKVAAFIN
AGSAEEIIFVKGTTEGINLVANSFGRHFLQPGDSIIITEMEHHANIVPWQMLAQERGLNLRVWPLQPDGTLDLARLPGLI
DASTKLLALTQVSNVLGTVNPVQEITAQAKAAGLKVLIDGAQAVMHQRVDVQALDCDFYVFSGHKLYGPSGIGILYGRQA
LLQQMPPWEGGGSMIQQVSLTAGTTYAEPPWRFEAGSPNTAGMMGLGAAIDYVNTLGLEAIGDYEQSLMHYALEALQQVP
RLKIYGPAERAGVIAFNLGEHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYNVPSMCRASLALYNTRDEVDRLVAGLQRI
QKLLG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=271, Percent_Identity=29.520295202952, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI156713448, Length=285, Percent_Identity=29.4736842105263, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=71.1822660098522, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=42.4317617866005, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994898, Length=182, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=247, Percent_Identity=29.9595141700405, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=387, Percent_Identity=26.8733850129199, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=240, Percent_Identity=31.6666666666667, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129463, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUFS_SERP5 (A8GDU4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478412.1
- ProteinModelPortal:   A8GDU4
- SMR:   A8GDU4
- STRING:   A8GDU4
- GeneID:   5605752
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2183
- eggNOG:   COG0520
- HOGENOM:   HBG635316
- OMA:   EEDNANV
- BioCyc:   SPRO399741:SPRO_2183-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01831
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7; =4.4.1.16

Molecular weight: Translated: 44307; Mature: 44176

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 364-364

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPIERVRSEFPLLAREVNGQPLAYLDSAASAQKPQAVIDRELDFYRHGYAAVHRGIHT
CCCCHHHHHHHCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSAEATQEMEAVREKVAAFINAGSAEEIIFVKGTTEGINLVANSFGRHFLQPGDSIIITE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEE
MEHHANIVPWQMLAQERGLNLRVWPLQPDGTLDLARLPGLIDASTKLLALTQVSNVLGTV
EHHCCCCCHHHHHHHHCCCEEEEEECCCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHCCC
NPVQEITAQAKAAGLKVLIDGAQAVMHQRVDVQALDCDFYVFSGHKLYGPSGIGILYGRQ
CHHHHHHHHHHHCCEEEEECHHHHHHHHCCCEEEEEEEEEEEECCEEECCCCCCHHHHHH
ALLQQMPPWEGGGSMIQQVSLTAGTTYAEPPWRFEAGSPNTAGMMGLGAAIDYVNTLGLE
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCHH
AIGDYEQSLMHYALEALQQVPRLKIYGPAERAGVIAFNLGEHHAYDVGSFLDQYGIAIRT
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEC
GHHCAMPLMAFYNVPSMCRASLALYNTRDEVDRLVAGLQRIQKLLG
CCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SFPIERVRSEFPLLAREVNGQPLAYLDSAASAQKPQAVIDRELDFYRHGYAAVHRGIHT
CCCHHHHHHHCCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSAEATQEMEAVREKVAAFINAGSAEEIIFVKGTTEGINLVANSFGRHFLQPGDSIIITE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEE
MEHHANIVPWQMLAQERGLNLRVWPLQPDGTLDLARLPGLIDASTKLLALTQVSNVLGTV
EHHCCCCCHHHHHHHHCCCEEEEEECCCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHCCC
NPVQEITAQAKAAGLKVLIDGAQAVMHQRVDVQALDCDFYVFSGHKLYGPSGIGILYGRQ
CHHHHHHHHHHHCCEEEEECHHHHHHHHCCCEEEEEEEEEEEECCEEECCCCCCHHHHHH
ALLQQMPPWEGGGSMIQQVSLTAGTTYAEPPWRFEAGSPNTAGMMGLGAAIDYVNTLGLE
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCHH
AIGDYEQSLMHYALEALQQVPRLKIYGPAERAGVIAFNLGEHHAYDVGSFLDQYGIAIRT
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEC
GHHCAMPLMAFYNVPSMCRASLALYNTRDEVDRLVAGLQRIQKLLG
CCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA