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The map label for this gene is thrS

Identifier: 157370384

GI number: 157370384

Start: 2339740

End: 2341668

Strand: Direct

Name: thrS

Synonym: Spro_2144

Alternate gene names: 157370384

Gene position: 2339740-2341668 (Clockwise)

Preceding gene: 157370383

Following gene: 157370385

Centisome position: 42.94

GC content: 51.63

Gene sequence:

>1929_bases
ATGCCTGTTATTACTCTTCCTGACGGAAGTCAGCGTCATTTCGATCACCCTGTTTCCCCTTTGGATGTTGCCCGCGATAT
CGGCCCTGGCCTGGCGAAAGCCTGTATTGCCGGCCGTGTAAACGGTGAATTGGTTGATGCCGGCGATCTGATCGAATCAG
ATGCGCAACTGGCGATCATCACCATCAAGGACGCCGAAGGCCTGGAAATCATGCGCCACTCCTGTGCGCACCTGCTGGGT
CATGCGATCAAACAACTGTGGCCAGACACCAAAATGGCGATCGGTCCAGTGATCGACAATGGTTTCTATTATGACGTTGA
TATTGACCGTACCCTGACACAGGAAGACCTGGATCTGCTGGAAAAGCGGATGCATGAGTTGGCCGACAAAGATTATGACG
TCATCAAGAAAAAGGTTAGCTGGCAAGAAGCTCGCGATACCTTTGCTGCGCGTGGTGAAGACTACAAAGTGGCAATTCTG
GATGAGAACATCAGCCATGACGACCGTCCTGGCCTGTATCACCATGAAGAATATGTCGACATGTGCCGTGGGCCGCACGT
GCCGAACATGCGTTTCTGCCATCATTTCAAACTGCAGAAAACTTCGGGCGCGTACTGGCGTGGCGACAGCAAAAATAAAA
TGCTGCAACGCATCTACGGTACTGCCTGGGCAGACAAGAAACAGCTGAATGCCTACCTGCAGCGTCTGGAAGAAGCCGCC
AAGCGTGACCACCGCAAGATCGGTAAGCAGCTCGACCTGTACCATATGCAGGAAGAAGCGCCGGGCATGGTGTTCTGGCA
CAACGATGGCTGGACTATTTTCCGCGAGCTGGAAGCCTTTGTGCGCATGAAGCTCAAGGAATACCAGTATCAGGAAGTGA
AAGGGCCATTTATGATGGACCGTGTGCTGTGGGAAAAAACCGGCCACTGGGAAAACTATAAAGACGCCATGTTCACCACC
TCGTCGGAAAACCGCGAGTATTGCATCAAGCCGATGAACTGCCCGGGTCACGTGCAGATCTTCAATCAGGGCCTGAAGTC
TTACCGCGATTTGCCGCTGCGTATGGGCGAATTCGGCAGTTGCCATCGTAACGAGCCTTCGGGTTCTCTGCATGGCCTGA
TGCGCGTGCGTGGTTTCACCCAGGATGACGCCCATATCTTCTGTACTGAAGAGCAGGTGCGTGCCGAAGTGAACGAATGC
ATCAGAATGGTCTATGATGTGTACGGCACCTTTGGCTTCGACAAGATTGCGGTAAAACTTTCTACCCGTCCTGAGAAGCG
CATTGGTACTGACGATATGTGGACCCGTGCGGAAGAAGATCTGGCCGCTGCGCTGACTGAAAACGGGATTCCGTTTGAAT
ATCAGCCGGGTGAGGGTGCCTTCTACGGACCAAAAATTGAATTTACTCTGCATGATTGTTTGGATCGTGCATGGCAATGT
GGTACCGTGCAGCTCGATTTCTTCTTACCGGGCCGTTTAGGCGCATCGTATGTTGGCGAAAACAACGATCGCGTGGTCCC
GGTAATGATTCACCGTGCTATTTTGGGCTCCATGGAGCGTTTCATCGGTATCCTTACCGAAGAATACGCAGGGTTCTACC
CAACCTGGATTGCTCCGGTACAGGTGGTGGTGATGAATATCACCGACAGCCAGTCTGATTATGTCCAGCAATTGACCAAA
AAATTGCAGGACGCAGGTATTCGCGTTAAAGCGGACTTGAGAAATGAGAAGATTGGCTTTAAAATTCGCGAACATACTTT
ACGACGGGTTCCTTACATGTTGGTGTGCGGTGATAAAGAGGTCGAATCAGGCAAAGTTGCCGTTCGTACCCGCCGTGGCA
AAGACCTGGGAAGCCTGGACGTAAATGAAGTCGTAGACAAGCTGCTAAAAGAGATTCGCAGCCGTAGTCTTCATCAACTG
GAGGAATAA

Upstream 100 bases:

>100_bases
TGTGGGCGAGATCTGAAACCTAACTGACTAAATCCCAACCCAATTTTCGTACTGCATGTGATCTGTCGTGTGGGTCACCA
CTGTAGATAAGGAATTATTA

Downstream 100 bases:

>100_bases
AGTATTAAAGGCGGAAAACGAGTTCAACCGGCGCGTCCTAATCGCATTAACAGAGAAATTCGCGCGCAAGAAGTTCGCCT
AACCGGCGTCGATGGCGAGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSQRHFDHPVSPLDVARDIGPGLAKACIAGRVNGELVDAGDLIESDAQLAIITIKDAEGLEIMRHSCAHLLG
HAIKQLWPDTKMAIGPVIDNGFYYDVDIDRTLTQEDLDLLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAIL
DENISHDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWADKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMGEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVRAEVNEC
IRMVYDVYGTFGFDKIAVKLSTRPEKRIGTDDMWTRAEEDLAAALTENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFFLPGRLGASYVGENNDRVVPVMIHRAILGSMERFIGILTEEYAGFYPTWIAPVQVVVMNITDSQSDYVQQLTK
KLQDAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSLDVNEVVDKLLKEIRSRSLHQL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSQRHFDHPVSPLDVARDIGPGLAKACIAGRVNGELVDAGDLIESDAQLAIITIKDAEGLEIMRHSCAHLLG
HAIKQLWPDTKMAIGPVIDNGFYYDVDIDRTLTQEDLDLLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAIL
DENISHDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWADKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMGEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVRAEVNEC
IRMVYDVYGTFGFDKIAVKLSTRPEKRIGTDDMWTRAEEDLAAALTENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFFLPGRLGASYVGENNDRVVPVMIHRAILGSMERFIGILTEEYAGFYPTWIAPVQVVVMNITDSQSDYVQQLTK
KLQDAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSLDVNEVVDKLLKEIRSRSLHQL
EE
>Mature_641_residues
PVITLPDGSQRHFDHPVSPLDVARDIGPGLAKACIAGRVNGELVDAGDLIESDAQLAIITIKDAEGLEIMRHSCAHLLGH
AIKQLWPDTKMAIGPVIDNGFYYDVDIDRTLTQEDLDLLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILD
ENISHDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWADKKQLNAYLQRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYKDAMFTTS
SENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMGEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVRAEVNECI
RMVYDVYGTFGFDKIAVKLSTRPEKRIGTDDMWTRAEEDLAAALTENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDFFLPGRLGASYVGENNDRVVPVMIHRAILGSMERFIGILTEEYAGFYPTWIAPVQVVVMNITDSQSDYVQQLTKK
LQDAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSLDVNEVVDKLLKEIRSRSLHQLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=627, Percent_Identity=38.5964912280702, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI38202255, Length=643, Percent_Identity=38.4136858475894, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=653, Percent_Identity=35.5283307810107, Blast_Score=394, Evalue=1e-109,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=88.785046728972, Blast_Score=1215, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=629, Percent_Identity=37.3608903020668, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71984192, Length=629, Percent_Identity=37.3608903020668, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322112, Length=650, Percent_Identity=36.3076923076923, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=415, Percent_Identity=37.5903614457831, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=40, Blast_Score=490, Evalue=1e-138,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=40, Blast_Score=490, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=40, Blast_Score=490, Evalue=1e-138,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SERP5 (A8GDQ5)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478373.1
- ProteinModelPortal:   A8GDQ5
- SMR:   A8GDQ5
- STRING:   A8GDQ5
- GeneID:   5605934
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2144
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK00413
- BioCyc:   SPRO399741:SPRO_2144-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73830; Mature: 73699

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSQRHFDHPVSPLDVARDIGPGLAKACIAGRVNGELVDAGDLIESDAQLAII
CCEEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEECCCHHHCCCCCEEEE
TIKDAEGLEIMRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIDRTLTQEDLDLL
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISHDDRPGLYHHEEYVD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWADKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVLWEKTGHWENYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMGEFGS
HHHHHHCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVRAEVNECIRMVYDVYGTFGFDKIAVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
STRPEKRIGTDDMWTRAEEDLAAALTENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFFLPGRLGASYVGENNDRVVPVMIHRAILGSMERFIGILTEEYAGFYPTWIAPV
CEEEEEEEECCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCE
QVVVMNITDSQSDYVQQLTKKLQDAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
VESGKVAVRTRRGKDLGSLDVNEVVDKLLKEIRSRSLHQLEE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSQRHFDHPVSPLDVARDIGPGLAKACIAGRVNGELVDAGDLIESDAQLAII
CEEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEECCCHHHCCCCCEEEE
TIKDAEGLEIMRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIDRTLTQEDLDLL
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISHDDRPGLYHHEEYVD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWADKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEAFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVLWEKTGHWENYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMGEFGS
HHHHHHCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVRAEVNECIRMVYDVYGTFGFDKIAVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
STRPEKRIGTDDMWTRAEEDLAAALTENGIPFEYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFFLPGRLGASYVGENNDRVVPVMIHRAILGSMERFIGILTEEYAGFYPTWIAPV
CEEEEEEEECCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCE
QVVVMNITDSQSDYVQQLTKKLQDAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
VESGKVAVRTRRGKDLGSLDVNEVVDKLLKEIRSRSLHQLEE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA