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The map label for this gene is cscR [H]

Identifier: 157370323

GI number: 157370323

Start: 2274722

End: 2275723

Strand: Direct

Name: cscR [H]

Synonym: Spro_2081

Alternate gene names: 157370323

Gene position: 2274722-2275723 (Clockwise)

Preceding gene: 157370322

Following gene: 157370335

Centisome position: 41.75

GC content: 60.38

Gene sequence:

>1002_bases
ATGGCCTCGCTGAAAGACGTTGCCAAACTTGCCGGGGTATCGTTAATGACGGTATCCCGCGCCATCAACGAGCCCGATAA
GCTGCGGCCGGACACCTACCAACGCGTTAAGCTGGCAATTGACCAACTCGATTACGTGCCCGATCTCGCGGCGCGGCGTA
TTCGCGGTGACAGCAGCCGGGTGCAAACCCTCGGCGTGCTGGCGCTGGATACCGCGACCACCCCTTTCTCGGTTGACATG
ATCCTGTCGATTGAAAAAACCGCGCGTGAACACGGCTGGAACAGTTTTGTCGTCAACCTGTTCGCCGATGACAGCGCGGA
GCACACCATCGATTTGCTGCTGGCGCATCGGCCGGACGGGGTGATCTTCACCACCATGGGGCTGCGCCAGGTGAGTCTGC
CTGCCAAATTGCTGGATAAAAAACTGGTGCTGGCCAATTGCGTCTGCCCGGAACATGCGGTTGCCAGCTACATCCCCGAT
GATGAGCAGGGGCAGTACGATGCTATGCGTACACTGATCGCCAAAGGGTATCGTGCGCCGCTGTGCATTCACCTGCCGGA
AAATACCCTGGCGGCCGGGTTGCGCCGTCGTGGGCTGGAGCGAGCCTGGCGTGAGGCCGGTGGCGACGTTGAGCGGTTGC
GGCAATATCATCTTGATCTGACCGACGGCGACGAGCACTACCGCGACAGCGTGGAACTGCTGCAACGGCATTTCTCGCCG
GGGCAGCGCGATTGCGATGTGGTGGTGTGCGGCAACGATCGGGTGGCGTTTATGGTCTACCAGGTGCTGTTGGCACAGGG
CTGGAAAATCCCCCAGCAGGTCGGGGTGCTGGGCTATGACAATATGGTCGGCATTGGTCAACTGTTCCTGCCGCCGCTGA
CCACGGTACAACTGCCGCACTACGAATTGGGCCGCCAGGCGGCGCTGCACCTGATTAATCAGCTGGATCACCGGGAGACG
CGAAAAGTGGCTTGCCCGCTGCTGCTGCGCGAATCACTTTAA

Upstream 100 bases:

>100_bases
GTTATTCTGTGGGCCGACATCACACCCGGCTAAAGTGGGCTAGAGTCCGGCGCTAAGTTGTGGGATCATCTGGTTTTCTA
TCCGACACAGAGAAGGGCGC

Downstream 100 bases:

>100_bases
TCAATCAGGGCGCGCTATATGTGCCTTGTCAGATTCTAAGTTGCCTTTAAGGCTGAGATACCCGGGCCTAGCGCACCGAG
GGGCCATTATGGGACACATC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Csc operon regulatory protein [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MASLKDVAKLAGVSLMTVSRAINEPDKLRPDTYQRVKLAIDQLDYVPDLAARRIRGDSSRVQTLGVLALDTATTPFSVDM
ILSIEKTAREHGWNSFVVNLFADDSAEHTIDLLLAHRPDGVIFTTMGLRQVSLPAKLLDKKLVLANCVCPEHAVASYIPD
DEQGQYDAMRTLIAKGYRAPLCIHLPENTLAAGLRRRGLERAWREAGGDVERLRQYHLDLTDGDEHYRDSVELLQRHFSP
GQRDCDVVVCGNDRVAFMVYQVLLAQGWKIPQQVGVLGYDNMVGIGQLFLPPLTTVQLPHYELGRQAALHLINQLDHRET
RKVACPLLLRESL

Sequences:

>Translated_333_residues
MASLKDVAKLAGVSLMTVSRAINEPDKLRPDTYQRVKLAIDQLDYVPDLAARRIRGDSSRVQTLGVLALDTATTPFSVDM
ILSIEKTAREHGWNSFVVNLFADDSAEHTIDLLLAHRPDGVIFTTMGLRQVSLPAKLLDKKLVLANCVCPEHAVASYIPD
DEQGQYDAMRTLIAKGYRAPLCIHLPENTLAAGLRRRGLERAWREAGGDVERLRQYHLDLTDGDEHYRDSVELLQRHFSP
GQRDCDVVVCGNDRVAFMVYQVLLAQGWKIPQQVGVLGYDNMVGIGQLFLPPLTTVQLPHYELGRQAALHLINQLDHRET
RKVACPLLLRESL
>Mature_332_residues
ASLKDVAKLAGVSLMTVSRAINEPDKLRPDTYQRVKLAIDQLDYVPDLAARRIRGDSSRVQTLGVLALDTATTPFSVDMI
LSIEKTAREHGWNSFVVNLFADDSAEHTIDLLLAHRPDGVIFTTMGLRQVSLPAKLLDKKLVLANCVCPEHAVASYIPDD
EQGQYDAMRTLIAKGYRAPLCIHLPENTLAAGLRRRGLERAWREAGGDVERLRQYHLDLTDGDEHYRDSVELLQRHFSPG
QRDCDVVVCGNDRVAFMVYQVLLAQGWKIPQQVGVLGYDNMVGIGQLFLPPLTTVQLPHYELGRQAALHLINQLDHRETR
KVACPLLLRESL

Specific function: Repressor for the csc operon. Binds D-fructose as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=30.5882352941176, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790194, Length=338, Percent_Identity=28.4023668639053, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=25.7575757575758, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789202, Length=337, Percent_Identity=28.7833827893175, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787948, Length=324, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788474, Length=314, Percent_Identity=26.4331210191083, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=26.0736196319018, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786540, Length=323, Percent_Identity=23.8390092879257, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=25.5451713395639, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790689, Length=330, Percent_Identity=24.8484848484848, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789068, Length=323, Percent_Identity=23.8390092879257, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37262; Mature: 37131

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLKDVAKLAGVSLMTVSRAINEPDKLRPDTYQRVKLAIDQLDYVPDLAARRIRGDSSR
CCCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VQTLGVLALDTATTPFSVDMILSIEKTAREHGWNSFVVNLFADDSAEHTIDLLLAHRPDG
HHHEEEEEEECCCCCEEEEHEEEEHHHHHHCCCCEEEEEEEECCCCHHEEEEHEEECCCC
VIFTTMGLRQVSLPAKLLDKKLVLANCVCPEHAVASYIPDDEQGQYDAMRTLIAKGYRAP
EEEEECCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
LCIHLPENTLAAGLRRRGLERAWREAGGDVERLRQYHLDLTDGDEHYRDSVELLQRHFSP
EEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
GQRDCDVVVCGNDRVAFMVYQVLLAQGWKIPQQVGVLGYDNMVGIGQLFLPPLTTVQLPH
CCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHCCCCCEEECCH
YELGRQAALHLINQLDHRETRKVACPLLLRESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASLKDVAKLAGVSLMTVSRAINEPDKLRPDTYQRVKLAIDQLDYVPDLAARRIRGDSSR
CCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VQTLGVLALDTATTPFSVDMILSIEKTAREHGWNSFVVNLFADDSAEHTIDLLLAHRPDG
HHHEEEEEEECCCCCEEEEHEEEEHHHHHHCCCCEEEEEEEECCCCHHEEEEHEEECCCC
VIFTTMGLRQVSLPAKLLDKKLVLANCVCPEHAVASYIPDDEQGQYDAMRTLIAKGYRAP
EEEEECCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
LCIHLPENTLAAGLRRRGLERAWREAGGDVERLRQYHLDLTDGDEHYRDSVELLQRHFSP
EEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
GQRDCDVVVCGNDRVAFMVYQVLLAQGWKIPQQVGVLGYDNMVGIGQLFLPPLTTVQLPH
CCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHCCCCCEEECCH
YELGRQAALHLINQLDHRETRKVACPLLLRESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA