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The map label for this gene is ybiC [H]

Identifier: 157370252

GI number: 157370252

Start: 2202261

End: 2203349

Strand: Direct

Name: ybiC [H]

Synonym: Spro_2010

Alternate gene names: 157370252

Gene position: 2202261-2203349 (Clockwise)

Preceding gene: 157370251

Following gene: 157370259

Centisome position: 40.42

GC content: 58.49

Gene sequence:

>1089_bases
ATGAGCACTGAACACCGTATCGATCGCCAATGTCTTGAGCAGTTTGTGCAGGCGATTTGGCGCCATGCCGGCAGTACCGA
TCGAGAGGCCGGGTTAGTGGCCGAACATCTGGTTCAGGCCAATCTGGCCGGACACGACTCCCACGGCGTCGGCATGATCC
CGAGCTATATGGCGTCGCTGGCGCAGGGGCATTTACAGCTTAACGTTCATGCCCAGGTGGTACGCGACGCCGGTGCGGTC
CTGACGATTGACGGTGGTCAGGGTTTCGGCCAGGTGGTCGCCAGTGAGGCGATGGATAAAGGCATCGAACGAGCCAGGCA
ACTGGGGCTGGCGGCGGTGGCATTAAACAATTCGCATCACATCGGCCGTATTGGCCACTGGGCTGAACAGTGTGCACGCG
CCGGTTTTATCTCTATTCACTTCGTCAATGTCGTGGGCGACCCTATGGTGGCACCCTTTGGCGGCAGCGATCGTCGCTTT
GGTACCAACCCCTTCTGCGTTATTTTCCCCCGTCCCGGTAAAAAGCCGCTGCTGCTGGATTTCGCCACCAGCGGCATCGC
TTTTGGTAAAACCCGCGTGGCCTACAACAAAGGTCTGACCGTCGCGCCGGGCTATCTGATTGACCAGCATGGACAACCCA
CAGACGAGCCCAAGGTGATGCACGAGCAGCCGTTTGGTTCGCTGCTGCCCTTTGGTGCGCATAAAGGTTATGCACTGGCC
GCCCTGTGCGAGATCCTCGGCGGTGCACTGTCGGGCGGGAGAACTACCCATAGTGCTACGCTGAAATCCAACAGCGACGC
CATTTTCAACTGTATGACCACCATTATCCTCAACCCAGAGGCCTTTGCGGCACCTGAGATGCAAAGTGAGGCTGAGGCGT
TTATTGACTGGGTGAAGGCCTCACCGCCAAGTGACGGTCGGCCGATTGAGGTGCCGGGGGAGTGGGAAGAGGCTAATCGC
GAACAACGTTTGCAACAGGGGATCCCGATAGATGCCAATACCTGGCAGCAGATTTGTGCGGCAGCCAGACAGGCGGGCAT
GCCTGACGAGGAGCTTGATGCTTACCTGACACAGGCGCTGCGAGCATAA

Upstream 100 bases:

>100_bases
GAACGCGCCAAATAGCCCCGATTGCGATTATTATAATTGCTTGCCGTAACAATGATTTGCTCCTAGTGTAGAACATATTT
TCCGCACCAGGAGCCGTATC

Downstream 100 bases:

>100_bases
AAAAAGCCACTCGCCTGGGGGCGGGTGGCTTTATCAGAATGACTTCAGCTTCAGTCTTTAAAATACCAGTAGCCGTTATT
GATCAGTGCGGTCAGCAGCG

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSTEHRIDRQCLEQFVQAIWRHAGSTDREAGLVAEHLVQANLAGHDSHGVGMIPSYMASLAQGHLQLNVHAQVVRDAGAV
LTIDGGQGFGQVVASEAMDKGIERARQLGLAAVALNNSHHIGRIGHWAEQCARAGFISIHFVNVVGDPMVAPFGGSDRRF
GTNPFCVIFPRPGKKPLLLDFATSGIAFGKTRVAYNKGLTVAPGYLIDQHGQPTDEPKVMHEQPFGSLLPFGAHKGYALA
ALCEILGGALSGGRTTHSATLKSNSDAIFNCMTTIILNPEAFAAPEMQSEAEAFIDWVKASPPSDGRPIEVPGEWEEANR
EQRLQQGIPIDANTWQQICAAARQAGMPDEELDAYLTQALRA

Sequences:

>Translated_362_residues
MSTEHRIDRQCLEQFVQAIWRHAGSTDREAGLVAEHLVQANLAGHDSHGVGMIPSYMASLAQGHLQLNVHAQVVRDAGAV
LTIDGGQGFGQVVASEAMDKGIERARQLGLAAVALNNSHHIGRIGHWAEQCARAGFISIHFVNVVGDPMVAPFGGSDRRF
GTNPFCVIFPRPGKKPLLLDFATSGIAFGKTRVAYNKGLTVAPGYLIDQHGQPTDEPKVMHEQPFGSLLPFGAHKGYALA
ALCEILGGALSGGRTTHSATLKSNSDAIFNCMTTIILNPEAFAAPEMQSEAEAFIDWVKASPPSDGRPIEVPGEWEEANR
EQRLQQGIPIDANTWQQICAAARQAGMPDEELDAYLTQALRA
>Mature_361_residues
STEHRIDRQCLEQFVQAIWRHAGSTDREAGLVAEHLVQANLAGHDSHGVGMIPSYMASLAQGHLQLNVHAQVVRDAGAVL
TIDGGQGFGQVVASEAMDKGIERARQLGLAAVALNNSHHIGRIGHWAEQCARAGFISIHFVNVVGDPMVAPFGGSDRRFG
TNPFCVIFPRPGKKPLLLDFATSGIAFGKTRVAYNKGLTVAPGYLIDQHGQPTDEPKVMHEQPFGSLLPFGAHKGYALAA
LCEILGGALSGGRTTHSATLKSNSDAIFNCMTTIILNPEAFAAPEMQSEAEAFIDWVKASPPSDGRPIEVPGEWEEANRE
QRLQQGIPIDANTWQQICAAARQAGMPDEELDAYLTQALRA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=358, Percent_Identity=65.3631284916201, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786727, Length=343, Percent_Identity=28.8629737609329, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790000, Length=322, Percent_Identity=26.7080745341615, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=326, Percent_Identity=30.0613496932515, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17536633, Length=360, Percent_Identity=26.1111111111111, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667908, Length=299, Percent_Identity=27.4247491638796, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45553211, Length=299, Percent_Identity=27.4247491638796, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24667912, Length=299, Percent_Identity=27.4247491638796, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24667904, Length=299, Percent_Identity=27.4247491638796, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24658010, Length=323, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648360, Length=323, Percent_Identity=24.4582043343653, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38911; Mature: 38780

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEHRIDRQCLEQFVQAIWRHAGSTDREAGLVAEHLVQANLAGHDSHGVGMIPSYMASL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AQGHLQLNVHAQVVRDAGAVLTIDGGQGFGQVVASEAMDKGIERARQLGLAAVALNNSHH
HCCCEEEEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
IGRIGHWAEQCARAGFISIHFVNVVGDPMVAPFGGSDRRFGTNPFCVIFPRPGKKPLLLD
CCHHHHHHHHHHHCCEEEEEEEEECCCCEECCCCCCCCCCCCCCEEEEECCCCCCCEEEE
FATSGIAFGKTRVAYNKGLTVAPGYLIDQHGQPTDEPKVMHEQPFGSLLPFGAHKGYALA
ECCCCEECCCEEEEECCCCEECCCCEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHH
ALCEILGGALSGGRTTHSATLKSNSDAIFNCMTTIILNPEAFAAPEMQSEAEAFIDWVKA
HHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHEECCHHHCCCCHHHHHHHHHHHHHC
SPPSDGRPIEVPGEWEEANREQRLQQGIPIDANTWQQICAAARQAGMPDEELDAYLTQAL
CCCCCCCEEECCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RA
CC
>Mature Secondary Structure 
STEHRIDRQCLEQFVQAIWRHAGSTDREAGLVAEHLVQANLAGHDSHGVGMIPSYMASL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AQGHLQLNVHAQVVRDAGAVLTIDGGQGFGQVVASEAMDKGIERARQLGLAAVALNNSHH
HCCCEEEEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
IGRIGHWAEQCARAGFISIHFVNVVGDPMVAPFGGSDRRFGTNPFCVIFPRPGKKPLLLD
CCHHHHHHHHHHHCCEEEEEEEEECCCCEECCCCCCCCCCCCCCEEEEECCCCCCCEEEE
FATSGIAFGKTRVAYNKGLTVAPGYLIDQHGQPTDEPKVMHEQPFGSLLPFGAHKGYALA
ECCCCEECCCEEEEECCCCEECCCCEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHH
ALCEILGGALSGGRTTHSATLKSNSDAIFNCMTTIILNPEAFAAPEMQSEAEAFIDWVKA
HHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHEECCHHHCCCCHHHHHHHHHHHHHC
SPPSDGRPIEVPGEWEEANREQRLQQGIPIDANTWQQICAAARQAGMPDEELDAYLTQAL
CCCCCCCEEECCCCHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]