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The map label for this gene is cycA [H]

Identifier: 157370067

GI number: 157370067

Start: 2007837

End: 2009237

Strand: Reverse

Name: cycA [H]

Synonym: Spro_1825

Alternate gene names: 157370067

Gene position: 2009237-2007837 (Counterclockwise)

Preceding gene: 157370068

Following gene: 157370065

Centisome position: 36.87

GC content: 56.1

Gene sequence:

>1401_bases
ATGGTAGATCACTCTAAAATAGCCGCAGAGGCCACGCCAGAATCAGAAGATCATCTACGCCGAAACCTAACTAACCGACA
TATTCAACTGATCGCCATCGGCGGTGCCATAGGTACGGGTCTGTTTATGGGTTCCGGCAAAACCATCAGCCTGGCCGGGC
CTTCGATCATCTTCGTGTACATGATTATCGGCTTTATGCTGTTCTTCGTGATGCGCGCCATGGGCGAGCTGCTGCTCTCC
AATCTGGAATATAAATCCTTCAGCGATTTCGCCGCCGATCTGCTCGGCCCCTGGGCCGGCTTCTTTACCGGCTGGACCTA
CTGGTTCTGCTGGGTGGTCACCGGTATTGCCGACGTGGTGGCGATCACCGCCTACGCACAGTTCTGGTTCCCCGGACTGT
CACAGTGGATCGCTTCGTTGCTGTGCATATTGCTGTTGCTGGGCCTGAACCTGGCGACGGTGAAGATGTTTGGTGAGATG
GAATTCTGGTTCGCGATGATCAAAATCGTCGCCATTGTCGGGCTGATCATCGCCGGGCTGGTGATGATCGCCATGCAGTT
CCAGTCACCAACCGGCACCGTCGCGTCGTTCTCACACCTGTGGAATGACGGCGGTATGTTCCCGAAAGGCATCAGCGGCT
TCTTCGCCGGCTTCCAGATTGCGGTGTTCGCCTTTGTCGGTATTGAGCTGGTGGGTACCACCGCGGCTGAAACCAAAGAC
CCGGAAAAAGTGCTGCCGCGCGCGATTAACTCGATTCCTATCCGCATCATCATGTTCTACGTGTTCGCCCTGATCGTGAT
TATGTCGGTCACGCCATGGAGTTCCGTGGTCGCCGACAAAAGCCCGTTCGTAGAACTGTTTGTGCTGATTGGCCTGCCTG
CGGCGGCCAGCGTGATCAACTTTGTGGTGCTGACCTCCGCCGCCTCTTCCGCCAACAGTGGCGTGTTCTCTACCAGCCGT
ATGCTGTTCGGTCTGGCGCAGGAAGGCGATGCACCCAAGTCGTTCGCCCACCTGTCCAAGCGGGCGGTGCCGGCTAACGG
CCTGACCTTCTCCTGTATCTGCCTGTTGGGTGGGGTGGTACTGATTTACCTGATCCCGAACGTGATGACGGTATTCACGC
TGGTAACCACCGTCTCGGCGATACTGTTTATGTTTGTCTGGACCATTATCCTGTGCTCGTATCTGGTTTACCGTAAGCAA
CGCCCGGTGCTGCACCAGAAATCGATCTACAAGATGCCGGCCGGCAAACTGATGTGCTGGGTCTGTATGGCGTTCTTCGC
CTTTGTGTTGGTGTTGCTGACGCTACGCGAAGACACCCGTCAGGCGCTGATCGTCACGCCACTGTGGTTTGTGGTGCTCG
GTCTGTCCTACGTGTTCCTGCGCAAAAAGAAAACCGCTTAA

Upstream 100 bases:

>100_bases
ACTACCTTACTAAATCTGGCACAACCAGATAATCGTATAAAAAAGAGCCACTTCAGAGCTCACTATTTCACTCATGACAG
GTAAAACAGGACATCATCAG

Downstream 100 bases:

>100_bases
CATTCCCCGGGGGATAGCTCGCTATCCCCCTGCTCTCATCCGCCTAGCGCGGCCGAATACCCTCGATAATCACCCGCTGC
ACGTTCTCCACCGTCTGCTG

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MVDHSKIAAEATPESEDHLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGFFTGWTYWFCWVVTGIADVVAITAYAQFWFPGLSQWIASLLCILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVGLIIAGLVMIAMQFQSPTGTVASFSHLWNDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKVLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVADKSPFVELFVLIGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGDAPKSFAHLSKRAVPANGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKQ
RPVLHQKSIYKMPAGKLMCWVCMAFFAFVLVLLTLREDTRQALIVTPLWFVVLGLSYVFLRKKKTA

Sequences:

>Translated_466_residues
MVDHSKIAAEATPESEDHLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGFFTGWTYWFCWVVTGIADVVAITAYAQFWFPGLSQWIASLLCILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVGLIIAGLVMIAMQFQSPTGTVASFSHLWNDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKVLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVADKSPFVELFVLIGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGDAPKSFAHLSKRAVPANGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKQ
RPVLHQKSIYKMPAGKLMCWVCMAFFAFVLVLLTLREDTRQALIVTPLWFVVLGLSYVFLRKKKTA
>Mature_466_residues
MVDHSKIAAEATPESEDHLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFAADLLGPWAGFFTGWTYWFCWVVTGIADVVAITAYAQFWFPGLSQWIASLLCILLLLGLNLATVKMFGEM
EFWFAMIKIVAIVGLIIAGLVMIAMQFQSPTGTVASFSHLWNDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKVLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVADKSPFVELFVLIGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGDAPKSFAHLSKRAVPANGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKQ
RPVLHQKSIYKMPAGKLMCWVCMAFFAFVLVLLTLREDTRQALIVTPLWFVVLGLSYVFLRKKKTA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=22.5352112676056, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI181337167, Length=342, Percent_Identity=22.5146198830409, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI115648063, Length=459, Percent_Identity=25.7080610021786, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI115648022, Length=459, Percent_Identity=25.7080610021786, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790653, Length=466, Percent_Identity=85.6223175965665, Blast_Score=814, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=455, Percent_Identity=41.3186813186813, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=38.0129589632829, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=41.0989010989011, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=41.743119266055, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=38.4803921568627, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI1788480, Length=452, Percent_Identity=36.0619469026549, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87081708, Length=398, Percent_Identity=34.4221105527638, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=439, Percent_Identity=32.1184510250569, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI2367353, Length=412, Percent_Identity=24.2718446601942, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87082023, Length=413, Percent_Identity=21.0653753026634, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=367, Percent_Identity=25.3405994550409, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=462, Percent_Identity=32.034632034632, Blast_Score=206, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=425, Percent_Identity=32.9411764705882, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=415, Percent_Identity=31.3253012048193, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=456, Percent_Identity=30.0438596491228, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=29.4536817102138, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=421, Percent_Identity=29.4536817102138, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=454, Percent_Identity=28.4140969162996, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.8115942028986, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=404, Percent_Identity=28.2178217821782, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=27.2058823529412, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=26.6187050359712, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=26.4851485148515, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=438, Percent_Identity=25.7990867579909, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=26.7303102625298, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=445, Percent_Identity=27.4157303370787, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=28.9340101522843, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=422, Percent_Identity=26.7772511848341, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320364, Length=489, Percent_Identity=22.6993865030675, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550968, Length=482, Percent_Identity=26.5560165975104, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921172, Length=482, Percent_Identity=26.5560165975104, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666159, Length=406, Percent_Identity=20.4433497536946, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221512776, Length=406, Percent_Identity=20.4433497536946, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51147; Mature: 51147

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHSKIAAEATPESEDHLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFAADLLGPWAGFFTGWTYWFCWVVTGIADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSQWIASLLCILLLLGLNLATVKMFGEMEFWFAMIKIVAIVGLIIAGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMQFQSPTGTVASFSHLWNDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKVLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVADKSPFVELFVLIGLPAAASVIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGDAPKSFAHLSKRAVPANGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKQRPVLHQKSIYKMPAGKLMCW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VCMAFFAFVLVLLTLREDTRQALIVTPLWFVVLGLSYVFLRKKKTA
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDHSKIAAEATPESEDHLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFAADLLGPWAGFFTGWTYWFCWVVTGIADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSQWIASLLCILLLLGLNLATVKMFGEMEFWFAMIKIVAIVGLIIAGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMQFQSPTGTVASFSHLWNDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKVLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVADKSPFVELFVLIGLPAAASVIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGDAPKSFAHLSKRAVPANGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKQRPVLHQKSIYKMPAGKLMCW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VCMAFFAFVLVLLTLREDTRQALIVTPLWFVVLGLSYVFLRKKKTA
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]