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The map label for this gene is pncB

Identifier: 157369975

GI number: 157369975

Start: 1906280

End: 1907485

Strand: Reverse

Name: pncB

Synonym: Spro_1732

Alternate gene names: 157369975

Gene position: 1907485-1906280 (Counterclockwise)

Preceding gene: 157369976

Following gene: 157369974

Centisome position: 35.01

GC content: 55.06

Gene sequence:

>1206_bases
ATGACTCAATACGCCTCCCCGATTTTGACATCACTGCTTGATACTGATGCCTACAAGCTTCATATGCAGCAAGCAGTGTT
TCATCGCTATCCCGCTATCAGCGTGGCGGCGGAATTCCGCTGCCGTGGTGACGAGCTGCTTGGCGAATATGCCGACGAAA
TTGGTGCGCAAATCGCACTGATGAGCCAGTTGGCGCTGACAGACGCTGAGTTCGACTATCTCTCAGGGCTGCCCTTCTTC
CGTGAGGATTACCTGAACTGGCTGCGCGATTTCCGCTACGATCCGCAACAGGTCCAGATCGAGAACCACGCGGGCAAGCT
GCATATTCGCATTGCCGGCCCGTGGCGCGAAGTGATCATGTGGGAAGTCCCACTGCTGGCGGTAATCAGCGAAGTGGTAC
ATCGCCATCGCTCACCGGATGTCACGCCAGAGATGGCGGTAGCCCATTTGCGCAACAAGCTCGCACAGTTTAAAGCCATG
AGTAGCGATGTGGATATTTCTCGCTTCAAGCTGATGGACTTCGGCACCCGCCGCCGTTTTTCACAGGCTGTGCAGCAGGC
AATCGTCGGCACGCTGAAAAACGAATTCCCGTATCTGGTGGGGACCAGCAACTACGATCTGGCGCACCAGCTTGATCTTG
CACCAGTTGGTACCCAGGCTCATGAATGGTTCCAGGCTCATCAGCAGATCAGCCCGGTGTTGGCCAACAGTCAGCGGGCG
GCACTGCAGGCCTGGCTGGATGAATACCCGGATCAGCTTGGTATTGCACTGACCGACTGCATCACCATGGATGCCTTCCT
GCGTGATTTCGGCCCGCAGTTTGCCCAACGCTATCAGGGCCTGCGCCATGACTCAGGCGATCCGTTCGAATGGGGCGAAA
AAGCCATCGCGCATTTCCAGAAGCTGGGGATTGATCCGATGAGCAAAACTCTGGTGTTCTCCGATAACCTGGATCTGGAC
AAAGCACTGGCGCTTTACCGCCACTTCTACCAACGCGTCAACCTGGTGTTCGGTATAGGTACGCGTCTGACCTGCGATAT
TCCCGGGGTTAAACCGCTGAATATCGTTATCAAACTGGTCGAATGCAAAGGCAAACCAGTGGCTAAACTCTCCGACAGCC
CGGGTAAAACCATCTGTCAGGATCAGGCCTTTGTAAAAGCGTTACGCAAAGCCTTCGATCTGCCGCTGGTAAAAAAAGCG
AGCTAG

Upstream 100 bases:

>100_bases
TGATGCAGCTTCAATAACAGGATAATCCGGGTATACTCCCCCCACTTTTTTTGATTATCCGGATTTGGACACGCGCCTGA
CGAGGATGCAGTAACGCGCT

Downstream 100 bases:

>100_bases
CCCCCTGCCCGATAAACGTTAAAAAGCCGGCTGAAGACCTCACGCCGGCTTTTCCTTCTTTATATAGTCCTTCTCTTTGT
TCCCTTTTCGCCCAGCCCCA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTQYASPILTSLLDTDAYKLHMQQAVFHRYPAISVAAEFRCRGDELLGEYADEIGAQIALMSQLALTDAEFDYLSGLPFF
REDYLNWLRDFRYDPQQVQIENHAGKLHIRIAGPWREVIMWEVPLLAVISEVVHRHRSPDVTPEMAVAHLRNKLAQFKAM
SSDVDISRFKLMDFGTRRRFSQAVQQAIVGTLKNEFPYLVGTSNYDLAHQLDLAPVGTQAHEWFQAHQQISPVLANSQRA
ALQAWLDEYPDQLGIALTDCITMDAFLRDFGPQFAQRYQGLRHDSGDPFEWGEKAIAHFQKLGIDPMSKTLVFSDNLDLD
KALALYRHFYQRVNLVFGIGTRLTCDIPGVKPLNIVIKLVECKGKPVAKLSDSPGKTICQDQAFVKALRKAFDLPLVKKA
S

Sequences:

>Translated_401_residues
MTQYASPILTSLLDTDAYKLHMQQAVFHRYPAISVAAEFRCRGDELLGEYADEIGAQIALMSQLALTDAEFDYLSGLPFF
REDYLNWLRDFRYDPQQVQIENHAGKLHIRIAGPWREVIMWEVPLLAVISEVVHRHRSPDVTPEMAVAHLRNKLAQFKAM
SSDVDISRFKLMDFGTRRRFSQAVQQAIVGTLKNEFPYLVGTSNYDLAHQLDLAPVGTQAHEWFQAHQQISPVLANSQRA
ALQAWLDEYPDQLGIALTDCITMDAFLRDFGPQFAQRYQGLRHDSGDPFEWGEKAIAHFQKLGIDPMSKTLVFSDNLDLD
KALALYRHFYQRVNLVFGIGTRLTCDIPGVKPLNIVIKLVECKGKPVAKLSDSPGKTICQDQAFVKALRKAFDLPLVKKA
S
>Mature_400_residues
TQYASPILTSLLDTDAYKLHMQQAVFHRYPAISVAAEFRCRGDELLGEYADEIGAQIALMSQLALTDAEFDYLSGLPFFR
EDYLNWLRDFRYDPQQVQIENHAGKLHIRIAGPWREVIMWEVPLLAVISEVVHRHRSPDVTPEMAVAHLRNKLAQFKAMS
SDVDISRFKLMDFGTRRRFSQAVQQAIVGTLKNEFPYLVGTSNYDLAHQLDLAPVGTQAHEWFQAHQQISPVLANSQRAA
LQAWLDEYPDQLGIALTDCITMDAFLRDFGPQFAQRYQGLRHDSGDPFEWGEKAIAHFQKLGIDPMSKTLVFSDNLDLDK
ALALYRHFYQRVNLVFGIGTRLTCDIPGVKPLNIVIKLVECKGKPVAKLSDSPGKTICQDQAFVKALRKAFDLPLVKKAS

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=401, Percent_Identity=74.0648379052369, Blast_Score=620, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6324783, Length=418, Percent_Identity=31.5789473684211, Blast_Score=204, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_SERP5 (A8GCJ6)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477964.1
- ProteinModelPortal:   A8GCJ6
- SMR:   A8GCJ6
- STRING:   A8GCJ6
- GeneID:   5604586
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1732
- eggNOG:   COG1488
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- ProtClustDB:   PRK05321
- BioCyc:   SPRO399741:SPRO_1732-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 45453; Mature: 45321

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYASPILTSLLDTDAYKLHMQQAVFHRYPAISVAAEFRCRGDELLGEYADEIGAQIAL
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MSQLALTDAEFDYLSGLPFFREDYLNWLRDFRYDPQQVQIENHAGKLHIRIAGPWREVIM
HHHHHHCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCHHHHHH
WEVPLLAVISEVVHRHRSPDVTPEMAVAHLRNKLAQFKAMSSDVDISRFKLMDFGTRRRF
HHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SQAVQQAIVGTLKNEFPYLVGTSNYDLAHQLDLAPVGTQAHEWFQAHQQISPVLANSQRA
HHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
ALQAWLDEYPDQLGIALTDCITMDAFLRDFGPQFAQRYQGLRHDSGDPFEWGEKAIAHFQ
HHHHHHHHCCHHHCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
KLGIDPMSKTLVFSDNLDLDKALALYRHFYQRVNLVFGIGTRLTCDIPGVKPLNIVIKLV
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHHHHH
ECKGKPVAKLSDSPGKTICQDQAFVKALRKAFDLPLVKKAS
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQYASPILTSLLDTDAYKLHMQQAVFHRYPAISVAAEFRCRGDELLGEYADEIGAQIAL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
MSQLALTDAEFDYLSGLPFFREDYLNWLRDFRYDPQQVQIENHAGKLHIRIAGPWREVIM
HHHHHHCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCHHHHHH
WEVPLLAVISEVVHRHRSPDVTPEMAVAHLRNKLAQFKAMSSDVDISRFKLMDFGTRRRF
HHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SQAVQQAIVGTLKNEFPYLVGTSNYDLAHQLDLAPVGTQAHEWFQAHQQISPVLANSQRA
HHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
ALQAWLDEYPDQLGIALTDCITMDAFLRDFGPQFAQRYQGLRHDSGDPFEWGEKAIAHFQ
HHHHHHHHCCHHHCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
KLGIDPMSKTLVFSDNLDLDKALALYRHFYQRVNLVFGIGTRLTCDIPGVKPLNIVIKLV
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHHHHH
ECKGKPVAKLSDSPGKTICQDQAFVKALRKAFDLPLVKKAS
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA