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The map label for this gene is dusC [H]

Identifier: 157369580

GI number: 157369580

Start: 1467809

End: 1468738

Strand: Direct

Name: dusC [H]

Synonym: Spro_1337

Alternate gene names: 157369580

Gene position: 1467809-1468738 (Clockwise)

Preceding gene: 157369579

Following gene: 157369583

Centisome position: 26.94

GC content: 59.03

Gene sequence:

>930_bases
ATGCGCGTATTATTGGCTCCGATGGAGGGCGTTCTCGATTCTTTGGTGCGTGAGCTGCTCACCGAAGTGAACGACTACGA
CCTGTGCATCACCGAATTCCTGCGCGTGGTTGATCAACTGCTGCCTGCCAAGTCTTTCTACCGCCTGTGCCCTGAACTGC
ATCACGCCAGCCGCACCCCGTCCGGCACGCTGGTTCGCATCCAATTGCTCGGTCAATACCCGCAATGGCTGGCAGAAAAT
GCTGCCCGTGCGGTTGAACTGGGTTCTTACGGTGTCGACCTCAACTGTGGTTGCCCATCCAAGCTGGTTAACGGCAGCGG
CGGTGGGGCGACGCTGCTCAAAGACCCGGAGCTGATTTACCAGGGCGCCAAAGCGATGCGTGCAGCGGTACCTGCCCATT
TGCCGGTAACGGTAAAAATACGCTTGGGCTGGGACAGCGACAGCCGCAGTTTTGAAATTGCCGATGCGGTGCAACAGGCG
GGGGCCACCGAATTGGCGGTGCATGGCCGTACCAAAGAGGACGGGTACAAGGCAGAACGCATCAACTGGGCGGCGATTGG
CGAGATCCGCCAGCGGCTGACCATTCCGGTGATCGCCAACGGCGAAATCTGGGACTACCAGAGCGCACAAGACTGCCTGC
AAACCACCGGCTGTGATGCGGTGATGCTGGGGCGCGGCGCATTAAACGTGCCGAACTTGAGCCGGGTGGTGAAATACAAC
GAACCGCGCATGCCCTGGCCGCAGGTGGTGCAATTGCTGCAAAAATACGTTCACCTGGAAAAACAGGGCGATACCGGCCT
GTACCATGTGGCGCGGATTAAACAGTGGCTGGGGTATTTGCGCAAAGAGTATGCAGAGGCGACGGAGCTGTTCGGCGAAG
TGCGTGCGCTGACCAACTCGAAGGACATTGCCCGGGTGATTTGCCGCTAG

Upstream 100 bases:

>100_bases
CGATTCGCCGTTTGAGCTAAGCGGTTTTATTCCCCCCAGATGCTTGTCTGCTGCGGGTATTCCCCCGTATCATTGCGCGT
CTTTTTTAGCAGGGGTGAAC

Downstream 100 bases:

>100_bases
CCATAATAAACCCACCTGGGGTGGGTTAGATTAATCTTGTTTCCTCATGCCCCTCTGGGTTGGCTGCCTCCATCGGGATA
AACGCTAGCCAACCTGAGAG

Product: tRNA-dihydrouridine synthase C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFLRVVDQLLPAKSFYRLCPELHHASRTPSGTLVRIQLLGQYPQWLAEN
AARAVELGSYGVDLNCGCPSKLVNGSGGGATLLKDPELIYQGAKAMRAAVPAHLPVTVKIRLGWDSDSRSFEIADAVQQA
GATELAVHGRTKEDGYKAERINWAAIGEIRQRLTIPVIANGEIWDYQSAQDCLQTTGCDAVMLGRGALNVPNLSRVVKYN
EPRMPWPQVVQLLQKYVHLEKQGDTGLYHVARIKQWLGYLRKEYAEATELFGEVRALTNSKDIARVICR

Sequences:

>Translated_309_residues
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFLRVVDQLLPAKSFYRLCPELHHASRTPSGTLVRIQLLGQYPQWLAEN
AARAVELGSYGVDLNCGCPSKLVNGSGGGATLLKDPELIYQGAKAMRAAVPAHLPVTVKIRLGWDSDSRSFEIADAVQQA
GATELAVHGRTKEDGYKAERINWAAIGEIRQRLTIPVIANGEIWDYQSAQDCLQTTGCDAVMLGRGALNVPNLSRVVKYN
EPRMPWPQVVQLLQKYVHLEKQGDTGLYHVARIKQWLGYLRKEYAEATELFGEVRALTNSKDIARVICR
>Mature_309_residues
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFLRVVDQLLPAKSFYRLCPELHHASRTPSGTLVRIQLLGQYPQWLAEN
AARAVELGSYGVDLNCGCPSKLVNGSGGGATLLKDPELIYQGAKAMRAAVPAHLPVTVKIRLGWDSDSRSFEIADAVQQA
GATELAVHGRTKEDGYKAERINWAAIGEIRQRLTIPVIANGEIWDYQSAQDCLQTTGCDAVMLGRGALNVPNLSRVVKYN
EPRMPWPQVVQLLQKYVHLEKQGDTGLYHVARIKQWLGYLRKEYAEATELFGEVRALTNSKDIARVICR

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family. DusC subfamily [H]

Homologues:

Organism=Homo sapiens, GI31742496, Length=158, Percent_Identity=34.8101265822785, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI8923374, Length=268, Percent_Identity=29.1044776119403, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40807366, Length=237, Percent_Identity=30.8016877637131, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI239788483, Length=177, Percent_Identity=31.638418079096, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI239788462, Length=177, Percent_Identity=31.638418079096, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788462, Length=307, Percent_Identity=85.0162866449512, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1789660, Length=264, Percent_Identity=32.9545454545455, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI145693211, Length=316, Percent_Identity=26.5822784810127, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144369, Length=168, Percent_Identity=36.3095238095238, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17507177, Length=154, Percent_Identity=35.0649350649351, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17510279, Length=149, Percent_Identity=30.8724832214765, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17543114, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323560, Length=199, Percent_Identity=31.1557788944724, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921524, Length=145, Percent_Identity=37.9310344827586, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585320, Length=241, Percent_Identity=32.3651452282158, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24580595, Length=201, Percent_Identity=31.3432835820896, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19920448, Length=201, Percent_Identity=31.3432835820896, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: 1.-.-.-

Molecular weight: Translated: 34356; Mature: 34356

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFLRVVDQLLPAKSFYRLCPELHHASRTP
CEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
SGTLVRIQLLGQYPQWLAENAARAVELGSYGVDLNCGCPSKLVNGSGGGATLLKDPELIY
CCCEEEEEECCCCHHHHHHHHHHHEECCCCCEEECCCCCHHHCCCCCCCCEEECCHHHHH
QGAKAMRAAVPAHLPVTVKIRLGWDSDSRSFEIADAVQQAGATELAVHGRTKEDGYKAER
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHH
INWAAIGEIRQRLTIPVIANGEIWDYQSAQDCLQTTGCDAVMLGRGALNVPNLSRVVKYN
CCHHHHHHHHHHEECEEEECCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCC
EPRMPWPQVVQLLQKYVHLEKQGDTGLYHVARIKQWLGYLRKEYAEATELFGEVRALTNS
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KDIARVICR
HHHHHHHCC
>Mature Secondary Structure
MRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFLRVVDQLLPAKSFYRLCPELHHASRTP
CEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
SGTLVRIQLLGQYPQWLAENAARAVELGSYGVDLNCGCPSKLVNGSGGGATLLKDPELIY
CCCEEEEEECCCCHHHHHHHHHHHEECCCCCEEECCCCCHHHCCCCCCCCEEECCHHHHH
QGAKAMRAAVPAHLPVTVKIRLGWDSDSRSFEIADAVQQAGATELAVHGRTKEDGYKAER
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCHHH
INWAAIGEIRQRLTIPVIANGEIWDYQSAQDCLQTTGCDAVMLGRGALNVPNLSRVVKYN
CCHHHHHHHHHHEECEEEECCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCC
EPRMPWPQVVQLLQKYVHLEKQGDTGLYHVARIKQWLGYLRKEYAEATELFGEVRALTNS
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KDIARVICR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]