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The map label for this gene is serA [H]

Identifier: 157369579

GI number: 157369579

Start: 1466769

End: 1467728

Strand: Direct

Name: serA [H]

Synonym: Spro_1336

Alternate gene names: 157369579

Gene position: 1466769-1467728 (Clockwise)

Preceding gene: 157369578

Following gene: 157369580

Centisome position: 26.92

GC content: 57.19

Gene sequence:

>960_bases
ATGAAACTAAAATGTGCCATTCTTGATGATTATCAGCAGGTCGCGCTCAGCATGGCCGACTGGTCTGCCCTCGGCGATCG
GGTTGAGGTGTTCAGCATCGGTCAACATTTTAGTGATGAAGCGGAACTGGCCGTGCATCTGCAGGACTGCGATATTTTGG
TGATTATGCGTGAACGCACGCCAATCACCGCCTCGCTACTGGCGCGTTTGCCTCAGCTAAAACTGTTGATCACCTCGGGC
ATGCGCAATGCCTCTATTGATTTGGCGGCGGCGGCACAGCGCGGGGTTATTGTCTGCGGCACCGCCAGCGGCTCAGCAGC
ACCGATGGAGCTAAGCTGGGCACTGTTGCTGGGGTTGGCAAAACATTTACTGGTGGAAAATCATGGCCTGCGTAATAACG
GGCCGTGGCAGCAAGCGGTTGGCGTGACCCTGCAGGGCAAGACGCTGGGCCTGCTGGGGTTGGGCAAGATTGGCAGCCAA
ATGGCGGTGGTGGCGCAGGCGTTTGGTATGCGGGTGCTGGCCTGGAGCCAAAACCTGACGGCAGAAAGGGCCGCCGAGGT
GGGGGTGACGCTGGCAGCATCCAAACAGGCGCTGTTTGAACAGAGCGACTTTGTTTCGGTTCATCTGGTGCTCAGTGAAC
GTAGTCGTGGGCTGGTGGGCCGGCCAGAGCTGCAGGCGATGAAGAAAACCGCTTATCTGATCAATACCTCGCGTGCGGCG
ATTGTCGATCGCAGCGCGTTGATTGACGCATTGCAGCAAGGGCAGATCGCCGGTGCCGGGCTGGACGTGTTTGAGGTTGA
ACCCTTGCCGAGTGACGACATTTTCCGCCAACTGTCCAACGTGTTGGCAACGCCGCATCTGGGTTATGTGGCCGACAGCA
ACTATCAAATCTATTTCCGCGAAGCGATCGAAAACATCGAGGCCTTTATCGCCGAAGAACCGATTCGCCGTTTGAGCTAA

Upstream 100 bases:

>100_bases
GTTAAATGGGTCGCACAGCGCCCTGGTGATTGAGAATGCCGATTGCCCGGTGCTGGTTGACGTGCGTGCCGACTGATTTT
GCCTAATCCCGGAGCCGAAG

Downstream 100 bases:

>100_bases
GCGGTTTTATTCCCCCCAGATGCTTGTCTGCTGCGGGTATTCCCCCGTATCATTGCGCGTCTTTTTTAGCAGGGGTGAAC
ATGCGCGTATTATTGGCTCC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKLKCAILDDYQQVALSMADWSALGDRVEVFSIGQHFSDEAELAVHLQDCDILVIMRERTPITASLLARLPQLKLLITSG
MRNASIDLAAAAQRGVIVCGTASGSAAPMELSWALLLGLAKHLLVENHGLRNNGPWQQAVGVTLQGKTLGLLGLGKIGSQ
MAVVAQAFGMRVLAWSQNLTAERAAEVGVTLAASKQALFEQSDFVSVHLVLSERSRGLVGRPELQAMKKTAYLINTSRAA
IVDRSALIDALQQGQIAGAGLDVFEVEPLPSDDIFRQLSNVLATPHLGYVADSNYQIYFREAIENIEAFIAEEPIRRLS

Sequences:

>Translated_319_residues
MKLKCAILDDYQQVALSMADWSALGDRVEVFSIGQHFSDEAELAVHLQDCDILVIMRERTPITASLLARLPQLKLLITSG
MRNASIDLAAAAQRGVIVCGTASGSAAPMELSWALLLGLAKHLLVENHGLRNNGPWQQAVGVTLQGKTLGLLGLGKIGSQ
MAVVAQAFGMRVLAWSQNLTAERAAEVGVTLAASKQALFEQSDFVSVHLVLSERSRGLVGRPELQAMKKTAYLINTSRAA
IVDRSALIDALQQGQIAGAGLDVFEVEPLPSDDIFRQLSNVLATPHLGYVADSNYQIYFREAIENIEAFIAEEPIRRLS
>Mature_319_residues
MKLKCAILDDYQQVALSMADWSALGDRVEVFSIGQHFSDEAELAVHLQDCDILVIMRERTPITASLLARLPQLKLLITSG
MRNASIDLAAAAQRGVIVCGTASGSAAPMELSWALLLGLAKHLLVENHGLRNNGPWQQAVGVTLQGKTLGLLGLGKIGSQ
MAVVAQAFGMRVLAWSQNLTAERAAEVGVTLAASKQALFEQSDFVSVHLVLSERSRGLVGRPELQAMKKTAYLINTSRAA
IVDRSALIDALQQGQIAGAGLDVFEVEPLPSDDIFRQLSNVLATPHLGYVADSNYQIYFREAIENIEAFIAEEPIRRLS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=257, Percent_Identity=35.408560311284, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=28.9156626506024, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=28.9156626506024, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=29.3172690763052, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=29.3172690763052, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI6912396, Length=211, Percent_Identity=33.6492890995261, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=29.7520661157025, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI87082289, Length=234, Percent_Identity=32.9059829059829, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=31.0077519379845, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787645, Length=231, Percent_Identity=32.4675324675325, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081824, Length=188, Percent_Identity=30.3191489361702, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=292, Percent_Identity=33.9041095890411, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=241, Percent_Identity=24.4813278008299, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=30.4918032786885, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=268, Percent_Identity=31.7164179104478, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=211, Percent_Identity=31.7535545023697, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=30.4832713754647, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=159, Percent_Identity=30.8176100628931, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=277, Percent_Identity=32.129963898917, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472511, Length=246, Percent_Identity=32.1138211382114, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28571528, Length=247, Percent_Identity=31.1740890688259, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=26.7924528301887, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=26.7924528301887, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=26.7924528301887, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574284, Length=265, Percent_Identity=26.7924528301887, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551003, Length=265, Percent_Identity=26.7924528301887, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585516, Length=149, Percent_Identity=26.8456375838926, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34485; Mature: 34485

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKCAILDDYQQVALSMADWSALGDRVEVFSIGQHFSDEAELAVHLQDCDILVIMRERT
CCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCC
PITASLLARLPQLKLLITSGMRNASIDLAAAAQRGVIVCGTASGSAAPMELSWALLLGLA
CCHHHHHHHCCCEEEEEECCCCCCCEEHEECCCCCEEEEECCCCCCCCHHHHHHHHHHHH
KHLLVENHGLRNNGPWQQAVGVTLQGKTLGLLGLGKIGSQMAVVAQAFGMRVLAWSQNLT
HHHHHHCCCCCCCCCHHHHHCEEECCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCC
AERAAEVGVTLAASKQALFEQSDFVSVHLVLSERSRGLVGRPELQAMKKTAYLINTSRAA
HHHHHHCCEEEECCHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHEEEECCCHH
IVDRSALIDALQQGQIAGAGLDVFEVEPLPSDDIFRQLSNVLATPHLGYVADSNYQIYFR
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCEEEHH
EAIENIEAFIAEEPIRRLS
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLKCAILDDYQQVALSMADWSALGDRVEVFSIGQHFSDEAELAVHLQDCDILVIMRERT
CCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCC
PITASLLARLPQLKLLITSGMRNASIDLAAAAQRGVIVCGTASGSAAPMELSWALLLGLA
CCHHHHHHHCCCEEEEEECCCCCCCEEHEECCCCCEEEEECCCCCCCCHHHHHHHHHHHH
KHLLVENHGLRNNGPWQQAVGVTLQGKTLGLLGLGKIGSQMAVVAQAFGMRVLAWSQNLT
HHHHHHCCCCCCCCCHHHHHCEEECCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCC
AERAAEVGVTLAASKQALFEQSDFVSVHLVLSERSRGLVGRPELQAMKKTAYLINTSRAA
HHHHHHCCEEEECCHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHEEEECCCHH
IVDRSALIDALQQGQIAGAGLDVFEVEPLPSDDIFRQLSNVLATPHLGYVADSNYQIYFR
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCEEEHH
EAIENIEAFIAEEPIRRLS
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]