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The map label for this gene is moaA [H]

Identifier: 157369563

GI number: 157369563

Start: 1451134

End: 1452117

Strand: Direct

Name: moaA [H]

Synonym: Spro_1320

Alternate gene names: 157369563

Gene position: 1451134-1452117 (Clockwise)

Preceding gene: 157369561

Following gene: 157369564

Centisome position: 26.63

GC content: 58.54

Gene sequence:

>984_bases
GTGCCGCAACTCATTGATGCTTATGAGCGCAAATTCTATTACTTGCGCCTGTCGATCACCGACGTGTGTAACTTTCGTTG
CACCTATTGTTTGCCGGATGGCTATCGCCCTAACGGCAGCCCGAAAACCTTCTTGTCGCTCGATGAGATCCGACGTGTCA
GCCGCGCCTTCGCCGAGCTGGGCACTGAAAAGGTGCGCCTGACCGGCGGTGAGCCTTCGCTGCGTCGCGATTTTACCGAG
ATCATTGCCGCCGTGCGTGAAAATCCGGCCGTTCGCCAGCTTGCCGTGACCACCAATGGCTACCGCCTGGCGCGCGACGT
TGCCGCCTGGCGTGACGCCGGCCTGACGGCGATCAACGTCAGCGTCGACAGTCTGGACCCCCGTCAATTTCACGCCATTA
CCGGCCAGGACAAATTCCGCCAGGTGATGGAGGGCATCGACGCCGCCTTTACCGCCGGGTTCAGCAAGGTCAAGGTCAAC
GCGGTGCTGATGCGTGACGTTAACCATCAGCAACTGGGCGCTTTCCTGCACTGGATAAAAGACCGTCCGATCCAACTGCG
TTTTATCGAGCTGATGGAAACCGGTGAGGGTGGCGACTTGTTCCGCAAACACCACGTGTCTGGCGAAGTGATCCGTTCGC
AACTGGAACAGCAGGGTTGGCAACTGCAACCGCGCGGCCGCAGCGACGGCCCGGCGCAGGTGTTTAGCCACCCGGATTAC
CAGGGCGAAGTGGGTTTAATCATGCCGTACGAAAAAGATTTCTGTGCCAGCTGCAACCGGCTGCGGGTTTCCGCCATCGG
TAATCTGCACCTGTGCCTGTTCGGTGAGCAGGGCATTAACCTGCGCGATCTGCTGGTGAATGACGGCCAGCTTGAAGAGT
TGAAGGATCGCATTCAGGGCGGGTTGCGGACCAAAAAGCAGACCCACTTCCTGCACCAGGGCAACAGTGGCATCACGCAG
AATTTGTCGTTTATCGGCGGATAA

Upstream 100 bases:

>100_bases
GTTGTTCTTGTGAACAATATGGCGCTTGGGCCGTGGCGAAGTCAGCCACCAGGGTGCAGAGCGGAAACGCTCGCATCTCC
CGACTTTGGAAGGTGTTATG

Downstream 100 bases:

>100_bases
ATTTTTCCAATTGCACGGGAGCAAGCAATGAGTCATGCCAGCAGTGAATTCATTCCGGCGCATATCGCTATTCTGACCGT
TTCGGACAGTCGCGGTGAAG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPQLIDAYERKFYYLRLSITDVCNFRCTYCLPDGYRPNGSPKTFLSLDEIRRVSRAFAELGTEKVRLTGGEPSLRRDFTE
IIAAVRENPAVRQLAVTTNGYRLARDVAAWRDAGLTAINVSVDSLDPRQFHAITGQDKFRQVMEGIDAAFTAGFSKVKVN
AVLMRDVNHQQLGAFLHWIKDRPIQLRFIELMETGEGGDLFRKHHVSGEVIRSQLEQQGWQLQPRGRSDGPAQVFSHPDY
QGEVGLIMPYEKDFCASCNRLRVSAIGNLHLCLFGEQGINLRDLLVNDGQLEELKDRIQGGLRTKKQTHFLHQGNSGITQ
NLSFIGG

Sequences:

>Translated_327_residues
MPQLIDAYERKFYYLRLSITDVCNFRCTYCLPDGYRPNGSPKTFLSLDEIRRVSRAFAELGTEKVRLTGGEPSLRRDFTE
IIAAVRENPAVRQLAVTTNGYRLARDVAAWRDAGLTAINVSVDSLDPRQFHAITGQDKFRQVMEGIDAAFTAGFSKVKVN
AVLMRDVNHQQLGAFLHWIKDRPIQLRFIELMETGEGGDLFRKHHVSGEVIRSQLEQQGWQLQPRGRSDGPAQVFSHPDY
QGEVGLIMPYEKDFCASCNRLRVSAIGNLHLCLFGEQGINLRDLLVNDGQLEELKDRIQGGLRTKKQTHFLHQGNSGITQ
NLSFIGG
>Mature_326_residues
PQLIDAYERKFYYLRLSITDVCNFRCTYCLPDGYRPNGSPKTFLSLDEIRRVSRAFAELGTEKVRLTGGEPSLRRDFTEI
IAAVRENPAVRQLAVTTNGYRLARDVAAWRDAGLTAINVSVDSLDPRQFHAITGQDKFRQVMEGIDAAFTAGFSKVKVNA
VLMRDVNHQQLGAFLHWIKDRPIQLRFIELMETGEGGDLFRKHHVSGEVIRSQLEQQGWQLQPRGRSDGPAQVFSHPDYQ
GEVGLIMPYEKDFCASCNRLRVSAIGNLHLCLFGEQGINLRDLLVNDGQLEELKDRIQGGLRTKKQTHFLHQGNSGITQN
LSFIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=308, Percent_Identity=38.6363636363636, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI22027536, Length=308, Percent_Identity=38.6363636363636, Blast_Score=215, Evalue=3e-56,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=78.5932721712538, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI32566331, Length=311, Percent_Identity=36.0128617363344, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=36.741214057508, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=309, Percent_Identity=34.9514563106796, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574490, Length=310, Percent_Identity=37.4193548387097, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574488, Length=310, Percent_Identity=37.4193548387097, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36908; Mature: 36776

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLIDAYERKFYYLRLSITDVCNFRCTYCLPDGYRPNGSPKTFLSLDEIRRVSRAFAEL
CCCHHHHHCCEEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHC
GTEKVRLTGGEPSLRRDFTEIIAAVRENPAVRQLAVTTNGYRLARDVAAWRDAGLTAINV
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEE
SVDSLDPRQFHAITGQDKFRQVMEGIDAAFTAGFSKVKVNAVLMRDVNHQQLGAFLHWIK
EECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCHHEEEEEEEEECCCHHHHHHHHHHHH
DRPIQLRFIELMETGEGGDLFRKHHVSGEVIRSQLEQQGWQLQPRGRSDGPAQVFSHPDY
CCCEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCCCHHHCCCCCC
QGEVGLIMPYEKDFCASCNRLRVSAIGNLHLCLFGEQGINLRDLLVNDGQLEELKDRIQG
CCCEEEEECCCCHHHCCCCCEEEEEECCEEEEEECCCCCCEEHEEECCCCHHHHHHHHHC
GLRTKKQTHFLHQGNSGITQNLSFIGG
CCCCCHHHHHHCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
PQLIDAYERKFYYLRLSITDVCNFRCTYCLPDGYRPNGSPKTFLSLDEIRRVSRAFAEL
CCHHHHHCCEEEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHC
GTEKVRLTGGEPSLRRDFTEIIAAVRENPAVRQLAVTTNGYRLARDVAAWRDAGLTAINV
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEE
SVDSLDPRQFHAITGQDKFRQVMEGIDAAFTAGFSKVKVNAVLMRDVNHQQLGAFLHWIK
EECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCHHEEEEEEEEECCCHHHHHHHHHHHH
DRPIQLRFIELMETGEGGDLFRKHHVSGEVIRSQLEQQGWQLQPRGRSDGPAQVFSHPDY
CCCEEEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCCCHHHCCCCCC
QGEVGLIMPYEKDFCASCNRLRVSAIGNLHLCLFGEQGINLRDLLVNDGQLEELKDRIQG
CCCEEEEECCCCHHHCCCCCEEEEEECCEEEEEECCCCCCEEHEEECCCCHHHHHHHHHC
GLRTKKQTHFLHQGNSGITQNLSFIGG
CCCCCHHHHHHCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]