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The map label for this gene is holA [H]

Identifier: 157369448

GI number: 157369448

Start: 1321081

End: 1322115

Strand: Reverse

Name: holA [H]

Synonym: Spro_1205

Alternate gene names: 157369448

Gene position: 1322115-1321081 (Counterclockwise)

Preceding gene: 157369449

Following gene: 157369447

Centisome position: 24.26

GC content: 58.07

Gene sequence:

>1035_bases
ATGATCCGTATTTACCCTGAACAACTTGCCGCGCAGCTCCGAGAGGGGCTGCGCGCTTGTTATTTATTGAGTGGCAATGA
ACCGCTGCTGTTGCAGGAAAGTCAGGATCTGATCCGCCAGACGGCACAGCAGCACCAGTTCACCGAGCACTACAGCATTT
CGCTTGATGCCCATACCGACTGGGACGCCATTTTCAGCATCTGTCAGGCGATGAGTCTGTTCGCCAGCCGTCAGACGCTG
TTGCTGATCTTCCCTGAAAACGGGCCGACCGCCCCGATAGGCGAACAGTTGATCAAGCTGGCTGCTCTGCTGCATGACGA
TATTTTGCTGATGCTGCGTGGGCCACGCCTCACCAAAGCTCAGGAAAACAGCGCCTGGTTCAAGGCACTCAGCCCGCATG
GCGCTTACGTCAGTTGCCAGACACCGGAGCAGGCGCAGTTACCCCGCTGGGTAGCCCAGCGCGCCAAAACCATGAAGCTG
GAACTGGACGACGCGGCCAATCAGTTGCTGTGTTACTGCTATGAAGGCAACCTGCTGGCGCTGTCGCAGGCGCTGGAACG
ACTGTCGTTATTGCATCCGGATGGCAAGCTCACGCTGCCGCGTGTCGAGCTGGCGGTCAATGACGCCGCGCACTTCACGC
CATTCCATTGGCTGGACGCCCTGCTGGCGGGTAAGAGCAAACGCGCTTGGCATATCCTGCAACAGATGCAGCAGGAAGAT
GTCGAACCGGTGATCCTGCTGCGCACCCTGCAACGCGAATTGCTGCAATTGCTGAACCTGCAACGACGCATGGCGTCAGT
GCCGCTGCGTACGCTGTTCGACCAGTACAAGGTCTGGCAAAACCGCCGTAACCTGGTCACCCAGGCATTGCAGCGGTTAT
CCGGTGCCCAGTTGCGGCAAGCGGTTCATCTGCTGACGCAGATTGAAATCACCCTTAAGCAGGATTACGGCCAGTCGGTC
TGGTCGGAACTGGAAACCCTGTCGATGCTGCTGTGCGGCAAACCTCTGGCCACGAGTTTTTCCGATGCCCACTAA

Upstream 100 bases:

>100_bases
AGCAACTGGTGCGTAAACTGCTGACGGTGCACGCGGCGGAAGAAGAAACGCAGCAGAAAGCCGCTGCGGCCGGTGAAAAA
GCGGCCAGTCGCGTAGATCA

Downstream 100 bases:

>100_bases
TTCGCAAGACACCACCGTCCTGCACGCCCTGTTTGGCGGCACCTTTGACCCAATCCATTACGGCCATCTGCGCCCGGTGG
AAGCGCTGGCGGCGGAGGCA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIRIYPEQLAAQLREGLRACYLLSGNEPLLLQESQDLIRQTAQQHQFTEHYSISLDAHTDWDAIFSICQAMSLFASRQTL
LLIFPENGPTAPIGEQLIKLAALLHDDILLMLRGPRLTKAQENSAWFKALSPHGAYVSCQTPEQAQLPRWVAQRAKTMKL
ELDDAANQLLCYCYEGNLLALSQALERLSLLHPDGKLTLPRVELAVNDAAHFTPFHWLDALLAGKSKRAWHILQQMQQED
VEPVILLRTLQRELLQLLNLQRRMASVPLRTLFDQYKVWQNRRNLVTQALQRLSGAQLRQAVHLLTQIEITLKQDYGQSV
WSELETLSMLLCGKPLATSFSDAH

Sequences:

>Translated_344_residues
MIRIYPEQLAAQLREGLRACYLLSGNEPLLLQESQDLIRQTAQQHQFTEHYSISLDAHTDWDAIFSICQAMSLFASRQTL
LLIFPENGPTAPIGEQLIKLAALLHDDILLMLRGPRLTKAQENSAWFKALSPHGAYVSCQTPEQAQLPRWVAQRAKTMKL
ELDDAANQLLCYCYEGNLLALSQALERLSLLHPDGKLTLPRVELAVNDAAHFTPFHWLDALLAGKSKRAWHILQQMQQED
VEPVILLRTLQRELLQLLNLQRRMASVPLRTLFDQYKVWQNRRNLVTQALQRLSGAQLRQAVHLLTQIEITLKQDYGQSV
WSELETLSMLLCGKPLATSFSDAH
>Mature_344_residues
MIRIYPEQLAAQLREGLRACYLLSGNEPLLLQESQDLIRQTAQQHQFTEHYSISLDAHTDWDAIFSICQAMSLFASRQTL
LLIFPENGPTAPIGEQLIKLAALLHDDILLMLRGPRLTKAQENSAWFKALSPHGAYVSCQTPEQAQLPRWVAQRAKTMKL
ELDDAANQLLCYCYEGNLLALSQALERLSLLHPDGKLTLPRVELAVNDAAHFTPFHWLDALLAGKSKRAWHILQQMQQED
VEPVILLRTLQRELLQLLNLQRRMASVPLRTLFDQYKVWQNRRNLVTQALQRLSGAQLRQAVHLLTQIEITLKQDYGQSV
WSELETLSMLLCGKPLATSFSDAH

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=343, Percent_Identity=72.8862973760933, Blast_Score=491, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39186; Mature: 39186

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIYPEQLAAQLREGLRACYLLSGNEPLLLQESQDLIRQTAQQHQFTEHYSISLDAHTD
CEEECHHHHHHHHHHHHHEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHEEEEEECCCC
WDAIFSICQAMSLFASRQTLLLIFPENGPTAPIGEQLIKLAALLHDDILLMLRGPRLTKA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCC
QENSAWFKALSPHGAYVSCQTPEQAQLPRWVAQRAKTMKLELDDAANQLLCYCYEGNLLA
CCCCHHHHCCCCCCCEEECCCCCHHHCHHHHHHHHHHEEEEECCCCCCEEEEEECCCCHH
LSQALERLSLLHPDGKLTLPRVELAVNDAAHFTPFHWLDALLAGKSKRAWHILQQMQQED
HHHHHHHHHHCCCCCCEECCEEEEEECCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
VEPVILLRTLQRELLQLLNLQRRMASVPLRTLFDQYKVWQNRRNLVTQALQRLSGAQLRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVHLLTQIEITLKQDYGQSVWSELETLSMLLCGKPLATSFSDAH
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIRIYPEQLAAQLREGLRACYLLSGNEPLLLQESQDLIRQTAQQHQFTEHYSISLDAHTD
CEEECHHHHHHHHHHHHHEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHEEEEEECCCC
WDAIFSICQAMSLFASRQTLLLIFPENGPTAPIGEQLIKLAALLHDDILLMLRGPRLTKA
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCC
QENSAWFKALSPHGAYVSCQTPEQAQLPRWVAQRAKTMKLELDDAANQLLCYCYEGNLLA
CCCCHHHHCCCCCCCEEECCCCCHHHCHHHHHHHHHHEEEEECCCCCCEEEEEECCCCHH
LSQALERLSLLHPDGKLTLPRVELAVNDAAHFTPFHWLDALLAGKSKRAWHILQQMQQED
HHHHHHHHHHCCCCCCEECCEEEEEECCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
VEPVILLRTLQRELLQLLNLQRRMASVPLRTLFDQYKVWQNRRNLVTQALQRLSGAQLRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVHLLTQIEITLKQDYGQSVWSELETLSMLLCGKPLATSFSDAH
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]