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The map label for this gene is mrdA [H]

Identifier: 157369444

GI number: 157369444

Start: 1317515

End: 1319410

Strand: Reverse

Name: mrdA [H]

Synonym: Spro_1201

Alternate gene names: 157369444

Gene position: 1319410-1317515 (Counterclockwise)

Preceding gene: 157369445

Following gene: 157369443

Centisome position: 24.21

GC content: 56.8

Gene sequence:

>1896_bases
ATGAAAATAGAACGTAACCCTTTTCGCGACTATACGGCTGAATCCGCCCTGTTTGTACGCCGCGCCCTGGTGGCGTTCCT
GGTCATCCTGGTGCTGACCGGCACCCTCATCGCCAATCTGTATAACCTGCAAATCGTCCGCTTTGAGGATTACCGTACCC
GCTCCAACGAAAACCGCATAAAACTGGTGCCGATCGCGCCCAGCCGCGGCATTATCTACGATCGCAACGGCACCCCGCTG
GCGCTCAATCGCACCATTTATCAACTGGAGCTGATGCCGGAAAAGGTCGATGACCTGAAGGCCACGCTACAGGCACTGCG
TCCGGTGGTCGATCTGACCGACGAAGACATCACCAACTTCGAGAAAGAGCGCAAACGCTCACGCCGCTTCGTCTCCATTC
CGGTGAAAACCGCCCTGAACGAAGTTCAGGTGGCGCGTTTTGCGGTTAACCAGTTCCGCTTCCCCGGCGTCGAGGTCAAA
GGCTACCAGCGTCGCTACTATCCTTATGGCTCCGCTCTGACCCATGTCATCGGCTACGTATCGAAAATCAACGACCGCGA
CGTCGAACGTCTGGATAAAGACGGCAAACTGGCCAACTACGCCGCCACGCACGATATCGGTAAGCTGGGCATCGAACGCT
ATTACGAAGAAACCCTGCATGGCAAAACCGGCTACGAAGAGGTTGAAGTCAACAACCGCGGCCGGGTGATCCGCCAACTG
CATGAACAACCCCCTTCCGCCGGTCAGGACGTTTACCTGACGCTGGATCTCAACCTGCAACGCTATATCGAGCAGTTGTT
GGTCGGCAGCCGTGCGGCCGTGGTGGTGAGCGATCCGCGCACCGGCGGCATTCTGGCGATGGTCTCTAACCCCAGCTATG
ATCCGAACCTGTTCGTTGATGGCATCTCCAGTAAAGACTATCAGGGGCTGCTCAACGATCCGAACCGGCCGTTGATTAAC
CGCGCCACGCAGGGGCTGTATCCACCGGCTTCTACGGTTAAACCCTACATTGCCGTCTCGGCGCTCAGTGCCGGGGTGAT
CACCAAAAACACCAGCCTGTTCGATCCCGGCTGGTGGCAATTGCCCGGCTCGGAAAAACGCTTCCGCGACTGGAAAAAAT
GGGGCCACGGCCGCCTGAACGTCACCAAAGCGCTGGAAGAGTCAGCGGATACCTTCTTCTATCAGGTCGCCTACGACATG
GGTATCGATCGCCTGTCGACCTGGCTGACCAAGTTCGGTTACGGCGATTATACCGGTATCGATCTGTCCGAAGAACGTTC
CGGCCTGATGCCGACCCGCGACTGGAAATTCAAGCGCTATAAAAAACCCTGGTATCAGGGAGACACCATTCCGGTGGGCA
TCGGCCAGGGCTACTGGACGGCAACGCCGATCCAGATGGCCAAGGCACTGACCACGCTGATTAACGACGGCAACGTCAAA
ACGCCACACCTGCTGCAGAGCACCAGAATCAATGGTGCGCTGGTGCCCTTCACCCAGGAAGAGAGCAAGCAGATCGGCGA
TATTCATTCAGGCTTCTGGGAAATTGCCAAAGACGGCATGTATGGTGTAGCCAACCGTCCGAACGGGACGGCGCGTAAGT
ACTTCTCGGATGCACCTTACAAAGCCGCGGCGAAATCGGGTACCGCACAGGTATTCGGCTACGAAACCTACAACGCCCAC
AAACTGGCGGAACACCTGCGTGACCATAAATTGATGACCGCCTTTGCTCCGTTCAACAATCCAACGGTATCGGTCGCTAT
CATTCTGGAAAACGGCGGCTCCGGTCCGGCGGTCGGGACGATCACCCGTCAGATCCTCGACCATATTTTGCTGGGCGACA
ACAATACGCAATTACCATCTGAAGCCCCACTGCCACCAGGCGTAGAGGGTGATTAA

Upstream 100 bases:

>100_bases
TGGCTGAAAGCCTCTATCGCGCCTGGAGTATTACAACAAATCATCCTTACCACCGGGAATAACCGGTGGTAACCGTGACA
GAGTGAAATAAAGCAGCGGG

Downstream 100 bases:

>100_bases
GGTAGAACATGACTGAAAGCCAACAAAAGGGCTCGATCTGGACCAAAATCCATATCGACCCCACATTCCTGCTATTAATT
CTGGCCCTGCTGGTCTACAG

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MKIERNPFRDYTAESALFVRRALVAFLVILVLTGTLIANLYNLQIVRFEDYRTRSNENRIKLVPIAPSRGIIYDRNGTPL
ALNRTIYQLELMPEKVDDLKATLQALRPVVDLTDEDITNFEKERKRSRRFVSIPVKTALNEVQVARFAVNQFRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKDGKLANYAATHDIGKLGIERYYEETLHGKTGYEEVEVNNRGRVIRQL
HEQPPSAGQDVYLTLDLNLQRYIEQLLVGSRAAVVVSDPRTGGILAMVSNPSYDPNLFVDGISSKDYQGLLNDPNRPLIN
RATQGLYPPASTVKPYIAVSALSAGVITKNTSLFDPGWWQLPGSEKRFRDWKKWGHGRLNVTKALEESADTFFYQVAYDM
GIDRLSTWLTKFGYGDYTGIDLSEERSGLMPTRDWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALTTLINDGNVK
TPHLLQSTRINGALVPFTQEESKQIGDIHSGFWEIAKDGMYGVANRPNGTARKYFSDAPYKAAAKSGTAQVFGYETYNAH
KLAEHLRDHKLMTAFAPFNNPTVSVAIILENGGSGPAVGTITRQILDHILLGDNNTQLPSEAPLPPGVEGD

Sequences:

>Translated_631_residues
MKIERNPFRDYTAESALFVRRALVAFLVILVLTGTLIANLYNLQIVRFEDYRTRSNENRIKLVPIAPSRGIIYDRNGTPL
ALNRTIYQLELMPEKVDDLKATLQALRPVVDLTDEDITNFEKERKRSRRFVSIPVKTALNEVQVARFAVNQFRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKDGKLANYAATHDIGKLGIERYYEETLHGKTGYEEVEVNNRGRVIRQL
HEQPPSAGQDVYLTLDLNLQRYIEQLLVGSRAAVVVSDPRTGGILAMVSNPSYDPNLFVDGISSKDYQGLLNDPNRPLIN
RATQGLYPPASTVKPYIAVSALSAGVITKNTSLFDPGWWQLPGSEKRFRDWKKWGHGRLNVTKALEESADTFFYQVAYDM
GIDRLSTWLTKFGYGDYTGIDLSEERSGLMPTRDWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALTTLINDGNVK
TPHLLQSTRINGALVPFTQEESKQIGDIHSGFWEIAKDGMYGVANRPNGTARKYFSDAPYKAAAKSGTAQVFGYETYNAH
KLAEHLRDHKLMTAFAPFNNPTVSVAIILENGGSGPAVGTITRQILDHILLGDNNTQLPSEAPLPPGVEGD
>Mature_631_residues
MKIERNPFRDYTAESALFVRRALVAFLVILVLTGTLIANLYNLQIVRFEDYRTRSNENRIKLVPIAPSRGIIYDRNGTPL
ALNRTIYQLELMPEKVDDLKATLQALRPVVDLTDEDITNFEKERKRSRRFVSIPVKTALNEVQVARFAVNQFRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKDGKLANYAATHDIGKLGIERYYEETLHGKTGYEEVEVNNRGRVIRQL
HEQPPSAGQDVYLTLDLNLQRYIEQLLVGSRAAVVVSDPRTGGILAMVSNPSYDPNLFVDGISSKDYQGLLNDPNRPLIN
RATQGLYPPASTVKPYIAVSALSAGVITKNTSLFDPGWWQLPGSEKRFRDWKKWGHGRLNVTKALEESADTFFYQVAYDM
GIDRLSTWLTKFGYGDYTGIDLSEERSGLMPTRDWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALTTLINDGNVK
TPHLLQSTRINGALVPFTQEESKQIGDIHSGFWEIAKDGMYGVANRPNGTARKYFSDAPYKAAAKSGTAQVFGYETYNAH
KLAEHLRDHKLMTAFAPFNNPTVSVAIILENGGSGPAVGTITRQILDHILLGDNNTQLPSEAPLPPGVEGD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=632, Percent_Identity=81.8037974683544, Blast_Score=1077, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=478, Percent_Identity=25.1046025104602, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70907; Mature: 70907

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIERNPFRDYTAESALFVRRALVAFLVILVLTGTLIANLYNLQIVRFEDYRTRSNENRI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEE
KLVPIAPSRGIIYDRNGTPLALNRTIYQLELMPEKVDDLKATLQALRPVVDLTDEDITNF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EKERKRSRRFVSIPVKTALNEVQVARFAVNQFRFPGVEVKGYQRRYYPYGSALTHVIGYV
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHH
SKINDRDVERLDKDGKLANYAATHDIGKLGIERYYEETLHGKTGYEEVEVNNRGRVIRQL
HHCCCHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPSAGQDVYLTLDLNLQRYIEQLLVGSRAAVVVSDPRTGGILAMVSNPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEE
GISSKDYQGLLNDPNRPLINRATQGLYPPASTVKPYIAVSALSAGVITKNTSLFDPGWWQ
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHCCEEECCCCCCCCCCEE
LPGSEKRFRDWKKWGHGRLNVTKALEESADTFFYQVAYDMGIDRLSTWLTKFGYGDYTGI
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCCCCC
DLSEERSGLMPTRDWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALTTLINDGNVK
CCCHHHCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
TPHLLQSTRINGALVPFTQEESKQIGDIHSGFWEIAKDGMYGVANRPNGTARKYFSDAPY
CCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCCCCC
KAAAKSGTAQVFGYETYNAHKLAEHLRDHKLMTAFAPFNNPTVSVAIILENGGSGPAVGT
HHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEECCCCCCHHHH
ITRQILDHILLGDNNTQLPSEAPLPPGVEGD
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIERNPFRDYTAESALFVRRALVAFLVILVLTGTLIANLYNLQIVRFEDYRTRSNENRI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCEE
KLVPIAPSRGIIYDRNGTPLALNRTIYQLELMPEKVDDLKATLQALRPVVDLTDEDITNF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EKERKRSRRFVSIPVKTALNEVQVARFAVNQFRFPGVEVKGYQRRYYPYGSALTHVIGYV
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHH
SKINDRDVERLDKDGKLANYAATHDIGKLGIERYYEETLHGKTGYEEVEVNNRGRVIRQL
HHCCCHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPSAGQDVYLTLDLNLQRYIEQLLVGSRAAVVVSDPRTGGILAMVSNPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEE
GISSKDYQGLLNDPNRPLINRATQGLYPPASTVKPYIAVSALSAGVITKNTSLFDPGWWQ
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCHHHHHHHHHCCEEECCCCCCCCCCEE
LPGSEKRFRDWKKWGHGRLNVTKALEESADTFFYQVAYDMGIDRLSTWLTKFGYGDYTGI
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCCCCC
DLSEERSGLMPTRDWKFKRYKKPWYQGDTIPVGIGQGYWTATPIQMAKALTTLINDGNVK
CCCHHHCCCCCCCCCCHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
TPHLLQSTRINGALVPFTQEESKQIGDIHSGFWEIAKDGMYGVANRPNGTARKYFSDAPY
CCHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCCCCC
KAAAKSGTAQVFGYETYNAHKLAEHLRDHKLMTAFAPFNNPTVSVAIILENGGSGPAVGT
HHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEECCCCCCHHHH
ITRQILDHILLGDNNTQLPSEAPLPPGVEGD
HHHHHHHHHEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]