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The map label for this gene is mrdB [H]

Identifier: 157369443

GI number: 157369443

Start: 1316394

End: 1317506

Strand: Reverse

Name: mrdB [H]

Synonym: Spro_1200

Alternate gene names: 157369443

Gene position: 1317506-1316394 (Counterclockwise)

Preceding gene: 157369444

Following gene: 157369442

Centisome position: 24.18

GC content: 56.15

Gene sequence:

>1113_bases
ATGACTGAAAGCCAACAAAAGGGCTCGATCTGGACCAAAATCCATATCGACCCCACATTCCTGCTATTAATTCTGGCCCT
GCTGGTCTACAGCGCGTTCGTGATGTGGAGCGCCAGCGGTCAGGATATTGGCATGATGGAGCGCAAGATCGGCCAGATTG
TCATGGGGCTGATAGTGATGGCCGTCATGGCGCAAATCCCGCCGCGGGTCTATGAAAGCTGGGCGCCGTATTTATATATT
TTCTGCGTGATCCTGCTGATACTGGTAGACGCTTTCGGCCAGATCAGTAAAGGCGCGCAGCGCTGGCTGGATCTTGGCTT
CGTGCGTTTCCAGCCGTCCGAGATCGCTAAAATCGCCGTGCCGCTGATGGTGGCGCGCTTTATGAACCGTGACGTCTGCC
CGCCTTCGCTAAAGAATACCGCGATTGCGCTGGTGCTGATTTTCCTGCCGACCCTGCTGGTCGCCGCGCAGCCCGATTTG
GGGACTTCGATTCTGATTGCCGCCTCCGGCCTGTTCGTGCTGTTCCTGTCCGGCATGAGCTGGAAACTGATCGCCGTAGC
CGCCGTGCTGCTGGCGGCCTTTATCCCGGTGCTGTGGTTCTTCCTGATGCACGGCTATCAGCGCGACCGCGTAATGATGC
TGCTGGATCCGGAAACCGACCCACTTGGCGCCGGTTACCATATTATTCAGTCGAAAATCGCCATCGGCTCAGGCGGCCTG
TCCGGCAAGGGCTGGCTGCACGGCACTCAGTCGCAGTTGGAATTCCTGCCGGAGCGCCACACGGACTTTATCTTCGCGGT
CCTGGCCGAAGAACTGGGGCTGATTGGGGTACTGGTGCTGCTGGCGCTGTACCTGCTGGTTATCATTCGTGGATTGATGA
TTGCCGCCAAGGCGCAAACCACCTTTGGGCGGGTGATGGTCGGCGGTCTGATGCTGATTTTGTTCGTTTATGTGTTTGTT
AACATTGGTATGGTCAGTGGCATTTTGCCGGTAGTTGGCGTACCTTTGCCTCTGGTCAGTTACGGGGGTTCGGCGCTGAT
TGTGCTTATGGCTGGGTTCGGCATTATCATGTCGATCCACACGCATCGAAAAATGATGTCCAAGAGTTTATAA

Upstream 100 bases:

>100_bases
CCCGTCAGATCCTCGACCATATTTTGCTGGGCGACAACAATACGCAATTACCATCTGAAGCCCCACTGCCACCAGGCGTA
GAGGGTGATTAAGGTAGAAC

Downstream 100 bases:

>100_bases
GGGGTGAGTAATGCGTAAGGAATGGCTTTGGGTCGGCGTTGTCGCGGTATTACTTTCCGCCTGTACCGCCCCGACCACGG
AACAGCAAGCGCCACCGCAG

Product: cell wall shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTESQQKGSIWTKIHIDPTFLLLILALLVYSAFVMWSASGQDIGMMERKIGQIVMGLIVMAVMAQIPPRVYESWAPYLYI
FCVILLILVDAFGQISKGAQRWLDLGFVRFQPSEIAKIAVPLMVARFMNRDVCPPSLKNTAIALVLIFLPTLLVAAQPDL
GTSILIAASGLFVLFLSGMSWKLIAVAAVLLAAFIPVLWFFLMHGYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
SGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLVLLALYLLVIIRGLMIAAKAQTTFGRVMVGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIIMSIHTHRKMMSKSL

Sequences:

>Translated_370_residues
MTESQQKGSIWTKIHIDPTFLLLILALLVYSAFVMWSASGQDIGMMERKIGQIVMGLIVMAVMAQIPPRVYESWAPYLYI
FCVILLILVDAFGQISKGAQRWLDLGFVRFQPSEIAKIAVPLMVARFMNRDVCPPSLKNTAIALVLIFLPTLLVAAQPDL
GTSILIAASGLFVLFLSGMSWKLIAVAAVLLAAFIPVLWFFLMHGYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
SGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLVLLALYLLVIIRGLMIAAKAQTTFGRVMVGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIIMSIHTHRKMMSKSL
>Mature_369_residues
TESQQKGSIWTKIHIDPTFLLLILALLVYSAFVMWSASGQDIGMMERKIGQIVMGLIVMAVMAQIPPRVYESWAPYLYIF
CVILLILVDAFGQISKGAQRWLDLGFVRFQPSEIAKIAVPLMVARFMNRDVCPPSLKNTAIALVLIFLPTLLVAAQPDLG
TSILIAASGLFVLFLSGMSWKLIAVAAVLLAAFIPVLWFFLMHGYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGLS
GKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLVLLALYLLVIIRGLMIAAKAQTTFGRVMVGGLMLILFVYVFVN
IGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIIMSIHTHRKMMSKSL

Specific function: This is one of the proteins responsible for the rod shape of E.coli. Is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=370, Percent_Identity=85.6756756756757, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1786277, Length=367, Percent_Identity=31.3351498637602, Blast_Score=170, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40436; Mature: 40305

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESQQKGSIWTKIHIDPTFLLLILALLVYSAFVMWSASGQDIGMMERKIGQIVMGLIVM
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AVMAQIPPRVYESWAPYLYIFCVILLILVDAFGQISKGAQRWLDLGFVRFQPSEIAKIAV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHH
PLMVARFMNRDVCPPSLKNTAIALVLIFLPTLLVAAQPDLGTSILIAASGLFVLFLSGMS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
WKLIAVAAVLLAAFIPVLWFFLMHGYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
SGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLVLLALYLLVIIRGLMIAAKAQT
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGRVMVGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIIMSIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
THRKMMSKSL
HHHHHHHHCC
>Mature Secondary Structure 
TESQQKGSIWTKIHIDPTFLLLILALLVYSAFVMWSASGQDIGMMERKIGQIVMGLIVM
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AVMAQIPPRVYESWAPYLYIFCVILLILVDAFGQISKGAQRWLDLGFVRFQPSEIAKIAV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHH
PLMVARFMNRDVCPPSLKNTAIALVLIFLPTLLVAAQPDLGTSILIAASGLFVLFLSGMS
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
WKLIAVAAVLLAAFIPVLWFFLMHGYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
SGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLIGVLVLLALYLLVIIRGLMIAAKAQT
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGRVMVGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIIMSIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
THRKMMSKSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]