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The map label for this gene is ppiB [H]

Identifier: 157369408

GI number: 157369408

Start: 1282361

End: 1282855

Strand: Reverse

Name: ppiB [H]

Synonym: Spro_1165

Alternate gene names: 157369408

Gene position: 1282855-1282361 (Counterclockwise)

Preceding gene: 157369410

Following gene: 157369407

Centisome position: 23.54

GC content: 51.31

Gene sequence:

>495_bases
ATGGTTACTTTCCACACTAATCACGGCGATATCGTTATCAACACCTTTGCTGACAAAGCGCCGGTTACCGTTGAAAACTT
CCTGAACTACTGCCGTGAAGGTTTCTACAATAACACCATTTTCCACCGTGTTATCAATGGCTTTATGGTTCAGGGCGGCG
GTTTTGAGCCAGGCATGACCCAGAAAGACACCAAAGCGACTATCAAGAACGAAGCCAACAACGGTCTGAAAAACACCATC
GGTACCCTGGCAATGGCTCGCACCAACGATCCACACTCTGCGACCGCACAGTTCTTCATCAACGTGGCAGACAACGACTT
CCTGAACTTCCGCGGCGAAAACGCGCAGGGCTGGGGCTACTGCGTATTTGCTGAAGTGGTTGAAGGCATGGACGTGGTTA
ACAAGATCAAAGCGGTGAAAACCGGCCGTAGCGGCATGCACCAGGACGTACCGGTAGAAGACGTCATCGTCACTAGCGTT
ACCGTCAGCGAGTAA

Upstream 100 bases:

>100_bases
TACCCGCTGCTGACTGATTAAAGGAGATATGTTATAACGGCGGTCTGATTGTTCACTCGATCCTTGTGACATCTCAATTC
ATCTTGTTAGGACTAAAACT

Downstream 100 bases:

>100_bases
TCGCGGCTGCATGAACACGCTGTTCATCGCAGATCTGCATTTAAGCGCACAGGAACCGGCAATCACTGCCGGTTTTCTGC
GTTTTTTGCGGCAAGATGCC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVTFHTNHGDIVINTFADKAPVTVENFLNYCREGFYNNTIFHRVINGFMVQGGGFEPGMTQKDTKATIKNEANNGLKNTI
GTLAMARTNDPHSATAQFFINVADNDFLNFRGENAQGWGYCVFAEVVEGMDVVNKIKAVKTGRSGMHQDVPVEDVIVTSV
TVSE

Sequences:

>Translated_164_residues
MVTFHTNHGDIVINTFADKAPVTVENFLNYCREGFYNNTIFHRVINGFMVQGGGFEPGMTQKDTKATIKNEANNGLKNTI
GTLAMARTNDPHSATAQFFINVADNDFLNFRGENAQGWGYCVFAEVVEGMDVVNKIKAVKTGRSGMHQDVPVEDVIVTSV
TVSE
>Mature_164_residues
MVTFHTNHGDIVINTFADKAPVTVENFLNYCREGFYNNTIFHRVINGFMVQGGGFEPGMTQKDTKATIKNEANNGLKNTI
GTLAMARTNDPHSATAQFFINVADNDFLNFRGENAQGWGYCVFAEVVEGMDVVNKIKAVKTGRSGMHQDVPVEDVIVTSV
TVSE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=31.9277108433735, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI7706339, Length=167, Percent_Identity=32.9341317365269, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=34.3558282208589, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.3170731707317, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.3170731707317, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.3170731707317, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI310110104, Length=135, Percent_Identity=37.037037037037, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI64276486, Length=113, Percent_Identity=38.9380530973451, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310129267, Length=135, Percent_Identity=36.2962962962963, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310120620, Length=135, Percent_Identity=36.2962962962963, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4758950, Length=156, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=85.3658536585366, Blast_Score=292, Evalue=9e-81,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=54.0372670807453, Blast_Score=170, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=36.1111111111111, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=36.1111111111111, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=162, Percent_Identity=35.1851851851852, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=33.7579617834395, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=30.1204819277108, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=168, Percent_Identity=29.7619047619048, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=145, Percent_Identity=37.2413793103448, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=135, Percent_Identity=36.2962962962963, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=168, Percent_Identity=36.9047619047619, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=31.547619047619, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=28.3132530120482, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24652460, Length=143, Percent_Identity=32.1678321678322, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=33.9393939393939, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647301, Length=158, Percent_Identity=33.5443037974684, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45549139, Length=136, Percent_Identity=38.2352941176471, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18040; Mature: 18040

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFHTNHGDIVINTFADKAPVTVENFLNYCREGFYNNTIFHRVINGFMVQGGGFEPGMT
CEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCC
QKDTKATIKNEANNGLKNTIGTLAMARTNDPHSATAQFFINVADNDFLNFRGENAQGWGY
CCCHHHHHHHCCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEE
CVFAEVVEGMDVVNKIKAVKTGRSGMHQDVPVEDVIVTSVTVSE
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MVTFHTNHGDIVINTFADKAPVTVENFLNYCREGFYNNTIFHRVINGFMVQGGGFEPGMT
CEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCC
QKDTKATIKNEANNGLKNTIGTLAMARTNDPHSATAQFFINVADNDFLNFRGENAQGWGY
CCCHHHHHHHCCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEE
CVFAEVVEGMDVVNKIKAVKTGRSGMHQDVPVEDVIVTSVTVSE
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]