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The map label for this gene is dppA [H]

Identifier: 157369218

GI number: 157369218

Start: 1070100

End: 1071698

Strand: Reverse

Name: dppA [H]

Synonym: Spro_0973

Alternate gene names: 157369218

Gene position: 1071698-1070100 (Counterclockwise)

Preceding gene: 157369224

Following gene: 157369217

Centisome position: 19.67

GC content: 58.35

Gene sequence:

>1599_bases
ATGCGTTTAAAACCAAGCACTATGGGTCTGTTATTAGCGGGAACCGGCCTGTTGACGGCGGGCCATGCCCTGGCCGCCAG
CGATACCCTGGTCTACTGCACCGTGGCCTCGCCGGAGTCTTTCAACCCGCAGCTATCGAGCTCCGGAACCACTTTTATCG
CCACCTCGCAGGTGTTGTACAACCGCCTGCTGACGCTGCGTGAAAGCGATAAAACCCCCGCTCCCTCACTGGCGACCGAG
TGGACCATCAGCCCGGACGGCAAGACCTACACCTTTACGCTGCGCAAGGGCGTGAAATTCAACAGCAACAAGTTCTTCAC
CCCAACGCGTGACTTCAACGCCGAGGACGTGGTGTTCACCGTGATGCGCCAAAAAGATGCCAATAATCCGTATCACAAGG
TGTCCGGCGGCAACTACGAGTACTTTACCGACACCGGGCTGGACAAACTGATCACCAAAGTGGAGGCGGTGGATAACGAC
CACGTGCGCTTTACGCTGAGCCAGCCTAACGCCGCCTTCCTGGCGGACTGGACCATGGACTTCGCTTCGATCCTTTCCGC
TGAATATGCCGATGCCATGCTGAAAAAAGGCACGCCGGAGAACGTCGATAACTGGCCGATCGGTACCGGTCCGTTCGCGC
TGCAACAGTACAAACAGGACTCACTGATCCGCTACATCGCCAACCCGCATTACTGGCAGGGCGAAGTGGCCAGCAAGCAC
CTGATTTTCTCCATCACGCCGAACCCGGAAACCCGGCTAGCGAAGCTGAAAACCAACGAGTGCCAGATTATCCCTGCCCC
GCTGGCAGAACAGTTTGACGCCATCAAGAACGACAAAAACCTGCAGCTGCACAGTATCGACGGCCTGAACGTCGGCTATC
TGGCGTTCAACACCCAGAAGAAGCCGTTTGATAATGTGCTGGTGCGCCAGGCGCTGAGCTATGCAGTGGACAAAAAGGCC
ATCGTCGCGGCGGTGTTCAAAGAAAGTGGCACCACGGCCAACTCGATACTGCCGCCGGGCATGCTGGGCTACAACGACAA
GCTGCCGGAATACGCCTATGATCCGCAGAAGGCGCGGGATCTGCTGAAACAGGCTGGGCTGGAAAAAGGCTTTGAGACCG
ATATCTGGTCGATGCCGGTAGCCCGCCCTTACAACCCTAACTCACGCCGCATCGCCCAGATGATCCAAAACGACTGGGCG
AAAGTGGGCGTGAAGGCCAAAATCGTCACCTGGGAATGGGGCCAGTACCTGGCCGGGCTGCGCAAAGGGGAACAGCAGAG
CGCGTTGTACGGCTGGATGTCGGATAACGGCGACCCGGACAACTTCGCCACGCTGCTCAACTGCGCCGGCGTGCAGACCG
GTGCCAATGCGGCCCGTTGGTGCGACAGCAGCTATGACAAGCTGATCCAGCAGGCAATTTCGGTCAGCGCCCCGGCCGAA
CGCGCCAAGCTTTATCAACAGGCGCAGGTGATTTTTGCCAAACAGCTCCCCCTGCTGCCATTGGCTAACGGCAAGGTGTT
CTACGCCACCCGCAGCAACGTCAGCGGCTATGTGGTTGACGTTAACGGCAGTGACTTCGCCAAAGCCAAGGCCGACTGA

Upstream 100 bases:

>100_bases
TCCCATATCTGCTATCAATCACTTATATTTAATTTGAGGGCTGCCTGAATGCCAATGCGGCGGCAGTGTCCTCAATCAAC
CTGAGGGAGCCATCCATTTT

Downstream 100 bases:

>100_bases
GTCGAAGCCCGCGCCGGATGATTTTCACATCCGGCGCTTTCCTCCTCTGTAACATTTGGTTACTCTCATCAGCACTGTGA
TTTAACATTCAAAGGCAACC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRLKPSTMGLLLAGTGLLTAGHALAASDTLVYCTVASPESFNPQLSSSGTTFIATSQVLYNRLLTLRESDKTPAPSLATE
WTISPDGKTYTFTLRKGVKFNSNKFFTPTRDFNAEDVVFTVMRQKDANNPYHKVSGGNYEYFTDTGLDKLITKVEAVDND
HVRFTLSQPNAAFLADWTMDFASILSAEYADAMLKKGTPENVDNWPIGTGPFALQQYKQDSLIRYIANPHYWQGEVASKH
LIFSITPNPETRLAKLKTNECQIIPAPLAEQFDAIKNDKNLQLHSIDGLNVGYLAFNTQKKPFDNVLVRQALSYAVDKKA
IVAAVFKESGTTANSILPPGMLGYNDKLPEYAYDPQKARDLLKQAGLEKGFETDIWSMPVARPYNPNSRRIAQMIQNDWA
KVGVKAKIVTWEWGQYLAGLRKGEQQSALYGWMSDNGDPDNFATLLNCAGVQTGANAARWCDSSYDKLIQQAISVSAPAE
RAKLYQQAQVIFAKQLPLLPLANGKVFYATRSNVSGYVVDVNGSDFAKAKAD

Sequences:

>Translated_532_residues
MRLKPSTMGLLLAGTGLLTAGHALAASDTLVYCTVASPESFNPQLSSSGTTFIATSQVLYNRLLTLRESDKTPAPSLATE
WTISPDGKTYTFTLRKGVKFNSNKFFTPTRDFNAEDVVFTVMRQKDANNPYHKVSGGNYEYFTDTGLDKLITKVEAVDND
HVRFTLSQPNAAFLADWTMDFASILSAEYADAMLKKGTPENVDNWPIGTGPFALQQYKQDSLIRYIANPHYWQGEVASKH
LIFSITPNPETRLAKLKTNECQIIPAPLAEQFDAIKNDKNLQLHSIDGLNVGYLAFNTQKKPFDNVLVRQALSYAVDKKA
IVAAVFKESGTTANSILPPGMLGYNDKLPEYAYDPQKARDLLKQAGLEKGFETDIWSMPVARPYNPNSRRIAQMIQNDWA
KVGVKAKIVTWEWGQYLAGLRKGEQQSALYGWMSDNGDPDNFATLLNCAGVQTGANAARWCDSSYDKLIQQAISVSAPAE
RAKLYQQAQVIFAKQLPLLPLANGKVFYATRSNVSGYVVDVNGSDFAKAKAD
>Mature_532_residues
MRLKPSTMGLLLAGTGLLTAGHALAASDTLVYCTVASPESFNPQLSSSGTTFIATSQVLYNRLLTLRESDKTPAPSLATE
WTISPDGKTYTFTLRKGVKFNSNKFFTPTRDFNAEDVVFTVMRQKDANNPYHKVSGGNYEYFTDTGLDKLITKVEAVDND
HVRFTLSQPNAAFLADWTMDFASILSAEYADAMLKKGTPENVDNWPIGTGPFALQQYKQDSLIRYIANPHYWQGEVASKH
LIFSITPNPETRLAKLKTNECQIIPAPLAEQFDAIKNDKNLQLHSIDGLNVGYLAFNTQKKPFDNVLVRQALSYAVDKKA
IVAAVFKESGTTANSILPPGMLGYNDKLPEYAYDPQKARDLLKQAGLEKGFETDIWSMPVARPYNPNSRRIAQMIQNDWA
KVGVKAKIVTWEWGQYLAGLRKGEQQSALYGWMSDNGDPDNFATLLNCAGVQTGANAARWCDSSYDKLIQQAISVSAPAE
RAKLYQQAQVIFAKQLPLLPLANGKVFYATRSNVSGYVVDVNGSDFAKAKAD

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=525, Percent_Identity=54.4761904761905, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1787551, Length=526, Percent_Identity=35.9315589353612, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1787052, Length=528, Percent_Identity=31.4393939393939, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787762, Length=529, Percent_Identity=25.7088846880907, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789397, Length=534, Percent_Identity=25.8426966292135, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1787495, Length=542, Percent_Identity=25.4612546125461, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789887, Length=453, Percent_Identity=25.60706401766, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081878, Length=532, Percent_Identity=24.0601503759398, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 58773; Mature: 58773

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKPSTMGLLLAGTGLLTAGHALAASDTLVYCTVASPESFNPQLSSSGTTFIATSQVLY
CCCCCCCCEEEEECCCHHHCCCCEECCCEEEEEEECCCCCCCCCCCCCCCEEEEEHHHHH
NRLLTLRESDKTPAPSLATEWTISPDGKTYTFTLRKGVKFNSNKFFTPTRDFNAEDVVFT
HHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCEECCCEEECCCCCCCCCHHEEE
VMRQKDANNPYHKVSGGNYEYFTDTGLDKLITKVEAVDNDHVRFTLSQPNAAFLADWTMD
EEHHCCCCCCCEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHH
FASILSAEYADAMLKKGTPENVDNWPIGTGPFALQQYKQDSLIRYIANPHYWQGEVASKH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LIFSITPNPETRLAKLKTNECQIIPAPLAEQFDAIKNDKNLQLHSIDGLNVGYLAFNTQK
EEEEECCCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCC
KPFDNVLVRQALSYAVDKKAIVAAVFKESGTTANSILPPGMLGYNDKLPEYAYDPQKARD
CCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LLKQAGLEKGFETDIWSMPVARPYNPNSRRIAQMIQNDWAKVGVKAKIVTWEWGQYLAGL
HHHHCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEHHHHHHHH
RKGEQQSALYGWMSDNGDPDNFATLLNCAGVQTGANAARWCDSSYDKLIQQAISVSAPAE
HCCCCHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHH
RAKLYQQAQVIFAKQLPLLPLANGKVFYATRSNVSGYVVDVNGSDFAKAKAD
HHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRLKPSTMGLLLAGTGLLTAGHALAASDTLVYCTVASPESFNPQLSSSGTTFIATSQVLY
CCCCCCCCEEEEECCCHHHCCCCEECCCEEEEEEECCCCCCCCCCCCCCCEEEEEHHHHH
NRLLTLRESDKTPAPSLATEWTISPDGKTYTFTLRKGVKFNSNKFFTPTRDFNAEDVVFT
HHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECCCEECCCEEECCCCCCCCCHHEEE
VMRQKDANNPYHKVSGGNYEYFTDTGLDKLITKVEAVDNDHVRFTLSQPNAAFLADWTMD
EEHHCCCCCCCEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEHHHHH
FASILSAEYADAMLKKGTPENVDNWPIGTGPFALQQYKQDSLIRYIANPHYWQGEVASKH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LIFSITPNPETRLAKLKTNECQIIPAPLAEQFDAIKNDKNLQLHSIDGLNVGYLAFNTQK
EEEEECCCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCC
KPFDNVLVRQALSYAVDKKAIVAAVFKESGTTANSILPPGMLGYNDKLPEYAYDPQKARD
CCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LLKQAGLEKGFETDIWSMPVARPYNPNSRRIAQMIQNDWAKVGVKAKIVTWEWGQYLAGL
HHHHCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEHHHHHHHH
RKGEQQSALYGWMSDNGDPDNFATLLNCAGVQTGANAARWCDSSYDKLIQQAISVSAPAE
HCCCCHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHH
RAKLYQQAQVIFAKQLPLLPLANGKVFYATRSNVSGYVVDVNGSDFAKAKAD
HHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]