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The map label for this gene is fadE [H]

Identifier: 157369194

GI number: 157369194

Start: 1045853

End: 1048309

Strand: Reverse

Name: fadE [H]

Synonym: Spro_0949

Alternate gene names: 157369194

Gene position: 1048309-1045853 (Counterclockwise)

Preceding gene: 157369197

Following gene: 157369193

Centisome position: 19.24

GC content: 58.73

Gene sequence:

>2457_bases
ATGATGGTTCTTAGTATTGTTGTTTTGCTGGCACTCATTGGTGTGGTGTTTTATCACCGAGTGAACCTCACCCTCAGTAG
CCTTATTCTTCTGGCGTACACCGCCGCCATGGGCGCTATCGGCCTGTGGAGCTTCTGGATGCTGCTGCCGCTGGCGATTA
TCCTGCTGCCGTTGAACGTCACCTCATTGCGTCGTTCAATGCTGTCCGCCCCGGCGCTGCGCGCATTCCGCAAGGTGATG
CCGCCAATGTCCACCACCGAAAAGGAAGCGATCGAAGCCGGGACCACCTGGTGGGAAGGCGATCTGTTCCGCGGTGCGCC
GGACTGGAACAAGCTGCATAACTACCCGAAACCGCAGTTGACCGCCGAAGAGCAGGCGTTCATCGACGGCCCGGTGGAAG
AAGCCTGCCGCATGGCCAACGACTTCCAAATCACCCACGAACTGGCCGATTTGCCGCCGGAACTGTGGGCATACCTGAAA
GAACACCGCTTCTTCGCGATGATCATCAAAAAAGAATACGGCGGCCTGGACTTCTCTCCTTATGCTCAGGCGCGCGTGCT
GCAAAAACTCTCCGGTGTTTCCGGTATTCTGGCCATCACCGTCGGCGTGCCAAACTCCCTCGGCCCCGGTGAACTGCTGC
AGCATTACGGTACTGACGAACAGAAAAACCATTACCTGCCAGGCCTGGCGCGCGGCGACGAGATCCCTTGTTTCGCCCTG
ACCAGCCCGGAAGCCGGTTCCGATGCCGGGGCCATTCCGGACGTCGGCACCGTCTGCATGGGTGATTGGCAAGGCGAACA
GGTGCTGGGCATGCGCCTGACCTGGAACAAACGCTATATCACGCTGGCACCGGTTGCGACCGTGCTGGGCCTGGCGTTCA
AACTGTATGACCCGAATCACCTGCTGGGCGATAACGAATCACCGGGCATCACCTGTGCGCTGATCCCAACCAGCACCCCA
GGTGTTGAAATCGGTAACCGCCACTTCCCGCTGAACGTGCCGTTCCAAAACGGCCCAACCCGCGGTAATGACGTGTTCGT
CCCTATTGATTACATCATCGGCGGGCCAAAAATGGCCGGTCAGGGCTGGCGTATGCTGGTTGAGTGCCTGTCGGTAGGCC
GTGGCATCACCCTGCCTTCCAACTCGACCGGTAGCGTGAAGTCCATGGCACTGGCGATTGGGGCATACGCCCATATCCGC
CGCCAGTTCAAGCTCTCAATCGGCAAGATGGAAGGTATCGAAGAGCCACTGGCGCGTATCGCCGGTAACACCTACGTGAT
GGATGCCGCGGCTACGCTTATCACCAGCGGCCTGATGCTGGGCGAGAAACCGGCCGTGCTGTCGGCCATCGTGAAATACC
ACTGTACCCATCGTGGCCAGCAGGCAATCATTGATGCAATGGATATCGCCGGCGGTAAAGGCATCATGCTGGGTAAATCC
AACTTCCTGGCCCGAGCCTATCAGGGCGCGCCTATCGCCATTACGGTAGAAGGCGCCAATATCCTGACTCGTACCATGAT
GATCTTCGGTCAGGGGGCTATCCGCTGCCATCCTTACGTGCTGGACGAAATGGCTGCAGCGCAGAAGAACGACCTGAACG
CCTATGACAAATTGCTGTTCGGTCATCTGGGCCACGTGGGCAGCAACAAGGTGCGCAGCTTCTGGCTGGGCCTGACTAAC
GGTCGCACCAGCAGCACACCAACCAAAGATGCGACTCGTCGTTATTACCAACAGTTGAACCGCCTGAGTGCTAACCTGGC
GCTGTTGTCAGACGTTTCCATGGGCGTGCTGGGCGGCAGTTTGAAGCGCCGTGAGCGTATCTCCGCCCGTCTGGGGGATA
TCCTCAGCCAAATGTATCTGGCTTCTGCGGCACTGAAACGTTTTGAAGATGAAGGCCGTCAGAAAGAAGATTTACCGCTG
GTACATTGGGCCGTGCAGGACAGTCTGCATCAGGCAGAACAGGCACTGGATGACCTGCTGCGCAACTTCCCGAACCGCTT
TATCGCCGGAGTGATGCGCCTGGTCGTCTTCCCGTTAGGCCGTGTCCATACTGCACCGTCTGACCGTCTGGATCACCAAT
TGGCCAAGATCATCCAACAGCCGTCTGCTACCCGCAGCCGTCTGGGCCGTGGCCAGTATCTGACACCCAGCGAGCACAAC
CCGGTTGGCCTGCTGGAAGCCGCACTGGCTGACGTGATCGCCGCCGAACCGATTCACGACCGTCTGTGCAAGGCGGCCGG
CAAGAACCTGCCGTTCACCCGACTGGATCGTCTGGCACAACGTGCACTGGAAGAAGGCAAGATCAGCGCCGATGAGGCGA
AGATCCTGGTGAAAGCCGAGGAGAGCCGTCTGCGTTCCATCAACGTGGATGACTTCGAGCCGGATGCGCTGGCGGCCAGT
AAGCCGGAAAAGCCACTCAAGCAGGATAAGCGCCTGAAACACACCGAAGCCGCGTAA

Upstream 100 bases:

>100_bases
TGTAATTAAACTGTAAATGCATTGATAAAAATATGGGGTTGTACTAAAACCTATTACATACACACAACAGGTCAGACCTC
TTGCCACTTTGGAGCTTCTT

Downstream 100 bases:

>100_bases
CTGCAAAAAACTGACTTACCCAGGGGCGATAATCATCGCCCTTTTCTATTTCTGCTTAAAAATGCGCAGTGCTCCGCAAC
GTTGCCAGAACGGCTAATTT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MMVLSIVVLLALIGVVFYHRVNLTLSSLILLAYTAAMGAIGLWSFWMLLPLAIILLPLNVTSLRRSMLSAPALRAFRKVM
PPMSTTEKEAIEAGTTWWEGDLFRGAPDWNKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLDFSPYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKNHYLPGLARGDEIPCFAL
TSPEAGSDAGAIPDVGTVCMGDWQGEQVLGMRLTWNKRYITLAPVATVLGLAFKLYDPNHLLGDNESPGITCALIPTSTP
GVEIGNRHFPLNVPFQNGPTRGNDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGSVKSMALAIGAYAHIR
RQFKLSIGKMEGIEEPLARIAGNTYVMDAAATLITSGLMLGEKPAVLSAIVKYHCTHRGQQAIIDAMDIAGGKGIMLGKS
NFLARAYQGAPIAITVEGANILTRTMMIFGQGAIRCHPYVLDEMAAAQKNDLNAYDKLLFGHLGHVGSNKVRSFWLGLTN
GRTSSTPTKDATRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQMYLASAALKRFEDEGRQKEDLPL
VHWAVQDSLHQAEQALDDLLRNFPNRFIAGVMRLVVFPLGRVHTAPSDRLDHQLAKIIQQPSATRSRLGRGQYLTPSEHN
PVGLLEAALADVIAAEPIHDRLCKAAGKNLPFTRLDRLAQRALEEGKISADEAKILVKAEESRLRSINVDDFEPDALAAS
KPEKPLKQDKRLKHTEAA

Sequences:

>Translated_818_residues
MMVLSIVVLLALIGVVFYHRVNLTLSSLILLAYTAAMGAIGLWSFWMLLPLAIILLPLNVTSLRRSMLSAPALRAFRKVM
PPMSTTEKEAIEAGTTWWEGDLFRGAPDWNKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLDFSPYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKNHYLPGLARGDEIPCFAL
TSPEAGSDAGAIPDVGTVCMGDWQGEQVLGMRLTWNKRYITLAPVATVLGLAFKLYDPNHLLGDNESPGITCALIPTSTP
GVEIGNRHFPLNVPFQNGPTRGNDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGSVKSMALAIGAYAHIR
RQFKLSIGKMEGIEEPLARIAGNTYVMDAAATLITSGLMLGEKPAVLSAIVKYHCTHRGQQAIIDAMDIAGGKGIMLGKS
NFLARAYQGAPIAITVEGANILTRTMMIFGQGAIRCHPYVLDEMAAAQKNDLNAYDKLLFGHLGHVGSNKVRSFWLGLTN
GRTSSTPTKDATRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQMYLASAALKRFEDEGRQKEDLPL
VHWAVQDSLHQAEQALDDLLRNFPNRFIAGVMRLVVFPLGRVHTAPSDRLDHQLAKIIQQPSATRSRLGRGQYLTPSEHN
PVGLLEAALADVIAAEPIHDRLCKAAGKNLPFTRLDRLAQRALEEGKISADEAKILVKAEESRLRSINVDDFEPDALAAS
KPEKPLKQDKRLKHTEAA
>Mature_818_residues
MMVLSIVVLLALIGVVFYHRVNLTLSSLILLAYTAAMGAIGLWSFWMLLPLAIILLPLNVTSLRRSMLSAPALRAFRKVM
PPMSTTEKEAIEAGTTWWEGDLFRGAPDWNKLHNYPKPQLTAEEQAFIDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLDFSPYAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKNHYLPGLARGDEIPCFAL
TSPEAGSDAGAIPDVGTVCMGDWQGEQVLGMRLTWNKRYITLAPVATVLGLAFKLYDPNHLLGDNESPGITCALIPTSTP
GVEIGNRHFPLNVPFQNGPTRGNDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGSVKSMALAIGAYAHIR
RQFKLSIGKMEGIEEPLARIAGNTYVMDAAATLITSGLMLGEKPAVLSAIVKYHCTHRGQQAIIDAMDIAGGKGIMLGKS
NFLARAYQGAPIAITVEGANILTRTMMIFGQGAIRCHPYVLDEMAAAQKNDLNAYDKLLFGHLGHVGSNKVRSFWLGLTN
GRTSSTPTKDATRRYYQQLNRLSANLALLSDVSMGVLGGSLKRRERISARLGDILSQMYLASAALKRFEDEGRQKEDLPL
VHWAVQDSLHQAEQALDDLLRNFPNRFIAGVMRLVVFPLGRVHTAPSDRLDHQLAKIIQQPSATRSRLGRGQYLTPSEHN
PVGLLEAALADVIAAEPIHDRLCKAAGKNLPFTRLDRLAQRALEEGKISADEAKILVKAEESRLRSINVDDFEPDALAAS
KPEKPLKQDKRLKHTEAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=656, Percent_Identity=23.6280487804878, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4557233, Length=422, Percent_Identity=27.2511848341232, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI4557235, Length=432, Percent_Identity=25, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI76496475, Length=411, Percent_Identity=25.3041362530414, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4501859, Length=340, Percent_Identity=26.7647058823529, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081702, Length=818, Percent_Identity=81.9070904645477, Blast_Score=1409, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=410, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=359, Percent_Identity=23.6768802228412, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=326, Percent_Identity=23.9263803680982, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=260, Percent_Identity=25.7692307692308, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363737, Length=414, Percent_Identity=27.0531400966184, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646207, Length=338, Percent_Identity=26.0355029585799, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356377, Length=281, Percent_Identity=28.4697508896797, Blast_Score=79, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666513, Length=330, Percent_Identity=26.3636363636364, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89517; Mature: 89517

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVLSIVVLLALIGVVFYHRVNLTLSSLILLAYTAAMGAIGLWSFWMLLPLAIILLPLNV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TSLRRSMLSAPALRAFRKVMPPMSTTEKEAIEAGTTWWEGDLFRGAPDWNKLHNYPKPQL
HHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFIDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLDFSP
CCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCCCH
YAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKNHYLPGLARGDEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
TSPEAGSDAGAIPDVGTVCMGDWQGEQVLGMRLTWNKRYITLAPVATVLGLAFKLYDPNH
CCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCCC
LLGDNESPGITCALIPTSTPGVEIGNRHFPLNVPFQNGPTRGNDVFVPIDYIIGGPKMAG
CCCCCCCCCEEEEEECCCCCCCCCCCEECCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGSVKSMALAIGAYAHIRRQFKLSIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AGNTYVMDAAATLITSGLMLGEKPAVLSAIVKYHCTHRGQQAIIDAMDIAGGKGIMLGKS
CCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECC
NFLARAYQGAPIAITVEGANILTRTMMIFGQGAIRCHPYVLDEMAAAQKNDLNAYDKLLF
HHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCHHHHHHHH
GHLGHVGSNKVRSFWLGLTNGRTSSTPTKDATRRYYQQLNRLSANLALLSDVSMGVLGGS
HHHCCCCCHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQMYLASAALKRFEDEGRQKEDLPLVHWAVQDSLHQAEQALDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RNFPNRFIAGVMRLVVFPLGRVHTAPSDRLDHQLAKIIQQPSATRSRLGRGQYLTPSEHN
HHCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEAALADVIAAEPIHDRLCKAAGKNLPFTRLDRLAQRALEEGKISADEAKILVKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
ESRLRSINVDDFEPDALAASKPEKPLKQDKRLKHTEAA
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMVLSIVVLLALIGVVFYHRVNLTLSSLILLAYTAAMGAIGLWSFWMLLPLAIILLPLNV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TSLRRSMLSAPALRAFRKVMPPMSTTEKEAIEAGTTWWEGDLFRGAPDWNKLHNYPKPQL
HHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFIDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLDFSP
CCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCCCH
YAQARVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKNHYLPGLARGDEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
TSPEAGSDAGAIPDVGTVCMGDWQGEQVLGMRLTWNKRYITLAPVATVLGLAFKLYDPNH
CCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCCC
LLGDNESPGITCALIPTSTPGVEIGNRHFPLNVPFQNGPTRGNDVFVPIDYIIGGPKMAG
CCCCCCCCCEEEEEECCCCCCCCCCCEECCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGSVKSMALAIGAYAHIRRQFKLSIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AGNTYVMDAAATLITSGLMLGEKPAVLSAIVKYHCTHRGQQAIIDAMDIAGGKGIMLGKS
CCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECC
NFLARAYQGAPIAITVEGANILTRTMMIFGQGAIRCHPYVLDEMAAAQKNDLNAYDKLLF
HHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCHHHHHHHH
GHLGHVGSNKVRSFWLGLTNGRTSSTPTKDATRRYYQQLNRLSANLALLSDVSMGVLGGS
HHHCCCCCHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQMYLASAALKRFEDEGRQKEDLPLVHWAVQDSLHQAEQALDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RNFPNRFIAGVMRLVVFPLGRVHTAPSDRLDHQLAKIIQQPSATRSRLGRGQYLTPSEHN
HHCCHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEAALADVIAAEPIHDRLCKAAGKNLPFTRLDRLAQRALEEGKISADEAKILVKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
ESRLRSINVDDFEPDALAASKPEKPLKQDKRLKHTEAA
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]