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The map label for this gene is fabF [H]

Identifier: 157369148

GI number: 157369148

Start: 1001906

End: 1003135

Strand: Direct

Name: fabF [H]

Synonym: Spro_0903

Alternate gene names: 157369148

Gene position: 1001906-1003135 (Clockwise)

Preceding gene: 157369147

Following gene: 157369149

Centisome position: 18.39

GC content: 58.21

Gene sequence:

>1230_bases
ATGACACAACGAGTGGTAGTTACCGGCATGGCAGGCGTGACCGCGTTTGGCAATAGCTGGGCAGACGTATCCAGCCGTCT
GCAGCAGGGCAAGAATGCGGTGCGTTATATGACGCAGTGGGAAGAGTATCAGGGGCTGAATACCCACCTTGGCGCGCCGG
TCGAGAATTTCGTGTTGCCGGAGCACTATACCCGCAAGCGCATTCGTTCGATGGGGCGGGTTTCACTGTTGGCCACCCGC
GCCACCGAACTGGCACTTGAGCAGGCTGGGTTACTGGGGCTGGCGGTACTGACCAATGGTGAGACCGGTATCGCCTACGG
TTCATCGACCGGTAGTACCAAGCCGGTCAGCGAGTTCGCCACCATGTTAACCGAGAAGCACACCGGCAATATTACCGGCA
CCACCTATGTGCAAATGATGCCTCATACCGCGGCGGTGAACACTGGCCTGTTCTTCGGCCTGCGCGGCCGGGTGATCCCG
ACTTCCAGCGCCTGCACCTCGGGCAGTCAGGCAATTGGCTACGCTTACGAGAGCATTCGCCACGGCTATCAGACAGTGAT
GGTGGCGGGCGGTGCCGAAGAACTGTGCCCTTCGGAGGCGGCGGTATTCGACACGCTGTTTGCCACCAGTCAGCAGAACG
ATCATCCGGAGCTTTCGCCACGTCCGTTTGACTGTCAACGTGACGGACTGGTGATTGGCGAAGGCGCCGGGACGCTGATC
CTGGAGTCGTTGGAGCACGCGTTGGCGCGTGGTGTCACCATTTATGGCGAGATTATCGGCTTCGCCACCAACTGCGATGC
GGCTCATATTACCCAGCCGCAGCAGGAAACCATGCAAATCTGCATGCAGCAGGCGCTGAAGGCCTCCGGGCTGGCGAGCA
GCGATATTGGTTATATTAGTGCCCACGGCACGGCGACCGATCGGGGTGATATCGCAGAAAGTCAGGCAACGGCAGCGATC
TTCGGCAATAGCACGCCGATTTCATCATTAAAAAGTTATTTTGGTCATACGCTGGGTGCCTGCGGCGCACTGGAAGCCTG
GATGGCGCTGGAAATGATGCGTGAAGGCCGCTTTGCGCCGACCATTAACCTCAGTGAACCGGACCGCGATTGTGGCGATC
TGGACTACATCATGGGCGGCTATCGTCAGATTGAGACCGAGTTTGTGCAATCAAACAACTTCGCGTTTGGTGGCATCAAT
ACCTCACTGATCCTGCGCCGCTGGTCGTAA

Upstream 100 bases:

>100_bases
TGGGCTCGGCGGAAGAGGTGGCCGGGCTGGCCAGCTATCTGATGTCGGATATCGCCGGCTATGTGACGCGGCAGGTCATT
TCCATTAATGGAGGAATGGT

Downstream 100 bases:

>100_bases
TTTTGCGTTGCCGGGGTGCTCACCCCGGCAATTGTTGCCGTTTAATCAAAAGTCTTATGCACAATAGGGCGTTTTTGATC
AACAAAACAGTTGCCATAAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTQRVVVTGMAGVTAFGNSWADVSSRLQQGKNAVRYMTQWEEYQGLNTHLGAPVENFVLPEHYTRKRIRSMGRVSLLATR
ATELALEQAGLLGLAVLTNGETGIAYGSSTGSTKPVSEFATMLTEKHTGNITGTTYVQMMPHTAAVNTGLFFGLRGRVIP
TSSACTSGSQAIGYAYESIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQQNDHPELSPRPFDCQRDGLVIGEGAGTLI
LESLEHALARGVTIYGEIIGFATNCDAAHITQPQQETMQICMQQALKASGLASSDIGYISAHGTATDRGDIAESQATAAI
FGNSTPISSLKSYFGHTLGACGALEAWMALEMMREGRFAPTINLSEPDRDCGDLDYIMGGYRQIETEFVQSNNFAFGGIN
TSLILRRWS

Sequences:

>Translated_409_residues
MTQRVVVTGMAGVTAFGNSWADVSSRLQQGKNAVRYMTQWEEYQGLNTHLGAPVENFVLPEHYTRKRIRSMGRVSLLATR
ATELALEQAGLLGLAVLTNGETGIAYGSSTGSTKPVSEFATMLTEKHTGNITGTTYVQMMPHTAAVNTGLFFGLRGRVIP
TSSACTSGSQAIGYAYESIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQQNDHPELSPRPFDCQRDGLVIGEGAGTLI
LESLEHALARGVTIYGEIIGFATNCDAAHITQPQQETMQICMQQALKASGLASSDIGYISAHGTATDRGDIAESQATAAI
FGNSTPISSLKSYFGHTLGACGALEAWMALEMMREGRFAPTINLSEPDRDCGDLDYIMGGYRQIETEFVQSNNFAFGGIN
TSLILRRWS
>Mature_408_residues
TQRVVVTGMAGVTAFGNSWADVSSRLQQGKNAVRYMTQWEEYQGLNTHLGAPVENFVLPEHYTRKRIRSMGRVSLLATRA
TELALEQAGLLGLAVLTNGETGIAYGSSTGSTKPVSEFATMLTEKHTGNITGTTYVQMMPHTAAVNTGLFFGLRGRVIPT
SSACTSGSQAIGYAYESIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQQNDHPELSPRPFDCQRDGLVIGEGAGTLIL
ESLEHALARGVTIYGEIIGFATNCDAAHITQPQQETMQICMQQALKASGLASSDIGYISAHGTATDRGDIAESQATAAIF
GNSTPISSLKSYFGHTLGACGALEAWMALEMMREGRFAPTINLSEPDRDCGDLDYIMGGYRQIETEFVQSNNFAFGGINT
SLILRRWS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=427, Percent_Identity=34.192037470726, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI223972627, Length=179, Percent_Identity=35.7541899441341, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI41872631, Length=272, Percent_Identity=28.3088235294118, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788663, Length=409, Percent_Identity=34.718826405868, Blast_Score=214, Evalue=5e-57,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=34.7517730496454, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=30.1204819277108, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=35.6060606060606, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17550940, Length=264, Percent_Identity=27.6515151515151, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=328, Percent_Identity=27.1341463414634, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=31.8485523385301, Blast_Score=179, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=34.6987951807229, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI19920632, Length=269, Percent_Identity=27.5092936802974, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221330659, Length=269, Percent_Identity=27.5092936802974, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24581345, Length=270, Percent_Identity=25.1851851851852, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43903; Mature: 43772

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRVVVTGMAGVTAFGNSWADVSSRLQQGKNAVRYMTQWEEYQGLNTHLGAPVENFVLP
CCCEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
EHYTRKRIRSMGRVSLLATRATELALEQAGLLGLAVLTNGETGIAYGSSTGSTKPVSEFA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCCCHHHHH
TMLTEKHTGNITGTTYVQMMPHTAAVNTGLFFGLRGRVIPTSSACTSGSQAIGYAYESIR
HHHHHHCCCCCCCEEEEEECCCHHHHCCCEEEECCCCEECCCCCCCCCCHHHHHHHHHHH
HGYQTVMVAGGAEELCPSEAAVFDTLFATSQQNDHPELSPRPFDCQRDGLVIGEGAGTLI
CCCEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LESLEHALARGVTIYGEIIGFATNCDAAHITQPQQETMQICMQQALKASGLASSDIGYIS
HHHHHHHHHCCEEEEEHHHEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
AHGTATDRGDIAESQATAAIFGNSTPISSLKSYFGHTLGACGALEAWMALEMMREGRFAP
ECCCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TINLSEPDRDCGDLDYIMGGYRQIETEFVQSNNFAFGGINTSLILRRWS
EECCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCEEECCCCCEEEEEECC
>Mature Secondary Structure 
TQRVVVTGMAGVTAFGNSWADVSSRLQQGKNAVRYMTQWEEYQGLNTHLGAPVENFVLP
CCEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCC
EHYTRKRIRSMGRVSLLATRATELALEQAGLLGLAVLTNGETGIAYGSSTGSTKPVSEFA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCCCHHHHH
TMLTEKHTGNITGTTYVQMMPHTAAVNTGLFFGLRGRVIPTSSACTSGSQAIGYAYESIR
HHHHHHCCCCCCCEEEEEECCCHHHHCCCEEEECCCCEECCCCCCCCCCHHHHHHHHHHH
HGYQTVMVAGGAEELCPSEAAVFDTLFATSQQNDHPELSPRPFDCQRDGLVIGEGAGTLI
CCCEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LESLEHALARGVTIYGEIIGFATNCDAAHITQPQQETMQICMQQALKASGLASSDIGYIS
HHHHHHHHHCCEEEEEHHHEEECCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEE
AHGTATDRGDIAESQATAAIFGNSTPISSLKSYFGHTLGACGALEAWMALEMMREGRFAP
ECCCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TINLSEPDRDCGDLDYIMGGYRQIETEFVQSNNFAFGGINTSLILRRWS
EECCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]