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The map label for this gene is tyrA [H]

Identifier: 157369125

GI number: 157369125

Start: 974321

End: 975442

Strand: Direct

Name: tyrA [H]

Synonym: Spro_0880

Alternate gene names: 157369125

Gene position: 974321-975442 (Clockwise)

Preceding gene: 157369124

Following gene: 157369129

Centisome position: 17.88

GC content: 55.26

Gene sequence:

>1122_bases
ATGGTGGCTGAACTGACCGCGTTACGCGATCAAATTGACGAAGTGGATAAGGCGCTGCTGGAGCTGCTGGCAAAACGCCT
GCAGCTGGTGGCAGAAGTGGGTGAGGTTAAGAGCCACCACGGGTTACCGGTATATGTTCCCGAGCGTGAGGCGGCGATGT
TGGCCTCACGGCGTCAGGAGGCAGAGAATCTGGGTGTACCGCCCGATCTGATTGAAGATGTACTGCGCCGGGTAATGCGT
GAATCTTATGTCAGTGAGAACGACAAAGGCTTTAAAACCCTGAACCCACAGCTGCGTCCTATTGTCATCATCGGCGGTAA
CGGCCAAATGGGACGGTTGTTTAATCGCCTGCTGACGCTGTCCGGCTACCAGGTCAAGGTATTGGATCAGCAAGACTGGC
CGCAGGCCGATGCTTTGCTGGCAGACGCCGGAATGGTGATTGTCAGCGTGCCGATTCACGTGACCGAGCAGGTGATTGAA
AGATTACCTCCGCTGCCGGCAGACTGTATCCTGGTCGATCTGGCGTCGGTAAAAAATCGCCCGCTAAATGCCATGTTGGC
AGCGCACTCTGGCCCGGTGGTGGGTCTGCATCCGATGTTTGGTCCGGACGTAGGCAGCGTGGCCAAGCAGGTGGTGGTCT
ATTGCGATGGCCGCGAGCCGCAAGCCTATCAATGGTTGCTGGAGCAATTGCAGGTATGGGGCGCGCGTTTGCACCGTATC
AGCGCGGTTGAGCACGATCAGAATATGGCCTTCATTCAGGCGCTGCGCCATTTTGCCACCTTTGCCTATGGCCTGCATTT
GGCGGAAGAAAACGTTCAGTTGGAACAGTTGCTGGCACTCTCTTCACCGATCTACCGGTTGGAATTGGCAATGGTCGGGC
GGCTGTTTGCGCAGGATCCGCAGTTGTACGCAGATATCATCATGTCGTCGGAAGAGAACATTGCGTTAATCAAACGCTAC
TACCAACGGTTTGGCGAGGCGATAAAACTGCTGGAACAGGGTGATAAACAGGCGTTTATCCAGAGTTTCCAAAAGGTCGA
GCATTGGTTTGGCGACTACGCGCAGCGTTTCCTGGTGGAAAGCCGTTCGTTGTTGCGCCAGGCGAACGACAGTCGACAAT
AA

Upstream 100 bases:

>100_bases
TGACGCCTGCATTAACTGGGAGAGTACCCAGACGCTGCTGCGCCATATGCACCAGGAACTCGGCACTGCGCTGACGGCAC
GTACTGGAGAGTAGTAAGTT

Downstream 100 bases:

>100_bases
AGTATCAGGGTTCGGCAATGCCGAACCCTTTTTTATCTCATTCAGGATGGGTTGACCGGCACCACGTTGTCGCTGGGGTA
GCAGCCCAACACCTTCAGCG

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MVAELTALRDQIDEVDKALLELLAKRLQLVAEVGEVKSHHGLPVYVPEREAAMLASRRQEAENLGVPPDLIEDVLRRVMR
ESYVSENDKGFKTLNPQLRPIVIIGGNGQMGRLFNRLLTLSGYQVKVLDQQDWPQADALLADAGMVIVSVPIHVTEQVIE
RLPPLPADCILVDLASVKNRPLNAMLAAHSGPVVGLHPMFGPDVGSVAKQVVVYCDGREPQAYQWLLEQLQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSEENIALIKRY
YQRFGEAIKLLEQGDKQAFIQSFQKVEHWFGDYAQRFLVESRSLLRQANDSRQ

Sequences:

>Translated_373_residues
MVAELTALRDQIDEVDKALLELLAKRLQLVAEVGEVKSHHGLPVYVPEREAAMLASRRQEAENLGVPPDLIEDVLRRVMR
ESYVSENDKGFKTLNPQLRPIVIIGGNGQMGRLFNRLLTLSGYQVKVLDQQDWPQADALLADAGMVIVSVPIHVTEQVIE
RLPPLPADCILVDLASVKNRPLNAMLAAHSGPVVGLHPMFGPDVGSVAKQVVVYCDGREPQAYQWLLEQLQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSEENIALIKRY
YQRFGEAIKLLEQGDKQAFIQSFQKVEHWFGDYAQRFLVESRSLLRQANDSRQ
>Mature_373_residues
MVAELTALRDQIDEVDKALLELLAKRLQLVAEVGEVKSHHGLPVYVPEREAAMLASRRQEAENLGVPPDLIEDVLRRVMR
ESYVSENDKGFKTLNPQLRPIVIIGGNGQMGRLFNRLLTLSGYQVKVLDQQDWPQADALLADAGMVIVSVPIHVTEQVIE
RLPPLPADCILVDLASVKNRPLNAMLAAHSGPVVGLHPMFGPDVGSVAKQVVVYCDGREPQAYQWLLEQLQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSEENIALIKRY
YQRFGEAIKLLEQGDKQAFIQSFQKVEHWFGDYAQRFLVESRSLLRQANDSRQ

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=373, Percent_Identity=86.058981233244, Blast_Score=662, Evalue=0.0,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42059; Mature: 42059

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAELTALRDQIDEVDKALLELLAKRLQLVAEVGEVKSHHGLPVYVPEREAAMLASRRQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
AENLGVPPDLIEDVLRRVMRESYVSENDKGFKTLNPQLRPIVIIGGNGQMGRLFNRLLTL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKVLDQQDWPQADALLADAGMVIVSVPIHVTEQVIERLPPLPADCILVDLASVKNR
CCCEEEEECCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
PLNAMLAAHSGPVVGLHPMFGPDVGSVAKQVVVYCDGREPQAYQWLLEQLQVWGARLHRI
CCHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSEENIALIKRYYQRFGEAIKLLEQGDKQAFIQSFQKVEHWFGDYAQRFLVE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRSLLRQANDSRQ
HHHHHHHHCCCCC
>Mature Secondary Structure
MVAELTALRDQIDEVDKALLELLAKRLQLVAEVGEVKSHHGLPVYVPEREAAMLASRRQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
AENLGVPPDLIEDVLRRVMRESYVSENDKGFKTLNPQLRPIVIIGGNGQMGRLFNRLLTL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
SGYQVKVLDQQDWPQADALLADAGMVIVSVPIHVTEQVIERLPPLPADCILVDLASVKNR
CCCEEEEECCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
PLNAMLAAHSGPVVGLHPMFGPDVGSVAKQVVVYCDGREPQAYQWLLEQLQVWGARLHRI
CCHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSEENIALIKRYYQRFGEAIKLLEQGDKQAFIQSFQKVEHWFGDYAQRFLVE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRSLLRQANDSRQ
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512561 [H]