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The map label for this gene is cysH

Identifier: 157369057

GI number: 157369057

Start: 908933

End: 909667

Strand: Direct

Name: cysH

Synonym: Spro_0812

Alternate gene names: 157369057

Gene position: 908933-909667 (Clockwise)

Preceding gene: 157369056

Following gene: 157369061

Centisome position: 16.68

GC content: 57.01

Gene sequence:

>735_bases
ATGGCTGAATTCAATCTGGCGGAGCTGAACGCGCTGCCCAAATCAGGGCAGGCGTTGTCACTGGCGGTGGTTAATGGTCA
GTTGGAAACCCTTTCCGCCGAGCAACGTGTCGAATGGGCGCTGGAGCATTTGCCGGGCGAGTTTGTACTCTCTTCAAGTT
TTGGCATTCAGGCGGCGGTGTGTTTGCACTTGGTGACCAGGATCAAACCGGATATCCCGGTGATCCTCACCGATACCGGC
TACCTGTTCCCGGAAACCTATCAGTTTATCGATCAATTGGCCGACAAGCTGAAGTTGAACCTGCAGGTGTTCCGCGCCGA
GCAGTCGCCTGCCTGGCAGGAGGCACGCTACGGCAAACTGTGGGAGCAGGGCGTTGAGGGCATTGAGAAATACAACCAAA
TCAACAAGGTTGAGCCGATGAATCGCGCGCTGGAAACCCTCGGCGGGCAGACCTGGTTCGCCGGCCTGCGTCGCGAACAA
TCGGGCAGTCGTGCTCACTTGCCGGTGTTGGCAGTGCAGCGCGGAGTGTTCAAGATCCTGCCGATTATCGACTGGGACAA
CCGAAAAATATATCAATACCTGACCGAGCACGGCCTGAGTTACCACCCGCTGTGGGAGCAAGGCTATCTGTCGGTAGGAG
ATACCCACACTACGCAGAAATGGGAACCGGGCATGAGCGAGGAAGAAACCCGCTTCTTCGGCCTGAAGCGTGAGTGCGGC
CTGCACGAAGGCTAA

Upstream 100 bases:

>100_bases
TCGATCCGGCGCAGGATTTCTGGGACTGACGCCATTTGGCCCCGCTGGTACAGGGGGCTGGATCTGCGCGGTATGATTCA
AGCATCAGGAGGCAGGCAAC

Downstream 100 bases:

>100_bases
TGTGTCAATCAAACTTCCAAGGGCTCAGCATTGGCTGGGCCCTTGTTAATTTAGCAGCATATGTCGCCAGAGTGCCGCAC
CGATATCTTGGCGGGTATGT

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAEFNLAELNALPKSGQALSLAVVNGQLETLSAEQRVEWALEHLPGEFVLSSSFGIQAAVCLHLVTRIKPDIPVILTDTG
YLFPETYQFIDQLADKLKLNLQVFRAEQSPAWQEARYGKLWEQGVEGIEKYNQINKVEPMNRALETLGGQTWFAGLRREQ
SGSRAHLPVLAVQRGVFKILPIIDWDNRKIYQYLTEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECG
LHEG

Sequences:

>Translated_244_residues
MAEFNLAELNALPKSGQALSLAVVNGQLETLSAEQRVEWALEHLPGEFVLSSSFGIQAAVCLHLVTRIKPDIPVILTDTG
YLFPETYQFIDQLADKLKLNLQVFRAEQSPAWQEARYGKLWEQGVEGIEKYNQINKVEPMNRALETLGGQTWFAGLRREQ
SGSRAHLPVLAVQRGVFKILPIIDWDNRKIYQYLTEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECG
LHEG
>Mature_243_residues
AEFNLAELNALPKSGQALSLAVVNGQLETLSAEQRVEWALEHLPGEFVLSSSFGIQAAVCLHLVTRIKPDIPVILTDTGY
LFPETYQFIDQLADKLKLNLQVFRAEQSPAWQEARYGKLWEQGVEGIEKYNQINKVEPMNRALETLGGQTWFAGLRREQS
GSRAHLPVLAVQRGVFKILPIIDWDNRKIYQYLTEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECGL
HEG

Specific function: Reduction of activated sulfate into sulfite

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily

Homologues:

Organism=Escherichia coli, GI1789121, Length=244, Percent_Identity=79.0983606557377, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6325425, Length=234, Percent_Identity=29.9145299145299, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSH_SERP5 (A8G9X8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477046.1
- ProteinModelPortal:   A8G9X8
- SMR:   A8G9X8
- STRING:   A8G9X8
- GeneID:   5603585
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0812
- eggNOG:   COG0175
- HOGENOM:   HBG758022
- OMA:   QVNPSAK
- ProtClustDB:   PRK02090
- BioCyc:   SPRO399741:SPRO_0812-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00063
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR011800
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00434
- TIGRFAMs:   TIGR02057

Pfam domain/function: PF01507 PAPS_reduct

EC number: =1.8.4.8

Molecular weight: Translated: 27755; Mature: 27624

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFNLAELNALPKSGQALSLAVVNGQLETLSAEQRVEWALEHLPGEFVLSSSFGIQAAV
CCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
CLHLVTRIKPDIPVILTDTGYLFPETYQFIDQLADKLKLNLQVFRAEQSPAWQEARYGKL
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHH
WEQGVEGIEKYNQINKVEPMNRALETLGGQTWFAGLRREQSGSRAHLPVLAVQRGVFKIL
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
PIIDWDNRKIYQYLTEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECG
CEEECCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHCCHHHCC
LHEG
CCCC
>Mature Secondary Structure 
AEFNLAELNALPKSGQALSLAVVNGQLETLSAEQRVEWALEHLPGEFVLSSSFGIQAAV
CCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
CLHLVTRIKPDIPVILTDTGYLFPETYQFIDQLADKLKLNLQVFRAEQSPAWQEARYGKL
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHH
WEQGVEGIEKYNQINKVEPMNRALETLGGQTWFAGLRREQSGSRAHLPVLAVQRGVFKIL
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
PIIDWDNRKIYQYLTEHGLSYHPLWEQGYLSVGDTHTTQKWEPGMSEEETRFFGLKRECG
CEEECCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHCCHHHCC
LHEG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA