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The map label for this gene is mazG [H]

Identifier: 157369038

GI number: 157369038

Start: 885228

End: 886022

Strand: Direct

Name: mazG [H]

Synonym: Spro_0793

Alternate gene names: 157369038

Gene position: 885228-886022 (Clockwise)

Preceding gene: 157369037

Following gene: 157369039

Centisome position: 16.25

GC content: 57.23

Gene sequence:

>795_bases
ATGACCCAATCTTCTCCGTTACAACGCTTGCTGAACATCATGAGAACGCTGCGCGATCCGCAGGCCGGTTGCCCGTGGGA
CCGCAAGCAGACCTTTGCCACTATCGCCCCTTACACGCTGGAAGAAACCTATGAGGTGCTGGATGCCATAGAGCGCCAGG
ACTACGGCGATCTTCGTGACGAACTGGGTGACCTGCTGTTCCAGGTGGTGTTTTACGCCCAGATGGGCCAGGAGCAGGGG
CTGTTTGACTTCGACGAGGTATGCAATGCCATCAGCGACAAGCTGGAACGCCGTCATCCGCATATCTTTGGCGAAGCCGA
TGCAGCAGACAGTGAGGCCGTTGCGGCGCGCTGGGAGCAACTGAAAGCCGGTGAACGCGCCGAGAAAGAGCTGCATTCGG
CGTTGGATGATATTCCGCAGGCGCTGCCGGCGTTGATGAAGGCGCATAAAATCCAAAAACGTTGCGCCTCGGTCGGTTTC
GACTGGCACACCCTGGGGCCGGTGCTGGACAAGGTGTACGAAGAGATCGACGAAGTGATGCATGAAGCGCGGCAGGCGGT
GGTCGACGAACAGAAGCTGGAAGAGGAAATCGGCGATTTGCTGTTCGCCACGGTGAATTTATCGCGTCATCTTGGCCATA
AGGCAGAAAACGCGCTACAGGCCGCCAATCGCAAGTTCGAACGCCGTTTCCGTCAGGTGGAAGAGATTGTCAAACAGCGC
GGGCTACAGATGGGCGAAGCTACGCTGGAGCAGATGGAAGAGGCGTGGCAACAGGTTAAACGCCAGGAAAACTAA

Upstream 100 bases:

>100_bases
GCCGGACGTGATTGATGCCAAACGACTGCACGGCAGTTAACCTTACATTTTTTATCGCGGGGCCCATATATTGGGCCTCG
CTCGTTTCAGAGACTTCGTC

Downstream 100 bases:

>100_bases
TCAGCAGCAGTGCTGTCCTATGATTATCGCAATGTTGATCGGCGACAAGATTTACGCAAGCTGAAACGGTTAAGCTCAGG
GTCATGGTTTGCTGAACTGT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTQSSPLQRLLNIMRTLRDPQAGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRDELGDLLFQVVFYAQMGQEQG
LFDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQLKAGERAEKELHSALDDIPQALPALMKAHKIQKRCASVGF
DWHTLGPVLDKVYEEIDEVMHEARQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIVKQR
GLQMGEATLEQMEEAWQQVKRQEN

Sequences:

>Translated_264_residues
MTQSSPLQRLLNIMRTLRDPQAGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRDELGDLLFQVVFYAQMGQEQG
LFDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQLKAGERAEKELHSALDDIPQALPALMKAHKIQKRCASVGF
DWHTLGPVLDKVYEEIDEVMHEARQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIVKQR
GLQMGEATLEQMEEAWQQVKRQEN
>Mature_263_residues
TQSSPLQRLLNIMRTLRDPQAGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRDELGDLLFQVVFYAQMGQEQGL
FDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQLKAGERAEKELHSALDDIPQALPALMKAHKIQKRCASVGFD
WHTLGPVLDKVYEEIDEVMHEARQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIVKQRG
LQMGEATLEQMEEAWQQVKRQEN

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=75.0972762645914, Blast_Score=406, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30405; Mature: 30273

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSSPLQRLLNIMRTLRDPQAGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRD
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ELGDLLFQVVFYAQMGQEQGLFDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LKAGERAEKELHSALDDIPQALPALMKAHKIQKRCASVGFDWHTLGPVLDKVYEEIDEVM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HEARQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIVKQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLQMGEATLEQMEEAWQQVKRQEN
CCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQSSPLQRLLNIMRTLRDPQAGCPWDRKQTFATIAPYTLEETYEVLDAIERQDYGDLRD
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
ELGDLLFQVVFYAQMGQEQGLFDFDEVCNAISDKLERRHPHIFGEADAADSEAVAARWEQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LKAGERAEKELHSALDDIPQALPALMKAHKIQKRCASVGFDWHTLGPVLDKVYEEIDEVM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HEARQAVVDEQKLEEEIGDLLFATVNLSRHLGHKAENALQAANRKFERRFRQVEEIVKQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLQMGEATLEQMEEAWQQVKRQEN
CCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]