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The map label for this gene is relA [H]

Identifier: 157369037

GI number: 157369037

Start: 882936

End: 885167

Strand: Direct

Name: relA [H]

Synonym: Spro_0792

Alternate gene names: 157369037

Gene position: 882936-885167 (Clockwise)

Preceding gene: 157369036

Following gene: 157369038

Centisome position: 16.2

GC content: 58.33

Gene sequence:

>2232_bases
ATGGTTGCGGTAAGAAGTGCACATCTGAACACGGCTGGCGAATTTGCTCTCGACGAGTGGATTGCCAGCTTGGGGCTACC
TAACCCGCAGTCATGTGAGCGATTAGCCGCAACCTGGCGCTACTGTGAGCAACAGACTCAGAACCATCCCAACGCGTCGC
TGTTACTGTGGCGCGGGCTGGAAATGGTGGAAATCCTCTCCACCCTGAGCATGGACAACGACAGCATGCGCGCCGCGCTG
CTGTTCCCGTTGGTGGATGCCGGTATCGTGGATGAAGAAACCCTGACCGAAGCCTTCGGCAAGGGCATCACCTACCTGGT
ACATGGCGTACGCGATATGGACGCCATCCGCCAACTGAAAGCCACCCAAAACGATTCAATGGCCTCCGAACAGGTCGACA
ACGTGCGCCGCATGCTGTTGGCGATGGTGGAGGATTTCCGCTGCGTGGTGATCAAGCTGGCGGAGCGTATCGCCCACCTG
CGTGAAGTGAAAGACGCGCCGGAAGACGAACGCGTCCTGGCGGCCAAAGAGTGTTCGAATATTTATGCGCCACTGGCCAA
CCGTCTCGGTATCGGCCAACTGAAATGGGAGCTGGAAGATTTCTGCTTCCGTTACCTGCACCCGGACGAATACAAACGCA
TCGCCAAGCTGCTGCATGAGCGCCGTATCGATCGCGAACAGTTTATCGATGATTTCGTCGCCTCGCTGCGTAATGCGATG
GTCGATGAAGGCGTCAAGGCGGACATCTACGGCCGTCCAAAACATATCTACAGCATCTGGCGCAAGATGCAGAAGAAGGC
GCTGGCGTTTGACGAGCTGTTTGACGTGCGCGCGGTGCGTGTGGTGGTCGAGCGCTTGCAGGACTGCTATGCGGCGCTGG
GGATTGTGCATACCCACTTCCGCCATCTGCCGGATGAGTTCGACGACTATGTCGCCAACCCGAAACCCAACGGTTACCAG
TCGATCCACACCGTGGTTCTGGGGCCACGCGGTAAAACGCTCGAGATCCAGATCCGTACCCGCCAGATGCATGAAGACGC
CGAACTGGGCGTGGCCGCGCACTGGAAATACAAAGAGGGTGCGGTTGCGACGGTACGTTCCGGCTATGAAGAACGCATCG
CCTGGCTACGCAAACTGATCGCCTGGCAGGAAGAGATGGCGGATTCCGGCGAAATGCTCGACGAGGTTCGCAGCCAGGTG
TTCGACGATCGGGTTTACGTGTTTACCCCGAAAGGCGACGTGGTGGATCTGCCGGCCGGCTCCACGCCGCTCGACTTTGC
CTATCATATTCACAGCGACGTTGGCCACCGCTGCATCGGCGCCAAAATTGGTGGCCGTATCGTGCCCTTTACCTATCAGT
TGCGGATGGGCGATCAGATTGAAATCATCACCCAGAAGCAGCCGAACCCAAGCCGCGACTGGCTGAACCCGAACCTGGGC
TATGTCACCACCAGCCGTGGGCGCTCCAAAATCCACAACTGGTTCCGCAAGCAGGATCGCGACAAGAACATCCTGGCCGG
TCGCCAAATGCTGGACAGCGAGCTGGAGCACCTCGGTATCAGCCTGAAAGAGGCCGAGAAACTGCTGATCCCGCGTTACA
ACATGAATTCGCTGGATGAAATACTGGCGGCGATTGGCGGCGGGGATATTCGCCTGAATCAGATGGTGAACTTCCTGCAG
GGTAAGTTCAACAAACCGAGTGCTGAGGAGCAGGATCGCGAAGCGTTGCGCCAGCTGGTGCAGCACAAAGCGCCGGCAGC
CACCCGCAGCAAGGACAACGGCCGGGTGGTGGTGGAAGGGGTAGGTAACCTGATGCACCACATTGCCCGCTGCTGCCAGC
CGATCCCGGGTGACGATATTATCGGCTTTATCACCCAGGGCCGCGGTATTTCGATCCACCGGGCAGACTGTGACCAACTG
GTGGATCTGCAGTCACACGCGCCGGAACGCATCGTTGACGCGGTGTGGGGCGAGAGCTATTCCAGCGGATACTCGCTGGT
GGTCCGCGTGATGGCCAACGATCGCAGTGGTCTGCTGCGCGACATCACCACCATTTTGGCCAACGAAAAGGTCAACGTGC
TGGGCGTGGCCAGCCGCAGCGACACCAAAAAGCAGTTGGCGACCATCGATATGGACATTGAAATCTACAACCAGCAGGTG
CTGGGCCGGGTATTGGCCAAGCTCAATCAACTGCCGGACGTGATTGATGCCAAACGACTGCACGGCAGTTAA

Upstream 100 bases:

>100_bases
GTGGATATTGGAGCGGTTTTCGCATACGGGGCATCTTGAGTCAATGGCGCTGTTGATTAACGGTTTTGCGCCAGAGGTCG
CTGCAAAGTAGGGAGAGGTT

Downstream 100 bases:

>100_bases
CCTTACATTTTTTATCGCGGGGCCCATATATTGGGCCTCGCTCGTTTCAGAGACTTCGTCATGACCCAATCTTCTCCGTT
ACAACGCTTGCTGAACATCA

Product: GDP/GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNASLLLWRGLEMVEILSTLSMDNDSMRAAL
LFPLVDAGIVDEETLTEAFGKGITYLVHGVRDMDAIRQLKATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHL
REVKDAPEDERVLAAKECSNIYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHFRHLPDEFDDYVANPKPNGYQ
SIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEGAVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQV
FDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
YVTTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDEILAAIGGGDIRLNQMVNFLQ
GKFNKPSAEEQDREALRQLVQHKAPAATRSKDNGRVVVEGVGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQL
VDLQSHAPERIVDAVWGESYSSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
LGRVLAKLNQLPDVIDAKRLHGS

Sequences:

>Translated_743_residues
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNASLLLWRGLEMVEILSTLSMDNDSMRAAL
LFPLVDAGIVDEETLTEAFGKGITYLVHGVRDMDAIRQLKATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHL
REVKDAPEDERVLAAKECSNIYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHFRHLPDEFDDYVANPKPNGYQ
SIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEGAVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQV
FDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
YVTTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDEILAAIGGGDIRLNQMVNFLQ
GKFNKPSAEEQDREALRQLVQHKAPAATRSKDNGRVVVEGVGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQL
VDLQSHAPERIVDAVWGESYSSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
LGRVLAKLNQLPDVIDAKRLHGS
>Mature_743_residues
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNASLLLWRGLEMVEILSTLSMDNDSMRAAL
LFPLVDAGIVDEETLTEAFGKGITYLVHGVRDMDAIRQLKATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHL
REVKDAPEDERVLAAKECSNIYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHFRHLPDEFDDYVANPKPNGYQ
SIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEGAVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQV
FDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
YVTTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDEILAAIGGGDIRLNQMVNFLQ
GKFNKPSAEEQDREALRQLVQHKAPAATRSKDNGRVVVEGVGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQL
VDLQSHAPERIVDAVWGESYSSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
LGRVLAKLNQLPDVIDAKRLHGS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=744, Percent_Identity=85.4838709677419, Blast_Score=1325, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=688, Percent_Identity=32.2674418604651, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84191; Mature: 84191

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNASLLLWRGL
CCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCH
EMVEILSTLSMDNDSMRAALLFPLVDAGIVDEETLTEAFGKGITYLVHGVRDMDAIRQLK
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECSN
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
HHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLPDEFDDYVANPKPNGYQSIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEG
HHCCHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHCCHHHCCEEEEEECCCC
AVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAG
CHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCEEECCCC
STPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
CCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
YVTTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDE
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
ILAAIGGGDIRLNQMVNFLQGKFNKPSAEEQDREALRQLVQHKAPAATRSKDNGRVVVEG
HHHHHCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHH
VGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQLVDLQSHAPERIVDAVWGESY
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCC
SSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHEECHHHHHHHHH
LGRVLAKLNQLPDVIDAKRLHGS
HHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MVAVRSAHLNTAGEFALDEWIASLGLPNPQSCERLAATWRYCEQQTQNHPNASLLLWRGL
CCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCH
EMVEILSTLSMDNDSMRAALLFPLVDAGIVDEETLTEAFGKGITYLVHGVRDMDAIRQLK
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ATQNDSMASEQVDNVRRMLLAMVEDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECSN
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IYAPLANRLGIGQLKWELEDFCFRYLHPDEYKRIAKLLHERRIDREQFIDDFVASLRNAM
HHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VDEGVKADIYGRPKHIYSIWRKMQKKALAFDELFDVRAVRVVVERLQDCYAALGIVHTHF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLPDEFDDYVANPKPNGYQSIHTVVLGPRGKTLEIQIRTRQMHEDAELGVAAHWKYKEG
HHCCHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHCCHHHCCEEEEEECCCC
AVATVRSGYEERIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAG
CHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCEEECCCC
STPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLRMGDQIEIITQKQPNPSRDWLNPNLG
CCCCHHHHHHHHHHCCEEECCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
YVTTSRGRSKIHNWFRKQDRDKNILAGRQMLDSELEHLGISLKEAEKLLIPRYNMNSLDE
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
ILAAIGGGDIRLNQMVNFLQGKFNKPSAEEQDREALRQLVQHKAPAATRSKDNGRVVVEG
HHHHHCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHH
VGNLMHHIARCCQPIPGDDIIGFITQGRGISIHRADCDQLVDLQSHAPERIVDAVWGESY
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCHHHHHHHHHCCHHHHHHHHHCCCC
SSGYSLVVRVMANDRSGLLRDITTILANEKVNVLGVASRSDTKKQLATIDMDIEIYNQQV
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHEECHHHHHHHHH
LGRVLAKLNQLPDVIDAKRLHGS
HHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]