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The map label for this gene is lpxC [H]

Identifier: 157369012

GI number: 157369012

Start: 856514

End: 857479

Strand: Direct

Name: lpxC [H]

Synonym: Spro_0767

Alternate gene names: 157369012

Gene position: 856514-857479 (Clockwise)

Preceding gene: 157369011

Following gene: 157369014

Centisome position: 15.72

GC content: 53.21

Gene sequence:

>966_bases
ATGCTGTATGCTTGGTCGGTAGGATTGATAACATTGCGAGATAAAACGATGATCAAACAACGGACATTAAAACGTATTGT
TCAGGCGACTGGTGTCGGTTTGCATACCGGCAAGAAAGTCACGCTGACAATGCGCCCCGCAGCGGCTAATACCGGGGTCA
TCTATCGTCGCACTGACTTGAATCCCCCGGTTGATTTTCCGGCTGATGCAAAATCCGTGCGTGATACCATGCTGTGCACC
TGCCTGGTGAACGAGCATGACGTGCGTATTTCTACCGTTGAGCATCTTAATGCCGCGCTGGCTGGTTTGGGTATCGACAA
CATCGTTATCGAAGTTGACGCCGCCGAAATTCCTATCATGGACGGCAGTGCCAGCCCGTTCGTCTTCCTGTTGCTGGATG
CCGGCATTGAAGAACTGAACTCTGCGAAGAAATTCCTGCGTCTGAAAGACACCGTGCGTGTTGAAGATGGCGACAAGTGG
GCCGAGCTGTCCCCGCATAACGGGTTCCGCCTGGACTTCACCATCGACTTCAACCACCCGGCTATCGATGCCAGTACGCA
ACGCTACCGCCTTGATTTTTCTGCCGACTCGTTCGTGCGTCAAATCAGTCGTGCGCGCACCTTCGGTTTTATGCGTGACA
TCGAGTATTTACAGTCACGTGGCCTGGCCCTGGGTGGCAGCTTTGACTGCGCTATCGTGGTGGATGATTACCGCGTTCTG
AACGAAGACGGCCTGCGCTTTGAAGACGAATTCGTACGCCACAAAATGCTGGACGCCATCGGCGACCTGTTCATGTGCGG
CCATAACATCATTGGCGCATTCACCGCGTACAAGTCTGGTCATGCGCTGAATAACAAACTGCTGCAAGCGGTTCTGGCGA
AACAGGAAGCGTGGGAATTTGTCACCTTCCAGGACGAAGCCGAAATGCCTTTGGCATTCAAAGCCCCGTCCACCGTATTG
GCATAA

Upstream 100 bases:

>100_bases
GACTATCTCGATATTCCTGCCTTCCTGCGCAAGCAGGCAGACTAAGAATATCCTGAGAATTTGGAATCTCCGCTCTTTGT
GCTAAACTGTCCCGCCGGCC

Downstream 100 bases:

>100_bases
GCTGATACCACTGATTATTTATCACGACTGGTAGCGTTGGCACCTTCTCCGGCCAGCGATGCCAGTCGTTCCAATATCTT
GCGCAGTTTTTCTGGGCTCC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLYAWSVGLITLRDKTMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAAANTGVIYRRTDLNPPVDFPADAKSVRDTMLCT
CLVNEHDVRISTVEHLNAALAGLGIDNIVIEVDAAEIPIMDGSASPFVFLLLDAGIEELNSAKKFLRLKDTVRVEDGDKW
AELSPHNGFRLDFTIDFNHPAIDASTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLALGGSFDCAIVVDDYRVL
NEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVL
A

Sequences:

>Translated_321_residues
MLYAWSVGLITLRDKTMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAAANTGVIYRRTDLNPPVDFPADAKSVRDTMLCT
CLVNEHDVRISTVEHLNAALAGLGIDNIVIEVDAAEIPIMDGSASPFVFLLLDAGIEELNSAKKFLRLKDTVRVEDGDKW
AELSPHNGFRLDFTIDFNHPAIDASTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLALGGSFDCAIVVDDYRVL
NEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVL
A
>Mature_321_residues
MLYAWSVGLITLRDKTMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAAANTGVIYRRTDLNPPVDFPADAKSVRDTMLCT
CLVNEHDVRISTVEHLNAALAGLGIDNIVIEVDAAEIPIMDGSASPFVFLLLDAGIEELNSAKKFLRLKDTVRVEDGDKW
AELSPHNGFRLDFTIDFNHPAIDASTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLALGGSFDCAIVVDDYRVL
NEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVL
A

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=91.1475409836066, Blast_Score=587, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 35775; Mature: 35775

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYAWSVGLITLRDKTMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAAANTGVIYRRTDL
CEEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCC
NPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVDAAEIPIM
CCCCCCCCCHHHHHHHEEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEEECCEEEEE
DGSASPFVFLLLDAGIEELNSAKKFLRLKDTVRVEDGDKWAELSPHNGFRLDFTIDFNHP
CCCCCCEEEEEEHHCHHHHHHHHHHHHHHCEEEECCCCCEEECCCCCCEEEEEEEECCCC
AIDASTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLALGGSFDCAIVVDDYRVL
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECEEEE
NEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEE
VTFQDEAEMPLAFKAPSTVLA
EEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MLYAWSVGLITLRDKTMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAAANTGVIYRRTDL
CEEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCC
NPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVDAAEIPIM
CCCCCCCCCHHHHHHHEEEEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEEEECCEEEEE
DGSASPFVFLLLDAGIEELNSAKKFLRLKDTVRVEDGDKWAELSPHNGFRLDFTIDFNHP
CCCCCCEEEEEEHHCHHHHHHHHHHHHHHCEEEECCCCCEEECCCCCCEEEEEEEECCCC
AIDASTQRYRLDFSADSFVRQISRARTFGFMRDIEYLQSRGLALGGSFDCAIVVDDYRVL
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECEEEE
NEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEE
VTFQDEAEMPLAFKAPSTVLA
EEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA