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The map label for this gene is hexR [H]

Identifier: 157368795

GI number: 157368795

Start: 608628

End: 609491

Strand: Direct

Name: hexR [H]

Synonym: Spro_0550

Alternate gene names: 157368795

Gene position: 608628-609491 (Clockwise)

Preceding gene: 157368783

Following gene: 157368796

Centisome position: 11.17

GC content: 60.07

Gene sequence:

>864_bases
ATGGGTGTTGAAATCGACATTATCTCGCGCATTACGGAGCGTTTTATCGAGCTGAGCAGCGCCGAAAAACGCATCGCACA
ATTCATTCTGGATGATGCGGAGGCGGTGACTGCCCTGCCGATTGCCGAATTGGCCCGGCAGGCTAACGTTAGCCAGGCTT
CGATCACTCGTTTCGCCAAAGCGCTGGGCTGCCGGGACGTGCGTGACCTTAAGGTCAAGCTGGTGCAGTCGCTGGCGGTG
GGGCAACGCTTCATTCACGAAGAGCCGGACCTCGAAGGAATTCAGGGGATTTATGAAAGCATCATCAATGTCCTGAATAT
AAATCGGCGGAGCCTCGATGACGCAGCGCTGGCCAAGGCGGTGGAGTTACTCAGTGGTGCACGACAAATTGTGGCGATGG
GTATGGGCGGCGGCTCGACCCTCTGCGCAGCAGAGATCCAGCATCGGCTGTTTCGTCTGGGGTTGCCGGTGACGGCACAA
AGTGATGGCTTGCTGGTGCGCATGATGGCGGCGGTGGTGAGCCGGCAGGATGTGGTGGTGGCGCTGTCACTGGGCGGCTA
CACGCAGGAAGTGGTGGAAAGTGCCGCCATTGCCCGCCAGTACGGGGCCAAAGTGGTGGTGATTGCTCCCGCCGGAACGC
CACTGGCGGCGCAGGCTGACGTGCTGTTGGCGTTGGTGGTGCAGGAAAATGATTACATCTACAAACCCAGCAGCTCGCGC
TACGCCATGCTGGCGATGGTGGACGTGCTGGCGACGGCGCTGGCCATGGCAAATAAACGCCAGTCCAGAGATCGGCTACG
CCGCATCAAGCTGGCGCTGGACAGCCATCGCGGAGGGGCCGATCGGCAACCATTGGGTGACTGA

Upstream 100 bases:

>100_bases
GTTGGGTACAAAGTATCATTTTTAGAACTGTTTTTTGTGTAGTCTTCCACTGTTTTCTTGCATTGTAAATGACAAAATTT
AACCACTATGAGGTCAGGCG

Downstream 100 bases:

>100_bases
GCAGGTCCCACAGACAATAACGGAAGGATAATGATTCATGCGGTATCAGTATCTGTTTAAAAATGTCACGGTGATCGACG
GCAGCGGTGGGCCACAGTAC

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MGVEIDIISRITERFIELSSAEKRIAQFILDDAEAVTALPIAELARQANVSQASITRFAKALGCRDVRDLKVKLVQSLAV
GQRFIHEEPDLEGIQGIYESIINVLNINRRSLDDAALAKAVELLSGARQIVAMGMGGGSTLCAAEIQHRLFRLGLPVTAQ
SDGLLVRMMAAVVSRQDVVVALSLGGYTQEVVESAAIARQYGAKVVVIAPAGTPLAAQADVLLALVVQENDYIYKPSSSR
YAMLAMVDVLATALAMANKRQSRDRLRRIKLALDSHRGGADRQPLGD

Sequences:

>Translated_287_residues
MGVEIDIISRITERFIELSSAEKRIAQFILDDAEAVTALPIAELARQANVSQASITRFAKALGCRDVRDLKVKLVQSLAV
GQRFIHEEPDLEGIQGIYESIINVLNINRRSLDDAALAKAVELLSGARQIVAMGMGGGSTLCAAEIQHRLFRLGLPVTAQ
SDGLLVRMMAAVVSRQDVVVALSLGGYTQEVVESAAIARQYGAKVVVIAPAGTPLAAQADVLLALVVQENDYIYKPSSSR
YAMLAMVDVLATALAMANKRQSRDRLRRIKLALDSHRGGADRQPLGD
>Mature_286_residues
GVEIDIISRITERFIELSSAEKRIAQFILDDAEAVTALPIAELARQANVSQASITRFAKALGCRDVRDLKVKLVQSLAVG
QRFIHEEPDLEGIQGIYESIINVLNINRRSLDDAALAKAVELLSGARQIVAMGMGGGSTLCAAEIQHRLFRLGLPVTAQS
DGLLVRMMAAVVSRQDVVVALSLGGYTQEVVESAAIARQYGAKVVVIAPAGTPLAAQADVLLALVVQENDYIYKPSSSRY
AMLAMVDVLATALAMANKRQSRDRLRRIKLALDSHRGGADRQPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=287, Percent_Identity=35.8885017421603, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082369, Length=271, Percent_Identity=24.3542435424354, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788767, Length=279, Percent_Identity=25.089605734767, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082130, Length=276, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30930; Mature: 30799

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVEIDIISRITERFIELSSAEKRIAQFILDDAEAVTALPIAELARQANVSQASITRFAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALGCRDVRDLKVKLVQSLAVGQRFIHEEPDLEGIQGIYESIINVLNINRRSLDDAALAKA
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VELLSGARQIVAMGMGGGSTLCAAEIQHRLFRLGLPVTAQSDGLLVRMMAAVVSRQDVVV
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEE
ALSLGGYTQEVVESAAIARQYGAKVVVIAPAGTPLAAQADVLLALVVQENDYIYKPSSSR
EEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEECCCEEECCCCCC
YAMLAMVDVLATALAMANKRQSRDRLRRIKLALDSHRGGADRQPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GVEIDIISRITERFIELSSAEKRIAQFILDDAEAVTALPIAELARQANVSQASITRFAK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALGCRDVRDLKVKLVQSLAVGQRFIHEEPDLEGIQGIYESIINVLNINRRSLDDAALAKA
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VELLSGARQIVAMGMGGGSTLCAAEIQHRLFRLGLPVTAQSDGLLVRMMAAVVSRQDVVV
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEE
ALSLGGYTQEVVESAAIARQYGAKVVVIAPAGTPLAAQADVLLALVVQENDYIYKPSSSR
EEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEECCCEEECCCCCC
YAMLAMVDVLATALAMANKRQSRDRLRRIKLALDSHRGGADRQPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]