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The map label for this gene is acs

Identifier: 157368546

GI number: 157368546

Start: 349967

End: 351925

Strand: Reverse

Name: acs

Synonym: Spro_0297

Alternate gene names: 157368546

Gene position: 351925-349967 (Counterclockwise)

Preceding gene: 157368548

Following gene: 157368545

Centisome position: 6.46

GC content: 56.41

Gene sequence:

>1959_bases
ATGAGCCAAGTGCATAAACACGCTATTCCTTCTGCAATTGCAGAACACGCCCTGATTAATCCGACGCAATATCAACAATA
TTATCAACAGTCTGTGCAAGACCCGGAAACGTTTTGGGGCGAGCAGGGAAAAATCCTGGACTGGATAAAACCTTATAGCC
GGGTGAAAAACACCTCGTTCGATCCAGGCCATATCAGCATTCGCTGGTTTGAAGACGGCACCCTTAACCTGGCGGCCAAC
TGCCTCGATCGCCACTTGGCCGAACGCGGCGACCAAACCGCCATTATCTGGGAAGGTGACGATCCCACCCAGTCAAAACA
GGTGACCTACAAACAACTGCACCACGATGTCTGCCAATTCGCCAACGTGCTGAAAAAGCTGGGCGTCAAGAAAGGCGACG
TCGTGGCGATCTATATGCCCATGGTGCCGGAAGCCGCTGTCGCCATGCTGGCCTGCGCCCGTATCGGGGCCGTGCATTCG
GTGATCTTTGGTGGTTTCTCGCCGGAAGCCGTAGCCGGACGTATTATCGATTCCAACTCTAAACTGGTTATCACCGCCGA
CGAAGGCCTGCGCGCCGGGCGTGCCGTTCCGCTGAAGAAAAACGTCGATGACGCGCTGAAAAATCCAGGCGTGAAAAGCA
TCACCAACGTGGTGGTATTCCAGCGTACCGGCAAACCGGGTTACTGGCAGGAAGGCCGCGATCTGTGGTGGCATGAACTG
ACTGCGGGGGTTTCCGCCGACTGCCCACCAGAAGAGATGAATGCGGAAGACCCGCTGTTTATCCTTTATACCTCCGGCTC
GACCGGTAAACCCAAGGGCGTGCTGCACACCACCGGCGGTTATCTGGTGTATGCCGCCATGACCTTTAAATACGTATTCG
ATTACCACGACGGCGACGTGTACTGGTGTACCGCCGACGTCGGTTGGGTCACCGGCCATAGCTATCTGCTGTACGGCCCG
CTGGCCTGCGGTGCCATTACCCTGATGTTTGAAGGGGTGCCGAACTACCCTGGCGTTAACCGTCTGTCACAGGTGATCGA
CAAGCACCAGGTCAATATCCTGTATACCGCCCCTACTGCCATTCGTGCCCTGATGGCCGAAGGTGACAAGGCGATCGAAG
GCACCAAACGCGATTCGCTGCGCATCATGGGCTCGGTCGGCGAGCCGATCAACCCGGAAGCCTGGGAGTGGTATTACAAT
AAAATCGGCAACGCCAAATGCCCGATCGTCGACACCTGGTGGCAGACCGAAACCGGCGGCTTTATGATCACTCCGCTGCC
CGGTGCCACCGAGTTGAAAGCCGGTTCCGCTACGCGGCCGTTCTTCGGTGTTCAACCGGCACTGGTCGATAATATCGGCA
CTGTGCAGGAGGGCGCCTGTGAAGGCAACCTGGTGATCACCGACTCCTGGCCAGGCCAGGCTCGCACGTTGTTCGGTGAC
CACGATCGTTTCGAACAAACCTACTTCTCCACCTTTAAGGGCATGTATTTCAGCGGTGACGGCGCACGCCGTGATGAAGA
CGGATACTACTGGATCACTGGCCGTGTCGATGACGTGCTTAACGTCTCCGGTCACCGTCTGGGCACCGCCGAGATTGAGT
CGGCCCTGGTTTCCCACCCGAAAATCGCCGAAGCGGCGGTGGTCGGCATCCCTCATAACATCAAGGGCCAGGCGATTTAC
GCCTATATCACACTGAACCACGGTGAAGAACCGACGCCTGAGCTATATACCGAAGTACGTAACTGGGTACGTAAAGAAAT
AGGACCGATCGCCACGCCGGACGTGCTGCACTGGACAGACTCCCTGCCAAAAACGCGTTCCGGCAAGATCATGCGTCGCA
TCCTGCGGAAAATTGCCGCCGGTGATACCAGCAATTTGGGAGATACCTCAACGCTGGCGGATCCGGCCGTAGTCGACAAG
CTGTTGGAAGAAAAACAATCAATGAAAGTTCCGTCGTAA

Upstream 100 bases:

>100_bases
TCGTTGCGTGATCTGCCGCCCAAAAAAGAAACAAAGAATCGGAGCAAACTATACTTAACCTCTAGTTGACATATTATTAA
CAACTTCAAGGAGAAAAGCC

Downstream 100 bases:

>100_bases
TTTCCGCCGCCTCAGGCCGATCAGCGGGAAAATAACCCGGTGATCGGCATCAAGCGCGGCGTACTCTATCAATACCTACT
GGAGATGCTCTGATGAATGA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSQVHKHAIPSAIAEHALINPTQYQQYYQQSVQDPETFWGEQGKILDWIKPYSRVKNTSFDPGHISIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPTQSKQVTYKQLHHDVCQFANVLKKLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPEAVAGRIIDSNSKLVITADEGLRAGRAVPLKKNVDDALKNPGVKSITNVVVFQRTGKPGYWQEGRDLWWHEL
TAGVSADCPPEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYVFDYHDGDVYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVIDKHQVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNAKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNIGTVQEGACEGNLVITDSWPGQARTLFGD
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHPKIAEAAVVGIPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPAVVDK
LLEEKQSMKVPS

Sequences:

>Translated_652_residues
MSQVHKHAIPSAIAEHALINPTQYQQYYQQSVQDPETFWGEQGKILDWIKPYSRVKNTSFDPGHISIRWFEDGTLNLAAN
CLDRHLAERGDQTAIIWEGDDPTQSKQVTYKQLHHDVCQFANVLKKLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHS
VIFGGFSPEAVAGRIIDSNSKLVITADEGLRAGRAVPLKKNVDDALKNPGVKSITNVVVFQRTGKPGYWQEGRDLWWHEL
TAGVSADCPPEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYVFDYHDGDVYWCTADVGWVTGHSYLLYGP
LACGAITLMFEGVPNYPGVNRLSQVIDKHQVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYN
KIGNAKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNIGTVQEGACEGNLVITDSWPGQARTLFGD
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHPKIAEAAVVGIPHNIKGQAIY
AYITLNHGEEPTPELYTEVRNWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPAVVDK
LLEEKQSMKVPS
>Mature_651_residues
SQVHKHAIPSAIAEHALINPTQYQQYYQQSVQDPETFWGEQGKILDWIKPYSRVKNTSFDPGHISIRWFEDGTLNLAANC
LDRHLAERGDQTAIIWEGDDPTQSKQVTYKQLHHDVCQFANVLKKLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSV
IFGGFSPEAVAGRIIDSNSKLVITADEGLRAGRAVPLKKNVDDALKNPGVKSITNVVVFQRTGKPGYWQEGRDLWWHELT
AGVSADCPPEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYVFDYHDGDVYWCTADVGWVTGHSYLLYGPL
ACGAITLMFEGVPNYPGVNRLSQVIDKHQVNILYTAPTAIRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNK
IGNAKCPIVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNIGTVQEGACEGNLVITDSWPGQARTLFGDH
DRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHPKIAEAAVVGIPHNIKGQAIYA
YITLNHGEEPTPELYTEVRNWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPAVVDKL
LEEKQSMKVPS

Specific function: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=52.1739130434783, Blast_Score=701, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=51.1764705882353, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=634, Percent_Identity=48.1072555205047, Blast_Score=624, Evalue=1e-179,
Organism=Homo sapiens, GI13375727, Length=637, Percent_Identity=37.519623233909, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI122937307, Length=562, Percent_Identity=28.2918149466192, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI42544132, Length=554, Percent_Identity=28.7003610108303, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI38505220, Length=517, Percent_Identity=29.9806576402321, Blast_Score=186, Evalue=9e-47,
Organism=Homo sapiens, GI31982927, Length=649, Percent_Identity=25.115562403698, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI115511026, Length=573, Percent_Identity=27.7486910994764, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI58082049, Length=572, Percent_Identity=25.3496503496504, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI157311624, Length=572, Percent_Identity=24.4755244755245, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI157311622, Length=572, Percent_Identity=24.4755244755245, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI187761345, Length=401, Percent_Identity=27.6807980049875, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI187761343, Length=401, Percent_Identity=27.6807980049875, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI42544134, Length=371, Percent_Identity=25.3369272237197, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI195947378, Length=467, Percent_Identity=25.2676659528908, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI156151445, Length=387, Percent_Identity=27.1317829457364, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790505, Length=652, Percent_Identity=84.6625766871166, Blast_Score=1169, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=643, Percent_Identity=36.0808709175739, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788107, Length=567, Percent_Identity=23.6331569664903, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI221142682, Length=532, Percent_Identity=23.8721804511278, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI145693145, Length=513, Percent_Identity=23.3918128654971, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786810, Length=563, Percent_Identity=23.6234458259325, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71983001, Length=640, Percent_Identity=49.6875, Blast_Score=626, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71982997, Length=640, Percent_Identity=49.6875, Blast_Score=626, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17569507, Length=636, Percent_Identity=21.2264150943396, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557194, Length=582, Percent_Identity=25.085910652921, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=576, Percent_Identity=25.5208333333333, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=585, Percent_Identity=24.1025641025641, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=550, Percent_Identity=23.2727272727273, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=543, Percent_Identity=22.4677716390424, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323182, Length=636, Percent_Identity=49.685534591195, Blast_Score=637, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=637, Percent_Identity=47.8806907378336, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319699, Length=378, Percent_Identity=25.1322751322751, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=654, Percent_Identity=53.0581039755352, Blast_Score=691, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.6939501779359, Blast_Score=633, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=55.9615384615385, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI21355225, Length=616, Percent_Identity=35.3896103896104, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=24.5353159851301, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24656500, Length=530, Percent_Identity=23.0188679245283, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581924, Length=560, Percent_Identity=20.8928571428571, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_SERP5 (A8G8G7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476535.1
- ProteinModelPortal:   A8G8G7
- SMR:   A8G8G7
- STRING:   A8G8G7
- GeneID:   5607236
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0297
- eggNOG:   COG0365
- HOGENOM:   HBG547964
- OMA:   ETASEHC
- ProtClustDB:   PRK00174
- BioCyc:   SPRO399741:SPRO_0297-MONOMER
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 71934; Mature: 71803

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVHKHAIPSAIAEHALINPTQYQQYYQQSVQDPETFWGEQGKILDWIKPYSRVKNTSF
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCC
DPGHISIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPTQSKQVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
ANVLKKLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNS
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCC
KLVITADEGLRAGRAVPLKKNVDDALKNPGVKSITNVVVFQRTGKPGYWQEGRDLWWHEL
EEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHEEEEEEEECCCCCCCCCCCHHHHHHH
TAGVSADCPPEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYVFDYHDGDV
HCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHEEEEEEEEEEECCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVIDKHQVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNAKCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNIGTVQEGACEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEECCC
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGIPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPIATPDVLHWTD
CHHCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCC
SLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPAVVDKLLEEKQSMKVPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQVHKHAIPSAIAEHALINPTQYQQYYQQSVQDPETFWGEQGKILDWIKPYSRVKNTSF
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCC
DPGHISIRWFEDGTLNLAANCLDRHLAERGDQTAIIWEGDDPTQSKQVTYKQLHHDVCQF
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
ANVLKKLGVKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNS
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCC
KLVITADEGLRAGRAVPLKKNVDDALKNPGVKSITNVVVFQRTGKPGYWQEGRDLWWHEL
EEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHEEEEEEEECCCCCCCCCCCHHHHHHH
TAGVSADCPPEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYVFDYHDGDV
HCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEHEEEEEEEEEEECCCE
YWCTADVGWVTGHSYLLYGPLACGAITLMFEGVPNYPGVNRLSQVIDKHQVNILYTAPTA
EEEECCCCEECCCCEEEECCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGDKAIEGTKRDSLRIMGSVGEPINPEAWEWYYNKIGNAKCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
FMITPLPGATELKAGSATRPFFGVQPALVDNIGTVQEGACEGNLVITDSWPGQARTLFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEECCC
HDRFEQTYFSTFKGMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHP
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KIAEAAVVGIPHNIKGQAIYAYITLNHGEEPTPELYTEVRNWVRKEIGPIATPDVLHWTD
CHHCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCC
SLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPAVVDKLLEEKQSMKVPS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA