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The map label for this gene is fimB [H]

Identifier: 157368467

GI number: 157368467

Start: 246627

End: 247202

Strand: Reverse

Name: fimB [H]

Synonym: Spro_0218

Alternate gene names: 157368467

Gene position: 247202-246627 (Counterclockwise)

Preceding gene: 157368468

Following gene: 157368466

Centisome position: 4.54

GC content: 53.65

Gene sequence:

>576_bases
ATGAAAAAAAACGTGCGAAAGCACCTAACGCGCCCGGAAATCGAGCGCATGCTCGCCGCCGCCGACAGCATCCCCGACCC
GGAACGTAACACCTGCCTGCTATGGATGTGTTTTGTCCACGGCTGTCGGGTCAGCGAGCTGACCGGAATGCACCTGGCAG
ATCTTGATATAGCCGGCGACAGTCTGTATGTCCGGCGTCTTAAAAATGGCCTGTCAACCATGCAACCCCTGCATCCCATG
GAGCGGAAGTTACTGGCACGCTGGTTACAACGCAGACAAAGCTATCCGGGGGCAAAAGATTACGATTGGCTATTTTTATC
TCACAAGGGTGGGCGACTTTCCCGCTCACGCATTTATCGGATACTGAAGGATTTAGGGGAACGGGCAGGATTATCTATTG
CTGTGCATCCACACATGTTACGCCATGCCTGTGGCTACGCGTTGGCTGACAAGGGGGCAGATACCCGGTTGATTCAGGAC
TATCTCGGCCACCGCAACATTCAGCACACTGTGCTGTACACAGCCAGTAATGTGGGACGATTCAGGGCGTTATGGGGGGA
GGAAAATGTTACATAA

Upstream 100 bases:

>100_bases
GTTCCCCTAATTACCGACACAATCCGCCTGCATTTCCTATACTCTCCTGCCGACCCATTTCAGGGCCGGGTTTTCTCCAT
TACCGTCAACAGGAGCCATG

Downstream 100 bases:

>100_bases
TGAGCCAAAGTGTCACTATTCTAGAATTCCGCTCATAAAAGCGTCAAGATTTTTTTAAGACCCGCCGCAATTTAAAATTT
TTATCTTTTAATATCATTAA

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKKNVRKHLTRPEIERMLAAADSIPDPERNTCLLWMCFVHGCRVSELTGMHLADLDIAGDSLYVRRLKNGLSTMQPLHPM
ERKLLARWLQRRQSYPGAKDYDWLFLSHKGGRLSRSRIYRILKDLGERAGLSIAVHPHMLRHACGYALADKGADTRLIQD
YLGHRNIQHTVLYTASNVGRFRALWGEENVT

Sequences:

>Translated_191_residues
MKKNVRKHLTRPEIERMLAAADSIPDPERNTCLLWMCFVHGCRVSELTGMHLADLDIAGDSLYVRRLKNGLSTMQPLHPM
ERKLLARWLQRRQSYPGAKDYDWLFLSHKGGRLSRSRIYRILKDLGERAGLSIAVHPHMLRHACGYALADKGADTRLIQD
YLGHRNIQHTVLYTASNVGRFRALWGEENVT
>Mature_191_residues
MKKNVRKHLTRPEIERMLAAADSIPDPERNTCLLWMCFVHGCRVSELTGMHLADLDIAGDSLYVRRLKNGLSTMQPLHPM
ERKLLARWLQRRQSYPGAKDYDWLFLSHKGGRLSRSRIYRILKDLGERAGLSIAVHPHMLRHACGYALADKGADTRLIQD
YLGHRNIQHTVLYTASNVGRFRALWGEENVT

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=180, Percent_Identity=53.3333333333333, Blast_Score=202, Evalue=1e-53,
Organism=Escherichia coli, GI1790768, Length=185, Percent_Identity=50.8108108108108, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1790244, Length=171, Percent_Identity=30.4093567251462, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1789261, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 21972; Mature: 21972

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNVRKHLTRPEIERMLAAADSIPDPERNTCLLWMCFVHGCRVSELTGMHLADLDIAGD
CCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHCCCEEEEEECCCC
SLYVRRLKNGLSTMQPLHPMERKLLARWLQRRQSYPGAKDYDWLFLSHKGGRLSRSRIYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHH
ILKDLGERAGLSIAVHPHMLRHACGYALADKGADTRLIQDYLGHRNIQHTVLYTASNVGR
HHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCH
FRALWGEENVT
HHHHCCCCCCC
>Mature Secondary Structure
MKKNVRKHLTRPEIERMLAAADSIPDPERNTCLLWMCFVHGCRVSELTGMHLADLDIAGD
CCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHCCCEEEEEECCCC
SLYVRRLKNGLSTMQPLHPMERKLLARWLQRRQSYPGAKDYDWLFLSHKGGRLSRSRIYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHH
ILKDLGERAGLSIAVHPHMLRHACGYALADKGADTRLIQDYLGHRNIQHTVLYTASNVGR
HHHHHHHHHCCEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCH
FRALWGEENVT
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]