Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 157368426

GI number: 157368426

Start: 200658

End: 201398

Strand: Reverse

Name: hemD [H]

Synonym: Spro_0177

Alternate gene names: 157368426

Gene position: 201398-200658 (Counterclockwise)

Preceding gene: 157368427

Following gene: 157368425

Centisome position: 3.7

GC content: 58.3

Gene sequence:

>741_bases
ATGACGATTCTGGTAACCCGCCCTTCTCCTTCGGGAGAGCAATTGGTAAGCCGACTGCGTGCGCTCGGCCGGGTTGCCTA
TCATGCCCCGCTGATCGATTTCGCCCCTGGCGGCGATCTGCCCAAACTGCCGCAGGCATTGCAGCAACTCAATGATGGCG
ATTTGGTGTTTATCCTGTCGCAACATTCGGTCAGCTACGCCAACTCGGTGATGGGTCGCGTTGGGCTGCCATGGCCGGCC
AGGTTGGCCTATTATGCTATCGGCCGTAACACCGCACTGGCGATGCACCGCATCAGCAGCCTGCCGGTGGAATATCCGCG
CGAGCAGGAAATCAGCGAAACGCTGCTCCTGTTGCCGGCGTTGCAGAATCTGGACGGTAAGCAGGCATTGATCCTGCGCG
GCAACGGCGGGCGTGAGCTGCTCGGCAACAGCCTGAGTGAGCGCGGCGCCGCCGTCAGCTATTATGAATGTTATCAACGC
AGCCCGGTGCATTATGATGGCAGCGAGCAAAGCGCCCACTGGCAACGTGCCGGTGTTGATACGCTGGTAGTCACCAGCGG
TGAAATGTTACAACAGCTCTATACTTTAGTTCCTGATTACTACCGTTCATCGTGGCTGTTGCGTTGCCGCCTGGTCGTAG
TGAGTGAACGCCTGGCTACCCTCGCCCAGGAATTGGGCTGGAGCACAATTCGGGTAGCTGATAACGCCGATAATGACGCG
CTGATCCGCGCGCTACAATAA

Upstream 100 bases:

>100_bases
CAGCGCTGGCGGAACAAATGGGCATTGAGCTGGCGGAAGAGTTGCTGGCGCAGGGCGCACGCGAAATTCTACAGGATGTT
TATCAGGGAAATCCTCCGGC

Downstream 100 bases:

>100_bases
ACCTGACTATGGGATGTGCCACTATGACGGAACAAAATACCCCCTCCGCCCCGGTTGAAGAGCCAACCCCAGTGGCTGAT
AGCCCCAAGCCACCAGACGC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILSQHSVSYANSVMGRVGLPWPA
RLAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPALQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQR
SPVHYDGSEQSAHWQRAGVDTLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDA
LIRALQ

Sequences:

>Translated_246_residues
MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILSQHSVSYANSVMGRVGLPWPA
RLAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPALQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQR
SPVHYDGSEQSAHWQRAGVDTLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDA
LIRALQ
>Mature_245_residues
TILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILSQHSVSYANSVMGRVGLPWPAR
LAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPALQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQRS
PVHYDGSEQSAHWQRAGVDTLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDAL
IRALQ

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=61.3821138211382, Blast_Score=318, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27228; Mature: 27097

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILS
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCEEEEEE
QHSVSYANSVMGRVGLPWPARLAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPA
CCCHHHHHHHHHCCCCCCHHHHHEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQRSPVHYDGSEQSAHWQRAGVD
HHCCCCCEEEEEECCCCHHHHCCCHHHCCCEEHHHHHHCCCCCCCCCCCCCCHHHHCCCC
TLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDA
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
LIRALQ
HHEECC
>Mature Secondary Structure 
TILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCCCEEEEEE
QHSVSYANSVMGRVGLPWPARLAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPA
CCCHHHHHHHHHCCCCCCHHHHHEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQRSPVHYDGSEQSAHWQRAGVD
HHCCCCCEEEEEECCCCHHHHCCCHHHCCCEEHHHHHHCCCCCCCCCCCCCCHHHHCCCC
TLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDA
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHH
LIRALQ
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]