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The map label for this gene is rmlA2 [H]

Identifier: 157368415

GI number: 157368415

Start: 187911

End: 188792

Strand: Direct

Name: rmlA2 [H]

Synonym: Spro_0166

Alternate gene names: 157368415

Gene position: 187911-188792 (Clockwise)

Preceding gene: 157368414

Following gene: 157368416

Centisome position: 3.45

GC content: 53.74

Gene sequence:

>882_bases
ATGAAAGGTATTATTCTGGCGGGCGGTTCCGGCACACGCTTGCATCCGATTACCCGCGGCGTATCCAAACAGCTATTACC
TATTTACGACAAGCCGATGATTTATTATCCACTGTCAGTTTTGATGCTGGCGGGGATCCGCGACATTTTAATCATCTCTA
CCCCAGAAGATTTACCCTCGTTCAAACGCTTATTGGGCAGCGGCGAAGAGTTCGGCATTAACCTCAGTTATGCCGAACAA
CCCAGTCCTGACGGCCTGGCGCAGGCATTTTTGATTGGCGAAGAATTCCTCGCCGGCGAGCCGAGCTGCCTGGTGCTGGG
TGACAACATTTACTTTGGCCAGGGCTTTAGTCCGAAACTGAAGACGGTTGCCGCCCGTACGCAGGGCGCTACCGTGTTCG
GTTATCAGGTAATGGATCCCGAGCGCTTTGGCGTGGTGGAGTTTGATGATAATTTCCGCGCGCTGTCGATCGAAGAAAAG
CCGAAAGCGCCTAAATCCAATTGGGCGGTGACCGGGCTGTATTTCTACGACAGCCAGGTTGTGGAGTTCGCCAAACAGGT
GAAACCTTCGGAGCGCGGCGAACTGGAGATCACCAGCATTAACCAGATGTATCTGGAGCGTGGTGAACTGACGGTTGAAC
TGTTGGGGCGCGGTTTCGCCTGGCTGGATACCGGCACACATGACAGCCTGCTGGAAGCCAGCAGCTTTGTGCAGACGGTG
GAAAAACGTCAGGGCTTTAAAATTGCCTGTCTGGAAGAAATTGCCTGGCGTAACGGCTGGCTGGACGATGAGGGCGTGAA
ACGCGCCGCACAATCGTTGCTCAAAACCGGTTATGGAAAATATCTGCTGGATCTGCTGCATGCACGCCCACGCCAGTATT
GA

Upstream 100 bases:

>100_bases
CGTTCAGGACGGTTCCTATGCGGGTGAACGATTAGGTTTATCCGACTAAATTTAGCGAGGCCACCGCTTAAGCGGTAGCC
CTGTGGATTCTGGAGTGAGT

Downstream 100 bases:

>100_bases
GCCATTAGCCTGGGAAACTGAGTTTTTCGCCCTTAATAGCGCCAAACTCAACTTCTCTACGGCGGCTCCGATGCTCACTG
AGGCCGAACTGGATGGCTAC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPEDLPSFKRLLGSGEEFGINLSYAEQ
PSPDGLAQAFLIGEEFLAGEPSCLVLGDNIYFGQGFSPKLKTVAARTQGATVFGYQVMDPERFGVVEFDDNFRALSIEEK
PKAPKSNWAVTGLYFYDSQVVEFAKQVKPSERGELEITSINQMYLERGELTVELLGRGFAWLDTGTHDSLLEASSFVQTV
EKRQGFKIACLEEIAWRNGWLDDEGVKRAAQSLLKTGYGKYLLDLLHARPRQY

Sequences:

>Translated_293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPEDLPSFKRLLGSGEEFGINLSYAEQ
PSPDGLAQAFLIGEEFLAGEPSCLVLGDNIYFGQGFSPKLKTVAARTQGATVFGYQVMDPERFGVVEFDDNFRALSIEEK
PKAPKSNWAVTGLYFYDSQVVEFAKQVKPSERGELEITSINQMYLERGELTVELLGRGFAWLDTGTHDSLLEASSFVQTV
EKRQGFKIACLEEIAWRNGWLDDEGVKRAAQSLLKTGYGKYLLDLLHARPRQY
>Mature_293_residues
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPEDLPSFKRLLGSGEEFGINLSYAEQ
PSPDGLAQAFLIGEEFLAGEPSCLVLGDNIYFGQGFSPKLKTVAARTQGATVFGYQVMDPERFGVVEFDDNFRALSIEEK
PKAPKSNWAVTGLYFYDSQVVEFAKQVKPSERGELEITSINQMYLERGELTVELLGRGFAWLDTGTHDSLLEASSFVQTV
EKRQGFKIACLEEIAWRNGWLDDEGVKRAAQSLLKTGYGKYLLDLLHARPRQY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1790224, Length=293, Percent_Identity=89.419795221843, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=64.7887323943662, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI133931050, Length=240, Percent_Identity=24.5833333333333, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=254, Percent_Identity=27.5590551181102, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355443, Length=250, Percent_Identity=25.2, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644084, Length=250, Percent_Identity=25.2, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32613; Mature: 32613

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPEDLPS
CCCEEEECCCCCEECHHHHCHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHH
FKRLLGSGEEFGINLSYAEQPSPDGLAQAFLIGEEFLAGEPSCLVLGDNIYFGQGFSPKL
HHHHHCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCHH
KTVAARTQGATVFGYQVMDPERFGVVEFDDNFRALSIEEKPKAPKSNWAVTGLYFYDSQV
HHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECHHH
VEFAKQVKPSERGELEITSINQMYLERGELTVELLGRGFAWLDTGTHDSLLEASSFVQTV
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACLEEIAWRNGWLDDEGVKRAAQSLLKTGYGKYLLDLLHARPRQY
HHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKGIILAGGSGTRLHPITRGVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPEDLPS
CCCEEEECCCCCEECHHHHCHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHH
FKRLLGSGEEFGINLSYAEQPSPDGLAQAFLIGEEFLAGEPSCLVLGDNIYFGQGFSPKL
HHHHHCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCHH
KTVAARTQGATVFGYQVMDPERFGVVEFDDNFRALSIEEKPKAPKSNWAVTGLYFYDSQV
HHHHHHCCCCEEEEEEEECCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEEEEEECHHH
VEFAKQVKPSERGELEITSINQMYLERGELTVELLGRGFAWLDTGTHDSLLEASSFVQTV
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHH
EKRQGFKIACLEEIAWRNGWLDDEGVKRAAQSLLKTGYGKYLLDLLHARPRQY
HHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]